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methoxyacetaldehyde
acetaldehyde, methoxy- (8CI,9CI)

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Name:2-methoxyacetaldehyde
CAS Number: 10312-83-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:233-693-5
FDA UNII: 5G4O7K64WA
Nikkaji Web:J54.041B
Beilstein Number:1738030
MDL:MFCD00059176
XlogP3-AA:-0.40 (est)
Molecular Weight:74.07922000
Formula:C3 H6 O2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 92.00 °C. @ 760.00 mm Hg
Vapor Pressure:406.300000 mmHg @ 25.00 °C. (est)
Flash Point: -38.00 °F. TCC ( -38.90 °C. ) (est)
logP (o/w): -0.640 (est)
Soluble in:
 water, 9.39e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Methoxyacetaldehyde 95%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Methoxyacetaldehyde
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 2330 mg/kg
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 382, 1969.

intraperitoneal-rat LDLo 487 mg/kg
Toxicology Letters. Vol. 32, Pg. 73, 1986.

Dermal Toxicity:
skin-rabbit LD50 1170 mg/kg
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 382, 1969.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for methoxyacetaldehyde usage levels up to:
 not for fragrance use.
 
Recommendation for methoxyacetaldehyde flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :91563
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 1233
WGK Germany:3
2-methoxyacetaldehyde
Chemidplus:0010312831
RTECS:AB2940000 for cas# 10312-83-1
 
References:
 2-methoxyacetaldehyde
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):91563
Pubchem (sid):135048261
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 acetaldehyde, 2-methoxy-
 acetaldehyde, methoxy- (8CI,9CI)
2-methoxyacetaldehyde
 methoxyethanal
 

Articles:

PubMed:Azithromycin-sulfonamide conjugates as inhibitors of resistant Streptococcus pyogenes strains.
PubMed:Efficient enzymatic synthesis of phosphoroselenoate RNA by using adenosine 5'-(alpha-P-seleno)triphosphate.
PubMed:Proteomic identification of less oxidized brain proteins in aged senescence-accelerated mice following administration of antisense oligonucleotide directed at the Abeta region of amyloid precursor protein.
PubMed:Biotic and abiotic degradation behaviour of ethylene glycol monomethyl ether (EGME).
PubMed:Gas chromatography-mass spectrometry of carbonyl compounds in cigarette mainstream smoke after derivatization with 2,4-dinitrophenylhydrazine.
PubMed:Oxidative generation of guanine radicals by carbonate radicals and their reactions with nitrogen dioxide to form site specific 5-guanidino-4-nitroimidazole lesions in oligodeoxynucleotides.
PubMed:Involvement of caspase 3 mediated apoptosis in hematopoietic cytotoxicity of metabolites of ethylene glycol monomethyl ether.
PubMed:High-throughput analysis of hemoglobin from neonates using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
PubMed:Immunochemical assay of hemoglobin with N(epsilon)-(carboxymethyl)lysine at lysine 66 of the beta chain.
PubMed:2-Methoxyethanol metabolism, embryonic distribution, and macromolecular adduct formation in the rat: the effect of radiofrequency radiation-induced hyperthermia.
PubMed:Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse.
PubMed:A novel compound heterozygote (FAP ATTR Arg104His/ATTR Val30Met) with high serum transthyretin (TTR) and retinol binding protein (RBP) levels.
PubMed:Concurrent teratogenic and mutagenic action of 2-methoxyethanol in Drosophila melanogaster larvae resulted in similar phenotypes: close resemblance to directed mutations.
PubMed:Apoptosis inhibition and ornithine decarboxylase superinduction as early epigenetic events in morphological transformation of Syrian hamster embryo cells exposed to 2-methoxyacetaldehyde, a metabolite of 2-methoxyethanol.
PubMed:Oligosaccharides of recombinant mouse gelatinase B variants.
PubMed:The role of metabolism in 2-methoxyethanol-induced suppression of in vitro polyclonal antibody responses by rat and mouse lymphocytes.
PubMed:Interaction of human CYP17 (P-450(17alpha), 17alpha-hydroxylase-17,20-lyase) with cytochrome b5: importance of the orientation of the hydrophobic domain of cytochrome b5.
PubMed:Effects of reactive oxygen species (ROS) modulators, TEMPOL and catalase, on methoxyacetaldehyde (MALD) -induced chromosome aberrations in Chinese hamster ovary (CHO)-AS52 cells.
PubMed:Induction of deletion mutations by methoxyacetaldehyde in Chinese hamster ovary (CHO)-AS52 cells.
PubMed:Mutagenicity and cytotoxicity of 2-butoxyethanol and its metabolite, 2-butoxyacetaldehyde, in Chinese hamster ovary (CHO-AS52) cells.
PubMed:Mutagenicity of ethylene glycol ethers and of their metabolites in Salmonella typhimurium his-.
PubMed:Cytogenetic effects of 2-methoxyethanol and its metabolite, methoxyacetaldehyde, in mammalian cells in vitro.
PubMed:Evaluation of the clastogenic effects of 2-methoxyethanol in mice.
PubMed:Methoxyacetaldehyde, an intermediate metabolite of 2-methoxyethanol, is immunosuppressive in the rat.
PubMed:Fluorometric determination of L-tryptophan with methoxyacetaldehyde.
PubMed:Mutagenicity and cytotoxicity of 2-methoxyethanol and its metabolites in Chinese hamster cells (the CHO/HPRT and AS52/GPT assays).
PubMed:Antimicrobial effects of some mono- and bishydrazones.
PubMed:N-(cyanomethyl)- and N-(2-methoxy-1-cyanoethyl)anthracyclines and related carboxyl derivatives.
PubMed:Testicular toxicity of 2-methoxyacetaldehyde, a possible metabolite of ethylene glycol monomethyl ether, in the rat.
PubMed:Testicular toxicity produced by ethylene glycol monomethyl and monoethyl ethers in the rat.
 
Notes:
shows testicular toxicity.
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