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pentanoic acid, 2,5-diamino-, (S)-

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Name:(2S)-2,5-diaminopentanoic acid
CAS Number: 70-26-8Picture of molecule3D/inchi
Other(deleted CASRN):410523-46-5
ECHA EINECS - REACH Pre-Reg:200-731-7
Nikkaji Web:J9.177D
Beilstein Number:1722298
XlogP3:-4.40 (est)
Molecular Weight:132.16304000
Formula:C5 H12 N2 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:special dietary and nutritional additives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Pubchem Patents:Search
Physical Properties:
Appearance:white powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 140.00 °C. @ 760.00 mm Hg
Melting Point: 215.00 °C. @ 760.00 mm Hg
Boiling Point: 308.00 to 309.00 °C. @ 760.00 mm Hg (est)
Flash Point: 285.00 °F. TCC ( 140.50 °C. ) (est)
logP (o/w): -4.220
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
Atlantic Chemicals
BOC Sciences
For experimental / research use only.
L-Ornithine;2,5-Diaminovaleric acid
Graham Chemical
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
special dietary and nutritional additives
Recommendation for laevo-ornithine usage levels up to:
 not for fragrance use.
Recommendation for laevo-ornithine flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1]
View page or View pdf

EPI System: View
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):70-26-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6262
National Institute of Allergy and Infectious Diseases:Data
(2S)-2,5-diaminopentanoic acid
 (2S)-2,5-diaminopentanoic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:70-26-8
Pubchem (cid):6262
Pubchem (sid):134971826
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
Golm Metabolome Database:Search
Metabolomics Database:Search
KEGG (GenomeNet):C01602
HMDB (The Human Metabolome Database):HMDB00214
YMDB (Yeast Metabolome Database):YMDB00353
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 apple custard apple fruit
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 beet root
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 garlic bulb
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 garlic leaf
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 melon bitter melon seed
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 mushroom shiitake mushroom fruit
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(2S)-2,5-diaminopentanoic acid
(S)-2,5-diaminopentanoic acid
(S)-2,5-diaminovaleric acid
(S)-alpha,delta-diaminovaleric acid
L( )-ornithine
 ornithine, L- (8CI)
 pentanoic acid, 2,5-diamino-, (S)-
L-norvaline, 5-amino-
an amino acid produced in the urea cycle by the splitting off of urea from arginine. A non-essential and nonprotein amino acid, ornithine is critical for the production of the body's proteins, enzymes and muscle tissue. Ornithine plays a central role in the urea cycle and is important for the disposal of excess nitrogen (ammonia). Ornithine is the starting point for the synthesis of many polyamines such as putrescine and spermine. Ornithine supplements are claimed to enhance the release of growth hormone and to burn excess body fat. Ornithine is necessary for proper immune function and good liver function.; AF112968; L-Ornithine is one of the products of the action of the enzyme arginase on L-arginine, creating urea. Therefore, ornithine is a central part of the urea cycle, which allows for the disposal of excess nitrogen. Ornithine is recycled and in a manner is a catalyst. First, ammonia is converted into carbamoyl phosphate (phosphate-CONH2), which creates one half of urea. Ornithine is converted into a urea derivative at the ? (terminal) nitrogen by carbamoyl phosphate. Another nitrogen is added from aspartate, producing the denitrogenated fumarate, and the resulting arginine (a guanidinium compound) is hydrolysed back to ornithine, producing urea. The nitrogens of urea come from the ammonia and aspartate, and the nitrogen in ornithine remains intact.; ORNT1). Mutations in the mitochondrial ornithine transporter result in hyperammonemia, hyperornithinemia, homocitrullinuria (HHH) syndrome, a disorder of the urea cycle. (PMID 16256388) The pathophysiology of the disease may involve diminished ornithine transport into mitochondria, resulting in ornithine accumulation in the cytoplasm and reduced ability to clear carbamoyl phosphate and ammonia loads. (OMIM 838970); Ornithine is an amino acid produced in the urea cycle by the splitting off of urea from arginine. It is a central part of the urea cycle, which allows for the disposal of excess nitrogen. L-Ornithine is also a precursor of citrulline and arginine. In order for ornithine produced in the cytosol to be converted to citrulline, it must first cross the inner mitochondrial membrane into the mitochondrial matrix where it is carbamylated by ornithine transcarbamylase. This transfer is mediated by the mitochondrial ornithine transporter (SLC25A15; Ornithine is an amino acid which plays a role in the urea cycle.
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