EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

neomycin sulfate
neodecadron

Supplier Sponsors

CAS Number: 1405-10-3Picture of molecule3D/inchi
Other(deleted CASRN):124847-89-8
ECHA EINECS - REACH Pre-Reg:215-773-1
FDA UNII: 057Y626693
MDL:MFCD00077833
Molecular Weight:712.72896000
Formula:C23 H48 N6 O17 S
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 927.10 °C. @ 760.00 mm Hg (est)
Flash Point: 958.00 °F. TCC ( 514.50 °C. ) (est)
logP (o/w): -3.655 (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
American International Chemical, LLC.
Neomycin Sulfate
BOC Sciences
For experimental / research use only.
Neomycin sulfate >98%
Odor: characteristic
Use: Neomycin sulfate belongs to a class of antibiotics known as the aminoglycosides.
EMD Millipore
For experimental / research use only.
Neomycin Sulfate
sds
Glentham Life Sciences
Neomycin sulfate
Penta International
NEOMYCIN SULFATE USP
Santa Cruz Biotechnology
For experimental / research use only.
Neomycin Sulfate ≥85% Neomycin B, remainder Neomycin C
Sigma-Aldrich: Sigma
For experimental / research use only.
Neomycin trisulfate salt hydrate powder
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intramuscular-guinea pig LD50 > 250 mg/kg
SENSE ORGANS AND SPECIAL SENSES: CHANGE IN ACUITY: EAR
Toxicology and Applied Pharmacology. Vol. 33, Pg. 320, 1975.

intramuscular-mouse LD50 142 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives of Internal Medicine. Vol. 119, Pg. 493, 1967.

intraperitoneal-mouse LD50 305 mg/kg
Antibiotics and Chemotherapy Vol. 8, Pg. 198, 1958.

intravenous-mouse LD50 17400 ug/kg
Archivum Immunologiae et Therapiae Experimentalis. Vol. 10, Pg. 947, 1962.

oral-mouse LD50 > 8000 mg(base)/kg
Antimicrobial Agents and Chemotherapy Vol. -, Pg. 138, 1963.

Dermal Toxicity:
subcutaneous-mouse LD50 190 mg/kg
Antibiotiki. Vol. 18, Pg. 444, 1973.

subcutaneous-rat LD50 200 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 597, 1962.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for neomycin sulfate usage levels up to:
 not for fragrance use.
 
Recommendation for neomycin sulfate flavor usage levels up to:
 not for flavor use.
 
Safety References:
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):1405-10-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :62403
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0001405103
RTECS:QP4375000 for cas# 1405-10-3
 
References:
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:1405-10-3
Pubchem (cid):62403
Pubchem (sid):135020733
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 biosol
 coly-mycin S otic
 cordran-N
neo-cort-dome
neo-cortef
neo-d-cortef
 fradiomycin sulfate
 lidamycin creme
neo-mantle creme
neo-medrol
 mycaifradin sulfate
 mycifradin
 mycigient
 myciguent
 neobiotic
 neodecadron
 neofracin
 neomix
 neomycin B sulfate
 neomycin sulphate
 neomycine sulfate
 neomycins sulfate
 neosone
 new france F
 otic-neo-cort-dome
 panolog cream
 pediotic suspension
 quintess-N
 spectrocin
 statrol
neo-synalar
 tresaderm
 

Articles:

PubMed:Recurrent epistaxis in children.
PubMed:Highly sensitive and selective colorimetric sensing of antibiotics in milk.
PubMed:Antibiotics conspicuously affect community profiles and richness, but not the density of bacterial cells associated with mucosa in the large and small intestines of mice.
PubMed:Contributions of PIP(2)-specific-phospholipase C and free salicylic acid to heat acclimation-induced thermotolerance in pea leaves.
PubMed:Pre-harvest interventions to reduce carriage of E. coli O157 by harvest-ready feedlot cattle.
PubMed:Variability of oral bioavailability for low dose methotrexate in rats.
PubMed:Evaluation of media for selective enumeration of Streptococcus thermophilus, Lactobacillus delbrueckii ssp. bulgaricus, Lactobacillus acidophilus, and bifidobacteria.
PubMed:Effects of contact sensitizers neomycin sulfate, benzocaine and 2,4-dinitrobenzene 1-sulfonate, sodium salt on viability, membrane integrity and IL-1 alpha mRNA expression of cultured normal human keratinocytes.
PubMed:Effect of neomycin on the hydrolysis and toxicity of vicine and convicine in rats.
PubMed:[Occurrence in the environment and among the population of antibiotic-resistant strains of pathogenic Escherichia].
PubMed:The effects of neomycin and oxytetracycline alone or combined upon the incidence of salmonellosis in broiler chickens.
PubMed:New medium for rapid screening and enumeration of Clostridium perfringens in foods.
PubMed:Effect of antibiotics on growth of the immature rat.
 
Notes:
antibiotic complex produced by streptomyces fradiae. it is composed of neomycins a, b, and c. it acts by inhibiting translation during protein synthesis.
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