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sodium phytate
hexakis(dihydrogen phosphate) myo-inositol sodium salt (9CI)


Name:sodium;(2,3,4,5,6-pentaphosphonooxycyclohexyl) hydrogen phosphate
CAS Number: 14306-25-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:238-242-6
Molecular Weight:682.01463128
Formula:C6 H17 Na O24 P6
NMR Predictor:Predict (works with chrome or firefox)
Category:chelating agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point:1190.70 °C. @ 760.00 mm Hg (est)
Flash Point:1245.00 °F. TCC ( 673.90 °C. ) (est)
logP (o/w): -8.465 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: chelating agents
oral care agents
BOC Sciences
For experimental / research use only.
Phytic acid sodium salt hydrate >98%
Odor: characteristic
Use: Phytic acid sodium salt is present in all eukaryotic cells. In plants, it is known to function as a [PO4]3- storage depot and precursor for other inositol phosphates and pyrophosphates. It has a high surface negative charge which makes it a potent chelat nutritional supplement
Jiangyin Healthway
Sodium Phytate
New functional food ingredients
Matrix Scientific
For experimental / research use only.
Sodium phytate, 85%
Santa Cruz Biotechnology
For experimental / research use only.
Phytic acid sodium salt ≥80%
Sigma-Aldrich: Sigma
For experimental / research use only.
Phytic acid sodium salt hydrate from rice
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-guinea pig LDLo 400 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.

intraperitoneal-mouse LD50 83 mg/kg
Pharmaceutical Sciences. Vol. 1, Pg. 311, 1995.

intravenous-rabbit LDLo 23 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.

intraperitoneal-rat LD50 195 mg/kg
French Demande Patent Document. Vol. #2515042

Dermal Toxicity:
subcutaneous-guinea pig LDLo 4000 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.

subcutaneous-rabbit LDLo 1400 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.

Inhalation Toxicity:
Not determined
Safety in Use Information:
Category: chelating agents
Recommendation for sodium phytate usage levels up to:
 not for fragrance use.
Recommendation for sodium phytate flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :23675791
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
sodium;(2,3,4,5,6-pentaphosphonooxycyclohexyl) hydrogen phosphate
 sodium;(2,3,4,5,6-pentaphosphonooxycyclohexyl) hydrogen phosphate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):23675791
Pubchem (sid):134989649
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
RSC Learn Chemistry:View
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
 hexakis(dihydrogen phosphate) myo-inositol sodium salt (9CI)
 inositol, hexakis(dihydrogen phosphate) sodium salt, myo-
 myo-inositol hexakis(dihydrogen phosphate) sodium salt
 myo-inositol, hexakis(dihydrogen phosphate), sodium salt
 phytic acid sodium salt
 sodium (2,3,4,5,6-pentaphosphonooxycyclohexyl) hydrogen phosphate
 sodium inositol hexaphosphate
 sodium;(2,3,4,5,6-pentaphosphonooxycyclohexyl) hydrogen phosphate


PubMed:Enhancement of Thermostability and Kinetic Efficiency of Aspergillus niger PhyA Phytase by Site-Directed Mutagenesis.
PubMed:Characterization, gene cloning, and sequencing of a fungal phytase, PhyA, from Penicillium oxalicum PJ3.
PubMed:[The novel intracellular phytase of enterobacteriaceae: isolation and properties].
PubMed:Influence of Annona muricata (soursop) on biodistribution of radiopharmaceuticals in rats.
PubMed:Partitioning of soil phosphorus regulates competition between Vaccinium vitis-idaea and Deschampsia cespitosa.
PubMed:Influence of dietary calcium level, calcium source, and phytase on bird performance and mineral digestibility during a natural necrotic enteritis episode.
PubMed:Purification and characterization of a thermostable extracellular phytase from Bacillus licheniformis PFBL-03.
PubMed:Purification and characterization of a novel neutral and heat-tolerant phytase from a newly isolated strain Bacillus nealsonii ZJ0702.
PubMed:Site-directed mutagenesis improves the thermostability and catalytic efficiency of Aspergillus niger N25 phytase mutated by I44E and T252R.
PubMed:The effects of phytic acid on the Maillard reaction and the formation of acrylamide.
PubMed:Isolation and identification of phytate-degrading rhizobacteria with activity of improving growth of poplar and Masson pine.
PubMed:A phytase characterized by relatively high pH tolerance and thermostability from the shiitake mushroom Lentinus edodes.
PubMed:Dual effects of sodium phytate on the structural stability and solubility of proteins.
PubMed:Purification, characterization and properties of phytase from Shigella sp. CD2.
PubMed:Degradation of Phytate Pentamagnesium Salt by Bacillus sp. T4 Phytase as a Potential Eco-friendly Feed Additive.
PubMed:Effects of inositol, inositol-generating phytase B applied alone, and in combination with 6-phytase A to phosphorus-deficient diets on laying performance, eggshell quality, yolk cholesterol, and fatty acid deposition in laying hens.
PubMed:Improvement of Phytase Activity by a New Saccharomyces cerevisiae Strain Using Statistical Optimization.
PubMed:Phytate-degrading Pediococcus pentosaceus CFR R123 for application in functional foods.
PubMed:Thermostable alkaline phytase from Bacillus sp. MD2: effect of divalent metals on activity and stability.
PubMed:A Thermostable phytase from Neosartorya spinosa BCC 41923 and its expression in Pichia pastoris.
PubMed:Microbial phytases in phosphorus acquisition and plant growth promotion.
PubMed:Purification and characterization of two distinct acidic phytases with broad pH stability from Aspergillus niger NCIM 563.
PubMed:Efficacy of different commercial phytase enzymes and development of an available phosphorus release curve for Escherichia coli-derived phytases in nursery pigs.
PubMed:High level expression of an acid-stable phytase from Citrobacter freundii in Pichia pastoris.
PubMed:Semi-rational site-directed mutagenesis of phyI1s from Aspergillus niger 113 at two residue to improve its phytase activity.
PubMed:Daily rhythms of locomotor activity, feeding behavior and dietary selection in Nile tilapia (Oreochromis niloticus).
PubMed:Effect of dietary sodium phytate and microbial phytase on the lipase activity and lipid metabolism of broiler chickens.
PubMed:Purification and characterisation of an extracellular phytase from Aspergillus niger 11T53A9.
PubMed:Effect of phytase on apparent total tract digestibility of phosphorus in corn-soybean meal diets fed to finishing pigs.
PubMed:A new method for gene synthesis and its high-level expression.
PubMed:Cloning and characterization of a novel phytase from wastewater treatment yeast Hansenula fabianii J640 and expression in Pichia pastoris.
PubMed:Identification, characterization, and overexpression of a phytase with potential industrial interest.
PubMed:Screening, selection and characterization of phytic acid degrading lactic acid bacteria from chicken intestine.
PubMed:Long-term marginal zinc supply is not detrimental to the skeleton of aged female rats.
PubMed:Ileal digestibility and endogenous flow of minerals and amino acids: responses to dietary phytic acid in piglets.
PubMed:A novel beta-propeller phytase from Pedobacter nyackensis MJ11 CGMCC 2503 with potential as an aquatic feed additive.
PubMed:Characterization of a HAP-phytase from a thermophilic mould Sporotrichum thermophile.
PubMed:Effects of low-phytic acid corn, low-phytic acid soybean meal, and phytase on nutrient digestibility and excretion in growing pigs.
PubMed:Dietary phytate (inositol hexaphosphate) regulates the activity of intestinal mucosa phytase.
PubMed:Gene cloning, expression, and characterization of a novel phytase from Dickeya paradisiaca.
PubMed:Simultaneous degradation of phytic acid and starch by an industrial strain of Saccharomyces cerevisiae producing phytase and alpha-amylase.
PubMed:Phytase from antarctic yeast strain Cryptococcus laurentii AL27.
PubMed:Cloning and expression of Bacillus phytase gene (phy) in Escherichia coli and recovery of active enzyme from the inclusion bodies.
PubMed:Complete hydrolysis of myo-inositol hexakisphosphate by a novel phytase from Debaryomyces castellii CBS 2923.
PubMed:Screening, cloning and overexpression of Aspergillus niger phytase (phyA) in Pichia pastoris with favourable characteristics.
PubMed:Evaluation of hepatobiliary excretion and enterobiliary reflux in rats with biliary obstruction submitted to bilioduodenal or biliojejunal anastomosis.
PubMed:Production, purification and characterization of thermostable phytase from thermophilic fungus Thermomyces lanuginosus TL-7.
PubMed:A novel phytase appA from Citrobacter amalonaticus CGMCC 1696: gene cloning and overexpression in Pichia pastoris.
PubMed:Cloning, expression, and enzyme characterization of an acid heat-stable phytase from Aspergillus fumigatus WY-2.
PubMed:Purification and characterization of a bacterial phytase whose properties make it exceptionally useful as a feed supplement.
PubMed:Aspergillus niger pH 2.1 optimum acid phosphatase with high affinity for phytate.
PubMed:Improved phytase production by a thermophilic mould Sporotrichum thermophile in submerged fermentation due to statistical optimization.
PubMed:The isolated gamma probe technique for sentinel node penile carcinoma detection is unreliable.
PubMed:[Overexpression of Citrobacter braakii phytase with high specific activity in Pichia pastoris].
PubMed:Supplementation effect of ectoine on thermostability of phytase.
PubMed:Comparative analysis of influence of promoters and inhibitors on in vitro available iron using two methods.
PubMed:A novel phytase with preferable characteristics from Yersinia intermedia.
PubMed:Production and characterization of thermostable alkaline phytase from Bacillus laevolacticus isolated from rhizosphere soil.
PubMed:Bioavailability of zinc glycinate in comparison with zinc sulphate in the presence of dietary phytate in an animal model with Zn labelled rats.
PubMed:Absorption of zinc and retention of calcium: dose-dependent inhibition by phytate.
PubMed:Effects of copper source and concentration on in vitro phytate phosphorus hydrolysis by phytase.
PubMed:Influence of an Escherichia coli-derived phytase on nutrient utilization in broiler starters fed diets containing varying concentrations of phytic acid.
PubMed:Biodistribution and localization of iodine-131-labeled metuximab in patients with hepatocellular carcinoma.
PubMed:Effect of sodium phytate supplementation on fat digestion and cholesterol metabolism in female rats.
PubMed:Effects of dietary zinc levels, phytic acid and resistant starch on zinc bioavailability in rats.
PubMed:Phosphatases of ericoid mycorrhizal fungi: kinetic properties and the effect of copper on activity.
PubMed:Expression of Escherichia coli AppA2 phytase in four yeast systems.
PubMed:Methodological aspects of measuring phytase activity and phytate phosphorus content in selected cereal grains and digesta and feces of pigs.
PubMed:Purification and properties of a phytate-degrading enzyme from Pantoea agglomerans.
PubMed:Characterization of an acid phosphatase from Lactobacillus pentosus: regulation and biochemical properties.
PubMed:The efficacy of an Escherichia coli-derived phytase preparation.
PubMed:[Effect of sodium phytate on alkaline phosphatase (ALP) activity in intraradical hyphae of AM fungi and development of its extraradical hyphae].
PubMed:Gene cloning, expression and characterization of novel phytase from Obesumbacterium proteus.
PubMed:Pharmacological zinc levels reduce the phosphorus-releasing efficacy of phytase in young pigs and chickens.
PubMed:Effect of dietary level of phytic acid on hepatic and serum lipid status in rats fed a high-sucrose diet.
PubMed:Effect of phytate on element bioavailability in the second generation of rats.
PubMed:Application of radionuclide imaging to hepatic impact injury in rabbits.
PubMed:Molecular and physiological characterisation of a 3-phytase from soil bacterium Klebsiella sp. ASR1.
PubMed:Purification and characterization of a phytase from Pseudomonas syringae MOK1.
PubMed:Isolation and characterization of a phytase with improved properties from Citrobacter braakii.
PubMed:In situ treatment of metals in contaminated soils with phytate.
PubMed:Purification and characterization of three phytases from germinated lupine seeds (Lupinus albus var. amiga).
PubMed:Culture conditions influencing phytase production of Mitsuokella jalaludinii, a new bacterial species from the rumen of cattle.
PubMed:Complex formation between phytic acid and divalent metal ions: a solution equilibria and solid state investigation.
PubMed:Purification and properties of extracellular phytase from Bacillus sp. KHU-10.
PubMed:Utilisation of phytate phosphorus by rumen bacteria in a semi-continuous culture system (Rusitec) in lactating goats fed on different forage to concentrate ratios.
PubMed:Ingestion of insoluble dietary fibre increased zinc and iron absorption and restored growth rate and zinc absorption suppressed by dietary phytate in rats.
PubMed:Purification and characterization of a phytate-degrading enzyme from germinated faba beans (Vicia faba Var. Alameda).
PubMed:Site-directed mutagenesis improves catalytic efficiency and thermostability of Escherichia coli pH 2.5 acid phosphatase/phytase expressed in Pichia pastoris.
PubMed:Inhibitory effect of wheat fibre extract on calcium absorption in Caco-2 cells: evidence for a role of associated phytate rather than fibre per se.
PubMed:Expression of the Aspergillus fumigatus phytase gene in Pichia pastoris and characterization of the recombinant enzyme.
PubMed:Supplemental sodium phytate and microbial phytase influence iron availability in growing rats.
PubMed:Quantification of inositol phosphates using (31)P nuclear magnetic resonance spectroscopy in animal nutrition.
PubMed:A novel staining method for detecting phytase activity.
PubMed:Inositol phosphates with different numbers of phosphate groups influence iron absorption in humans.
PubMed:Dietary intrinsic phytate protects colon from lipid peroxidation in pigs with a moderately high dietary iron intake.
PubMed:Cloning, sequencing, and expression of an Escherichia coli acid phosphatase/phytase gene (appA2) isolated from pig colon.
PubMed:Effect of dietary phytate on magnesium bioavailability and liver oxidant status in growing rats.
PubMed:Effect of sodium phytate, sodium pyrophosphate and sodium tripolyphosphate on physico-chemical characteristics of restructured beef.
PubMed:Fermentation of soybean meal with Aspergillus usamii improves zinc availability in rats.
PubMed:1alpha-hydroxycholecalciferol does not increase the specific activity of intestinal phytase but does improve phosphorus utilization in both cecectomized and sham-operated chicks fed cholecalciferol-adequate diets.
PubMed:Acetobacter cellulosic biofilms search for new modulators of cellulogenesis and native membrane treatments.
PubMed:Cadmium accumulation, zinc status, and mineral bioavailability of growing rats fed diets high in zinc with increasing amounts of phytic acid.
PubMed:Colon tumor promotion: is it a selective process? Effects of cholate, phytate, and food restriction in rats on proliferation and apoptosis in normal and aberrant crypts.
PubMed:Replacement of inorganic phosphorus by microbial phytase for young pigs fed on a maize-soyabean-meal diet.
PubMed:The influence of different protein sources on phytate inhibition of nonheme-iron absorption in humans.
PubMed:Degradation of stachyose, raffinose, melibiose and sucrose by different tempe-producing Rhizopus fungi.
PubMed:Effect of dietary sodium phytate on the hepatic and serum levels of lipids and on the hepatic activities of NADPH-generating enzymes in rats fed on sucrose.
PubMed:Utilization of water hyacinth cellulose for production of cellobiase-rich preparation by Aspergillus niger 1.
PubMed:Simple and rapid determination of phytase activity.
PubMed:Absorption and accumulation of cadmium, lead and mercury from foods by rats.
PubMed:Gastric acid production, iron status and dietary phytate alter enhancement by meat of iron absorption in rats.
PubMed:Kinetics and thermodynamics of the mechanism of interaction of sodium phytate with alpha-globulin.
PubMed:The role of acid phosphatase activity during enzymic dephosphorylation of phytates byAspergillus niger phytase.
PubMed:Inhibitory effect of soybean protein vs. casein on apparent absorption of magnesium in rats is due to greater excretion of endogenous magnesium.
PubMed:Aberrant crypts correlate with tumor incidence in F344 rats treated with azoxymethane and phytate.
PubMed:[Idiopathic hypercalciuria and bone density].
PubMed:Inhibitory effect of dietary soybean protein vs. casein on magnesium absorption in rats.
PubMed:Determination of phytic acid in cereals using ICP-AES to determine phosphorus.
PubMed:Inhibitory effects of phytic acid and other inositol phosphates on zinc and calcium absorption in suckling rats.
PubMed:Iron absorption in man: ascorbic acid and dose-dependent inhibition by phytate.
PubMed:Enhancement of Cu bioavailability in the rat by phytic acid.
PubMed:Preparation of inositol phosphates from sodium phytate by enzymatic and nonenzymatic hydrolysis.
PubMed:Inactivation of metalloenzymes by food constituents.
PubMed:Inactivation of metalloenzymes by lysinoalanine, phenylethylaminoalanine, alkali-treated food proteins, and sulfur amino acids.
PubMed:Effect of phytate on aflatoxin formation by Aspergillus parasiticus grown on different grains.
PubMed:A stable isotope study of copper absorption in young men: effect of phytate and alpha-cellulose.
PubMed:Influence of dietary calcium, phosphorus, zinc and sodium phytate level on cataract incidence, growth and histopathology in juvenile chinook salmon (Oncorhynchus tshawytscha).
PubMed:Studies of the chemical and biological properties of the liver-imaging agent 99mTc-phytate.
PubMed:Zinc utilization in the chick as influenced by dietary concentrations of calcium and phytate and by Eimeria acervulina infection.
PubMed:Possible mechanism behind the adjuvant action of phosphate derivatives on rectal absorption of cefoxitin in rats and dogs.
PubMed:A stable isotope study of zinc absorption in young men: effects of phytate and alpha-cellulose.
PubMed:Effects of dietary phytate, calcium and magnesium levels on zinc bioavailability to rats.
PubMed:[Relative evaluation of arterial and portal perfusion of the liver during scintigraphy using technetium 99m sodium phytate].
PubMed:A model to produce pure zinc deficiency in rats and its use to demonstrate that dietary phytate increases the excretion of endogenous zinc.
PubMed:Factors affecting the absorption of iron from cereals.
PubMed:The effect of phytic acid on in vitro rate of starch digestibility and blood glucose response.
PubMed:Production of aflatoxins on soybean and cottonseed meals.
PubMed:The effects of breads containing similar amounts of phytate but different amounts of wheat bran on calcium, zinc and iron balance in man.
PubMed:Availability to rats of zinc from soybean seeds as affected by maturity of seed, source of dietary protein, and soluble phytate.
PubMed:Effect of phytic acid on the absorption, distribution, and endogenous excretion of zinc in rats.
PubMed:Feed digestibility and mineral balance of the diet of young mice kept in mouse cages inside or outside an isolator, using varied concentrations of sodium phytate.
PubMed:Heterogeneous nature of alkaline phosphatase from rat liver.
PubMed:Effects of sodium phytate and benzethonium chloride rinses on plaque formation in humans.
PubMed:Comparative measurement of zinc absorption in rats with stable isotope 70Zn and radioisotope 65Zn.
PubMed:Effect of phytate:zinc molar ratio and isolated soybean protein on zinc bioavailability.
PubMed:Iron availability and absorption in rats fed sodium phytate.
PubMed:Technetium-99m calcium phytate--optimization of calcium content for liver and spleen scintigraphy: concise communication.
PubMed:[In vitro proteolysis of casein and gluten by pancreatic enzymes].
PubMed:Studies on the phytate: zinc molar contents in diets as a determinant of Zn availability to young rats.
PubMed:Effect of animal proteins on the absorption of food iron in man.
PubMed:Isolation of monoferric phytate from wheat bran and its biological value as an iron source to the rat.
PubMed:Effect of sodium phytate on the chemical and microbial composition of dental plaque in the monkey (Macaca fascicularis)
PubMed:Tests of sodium phytate as a protective agent against dental caries in the rat.
PubMed:Enzymes associated with protein bodies isolated from ungerminated barley seeds.
PubMed:[Changes in the serum calcium and the serum phosphorus in persons with uremia and in normal persons after administration of sodium phytate- and aluminum hydroxide].
PubMed:The effect of sodium phytate on the urinary excretion of calcium in patients immobilized by poliomyelitis.
PubMed:[The sodium phytate test in the aged].
PubMed:[The sodium phytate test in aged persons].
PubMed:[Diagnosis of osteopathies by the sodium phytate test].
PubMed:Calcium deprivation in hypoparathyroidism. A method of diagnosis using sodium phytate.
PubMed:[The respective role of the kidney, intestine and bone in osteomalacias with hypophosphoremia and vitamin resistance: treatment with the combination of massive vitamin therapy and sodium phytate].
PubMed:Dissolution of experimentally induced vesical calculi in rats by sodium phytate and sodium neutral phosphate treatment.
PubMed:Abnormalities of calcium metabolism in patients with idiopathic urinary calculi; effect of oral administration of sodium phytate.
PubMed:Effect of sodium phytate on the hypercalciuria of acute quadriplegia due to poliomyelitis; preliminary report.
PubMed:The cause of hypercalcuria in sarcoid and its treatment with cortisone and sodium phytate.
None found
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