EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

quercetin
4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-

Sponsors

Name:2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one
CAS Number: 117-39-5Picture of molecule3D/inchi
Other:73123-10-1
ECHA EINECS - REACH Pre-Reg:204-187-1
FDA UNII:9IKM0I5T1E
Nikkaji Web:J2.907F
Beilstein Number:0317313
MDL:MFCD00006828
XlogP3:1.50 (est)
Molecular Weight:302.23910000
Formula:C15 H10 O7
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:food additive and cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 341 P17 Quercetin View-notice PDF
GRN 341 P2 Quercetin View-notice PDF
GRN 341 P3 Quercetin View-notice PDF
 
Physical Properties:
Appearance:yellow needles (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 316.50 °C. @ 760.00 mm Hg
Boiling Point: 642.00 to 643.00 °C. @ 760.00 mm Hg (est)
Flash Point: 479.00 °F. TCC ( 248.10 °C. ) (est)
logP (o/w): 1.989 (est)
Soluble in:
 alcohol
 water, 60 mg/L @ 16C (exp)
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antioxidants
skin conditioning
 
Suppliers:
AIDP
Quercetin Dihydrate 95%
Amax Nutrasource
Quercetin, 95% Quercetin Dihydrate
AuNutra® Industries
Quercetin P.E.
BASF
Diminish the skin’s “orange peel” appearance with Flavenger™
BOC Sciences
For experimental / research use only.
Quercetin 0.99
Odor: characteristic
Use: Quercetin isolated from the flower bud of Sophora flavescens Ait. It has protective effects against chronic mixed reflux esophagitis in rats (Rattus norvegicus) by inhibiting the NF-kappaB p65 and interleukin-8 signaling pathway. anti-HIV; anti-tumor; anti-cancer; antioxidant;
Charkit Chemical
QUERCETIN ANHYDROUS 99.5%
Coompo
For experimental / research use only.
Quercetin from Plants ≥96%
Odor: characteristic
Use: Quercetin exerts many beneficial health effects, including improvement of cardiovascular health, reducing risk for cancer, protection against osteoporosis. This phytochemical has anti-inflammatory, anti-allergic and antitoxic effects. Most of these properties are linked to its strong antioxidant action of quercetin but quercetin also modulates the expression of specific enzymes. Quercetin induces apoptosis and influences protein and lipid kinase signaling pathways. Quercetin is a candidate for preventing obesity-related diseases. Quercetin may help to reduce symptoms of diabetes patients. One study showed that quercetin reduced blood glucose level and improved improved plasma insulin levels in streptozotocin-induced diabetic rats. An in-vitro study concluded that quercetin may have a pharmacological application in treating cardiovascular disease in diabetes mellitus patients. Quercetin shows anti-inflammatory action by its direct antioxidant action and inhibition of inflammatory mediators and enzymes, such as lipoxygenase. Quercetin also inhibits the release of histamine, which causes congestion, by basophils and mast cells. Studies have shown an improved lung function and lower risk of certain respiratory diseases (asthma and bronchitis) for people with high apple (rich in quercetin) intake. Patients with increased levels of inflammation and oxidative stress might benefit most from a quercetin supplementation. To investigate the effects of quercetin supplementation on incidence of upper respiratory tract infections and exercise-induced changes in immune function. Trained male cyclists were randomized to quercetin or placebo groups and, under double-blind procedures, received 3 weeks quercetin (1000 mg a day) or placebo before, during, and for 2 weeks after a 3-d period in which subjects cycled for 3 hours a day at approximately 57% Wmax. Quercetin versus placebo ingestion did not alter exercise-induced changes in several measures of immune function, but it significantly reduced upper respiratory tract infection incidence in cyclists during the 2-wk period after intensified exercise. Studies demonstrate that flavonoid-rich diets protect against myocardial infarction and stroke. As many other flavonoids, quercetin inhibits oxidation of LDL (bad) cholesterol, lowers blood pressure and reduces the risk of heart disease. Studies have shown that quercetin reduces cancer risk of prostate, ovary, breast, gastric and colon cells. Numerous in-vitro studies show that quercetin induces apoptosis of cancer cells through different mechanisms. Preliminary studies indicate that quercetin my inhibit the proliferation of androgen- independent human prostatic tumor cells. In rats, in combination with finasteride, it reduces prostate weight. Whether therapy alone benefits those with benign prostate hyperplasia is not clearly known at this time. Many flavonoids act as aromatase inhibitors. Quercetin supplementation has been linked with improved performance, but supporting evidence is week and often conflicting. Scientists suggest that quercetin may aid performance through its anti-inflammatory properties or by stimulating the activity of mitochondria.
Jiangyin Healthway
Quercetin 95%
New functional food ingredients
Maypro Industries
Quercetin
Penta International
QUERCETIN ANHYDROUS, Kosher
Qingdao Dacon Trading
Quercetin
Risun Ingredients
Quercetin 95%
Sinoway Industrial
For experimental / research use only.
Quercetin
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 161 mg/kg
Reviews of Environmental Contamination and Toxicology. Vol. 113, Pg. 47, 1990.

intravenous-rabbit LD50 100 mg/kg
FAO Nutrition Meetings Report Series. Vol. 46A, Pg. 18, 1969.

oral-mouse LD50 159 mg/kg
BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951.

intravenous-mouse LD50 18 mg/kg
U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02589

intraperitoneal-mouse LD50 3000 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64, Pg. 186, 1968.

Dermal Toxicity:
subcutaneous-mouse LD50 97 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS
Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: food additive and cosmetic agents
Recommendation for quercetin usage levels up to:
 not for fragrance use.
 
Recommendation for quercetin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):117-39-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5280343
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one
Chemidplus:0000117395
EPA/NOAA CAMEO:hazardous materials
RTECS:LK8750000 for cas# 117-39-5
 
References:
 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:117-39-5
Pubchem (cid):5280343
Pubchem (sid):135269910
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
UM BBD:Search
KEGG (GenomeNet):C00389
HMDB (The Human Metabolome Database):HMDB05794
FooDB:FDB011904
YMDB (Yeast Metabolome Database):YMDB01777
MedlinePlusSupp:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
Formulations/Preparations:
•supplied as capsules & tablets •glycosylated forms include rutin and quercetrin •intravenous soln in ethanol or dmso ...
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 almond plant
Search Trop Picture
 anise seed
Search Trop Picture
 apple fruit
Search Trop Picture
 apple heart wood
Search Trop Picture
 apple pericarp
Search Trop Picture
 apricot fruit
Search Trop Picture
 apricot plant
Search Trop Picture
 arrowroot leaf
Search Trop Picture
 ashitaba
Search Trop Picture
 asparagus root
Search Trop Picture
 avocado leaf
Search Trop Picture
 banana fruit
Search Trop Picture
 banana plant
Search Trop Picture
 basil leaf
Search Trop Picture
 basswood flower
Search Trop Picture
 bay laurel leaf
Search Trop Picture
 bean mung bean sprout
Search Trop Picture
 beet plant
Search Trop Picture
 bilberry leaf
Search Trop Picture
 blueberry plant
Search Trop Picture
 borage plant
Search Trop Picture
 breadfruit leaf
Search Trop Picture
 broccoli asparagus broccoli leaf
Search Trop Picture
 brussel sprout sprout
Search Trop Picture
 buckthorn sea buckthorn fruit
Search Trop Picture
 buckwheat plant
Search Trop Picture
 buckwheat seed
Search Trop Picture
 buckwheat sprout
Search Trop Picture
 buckwheat testa
Search Trop Picture
 cabbage leaf
Search Trop Picture
 cacao leaf
Search Trop Picture
 caper flower
Search Trop Picture
 caraway flower
Search Trop Picture
 caraway leaf
Search Trop Picture
 caraway seed
Search Trop Picture
 carob bean
Search Trop Picture
 carrot seed
Search Trop Picture
 cayenne fruit
Search Trop Picture
 celery plant
Search Trop Picture
 chamomile sweet false chamomile plant
Search Trop Picture
 cherry sour cherry fruit
Search Trop Picture
 chestnut sweet chestnut bark
Search Trop Picture
 chestnut sweet chestnut leaf
Search Trop Picture
 chestnut sweet chestnut wood
Search Trop Picture
 chicory plant
Search Trop Picture
 chicory seed
Search Trop Picture
 chive leaf
Search Trop Picture
 clove fruit
Search Trop Picture
 coriander fruit
Search Trop Picture
 coriander leaf
Search Trop Picture
 coriander shoot
Search Trop Picture
 corn pollen
Search Trop Picture
 cotton plant
Search Trop Picture
 cranberry fruit
Search Trop Picture
 currant black currant fruit
Search Trop Picture
 currant black currant fruit juice
Search Trop Picture
 dandelion flower
Search Trop Picture
 date palm pollen
Search Trop Picture
 dill plant
Search Trop Picture
 elder black elder leaf
Search Trop Picture
 endive leaf
Search Trop Picture
 evening-primrose herb
Search Trop Picture
 evening-primrose leaf
Search Trop Picture
 fennel leaf
Search Trop Picture
 fennel seed
Search Trop Picture
 fenugreek flower
Search Trop Picture
 fenugreek leaf
Search Trop Picture
 fenugreek plant
Search Trop Picture
 fenugreek seed
Search Trop Picture
 fig plant
Search Trop Picture
 garlic bulb
Search Trop Picture
 ginger plant
Search Trop Picture
 ginkgo biloba biloba tissue culture
Search Trop Picture
 ginkgo biloba leaf
Search Trop Picture
 grape fruit
Search Trop Picture
 grape leaf
Search Trop Picture
 guava flower
Search Trop Picture
 guava fruit
Search Trop Picture
 guava heart wood
Search Trop Picture
 guava leaf
Search Trop Picture
 guava root
Search Trop Picture
 guava strawberry guava plant
Search Trop Picture
 hazelnut bark
Search Trop Picture
 horseradish leaf
Search Trop Picture
 kiwi plant
Search Trop Picture
 kohlrabi shoot
Search Trop Picture
 lemon flower
Search Trop Picture
 lemongrass plant
Search Trop Picture
 lettuce plant
Search Trop Picture
 loquat
Search Trop Picture
 loquat plant
Search Trop Picture
 lotus indian lotus flower
Search Trop Picture
 mango plant
Search Trop Picture
 marango flower
Search Trop Picture
 marango leaf
Search Trop Picture
 nutmeg plant
Search Trop Picture
 oat hay
Search Trop Picture
 okra flower
Search Trop Picture
 olive stem
Search Trop Picture
 onion
Search Trop Picture
 onion bulb
Search Trop Picture
 orange fruit
Search Trop Picture
 oregano leaf
Search Trop Picture
 oregano plant
Search Trop Picture
 parsley leaf
Search Trop Picture
 parsley plant
Search Trop Picture
 parsley tissue culture
Search Trop Picture
 parsnip leaf
Search Trop Picture
 peach plant
Search Trop Picture
 peanut plant
Search Trop Picture
 pear pericarp
Search Trop Picture
 pepper black pepper fruit
Search Trop Picture
 persimmon american persimmon plant
Search Trop Picture
 plum plant
Search Trop Picture
 pomegranate fruit
Search Trop Picture
 pomegranate leaf
Search Trop Picture
 pomegranate pericarp
Search Trop Picture
 pomegranate plant
Search Trop Picture
 potato flower
Search Trop Picture
 potato sweet potato root
Search Trop Picture
 raspberry red raspberry juice
Search Trop Picture
 rice
Search Trop Picture
 rose hips fruit
Search Trop Picture
 saffron flower
Search Trop Picture
 sorrel garden sorrel fruit
Search Trop Picture
 soybean shoot
Search Trop Picture
 spinach indian spinach plant
Search Trop Picture
 spinach leaf
Search Trop Picture
 sunflower flower
Search Trop Picture
 sunflower leaf
Search Trop Picture
 tarragon shoot
Search Trop Picture
 tea leaf
Search Trop Picture
 tea plant
Search Trop Picture
 tea shoot
Search Trop Picture
 tomato fruit
Search Trop Picture
 turmeric rhizome
Search Trop Picture
 walnut black walnut leaf
Search Trop Picture
 walnut english walnut leaf
Search Trop Picture
 wheat plant
Search Trop Picture
 
Synonyms:
4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-
 C.I. natural red 1
 C.I. natural yellow 10
 cyanidelonon 1522
 cyanidenolon 1522
3-(3,4-dichlorophenoxy)benzaldehyde
2-(3,4-dihydroxy-phenyl)-3,5,7-trihydroxy-chromen-4-one
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one
 flavone, 3,4',5,5',7-pentahydroxy-
 natural yellow 10
3,3',4,5,7-pentahydroxyflavone
3,3',4',5,7-pentahydroxyflavone
3,5,7,3',4'-pentahydroxyflavone
 quercetine
 sophoretin
3',4',5,7-tetrahydroxyflavan-3-ol
3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-on
3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-one
 xanthaurine
 

Articles:

PubMed:Simultaneous determination of caffeine and some selected polyphenols in Wuyi Rock tea by high-performance liquid chromatography.
PubMed:Metabolomic profiling and sensorial quality of 'Golden Delicious', 'Liberty', 'Santana', and 'Topaz' apples grown using organic and integrated production systems.
PubMed:Identification of tartary buckwheat tea aroma compounds with gas chromatography-mass spectrometry.
PubMed:On the formulation design and rheological evaluations of pectin-based functional gels.
PubMed:Insulin secretagogue, alpha-glucosidase and antioxidant activity of some selected spices in streptozotocin-induced diabetic rats.
PubMed:Atheroprotective and plaque-stabilizing effects of enzymatically modified isoquercitrin in atherogenic apoE-deficient mice.
PubMed:Identification and quantification of free radical scavengers in Pu-erh tea by HPLC-DAD-MS coupled online with 2,2'-Azinobis(3-ethylbenzthiazolinesulfonic acid) diammonium salt assay.
PubMed:Isolation and characterization of a novel glycosyltransferase that converts phloretin to phlorizin, a potent antioxidant in apple.
PubMed:Monosodium glutamate-induced oxidative damage and genotoxicity in the rat: modulatory role of vitamin C, vitamin E and quercetin.
PubMed:Influence of cooking process on phenolic marker compounds of vegetables.
PubMed:Researching on new species of "Mate": Ilex brevicuspis: phytochemical and pharmacology study.
PubMed:Dietary flavonoids: bioavailability, metabolic effects, and safety.
PubMed:Antioxidant activity of selected Indian spices.
PubMed:Purification, characterization, and substrate specificity of a novel highly glucose-tolerant beta-glucosidase from Aspergillus oryzae.
 
Notes:
a flavonol widely distributed in plants. it is an antioxidant, like many other phenolic heterocyclic compounds. glycosylated forms include rutin and quercetrin. Isol. from many plants, esp. fruits, such as Helichrysum, Euphorbia and Karwinskia spp. Present in the Solanaceae, Rhamnaceae, Passifloraceae and many other families. For example detected in almost all studied Umbelliferae. Nutriceutical with antiinflammatory props. and a positive influence on the blood lipid profile. Found in a wide variety of foodstuffs esp. apples, bee pollen, blackcurrants, capers, cocoa, cranberries, dock leaves, elderberries, fennel, lovage, red onions, ancho peppers, dill weed and tarragon
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2018 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy