EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

ferrous gluconate
iron(II) di-D-gluconate

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CAS Number: 299-29-6Picture of molecule3D/inchi
Molecular Weight:448.15708000
Formula:C12 H24 Fe O14
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:color, stabilizers, nutrient supplements
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Pubchem Patents:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1308 Ferrous gluconate View - review
JECFA Food Additive: Ferrous Gluconate
GSFA Codex: Ferrous gluconate (579)
DG SANTE Food Additives:ferrous gluconate
Physical Properties:
Appearance:yellowish gray to greenish yellow powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 673.60 °C. @ 760.00 mm Hg (est)
Flash Point: 707.00 °F. TCC ( 375.20 °C. ) (est)
logP (o/w): -3.175 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Insoluble in:
Organoleptic Properties:
Odor Description:at 100.00 %. caramellic
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
American Elements
Iron(II) Gluconate 99%
Odor: characteristic
Use: Iron(II) Gluconate (Ferrous Gluconate) is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
American International Chemical, LLC.
Iron Gluconate
BOC Sciences
For experimental / research use only.
Iron(II) gluconate 95%
For experimental / research use only.
Ferrous gluconate
Foodchem International
Ferrous Gluconate
Global Calcium
Ferrous Gluconate BP
Global Calcium
Ferrous Gluconate EP
Global Calcium
Ferrous Gluconate IP
Global Calcium
Ferrous Gluconate USP
Jost Chemical
Ferrous Gluconate EP Powder
Jost Chemical
Ferrous Gluconate USP/FCC Granular (-14 + 60)
Jost Chemical
Ferrous Gluconate USP/FCC Granular
Jost Chemical
Ferrous Gluconate USP/FCC Low HM Granular (-14+60)
Jost Chemical
Ferrous Gluconate USP/FCC Low HM Powder
Jost Chemical
Ferrous Gluconate USP/FCC Powder
Penta International
Penta International
Penta International
Penta International
Qingdao Dacon Trading
Ferrous Gluconate
United International
Ferrous Gluconate
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 2237 mg/kg
National Technical Information Service. Vol. UR-3490-168

oral-mouse LD50 3950 mg/kg
American Journal of the Medical Sciences. Vol. 241, Pg. 296, 1961.

intravenous-mouse LD50 199 mg/kg
American Journal of the Medical Sciences. Vol. 241, Pg. 296, 1961.

intraperitoneal-mouse LD50 160 mg/kg
American Journal of the Medical Sciences. Vol. 241, Pg. 296, 1961.

oral-child TDLo 162 mg/kg
JAMA, Journal of the American Medical Association. Vol. 218, Pg. 1179, 1971.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
color, stabilizers, nutrient supplements
Recommendation for ferrous gluconate usage levels up to:
 not for fragrance use.
Recommendation for ferrous gluconate flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):299-29-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :9291
National Institute of Allergy and Infectious Diseases:Data
iron; (2R,3R,4S,5S)-2,3,4,5,6-pentahydroxyhexanoic acid
 iron; (2R,3R,4S,5S)-2,3,4,5,6-pentahydroxyhexanoic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:299-29-6
Pubchem (cid):9291
Pubchem (sid):134975116
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):HMDB35997
FDA Listing of Food Additive Status:View
FDA Color Additive Status ListView
•capsules 435 mg (equivalent to 50 mg of elemental iron); elixir 300 mg (equivalent to 37.5 mg of elemental iron)5 ml; tablets 320 mg (equivalent to 40 mg of elemental iron). •grades: pharmaceutical, nf
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
 ferrin 55
 gluconic acid iron salt
 iron (II) di-D-gluconate
 iron digluconate
 iron gluconate
 iron, bis(D-gluconato-O1,O2)-
 iron; (2R,3R,4S,5S)-2,3,4,5,6-pentahydroxyhexanoic acid
 iron(II) di-D-gluconate


PubMed:Cardiovascular effects of hemoglobin response in patients receiving epoetin alfa and oral iron in heart failure with a preserved ejection fraction.
PubMed:A study on Fe(2+) - α-helical-rich keratin complex formation using isothermal titration calorimetry and molecular dynamics simulation.
PubMed:Comparison of two different laser wavelengths' dental bleaching results by photo-Fenton reaction: in vitro study.
PubMed:Comparison study of oral iron preparations using a human intestinal model.
PubMed:Inhibitory effect of iron on in vitro proliferation of smooth muscle cells.
PubMed:Occurrence of milnacipran-associated morbilliform rash and serotonin toxicity.
PubMed:[Importance of the different i.v. iron generations for everyday medical practice].
PubMed:Effect of chemical activation of 10% carbamide peroxide gel in tooth bleaching.
PubMed:Bioavailability of stabilised ferrous gluconate with glycine in fresh cheese matrix: a novel iron compound for food fortification.
PubMed:Tolerability of different oral iron supplements: a systematic review.
PubMed:A study of hydrogen peroxide chemistry and photochemistry in tea stain solution with relevance to clinical tooth whitening.
PubMed:Free radical polymerization of poly(ethylene glycol) diacrylate macromers: impact of macromer hydrophobicity and initiator chemistry on polymerization efficiency.
PubMed:Iron polymaltose versus ferrous gluconate in the prevention of iron deficiency anemia of infancy.
PubMed:Effectiveness of a large-scale iron-fortified milk distribution program on anemia and iron deficiency in low-income young children in Mexico.
PubMed:Beta-erythropoietin effects on ventricular remodeling, left and right systolic function, pulmonary pressure, and hospitalizations in patients affected with heart failure and anemia.
PubMed:Influence of blood donation on levels of water-soluble vitamins.
PubMed:Ferrous gluconate and ferrous sulfate added to a complementary food distributed by the Mexican nutrition program Oportunidades have a comparable efficacy to reduce iron deficiency in toddlers.
PubMed:Interactions between ethylenediaminetetraacetic acid (EDTA) and iron absorption pathways, in the Caco-2 model.
PubMed:The role of iron supplementation during epoietin treatment for cancer-related anemia.
PubMed:Cefdinir-associated "bloody stools" in an infant.
PubMed:[Efficacy of bolus intravenous iron treatment in peritoneal dialysis patients].
PubMed:Development of vaginal rings for sustained release of nonhormonal contraceptives and anti-HIV agents.
PubMed:Serum prohepcidin concentration: no association with iron absorption in healthy men; and no relationship with iron status in men carrying HFE mutations, hereditary haemochromatosis patients undergoing phlebotomy treatment, or pregnant women.
PubMed:Effect of high-dose iron supplements on fractional zinc absorption and status in pregnant women.
PubMed:Fortifying milk with ferrous gluconate and zinc oxide in a public nutrition program reduced the prevalence of anemia in toddlers.
PubMed:Intravenous iron following cardiac surgery does not increase the infection rate.
PubMed:The role of reduced iron powder in the fermentative production of tetanus toxin.
PubMed:Fortification of soy sauce using various iron sources: sensory acceptability and shelf stability.
PubMed:[Resorption and tolerance of the high doses of ferrous sulfate and ferrous gluconate in the patients on peritoneal dialysis].
PubMed:Gene expression in human small intestinal mucosa in vivo is mediated by iron-induced oxidative stress.
PubMed:Iron bioavailability from fortified petit suisse cheese determined by the prophylactic-preventive method.
PubMed:Are we giving too much iron? Low-dose iron therapy is effective in octogenarians.
PubMed:In vitro evaluation of iron solubility and dialyzability of various iron fortificants and of iron-fortified milk products targeted for infants and toddlers.
PubMed:Nutritional and technological behavior of stabilized iron-gluconate in wheat flour.
PubMed:Compensating for iron loss in regular blood donors using ferrous gluconate and ascorbic acid.
PubMed:Kinetics of iron-mediated artemisinin degradation: effect of solvent composition and iron salt.
PubMed:Milk versus medicine for the treatment of iron deficiency anaemia in hospitalised infants.
PubMed:[Treatment of iron-deficiency anaemia with ferrous gluconate].
PubMed:Oral iron therapy for anaemia after orthopaedic surgery: randomized clinical trial.
PubMed:[Study on treatment of iron-deficiency anemia by shengxuening].
PubMed:[Tot'hema--alternative in the treatment of iron deficiency and iron deficiency anemia].
PubMed:Daily doses of 20 mg of elemental iron compensate for iron loss in regular blood donors: a randomized, double-blind, placebo-controlled study.
PubMed:Efficacy of nonhormonal vaginal contraceptives from a hydrogel delivery system.
PubMed:Effect of heme oxygenase-1 inducer hemin on chronic renal failure rats.
PubMed:Iron supplements inhibit zinc but not copper absorption in vivo in ileostomy subjects.
PubMed:Stabilized ferrous gluconate as iron source for food fortification: bioavailability and toxicity studies in rats.
PubMed:[Quality rating of MR-cholangiopancreatography with oral application of iron oxide particles].
PubMed:Influence of iron status and iron supplements on natural killer cell activity in trained women runners.
PubMed:Mutagenicity and DNA-damaging activity caused by decomposed products of potassium sorbate reacting with ascorbic acid in the presence of Fe salt.
PubMed:Intravenous iron products.
PubMed:A comparison of iron availability from commercial iron preparations using an in vitro digestion/Caco-2 cell culture model.
PubMed:[The optimization of MR cholangiopancreatography].
PubMed:A new protocol of iron therapy combined with epoetin alpha as a treatment for preoperative autologous blood donation in gynaecological tumor surgery.
PubMed:The effect of combined iron therapy (Chemiron) and single iron therapy on the dexamethasone-estriol reaction test for placenta insufficiency during normal pregnancy.
PubMed:Long-term supplementation with iron does not enhance growth in malnourished Bangladeshi children.
PubMed:Iron absorption and therapy after gastric bypass.
PubMed:The utility of a growth factor: r-HuEPO as a treatment for preoperative autologous blood donation in gynecological tumor surgery.
PubMed:The effect of 61 days of combined iron (Chemiron) and single iron therapy on haemoglobin, packed cell volume, platelets and reticulocytes during pregnancy. Preliminary report.
PubMed:Short time effect of Chemiron (a combination iron preparation), single iron, and different magnesium salts on plasma. Magnesium concentration during early pregnancy in Nigerian women. A preliminary report.
PubMed:[Evaluation of hemoglobin and hematocrit in pregnant women receiving folate and iron supplements].
PubMed:Safety aspects of parenteral iron in patients with end-stage renal disease.
PubMed:The effect of some metal ions on volatile sulfur-containing compounds originating from the oral cavity.
PubMed:Long-term oral supplementation with iron is not harmful for young children in a poor community of Bangladesh.
PubMed:[Effectiveness and tolerability of oral liquid ferrous gluconate in iron-deficiency anemia in pregnancy and in the immediate post-partum period: comparison with other liquid or solid formulations containing bivalent or trivalent iron].
PubMed:[Effect of hemin in treating hemorrhagic anemia and toxicity].
PubMed:Therapeutic availability of iron administered orally as the ferrous gluconate together with magnesium-L-aspartate hydrochloride.
PubMed:Bionursing: signs of iron deficiency.
PubMed:Iron overdose and detection of gastrointestinal bleeding with the hemoccult and gastroccult assays.
PubMed:A Mössbauer and X-ray powder diffraction study of some ferrous hematinics.
PubMed:Potentiation of magnesium-deficiency-induced foetotoxicity by concomitant iron deficiency and its prevention by adequate supply via drinking water.
PubMed:Interactions between magnesium and iron. In vitro studies.
PubMed:Red cell collection by apheresis technology.
PubMed:Dysfunction of the blood-retina barrier following white light exposure. A tracer study with horseradish peroxidase and ferrous gluconate.
PubMed:Use of HemoQuant assays to assess the effect of oral iron preparations on stool hemoccult tests.
PubMed:[The use of drinking water as a vehicle of nutrients: experimental studies with iron].
PubMed:Is hematologic response to iron and erythropoietin in hemodialysis patients affected by other factors?
PubMed:Clinical and chemical interactions between iron preparations and ciprofloxacin.
PubMed:Porphyria cutanea tarda due to ferrous gluconate.
PubMed:Induction of hepatic metallothionein by intraperitoneal metal injection: an associated inflammatory response.
PubMed:An investigation into the effects of oral iron supplementation on in vivo Hemoccult stool testing.
PubMed:[Oral iron therapy. Bioavailability and therapeutic effectiveness of ferrous iron in effervescent tablets in posthemorrhagic iron deficiency anemia].
PubMed:Management of acute iron overdose.
PubMed:[Clinical experiences with iron-folic acid substitution in pregnancy in the form of an effervescent tablet].
PubMed:Iron supplementation in female blood donors deferred by copper sulfate screening.
PubMed:Alteration of methyldopa absorption, metabolism, and blood pressure control caused by ferrous sulfate and ferrous gluconate.
PubMed:Thrombocytopenia associated with repletion of iron in iron-deficiency anemia.
PubMed:Antenatal iron supplementation in sickle cell disease.
PubMed:Traditional treatment of pregnancy anaemia in Nigeria. An indication for modern therapeutics.
PubMed:[Oral and intramuscular intervention with dextriferron in growing male calves. 4. Development of food intake during the suckling period].
PubMed:Acute iron poisoning in children.
PubMed:Paramagnetic contrast agents in magnetic resonance imaging: research at Vanderbilt University.
PubMed:False-positive stool occult blood tests caused by iron preparations. A controlled study and review of literature.
PubMed:Ultrastructural abnormalities in carcinogen-induced hepatocellular altered foci identified by resistance to iron accumulation.
PubMed:Puerperal haematological indices.
PubMed:The persistence and phenotypic stability of transplanted rat liver neoplastic nodules.
PubMed:Microcytic normochromic anemia associated with iron storage by hypernephroma.
PubMed:Enhancement of rat hepatocellular-altered foci by the liver tumor promoter phenobarbital: evidence that foci are precursors of neoplasms and that the promoter acts on carcinogen-induced lesions.
PubMed:Quantitative kinetics of development of N-2-fluorenylacetamide-induced, altered (hyperplastic) hepatocellular foci resistant to iron accumulation and of their reversion or persistence following removal of carcinogen.
PubMed:Absorption and side-effects after peroral administration of sustained release iron tablets. Ferro-Retard compared with Ferronicum and Duroferon Duretter.
PubMed:[Plasma proteins in iron transport].
PubMed:Effects of concurrent drug therapy and of feeding on plasma chloramphenicol levels after oral administration of chloramphenicol in dogs.
PubMed:Experimental and clinical comparative study of iron carbohydrate complex with ferrous gluconate.
PubMed:Ferrous gluconate with ascorbic acid.
PubMed:[Plasma iron in normal and anemic persons treated with ferrous gluconate].
PubMed:The effect of pH on the stability of solutions of liver fraction I, N.F.X in the presence of ferrous lactate and ferrous gluconate.
PubMed:An experimental study of the toxicity of ferrous gluconate.
PubMed:The stability of aqueous solutions of ferrous gluconate.
PubMed:[Ferrous gluconate in therapy of iron deficiency anemia].
PubMed:Ferrous gluconate in anaemia of pregnancy.
iron important in this cpd. Dietary supplement, food colour for ripe olives Iron(II) gluconate, or ferrous gluconate, is a black compound often used as an iron supplement. It is the iron(II) salt of gluconic acid. It is marketed under brand names such as Fergon, Ferralet, and Simron. It is also present in the combination supplement dianazene, a vitamin mixture created by L. Ron Hubbard and used in the religion Scientology.
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