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Category:chelating agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 1190.70 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 1245.00 °F. TCC ( 673.90 °C. ) (est)
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| logP (o/w): | -8.465 (est) |
| Soluble in: |
| | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-guinea pig LDLo 400 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
intraperitoneal-mouse LD50 83 mg/kg
Pharmaceutical Sciences. Vol. 1, Pg. 311, 1995.
intravenous-rabbit LDLo 23 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
intraperitoneal-rat LD50 195 mg/kg
French Demande Patent Document. Vol. #2515042
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| Dermal Toxicity: |
subcutaneous-guinea pig LDLo 4000 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
subcutaneous-rabbit LDLo 1400 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | chelating agents |
| Recommendation for sodium phytate usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for sodium phytate flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | sodium;(2,3,4,5,6-pentaphosphonooxycyclohexyl) hydrogen phosphate |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 23675791 |
| Pubchem (sid): | 134989649 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | hexakis(dihydrogen phosphate) myo-inositol sodium salt (9CI) | | | inositol, hexakis(dihydrogen phosphate) sodium salt, myo- | | | myo-inositol hexakis(dihydrogen phosphate) sodium salt | | | myo-inositol, hexakis(dihydrogen phosphate), sodium salt | | | phytic acid sodium salt | | | sodium (2,3,4,5,6-pentaphosphonooxycyclohexyl) hydrogen phosphate | | | sodium inositol hexaphosphate | | | sodium;(2,3,4,5,6-pentaphosphonooxycyclohexyl) hydrogen phosphate |
Articles:
| PubMed:Enhancement of Thermostability and Kinetic Efficiency of Aspergillus niger PhyA Phytase by Site-Directed Mutagenesis. |
| PubMed:Characterization, gene cloning, and sequencing of a fungal phytase, PhyA, from Penicillium oxalicum PJ3. |
| PubMed:[The novel intracellular phytase of enterobacteriaceae: isolation and properties]. |
| PubMed:Influence of Annona muricata (soursop) on biodistribution of radiopharmaceuticals in rats. |
| PubMed:Partitioning of soil phosphorus regulates competition between Vaccinium vitis-idaea and Deschampsia cespitosa. |
| PubMed:Influence of dietary calcium level, calcium source, and phytase on bird performance and mineral digestibility during a natural necrotic enteritis episode. |
| PubMed:Purification and characterization of a thermostable extracellular phytase from Bacillus licheniformis PFBL-03. |
| PubMed:Purification and characterization of a novel neutral and heat-tolerant phytase from a newly isolated strain Bacillus nealsonii ZJ0702. |
| PubMed:Site-directed mutagenesis improves the thermostability and catalytic efficiency of Aspergillus niger N25 phytase mutated by I44E and T252R. |
| PubMed:The effects of phytic acid on the Maillard reaction and the formation of acrylamide. |
| PubMed:Isolation and identification of phytate-degrading rhizobacteria with activity of improving growth of poplar and Masson pine. |
| PubMed:A phytase characterized by relatively high pH tolerance and thermostability from the shiitake mushroom Lentinus edodes. |
| PubMed:Dual effects of sodium phytate on the structural stability and solubility of proteins. |
| PubMed:Purification, characterization and properties of phytase from Shigella sp. CD2. |
| PubMed:Degradation of Phytate Pentamagnesium Salt by Bacillus sp. T4 Phytase as a Potential Eco-friendly Feed Additive. |
| PubMed:Effects of inositol, inositol-generating phytase B applied alone, and in combination with 6-phytase A to phosphorus-deficient diets on laying performance, eggshell quality, yolk cholesterol, and fatty acid deposition in laying hens. |
| PubMed:Improvement of Phytase Activity by a New Saccharomyces cerevisiae Strain Using Statistical Optimization. |
| PubMed:Phytate-degrading Pediococcus pentosaceus CFR R123 for application in functional foods. |
| PubMed:Thermostable alkaline phytase from Bacillus sp. MD2: effect of divalent metals on activity and stability. |
| PubMed:A Thermostable phytase from Neosartorya spinosa BCC 41923 and its expression in Pichia pastoris. |
| PubMed:Microbial phytases in phosphorus acquisition and plant growth promotion. |
| PubMed:Purification and characterization of two distinct acidic phytases with broad pH stability from Aspergillus niger NCIM 563. |
| PubMed:Efficacy of different commercial phytase enzymes and development of an available phosphorus release curve for Escherichia coli-derived phytases in nursery pigs. |
| PubMed:High level expression of an acid-stable phytase from Citrobacter freundii in Pichia pastoris. |
| PubMed:Semi-rational site-directed mutagenesis of phyI1s from Aspergillus niger 113 at two residue to improve its phytase activity. |
| PubMed:Daily rhythms of locomotor activity, feeding behavior and dietary selection in Nile tilapia (Oreochromis niloticus). |
| PubMed:Effect of dietary sodium phytate and microbial phytase on the lipase activity and lipid metabolism of broiler chickens. |
| PubMed:Purification and characterisation of an extracellular phytase from Aspergillus niger 11T53A9. |
| PubMed:Effect of phytase on apparent total tract digestibility of phosphorus in corn-soybean meal diets fed to finishing pigs. |
| PubMed:A new method for gene synthesis and its high-level expression. |
| PubMed:Cloning and characterization of a novel phytase from wastewater treatment yeast Hansenula fabianii J640 and expression in Pichia pastoris. |
| PubMed:Identification, characterization, and overexpression of a phytase with potential industrial interest. |
| PubMed:Screening, selection and characterization of phytic acid degrading lactic acid bacteria from chicken intestine. |
| PubMed:Long-term marginal zinc supply is not detrimental to the skeleton of aged female rats. |
| PubMed:Ileal digestibility and endogenous flow of minerals and amino acids: responses to dietary phytic acid in piglets. |
| PubMed:A novel beta-propeller phytase from Pedobacter nyackensis MJ11 CGMCC 2503 with potential as an aquatic feed additive. |
| PubMed:Characterization of a HAP-phytase from a thermophilic mould Sporotrichum thermophile. |
| PubMed:Effects of low-phytic acid corn, low-phytic acid soybean meal, and phytase on nutrient digestibility and excretion in growing pigs. |
| PubMed:Dietary phytate (inositol hexaphosphate) regulates the activity of intestinal mucosa phytase. |
| PubMed:Gene cloning, expression, and characterization of a novel phytase from Dickeya paradisiaca. |
| PubMed:Simultaneous degradation of phytic acid and starch by an industrial strain of Saccharomyces cerevisiae producing phytase and alpha-amylase. |
| PubMed:Phytase from antarctic yeast strain Cryptococcus laurentii AL27. |
| PubMed:Cloning and expression of Bacillus phytase gene (phy) in Escherichia coli and recovery of active enzyme from the inclusion bodies. |
| PubMed:Complete hydrolysis of myo-inositol hexakisphosphate by a novel phytase from Debaryomyces castellii CBS 2923. |
| PubMed:Screening, cloning and overexpression of Aspergillus niger phytase (phyA) in Pichia pastoris with favourable characteristics. |
| PubMed:Evaluation of hepatobiliary excretion and enterobiliary reflux in rats with biliary obstruction submitted to bilioduodenal or biliojejunal anastomosis. |
| PubMed:Production, purification and characterization of thermostable phytase from thermophilic fungus Thermomyces lanuginosus TL-7. |
| PubMed:A novel phytase appA from Citrobacter amalonaticus CGMCC 1696: gene cloning and overexpression in Pichia pastoris. |
| PubMed:Cloning, expression, and enzyme characterization of an acid heat-stable phytase from Aspergillus fumigatus WY-2. |
| PubMed:Purification and characterization of a bacterial phytase whose properties make it exceptionally useful as a feed supplement. |
| PubMed:Aspergillus niger pH 2.1 optimum acid phosphatase with high affinity for phytate. |
| PubMed:Improved phytase production by a thermophilic mould Sporotrichum thermophile in submerged fermentation due to statistical optimization. |
| PubMed:The isolated gamma probe technique for sentinel node penile carcinoma detection is unreliable. |
| PubMed:[Overexpression of Citrobacter braakii phytase with high specific activity in Pichia pastoris]. |
| PubMed:Supplementation effect of ectoine on thermostability of phytase. |
| PubMed:Comparative analysis of influence of promoters and inhibitors on in vitro available iron using two methods. |
| PubMed:A novel phytase with preferable characteristics from Yersinia intermedia. |
| PubMed:Production and characterization of thermostable alkaline phytase from Bacillus laevolacticus isolated from rhizosphere soil. |
| PubMed:Bioavailability of zinc glycinate in comparison with zinc sulphate in the presence of dietary phytate in an animal model with Zn labelled rats. |
| PubMed:Absorption of zinc and retention of calcium: dose-dependent inhibition by phytate. |
| PubMed:Effects of copper source and concentration on in vitro phytate phosphorus hydrolysis by phytase. |
| PubMed:Influence of an Escherichia coli-derived phytase on nutrient utilization in broiler starters fed diets containing varying concentrations of phytic acid. |
| PubMed:Biodistribution and localization of iodine-131-labeled metuximab in patients with hepatocellular carcinoma. |
| PubMed:Effect of sodium phytate supplementation on fat digestion and cholesterol metabolism in female rats. |
| PubMed:Effects of dietary zinc levels, phytic acid and resistant starch on zinc bioavailability in rats. |
| PubMed:Phosphatases of ericoid mycorrhizal fungi: kinetic properties and the effect of copper on activity. |
| PubMed:Expression of Escherichia coli AppA2 phytase in four yeast systems. |
| PubMed:Methodological aspects of measuring phytase activity and phytate phosphorus content in selected cereal grains and digesta and feces of pigs. |
| PubMed:Purification and properties of a phytate-degrading enzyme from Pantoea agglomerans. |
| PubMed:Characterization of an acid phosphatase from Lactobacillus pentosus: regulation and biochemical properties. |
| PubMed:The efficacy of an Escherichia coli-derived phytase preparation. |
| PubMed:[Effect of sodium phytate on alkaline phosphatase (ALP) activity in intraradical hyphae of AM fungi and development of its extraradical hyphae]. |
| PubMed:Gene cloning, expression and characterization of novel phytase from Obesumbacterium proteus. |
| PubMed:Pharmacological zinc levels reduce the phosphorus-releasing efficacy of phytase in young pigs and chickens. |
| PubMed:Effect of dietary level of phytic acid on hepatic and serum lipid status in rats fed a high-sucrose diet. |
| PubMed:Effect of phytate on element bioavailability in the second generation of rats. |
| PubMed:Application of radionuclide imaging to hepatic impact injury in rabbits. |
| PubMed:Molecular and physiological characterisation of a 3-phytase from soil bacterium Klebsiella sp. ASR1. |
| PubMed:Purification and characterization of a phytase from Pseudomonas syringae MOK1. |
| PubMed:Isolation and characterization of a phytase with improved properties from Citrobacter braakii. |
| PubMed:In situ treatment of metals in contaminated soils with phytate. |
| PubMed:Purification and characterization of three phytases from germinated lupine seeds (Lupinus albus var. amiga). |
| PubMed:Culture conditions influencing phytase production of Mitsuokella jalaludinii, a new bacterial species from the rumen of cattle. |
| PubMed:Complex formation between phytic acid and divalent metal ions: a solution equilibria and solid state investigation. |
| PubMed:Purification and properties of extracellular phytase from Bacillus sp. KHU-10. |
| PubMed:Utilisation of phytate phosphorus by rumen bacteria in a semi-continuous culture system (Rusitec) in lactating goats fed on different forage to concentrate ratios. |
| PubMed:Ingestion of insoluble dietary fibre increased zinc and iron absorption and restored growth rate and zinc absorption suppressed by dietary phytate in rats. |
| PubMed:Purification and characterization of a phytate-degrading enzyme from germinated faba beans (Vicia faba Var. Alameda). |
| PubMed:Site-directed mutagenesis improves catalytic efficiency and thermostability of Escherichia coli pH 2.5 acid phosphatase/phytase expressed in Pichia pastoris. |
| PubMed:Inhibitory effect of wheat fibre extract on calcium absorption in Caco-2 cells: evidence for a role of associated phytate rather than fibre per se. |
| PubMed:Expression of the Aspergillus fumigatus phytase gene in Pichia pastoris and characterization of the recombinant enzyme. |
| PubMed:Supplemental sodium phytate and microbial phytase influence iron availability in growing rats. |
| PubMed:Quantification of inositol phosphates using (31)P nuclear magnetic resonance spectroscopy in animal nutrition. |
| PubMed:A novel staining method for detecting phytase activity. |
| PubMed:Inositol phosphates with different numbers of phosphate groups influence iron absorption in humans. |
| PubMed:Dietary intrinsic phytate protects colon from lipid peroxidation in pigs with a moderately high dietary iron intake. |
| PubMed:Cloning, sequencing, and expression of an Escherichia coli acid phosphatase/phytase gene (appA2) isolated from pig colon. |
| PubMed:Effect of dietary phytate on magnesium bioavailability and liver oxidant status in growing rats. |
| PubMed:Effect of sodium phytate, sodium pyrophosphate and sodium tripolyphosphate on physico-chemical characteristics of restructured beef. |
| PubMed:Fermentation of soybean meal with Aspergillus usamii improves zinc availability in rats. |
| PubMed:1alpha-hydroxycholecalciferol does not increase the specific activity of intestinal phytase but does improve phosphorus utilization in both cecectomized and sham-operated chicks fed cholecalciferol-adequate diets. |
| PubMed:Acetobacter cellulosic biofilms search for new modulators of cellulogenesis and native membrane treatments. |
| PubMed:Cadmium accumulation, zinc status, and mineral bioavailability of growing rats fed diets high in zinc with increasing amounts of phytic acid. |
| PubMed:Colon tumor promotion: is it a selective process? Effects of cholate, phytate, and food restriction in rats on proliferation and apoptosis in normal and aberrant crypts. |
| PubMed:Replacement of inorganic phosphorus by microbial phytase for young pigs fed on a maize-soyabean-meal diet. |
| PubMed:The influence of different protein sources on phytate inhibition of nonheme-iron absorption in humans. |
| PubMed:Degradation of stachyose, raffinose, melibiose and sucrose by different tempe-producing Rhizopus fungi. |
| PubMed:Effect of dietary sodium phytate on the hepatic and serum levels of lipids and on the hepatic activities of NADPH-generating enzymes in rats fed on sucrose. |
| PubMed:Utilization of water hyacinth cellulose for production of cellobiase-rich preparation by Aspergillus niger 1. |
| PubMed:Simple and rapid determination of phytase activity. |
| PubMed:Absorption and accumulation of cadmium, lead and mercury from foods by rats. |
| PubMed:Gastric acid production, iron status and dietary phytate alter enhancement by meat of iron absorption in rats. |
| PubMed:Kinetics and thermodynamics of the mechanism of interaction of sodium phytate with alpha-globulin. |
| PubMed:The role of acid phosphatase activity during enzymic dephosphorylation of phytates byAspergillus niger phytase. |
| PubMed:Inhibitory effect of soybean protein vs. casein on apparent absorption of magnesium in rats is due to greater excretion of endogenous magnesium. |
| PubMed:Aberrant crypts correlate with tumor incidence in F344 rats treated with azoxymethane and phytate. |
| PubMed:[Idiopathic hypercalciuria and bone density]. |
| PubMed:Inhibitory effect of dietary soybean protein vs. casein on magnesium absorption in rats. |
| PubMed:Determination of phytic acid in cereals using ICP-AES to determine phosphorus. |
| PubMed:Inhibitory effects of phytic acid and other inositol phosphates on zinc and calcium absorption in suckling rats. |
| PubMed:Iron absorption in man: ascorbic acid and dose-dependent inhibition by phytate. |
| PubMed:Enhancement of Cu bioavailability in the rat by phytic acid. |
| PubMed:Preparation of inositol phosphates from sodium phytate by enzymatic and nonenzymatic hydrolysis. |
| PubMed:Inactivation of metalloenzymes by food constituents. |
| PubMed:Inactivation of metalloenzymes by lysinoalanine, phenylethylaminoalanine, alkali-treated food proteins, and sulfur amino acids. |
| PubMed:Effect of phytate on aflatoxin formation by Aspergillus parasiticus grown on different grains. |
| PubMed:A stable isotope study of copper absorption in young men: effect of phytate and alpha-cellulose. |
| PubMed:Influence of dietary calcium, phosphorus, zinc and sodium phytate level on cataract incidence, growth and histopathology in juvenile chinook salmon (Oncorhynchus tshawytscha). |
| PubMed:Studies of the chemical and biological properties of the liver-imaging agent 99mTc-phytate. |
| PubMed:Zinc utilization in the chick as influenced by dietary concentrations of calcium and phytate and by Eimeria acervulina infection. |
| PubMed:Possible mechanism behind the adjuvant action of phosphate derivatives on rectal absorption of cefoxitin in rats and dogs. |
| PubMed:A stable isotope study of zinc absorption in young men: effects of phytate and alpha-cellulose. |
| PubMed:Effects of dietary phytate, calcium and magnesium levels on zinc bioavailability to rats. |
| PubMed:[Relative evaluation of arterial and portal perfusion of the liver during scintigraphy using technetium 99m sodium phytate]. |
| PubMed:A model to produce pure zinc deficiency in rats and its use to demonstrate that dietary phytate increases the excretion of endogenous zinc. |
| PubMed:Factors affecting the absorption of iron from cereals. |
| PubMed:The effect of phytic acid on in vitro rate of starch digestibility and blood glucose response. |
| PubMed:Production of aflatoxins on soybean and cottonseed meals. |
| PubMed:The effects of breads containing similar amounts of phytate but different amounts of wheat bran on calcium, zinc and iron balance in man. |
| PubMed:Availability to rats of zinc from soybean seeds as affected by maturity of seed, source of dietary protein, and soluble phytate. |
| PubMed:Effect of phytic acid on the absorption, distribution, and endogenous excretion of zinc in rats. |
| PubMed:Feed digestibility and mineral balance of the diet of young mice kept in mouse cages inside or outside an isolator, using varied concentrations of sodium phytate. |
| PubMed:Heterogeneous nature of alkaline phosphatase from rat liver. |
| PubMed:Effects of sodium phytate and benzethonium chloride rinses on plaque formation in humans. |
| PubMed:Comparative measurement of zinc absorption in rats with stable isotope 70Zn and radioisotope 65Zn. |
| PubMed:Effect of phytate:zinc molar ratio and isolated soybean protein on zinc bioavailability. |
| PubMed:Iron availability and absorption in rats fed sodium phytate. |
| PubMed:Technetium-99m calcium phytate--optimization of calcium content for liver and spleen scintigraphy: concise communication. |
| PubMed:[In vitro proteolysis of casein and gluten by pancreatic enzymes]. |
| PubMed:Studies on the phytate: zinc molar contents in diets as a determinant of Zn availability to young rats. |
| PubMed:Effect of animal proteins on the absorption of food iron in man. |
| PubMed:Isolation of monoferric phytate from wheat bran and its biological value as an iron source to the rat. |
| PubMed:Effect of sodium phytate on the chemical and microbial composition of dental plaque in the monkey (Macaca fascicularis) |
| PubMed:Tests of sodium phytate as a protective agent against dental caries in the rat. |
| PubMed:Enzymes associated with protein bodies isolated from ungerminated barley seeds. |
| PubMed:[Changes in the serum calcium and the serum phosphorus in persons with uremia and in normal persons after administration of sodium phytate- and aluminum hydroxide]. |
| PubMed:The effect of sodium phytate on the urinary excretion of calcium in patients immobilized by poliomyelitis. |
| PubMed:[The sodium phytate test in the aged]. |
| PubMed:[The sodium phytate test in aged persons]. |
| PubMed:APPARENT DEPRESSION IN THE ABSORPTION OF STRYCHNINE, ALCOHOL AND SULPHANILAMIDE AFTER ORAL ADMINISTRATION OF SODIUM FLUORIDE, SODIUM OXALATE, TETRACEMIN AND SODIUM PHYTATE. |
| PubMed:[HYPERCALCEMIA TREATED WITH SODIUM PHYTATE]. |
| PubMed:CARIOSTATIC EFFECT OF PHOSPHATES. |
| PubMed:HYPERCALCAEMIA TREATED WITH SODIUM PHYTATE. |
| PubMed:[Diagnosis of osteopathies by the sodium phytate test]. |
| PubMed:Calcium deprivation in hypoparathyroidism. A method of diagnosis using sodium phytate. |
| PubMed:[The respective role of the kidney, intestine and bone in osteomalacias with hypophosphoremia and vitamin resistance: treatment with the combination of massive vitamin therapy and sodium phytate]. |
| PubMed:Dissolution of experimentally induced vesical calculi in rats by sodium phytate and sodium neutral phosphate treatment. |
| PubMed:Abnormalities of calcium metabolism in patients with idiopathic urinary calculi; effect of oral administration of sodium phytate. |
| PubMed:Effect of sodium phytate on the hypercalciuria of acute quadriplegia due to poliomyelitis; preliminary report. |
| PubMed:The cause of hypercalcuria in sarcoid and its treatment with cortisone and sodium phytate. |
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3D/inchi