|
Category:herbicides / pesticides
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white crystalline solid (est) |
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 136.00 °C. @ 760.00 mm Hg
|
| Vapor Pressure: | 1.500000 mmHg @ 1.50 °C. (est) |
| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est)
|
| logP (o/w): | 1.150 |
| Soluble in: |
| | water, 630 mg/L @ 25 °C (exp) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-duck LD50 1142 mg/kg
Pesticide Manual. Vol. 9, Pg. 326, 1991.
oral-guinea pig LD50 176 mg/kg
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 64, 1982.
oral-mouse LD50 266 mg/kg
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 64, 1982.
oral-quail LD50 788 mg/kg
Pesticide Manual. Vol. 9, Pg. 326, 1991.
oral-rabbit LD50 535 mg/kg
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 64, 1982.
oral-rat LD50 660 mg/kg
GASTROINTESTINAL: OTHER CHANGES
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Toxicology and Applied Pharmacology. Vol. 3, Pg. 127, 1961.
unreported-rat LD50 1000 mg/kg
"Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 239, 1971.
|
| Dermal Toxicity: |
skin-guinea pig LDLo 2000 mg/kg
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 64, 1982.
skin-rabbit LD50 2100 mg/kg
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
BLOOD: HEMORRHAGE
Toxicology and Applied Pharmacology. Vol. 3, Pg. 127, 1961.
skin-rat LD50 > 6000 mg/kg
Farm Chemicals Handbook. Vol. -, Pg. C116, 1991.
|
| Inhalation Toxicity: |
inhalation-mouse LC50 129 mg/m3/2H
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 64, 1982.
|
Safety in Use Information:
| Category: | | herbicides / pesticides |
| Recommendation for dodine usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for dodine flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
European Food Safety Authority (EFSA) reference(s):
|
Reasoned opinion on the review of the existing maximum residue levels (MRLs) for dodine according to Article 12 of Regulation (EC) No 396/2005
View page or View pdf
|
Retrospective analysis of the immunotoxic effects of plant protection products as reported in the Draft Assessment Reports for their peer review at EU level
View page or View pdf
|
Peer review of the pesticide risk assessment for the active substance dodine in light of confirmatory data submitted
View page or View pdf
|
| EPI System: View |
| EPA-Iris:IRIS |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA GENetic TOXicology:Search |
| EPA Substance Registry Services (TSCA):2439-10-3 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :17110 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| acetic acid;2-dodecylguanidine |
| Chemidplus:0002439103 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:MF1750000 for cas# 2439-10-3 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | aadodin | | | acetic acid;2-dodecylguanidine | | | carpene | | | curitan | | | cyprex | | | cyprex 65W | | | dodecyl guanidine monoacetate | | | dodecylguanidine acetate | | N- | dodecylguanidine acetate | | | dodecylguanidine monoacetate | | 1- | dodecylguanidinium acetate | | | doguadine | | | guanidine, dodecyl-, monoacetate | | | guanidine, N-dodecyl-, acetate (1:1) | | | karpen | | | laurylguanidine acetate | | | melprex | | | melprex 65 | | | melprex 65W | | | questuran | | | radspor | | | syllit | | | syllit 65 | | | tsitrex | | | venturol | | | vondodine |
Articles:
| PubMed:Dodine as a protein denaturant: the best of two worlds? |
| PubMed:Combined toxicity of pesticide mixtures on green algae and photobacteria. |
| PubMed:Evaluation of dodine, fluopyram and penthiopyrad for the management of leaf spot and powdery mildew of tart cherry, and fungicide sensitivity screening of Michigan populations of Blumeriella jaapii. |
| PubMed:A novel dodine-free selective medium based on the use of cetyl trimethyl ammonium bromide (CTAB) to isolate Beauveria bassiana, Metarhizium anisopliae sensu lato and Paecilomyces lilacinus from soil. |
| PubMed:Determination of dodine in fruit samples by liquid chromatography electrospray ionization-tandem mass spectrometry. |
| PubMed:A new effect residual ratio (ERR) method for the validation of the concentration addition and independent action models. |
| PubMed:Effect of occupational exposure to multiple pesticides on translocation yield and chromosomal aberrations in lymphocytes of plant workers. |
| PubMed:[Analytical method of dodine in agricultural products by LC/MS]. |
| PubMed:Utility of six fungicides for selective isolation of Evlachovaea sp. and Tolypocladium cylindrosporum. |
| PubMed:Evidence for the Predisposition of Fungicide-Resistant Isolates of Venturia inaequalis to a Preferential Selection for Resistance to Other Fungicides. |
| PubMed:Management of apple scab (Venturia inaequalis) in Romania based on electronic warnings. |
| PubMed:Comment on "Determination of the critical micelle concentration of dodecylguanidine monoacetate (dodine)". |
| PubMed:In vitro susceptibility to fungicides by invertebrate-pathogenic and saprobic fungi. |
| PubMed:Impact of fungal drug transporters on fungicide sensitivity, multidrug resistance and virulence. |
| PubMed:The potential for enhanced fungicide resistance in Beauveria bassiana through strain discovery and artificial selection. |
| PubMed:Isolation of Beauveria bassiana and Metarhizium anisopliae var. anisopliae from Boophilus microplus tick (Canestrini, 1887), in Rio de Janeiro State, Brazil. |
| PubMed:[Renal dysfunction in chemical plant workers producing dust pesticides]. |
| PubMed:Humoral and cellular immunity rates in chemical plant workers producing dust pesticides. |
| PubMed:Induction of rat liver cytochrome P450 isoenzymes CYP 1A and CYP 2B by different fungicides, nitrofurans, and quercetin. |
| PubMed:A new 2D-TLC bioautography method for the discovery of novel antifungal agents To control plant pathogens. |
| PubMed:[Bronchial hyperreactivity in chemical plant workers employed in the production of dust pesticides]. |
| PubMed:Alterations of male Wistar rat jejunum induced by Dodine (n-dodecylguanidine acetate). |
| PubMed:The role of respiratory muscles in the impairment of the respiratory system function in the workers of a chemical plant division producing pesticides. |
| PubMed:Effects of n-dodecylguanidine on A-type potassium channels: role of external surface charges in channel gating. |
| PubMed:[Allergic diseases caused by pesticides: 3 case reports]. |
| PubMed:Dodecylguanidine monoacetate (dodine) causes severe membrane damage in Pseudomonas syringae above the critical micelle concentration. |
| PubMed:Mode of antibacterial action of dodine (dodecylguanidine monoacetate) in Pseudomonas syringae. |
| PubMed:Damage to the cytoplasmic membrane and cell death caused by dodine (dodecylguanidine monoacetate) in Pseudomonas syringae ATCC 12271. |
| PubMed:Neutrophil function in chemical plant workers employed in the production of dust pesticides. |
| PubMed:[Poisoning with monocrotophos, dinocap, diodine and isopropyl alcohol]. |
| PubMed:Gas-liquid chromatographic method for the determination of dodine in fruit. |
| PubMed:Experimental verification of the possibility of in vivo formation of nitrosocompounds upon combined action of dodecylguanidineacetate and sodium nitrite. |
| PubMed:[Determination of dodine in selected plant material]. |
| PubMed:[Antimicrobial properties of dodecylguanidine acetate]. |
| PubMed:[Film-forming formulation for treating the surgical field]. |
| PubMed:Carcinogenic effect of a quanidine pesticide administered with sodium nitrite on adult mice and on the offspring after prenatal exposure. |
| PubMed:Microbiological mutagenicity studies of pesticides in vitro. |
| PubMed:Fatal poisoning with a plant protective containing monocrotophos, dodine and dinocap. |
| PubMed:Mutagenic and recombinogenic action of pesticides in Aspergillus nidulans. |
| PubMed:The effect of ionic surface-active agents on macroconidial plasma membrane of Fusarium sulphureum. |
| PubMed:Formation of mutagenic N-nitroso compounds from the pesticides prometryne, dodine and carbaryl in the presence of nitrite at pH 1. |
| PubMed:A gas-liquid chromatographic method for the determination of dodine residues on foods. |
| PubMed:Genetic analysis of dodine resistance in Nectria haematococca (syn. Hypomyces solani). |
| PubMed:The induction of dodine tolerance in Fusarium oxysporum f. melonis: a technique applicable to the study of the bionomics of soil-borne fungal pathogens. |
| PubMed:Radiation-induced resistance to dodine in Hypopyces. |
| PubMed:Uptake and binding of dodine acetate by fungal spores. |
| PubMed:Acute and chronic toxicity of dodine (n-dodecylguanidine acetate). |
|
3D/inchi