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Category:pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white crystals or powder (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 423.80 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.000000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 410.00 °F. TCC ( 210.10 °C. ) (est)
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| logP (o/w): | 2.751 (est) |
| Soluble in: |
| | water, 119.7 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-child LDLo 42 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
GASTROINTESTINAL: NAUSEA OR VOMITING
Lancet. Vol. 2, Pg. 809, 1952.
intravenous-guinea pig LD50 24400 ug/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 313, 1958.
intraperitoneal-mouse LD50 100 mg/kg
Planta Medica. Vol. 42, Pg. 75, 1981.
intravenous-mouse LD50 23 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 47, 1965.
oral-mouse LD50 220 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 47, 1965.
oral-rat LD50 513 mg/kg
Toxicology and Applied Pharmacology. Vol. 1, Pg. 42, 1959.
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| Dermal Toxicity: |
subcutaneous-guinea pig LD50 44 mg/kg
Annales Pharmaceutiques Francaises. Vol. 20, Pg. 463, 1962.
subcutaneous-mouse LD50 141 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 940, 1964.
subcutaneous-rat LDLo 150 mg/kg
BEHAVIORAL: TREMOR
Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 144, Pg. 887, 1950.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | pharmaceuticals / chemical synthisis |
| Recommendation for pyrilamine maleate usage levels up to: | | | not for fragrance use.
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| Recommendation for pyrilamine maleate flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | (Z)-but-2-enedioicacid;N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5284451 |
| Pubchem (sid): | 134972293 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | anisopyradamine | | | anthisan | | (Z)- | but-2-enedioicacid;N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine | | | diaminide maleate | | 2-((2-( | dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridine maleate | | 2-[[2-( | dimethylamino)ethyl](p-methoxybenzyl)amino]pyridine bimaleate | | 2-[[2-( | dimethylamino)ethyl](p-methoxybenzyl)amino]pyridine maleate | | [2-( | dimethylamino)ethyl][(4-methoxyphenyl)methyl]-2-pyridylamine, (2Z)but-2-enedioic acid | | | dorantamin maleate | | | enrumay | | 1,2- | ethanediamine, N-[ (4-methoxyphenyl)methyl]-N', N'-dimethyl-N-2-pyridinyl-, (Z)-2-butenedioate (1:1) | | 1,2- | ethanediamine, N1-[(4-methoxyphenyl)methyl]-N2,N2-dimethyl-N1-2-pyridinyl-, (2Z)-2-butenedioate (1:1) | | | histatex | | | histavet-P | | | mepiramine maleate | | | mepyramine hydrogen maleinate | | | mepyramine maleate | | N-p- | methoxybenzyl-N',N'-dimethyl-N-a-pyridylethylenediamine maleate | | N-(p- | methoxybenzyl)-N, N'-dimethyl-N-2-pyridyl-1,2-ethanediamine, maleic acid salt | | N-(4- | methoxybenzyl)-N',N'-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine (2Z)-2-butenedioate (1:1) | | N-(4- | methoxybenzyl)-N',N'-dimethyl-N-(pyridin-2-yl)ethane-1,2-diamine (2Z)-but-2-enedioate (1:1) | | N-(4- | methoxybenzyl)-N',N'-dimethyl-N-pyridin-2-ylethane-1,2-diamine (2Z)-but-2-enedioate | | N-(4- | methoxyphenyl)methyl-N',N'-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine maleate salt | | N-[(4- | methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl-1,2-ethanediamine (2Z)-2-butenedioate (1:1) | | | paraminyl maleate | | | pyra maleate | | | pyramal maleate | | | pyranilamine maleate | | | pyranisamine maleate | | | pyridine, 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-, maleate (1:1) | | | pyridine, 2-[[2- (dimethylamino)ethyl](p-methoxybenzyl)amino]-, maleate (1:1) | | | stangen maleate | | | statomin maleate | | | thylogen |
Articles:
| PubMed:Histamine in the locus coeruleus promotes descending noradrenergic inhibition of neuropathic hypersensitivity. |
| PubMed:Lymphatic diamine oxidase secretion stimulated by fat absorption is linked with histamine release. |
| PubMed:Evaluation of In Vitro Uterotonic Activities of Fruit Extracts of Ficus asperifolia in Rats. |
| PubMed:Antihistaminic drugs modify casein-induced inflammation in the rat. |
| PubMed:Prevalence and impact of primary dysmenorrhea among Mexican high school students. |
| PubMed:Effects of inhaled monoethanolamine on bronchoconstriction. |
| PubMed:Patterns of prescription and self-medication for treating primary dysmenorrhea in a Mexican population. |
| PubMed:Stimulation of brain mast cells by compound 48/80, a histamine liberator, evokes renin and vasopressin release in dogs. |
| PubMed:Minimal role for H1 and H2 histamine receptors in cutaneous thermal hyperemia to local heating in humans. |
| PubMed:Relaxant effects of the neutral extract of the leaves of Bidens pilosa Linn on isolated rat vascular smooth muscle. |
| PubMed:Involvement of histamine H1 and H2 receptors in the regulation of STAT-1 phosphorylation: inverse agonism exhibited by the receptor antagonists. |
| PubMed:H1 but not H2 histamine receptor activation contributes to the rise in skin blood flow during whole body heating in humans. |
| PubMed:Degranulation of mast cells located in median eminence in response to compound 48/80 evokes adrenocortical secretion via histamine and CRF in dogs. |
| PubMed:Interactions of eosinophil granule proteins with skin: limits of detection, persistence, and vasopermeabilization. |
| PubMed:Regulation by prostaglandin E2 and histamine of angiogenesis in inflammatory granulation tissue. |
| PubMed:Non-adrenergic non-cholinergic excitatory innervation in the airways: role of neurokinin-2 receptors. |
| PubMed:Neurochemical regulation of cough response to capsaicin in guinea-pigs. |
| PubMed:NTP Hepatotoxicity Studies of the Liver Carcinogen Methapyrilene Hydrochloride (CAS No. 135-23-9) Administered in Feed to Male F344/N Rats. |
| PubMed:Enhancement by histamine of vascular endothelial growth factor production in granulation tissue via H(2) receptors. |
| PubMed:Histamine induced decrease of lecithin levels in broncho-alveolar lavage fluid of rats is mediated by H2 receptor. |
| PubMed:Effect of pyloric blockade and infusion of histamine or pentagastrin on gastric secretion in horses. |
| PubMed:Histamine-induced gastric acid secretion in horses. |
| PubMed:Evidence for hypernociception induction following histamine H1 receptor activation in rodents. |
| PubMed:Effect of antioxidants, anti-inflammatory drugs, and histamine antagonists on sparfloxacin-induced phototoxicity in mice. |
| PubMed:Chronic feeding study of pyrilamine in Fischer 344 rats. |
| PubMed:N(+)-glucuronidation of aliphatic tertiary amines, a general phenomenon in the metabolism of H1-antihistamines in humans. |
| PubMed:The acetylcholine-induced flare response in evaluation of small fiber dysfunction. |
| PubMed:High-performance liquid chromatography of the antihistamine pyrilamine and its N-oxide using electrochemical detection. |
| PubMed:Uterotropic actions of relaxin in prepubertal gilts. |
| PubMed:Pharmacologic modulation of vascular permeability in ocular allergy in the rat. |
| PubMed:Association of fever with late-onset pulmonary hypersensitivity responses in the guinea pig. |
| PubMed:Formation of ovarian follicular cysts and corpora lutea after treatment with antihistamine or indomethacin in prepubertal gilts. |
| PubMed:The probable role of histamine in the rostral hypothalamus on the prolactin and luteinizing hormone release induced by estrogen in conscious spayed rats. |
| PubMed:Adrenergic and histaminergic neural interactions in dog paws. |
| PubMed:Effect of histamine on proliferation of normal human adult lung fibroblasts. |
| PubMed:Analysis of some dosage forms containing pyridine derivatives using a cyclodextrin bonded stationary phase in HPLC. |
| PubMed:Metabolism of pyrilamine maleate in Fischer 344 rats, Part I: Activity excretion profiles. |
| PubMed:The metabolism and elimination of pyrilamine maleate in the rat. |
| PubMed:Microbial transformation of the antihistamine pyrilamine maleate. Formation of potential mammalian metabolites. |
| PubMed:H1 action of histamine on aldosterone and cortisol secretion by perfused dog adrenal. |
| PubMed:Liquid chromatographic determination of organic nitrogenous bases in dosage forms: a progress report. |
| PubMed:Unusual effects of histamine antagonists on canine nasal blood vessels. |
| PubMed:Some respiratory and enteric diseases of cattle: an update. |
| PubMed:PAF-acether-induced plasma exudation in rat skin is independent of platelets and neutrophils. |
| PubMed:Trace analysis of the antihistamines methapyrilene hydrochloride, pyrilamine maleate and triprolidine hydrochloride monohydrate in animal feed, human urine and wastewater by high-performance liquid chromatography and gas chromatography with nitrogen-phosphorus detection. |
| PubMed:Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats. |
| PubMed:Bioassays of smooth muscle contracting agents in cotton mill dust and bract extracts: arachidonic acid metabolites as possible mediators of the acute byssinotic reaction. |
| PubMed:Inhibition of bone resorption in tissue culture by H1-receptor antagonists. |
| PubMed:Measurement of canine gastric vascular permeability to plasma proteins in the normal and protein-losing states. |
| PubMed:Pharmacological studies of sensitized canine pulmonary blood vessels. |
| PubMed:GLC analysis of menthol, phenol, benzocaine, and pyrilamine maleate in aerosol spray lotion. |
| PubMed:Characterization of DNA repair elicited by carcinogens and drugs in the hepatocyte primary culture/DNA repair test. |
| PubMed:High-pressure liquid chromatographic determination of methscopolamine nitrate, phenylpropanolamine hydrochloride, pyrilamine maleate, and pheniramine maleate in tablets. |
| PubMed:Pulmonary polyamine permeability factor. |
| PubMed:An agent that releases basophil and mast cell histamine but blocks cyclooxygenase and lipoxygenase metabolism of arachidonic acid inhibits immunoglobulin E-mediated asthma in rhesus monkeys. |
| PubMed:Simultaneous GLC analysis of salicylamide, phenylpropanolamine hydrochloride, caffeine, chlorpheniramine maleate, phenylephrine hydrochloride, and pyrilamine maleate in capsule preparations. |
| PubMed:The induction of unscheduled DNA synthesis by antihistamines in primary hepatocyte cultures. |
| PubMed:Negligible potency of acetylcholine in increasing vascular permeability. |
| PubMed:Acute systemic anaphylaxis in adult domestic fowl: evidence for the protective role of H2-histaminergic and beta 2-adrenergic receptors. |
| PubMed:Potentiation by D-penicillamine and other sulfhydryl agents of the vascular response to histamine in the anaesthetized dog. |
| PubMed:Cutaneous vascular histamine H1 and H2 receptors in the guinea-pig: the histamine skin wheal as a cutaneous vascular model. |
| PubMed:Toxic encephalopathy related to antihistamine-barbiturate antiemetic medication. |
| PubMed:Quantitative determinations of codeine phosphate, guaifenesin, pheniramine maleate, phenylpropanolamine hydrochloride, and pyrilamine maleate in an expectorant by high-pressure liquid chromatography. |
| PubMed:Quantitative determination of four antihistamines in combination by high-pressure liquid chromatography. |
| PubMed:Metabolic studies of guinea pig basophilic leukocytes in short-term tissue culture. I. Measurement of histaminesynthesizing capacity by using an isotopic-thin layer chromatographic assay. |
| PubMed:Comparison of stability-indicating assay methods: ultraviolet, high pressure liquid chromatography and acid dye. |
| PubMed:Aggregation of antihistamines in aqueous solution: effect of counterions on self-association of pyridine derivatives. |
| PubMed:Comparison of the ocular effects of circulating endotoxin and immune complexes: role of vasoactive amines. |
| PubMed:A clinical comparison of rectal pyrilamine maleate and trimethobenzamide hydrochloride for the control of vomiting in children. |
| PubMed:Spectrophotometric determination of acetaminophen, phenylephrine hydrochloride, codeine phosphate, and pyrilamine maleate in tablets or powder. |
| PubMed:[The combination of phenylpropanolamine hydrochloride, pyrilamine maleate, pheniramine maleate in the therapy of some inflammatory and reactive processes of the main airways: electrophotoplethysmographic and clinical study]. |
| PubMed:Suppressive effects of pyrilamine maleate and d-lysergic acid diethylamide (LSD-25) on early corneal lesions produced in vitro by Newcastle disease virus (NDV) and compound 48/80. |
| PubMed:Evaluation of a combination of pheniraminemaleate, pyrilamine maleate, and propanolamine hydrochloride (triaminic) as a diuretic agent. |
| PubMed:Pyrilamine maleate in the treatment of pruritic dermatoses. |
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3D/inchi