calcium glycerophosphate
1,2,3-propanetriol, 2-(dihydrogen phosphate), calcium salt (1:1)
any salt or ester of glycerophosphoric acid. Used as a food additive [EAFUS]
  • American International Chemical, LLC.
    • American International Chemical, Inc.
      Consistent sources
      North American supplier for globally sourced ingredients.
      AIC is a Framingham, MA based ISO Certified sales and marketing company serving the food, pharmaceutical, nutritional, personal care, biotech, and industrial markets of North America since 1972. Our success is a result of a company culture built on customer needs, along with partnerships with global manufacturers committed to the rigors and demands of the North American market. Our team of 30 Sales Representatives, along with our 19 strategically located warehouses are ready to supply product when and where you need it.
      Email: Info
      Voice: (800) 238-0001
      CGPAUP Calcium Glycerophosphate 19.1
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 60 years of synthesis experience and multi-purpose plants enable TCI to offer more than 27,000 products as well as custom synthesis. TCI established overseas facilities in North America, Europe, China and India to serve customers worldwide.
      Email: Sales
      US Email: Sales
      Email: Global Business
      Voice: +81-3-5640-8878
      Fax: +81-3-5640-8902
      US Voice: 800-423-8616
      US Fax: 888-520-1075
      Tokyo Tel:03-5640-8851
      Tokyo Fax:03-5640-8865
      G0095 Calcium Glycerophosphate Hydrate >95.0%(T)
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calcium 1,3-dihydroxypropan-2-yl phosphate (Click)
CAS Number: 27214-00-2Picture of molecule
ECHA EINECS - REACH Pre-Reg: 248-328-5
Nikkaji Web: J21.622D
MDL: MFCD00042643
Molecular Weight: 210.13575200
Formula: C3 H7 Ca O6 P
NMR Predictor: Predict (works with chrome or firefox)
Category: nutrient supplements
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1201 Calcium glycerophosphate (packaging) View-review
FDA Regulation:
Subpart C--Substances for Use as Components of Coatings
Sec. 175.300 Resinous and polymeric coatings.

Subpart B--Specific Prior-Sanctioned Food Ingredients
Sec. 181.29 Stabilizers.

Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1201 Calcium glycerophosphate.
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 487.00 to  489.00 °C. @ 760.00 mm Hg
Flash Point: 480.00 °F. TCC ( 248.89 °C. )
logP (o/w): -2.408 (est)
Soluble in:
 water, 2.00E+04 mg/L @ 25 °C (exp)
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Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antiplaque agents
oral care agents
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American Elements
Calcium Glycerophosphate 99%
Odor: characteristic
Use: Calcium Glycerophosphate is one of numerous organo-metallic compounds sold by American Elements under the tradename AE Organo-Metallics™ for uses requiring non-aqueous solubility such as recent solar energy and water treatment applications. Calcium Glycerophosphate is generally immediately available in most volumes, including bulk quantities. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
American International Chemical, LLC.
Calcium Glycerophosphate 19.1
BOC Sciences
For experimental / research use only.
Calcium Glycerophosphate > 95%
Odor: characteristic
Use: Calcium Glycerophosphate is a mineral supplement used to neutralize acidic foods when consumed and to protect teeth.
For experimental / research use only.
Calcium Glycerophosphate
Global Calcium
Calcium Glycerophosphate EP
Penta International
Sarchem Laboratories
For experimental / research use only.
Calcium Glycerophosphate
For experimental / research use only.
Calcium Glycerophosphate Hydrate >95.0%(T)
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Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: nutrient supplements
Recommendation for calcium glycerophosphate usage levels up to:
 not for fragrance use.
Recommendation for calcium glycerophosphate flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 27214-00-2
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 62820
National Institute of Allergy and Infectious Diseases: Data
 calcium 1,3-dihydroxypropan-2-yl phosphate
Chemidplus: 0027214002
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 calcium 1,3-dihydroxypropan-2-yl phosphate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 27214-00-2
Pubchem (cid): 62820
Pubchem (sid): 135260102
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
KEGG (GenomeNet): C12935
HMDB (The Human Metabolome Database): Search
FooDB: FDB009054
Export Tariff Code: 2919.90.5050
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
None Found
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Potential Uses:
 oral care agents 
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Occurrence (nature, food, other): note
 not found in nature
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 calcium 1,3-dihydroxypropan-2-yl phosphate
 calcium glycerino-phosphoricum
 calcium glycerophosphoricum
1,2,3-propanetriol, 2-(dihydrogen phosphate), calcium salt (1:1)
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PubMed: In situ evaluation of low-fluoride toothpastes associated to calcium glycerophosphate on enamel remineralization.
PubMed: Longitudinal evaluation of fluoride levels in nails of 18-30-month-old children that were using toothpastes with 500 and 1100 μg F/g.
PubMed: Incorporation of Ca and P on anodized titanium surface: Effect of high current density.
PubMed: The effects of low-fluoride toothpaste supplemented with calcium glycerophosphate on enamel demineralization.
PubMed: Effect of low-fluoride dentifrices supplemented with calcium glycerophosphate on enamel demineralization in situ.
PubMed: Magnesium-enhanced enzymatically mineralized platelet-rich fibrin for bone regeneration applications.
PubMed: In vitro and in vivo enzyme-mediated biomineralization of oligo(poly(ethylene glycol) fumarate hydrogels.
PubMed: Acceleration of gelation and promotion of mineralization of chitosan hydrogels by alkaline phosphatase.
PubMed: Grape seed extract as a potential remineralizing agent: a comparative in vitro study.
PubMed: Calcium glycerophosphate supplemented to soft drinks reduces bovine enamel erosion.
PubMed: Enzymatically induced mineralization of platelet-rich fibrin.
PubMed: Comparative efficacy of dentifrice containing sodium monofluorophosphate + calcium glycerophosphate and non-fluoridated dentifrice: A randomized, double-blind, prospective study.
PubMed: An RCT on the effects of topical CGP on surgical wound appearance and residual scarring in bilateral total-knee arthroplasty patients.
PubMed: Diet and its role in interstitial cystitis/bladder pain syndrome (IC/BPS) and comorbid conditions.
PubMed: An electron microscopical study on the growth of TiO2-Ag antibacterial coatings on Ti6Al7Nb biomedical alloy.
PubMed: Dietary consumption triggers in interstitial cystitis/bladder pain syndrome patients.
PubMed: Effect of a calcium glycerophosphate fluoride dentifrice formulation on enamel demineralization in situ.
PubMed: [Technology of production and biological activity of toothpaste from Rubus idaeus].
PubMed: In vitro antibacterial activity of porous TiO2-Ag composite layers against methicillin-resistant Staphylococcus aureus.
PubMed: Comparison of the remineralizing effect of a sodium fluoride mouthrinse versus a sodium monofluorophosphate and calcium mouthrinse: an in vitro study.
PubMed: Rats fed the dietary supplement vitamix® (ceregumil® with vitamins) show greater physical resistance and antioxidant capacity.
PubMed: Patient perceived outcomes of treatments used for interstitial cystitis.
PubMed: Determination of calcium salt solubility with changes in pH and P(CO(2)), simulating varying gastrointestinal environments.
PubMed: Complementary and alternative therapies as treatment approaches for interstitial cystitis.
PubMed: [Effects of voltage during anodization on titanium surface on cell attachment and spreading of osteoblasts].
PubMed: [Effect of cultivation conditions of Bacillus subtilis IMV B-7023 on surface properties of cells].
PubMed: Effect of calcium glycerophosphate on demineralization in an in vitro biofilm model.
PubMed: The effect of calcium salts, ascorbic acid and peptic pH on calcium, zinc and iron bioavailabilities from fortified human milk using an in vitro digestion/Caco-2 cell model.
PubMed: Cellular reactions of osteoblasts to micron- and submicron-scale porous structures of titanium surfaces.
PubMed: Calcium glycerophosphate and caries: a review of the literature.
PubMed: Antiplaque and antigingivitis efficacy of toothpastes containing Triclosan and fluoride.
PubMed: Effects of topography and composition of titanium surface oxides on osteoblast responses.
PubMed: In vitro osteoblast response to anodized titanium and anodized titanium followed by hydrothermal treatment.
PubMed: A randomised controlled trial of the efficacy of supervised toothbrushing in high-caries-risk children.
PubMed: Expression of alkaline phosphatase induces rapid and artificial mineralization in specific transformed Escherichia coli.
PubMed: Calcium L-edge XANES study of some calcium compounds.
PubMed: Anodic oxide films containing Ca and P of titanium biomaterial.
PubMed: The efficacy of calcium glycerophosphate in the prevention of food-related flares in interstitial cystitis.
PubMed: A fortifier comprising protein, vitamins, and calcium-glycerophosphate for preterm human milk.
PubMed: Structure and chemical composition of an experimentally formed apical barrier after the application of calcium-glycerophosphate.
PubMed: Randomized trial of calcium glycerophosphate-supplemented infant formula to prevent lead absorption.
PubMed: Moderate nutrient supplementation of mother's milk for preterm infants supports adequate bone mass and short-term growth: a randomized, controlled trial.
PubMed: Effects of iron salts in sucrose on dental caries and plaque in rats.
PubMed: Calcium and phosphorus supplementation of iron-fortified infant formula: no effect on iron status of healthy full-term infants.
PubMed: Non-fluoride anticaries agents.
PubMed: Normal values for random urinary calcium to creatinine ratios in infancy.
PubMed: Calcium binding to phospholipid: structural study of calcium glycerophosphate.
PubMed: [Assessment of apples treated with calcium glycerophosphate and desoxon].
PubMed: Efficacy of calcium glycerophosphate vs conventional mineral salts for total parenteral nutrition in low-birth-weight infants: a randomized clinical trial.
PubMed: Calcium glycerophosphate as a source of calcium and phosphorus in total parenteral nutrition solutions.
PubMed: Fluoride, calcium and inorganic phosphorus concentrations in approximal plaque collected from young adults 1 and 24 h after toothbrushing with fluoride toothpastes.
PubMed: [The effect of calcium glycerophosphate and Remodent on the dental enamel permeability in dogs with fluorosis].
PubMed: In vitro solubility of calcium glycerophosphate versus conventional mineral salts in pediatric parenteral nutrition solutions.
PubMed: Effect of brushing with fluoride toothpastes on the fluoride, calcium, and inorganic phosphorus concentrations in approximal plaque of young adults.
PubMed: A four-year clinical study to determine the caries-inhibiting effect of calcium glycerophosphate and sodium fluoride in calcium carbonate base dentifrices containing sodium monofluorophosphate.
PubMed: [Experience in treating adolescents with hypogonadism].
PubMed: Effects on caries in rats of calcium glycerophosphate and sodium fluoride administered separately and together.
PubMed: The effect of mouthrinse containing calcium glycerophosphate on the chemical composition and development of plaque in humans.
PubMed: A 3-year clinical trial of calcium carbonate dentifrice containing calcium glycerophosphate and sodium monofluorophosphate.
PubMed: Increased plaque calcium and phosphorus concentrations after using a calcium carbonate toothpaste containing calcium glycerophosphate and sodium monofluorophosphate. Pilot study.
PubMed: Dental caries in laboratory rats from breakfast cereals and its control by a calcium glycerophosphate additive.
PubMed: Effects of calcium glycerophosphate and sodium fluoride on the induction in vivo of caries-like changes in human dental enamel.
PubMed: The effect of calcium on lead absorption in rats.
PubMed: Dissolution of two commercial preparations of calcium glycerophosphate in human saliva.
PubMed: Cariostatic activity of calcium glycerophosphate in hamsters: topical vs dietary administration.
PubMed: [Enhancing the solubility of calcium glycerophosphate by using mixtures of calcium gluconate and boric acid in various molar proportions for the preparation of injectable solutions for veterinary use].
PubMed: Calcium glycerophosphate and dental plaque. Clinical pilot study.
PubMed: The cariostatic effect of calcium glycerophosphate in monkeys.
PubMed: The cariostatic effect of calcium glycerophosphate in monkeys (M. irus).
PubMed: The Effects of Calcium Glycerophosphate, Sodium Glycerophosphate and Sodium Dihydrogen Phosphate upon the Skeleton of Rats kept on a Diet Deficient only in Fat-soluble Factor.
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