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sodium feredetate
acetic acid, (ethylenedinitrilo)tetra-, sodium salt, iron complex

Supplier Sponsors

CAS Number: 15708-41-5Picture of molecule3D/inchi
Other(deleted CASRN):11079-05-3
ECHA EINECS - REACH Pre-Reg:239-802-2
FDA UNII: 403J23EMFA
Nikkaji Web:J2.239.441J
MDL:MFCD00078215
Molecular Weight:367.04800928
Formula:C10 H12 Fe N2 Na O8
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:nutrient supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
1980 Sodium ferric EDTA View - review
GRN 152 Sodium iron EDTA View - notice PDF
GRN 178 Sodium iron EDTA View - notice PDF
JECFA Food Additive: Sodium Iron (III) Ethylenediaminetetraacetate, Trihydrate
FDA Mainterm (IAUFC):15708-41-5 ; EDTA, IRON (III) SODIUM
 
Physical Properties:
Appearance:pale yellow powder (est)
Assay: 80.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 614.20 °C. @ 760.00 mm Hg (est)
Flash Point: 617.00 °F. TCC ( 325.20 °C. ) (est)
logP (o/w): -0.434 (est)
Soluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Akzo Nobel
Ferrazone®
BOC Sciences
For experimental / research use only.
edta iron(iii) sodium salt >90.0%
Glentham Life Sciences
EDTA ferric sodium salt
Jiangyin Healthway
EDTA - Fe Na
New functional food ingredients
Jiangyin Healthway
NaFeEDTA
Santa Cruz Biotechnology
For experimental / research use only.
EDTA Iron(III) sodium salt ≥99%
Sigma-Aldrich: Sigma
For experimental / research use only.
Ethylenediaminetetraacetic acid ferric sodium salt
sds
TCI AMERICA
For experimental / research use only.
Ethylenediaminetetraacetic Acid Monosodium Ferric Salt Hydrate >90.0%(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 5000 mg/kg
Ciba-Geigy Toxicology Data/Indexes. Vol. -, Pg. -, 1977.

oral-mouse LD50 5000 mg/kg
Ciba-Geigy Toxicology Data/Indexes. Vol. -, Pg. -, 1977.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
nutrient supplements
Recommendation for sodium feredetate usage levels up to:
 not for fragrance use.
 
Recommendation for sodium feredetate flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the use of ferric sodium EDTA as a source of iron added for nutritional purposes to foods for the general population (including food supplements) and to foods for particular nutritional uses
View page or View pdf

Technical report on the technical assistance for the evaluation of additional information on ferric sodium EDTA as a novel food
View page or View pdf

Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):15708-41-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :27461
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
sodium; 2-[2-[bis(2-oxido-2-oxoethyl)amino]ethyl-(2-oxido-2-oxoethyl)amino] acetate; iron(3+)
Chemidplus:0015708415
RTECS:AH4900000 for cas# 15708-41-5
 
References:
 sodium; 2-[2-[bis(2-oxido-2-oxoethyl)amino]ethyl-(2-oxido-2-oxoethyl)amino] acetate; iron(3+)
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:15708-41-5
Pubchem (cid):27461
Pubchem (sid):134992125
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
KEGG (GenomeNet):D07145
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2922.49.8000
FDA Listing of Food Additive Status:View
ChemSpider:View
FAO:SODIUM IRON (III) ETHYLENEDIAMINETETRAACETATE, TRIHYDRATE
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 acetic acid, (ethylenedinitrilo)tetra-, sodium salt, iron complex
 EDTA ferric sodium salt
 EDTA iron(III) sodium salt
[[N,N'-ethanediylbis[N-(carboxymethyl)glycinato]](4-)]-N,N',O,O',ON,ON'-ferrate(1-) Sodium
 ethylenediaminetetraacetic acid ferric sodium salt
 ethylenediaminetetraacetic acid,monosodium ferric salt
(ethylenedinitrilo)tetraacetic acid, monosodium iron salt
 ferrate(1-), ((ethylenedinitrilo)tetraacetato)-, sodium (8CI)
 ferrazone
 ferric sodium edetate
 ferric sodium EDTA
 ferric sodium ethylenediaminetetraacetate
 iron chelate of the monosodium salt of (ethylenedinitrilo) tetraacetic acid
 iron chelate of the monosodium salt of (ethylenedinitrilo)tetraacetic acid
 iron sodium ethylenediaminetetraacetate (1:1:1)
 iron(3+) sodium 2,2',2'',2'''-(1,2-ethanediyldinitrilo)tetraacetate
 iron(3+) sodium 2,2',2'',2'''-(1,2-ethanediyldinitrilo)tetraacetate (1:1:1)
 iron(3+) sodium 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate
 iron(3+) sodium 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate (1:1:1)
 iron(III)-sodium ethylenediaminetetraacetate hydrate
 sodium ((ethylenedinitrilo)tetraacetato)ferrate(1-)
 sodium (N,N,N',N'-ethylenediaminetetraacetato)ferrate(1-)
 sodium [(ethylenedinitrilo)tetraacetato]ferrate(1-)
 sodium ferric EDTA
 sodium ferric ethylenediaminetetraacetate
 sodium iron edetate
 sodium iron EDTA
 sodium Iron(III) ethylene diamine tetraacetate trihydrate
 sodium iron(III) ethylenediaminetetraacetate
 sodium ironedetate
 sodium; 2-[2-[bis(2-oxido-2-oxoethyl)amino]ethyl-(2-oxido-2-oxoethyl)amino] acetate; iron(3+)
 

Articles:

PubMed:[Meta analysis of condiments fortified with sodium iron ethylenediaminetetraacetate on the prevention and treatment of anemia].
PubMed:Reasons for raising the maximum acceptable daily intake of EDTA and the benefits for iron fortification of foods for children 6-24 months of age.
PubMed:Impact of activation methods on persulfate oxidation of methyl tert-butyl ether.
PubMed:Rapid quantification of iron content in fish sauce and soy sauce: a promising tool for monitoring fortification programs.
PubMed:Fish sauce, soy sauce, and vegetable oil fortification in Cambodia: where do we stand to date?
PubMed:Differences in circulating non-transferrin-bound iron after oral administration of ferrous sulfate, sodium iron EDTA, or iron polymaltose in women with marginal iron stores.
PubMed:Sodium iron EDTA and ascorbic acid, but not polyphenol oxidase treatment, counteract the strong inhibitory effect of polyphenols from brown sorghum on the absorption of fortification iron in young women.
PubMed:Iron bioavailability from a lipid-based complementary food fortificant mixed with millet porridge can be optimized by adding phytase and ascorbic acid but not by using a mixture of ferrous sulfate and sodium iron EDTA.
PubMed:Fortification of wheat flour and maize meal with different iron compounds: results of a series of baking trials.
PubMed:Fortification of staple cereal flours with iron and other micronutrients: cost implications of following World Health Organization-endorsed recommendations.
PubMed:Effect of wheat flour fortified with sodium iron EDTA on urinary zinc excretion in school-aged children.
PubMed:Oral administration of ferrous sulfate, but not of iron polymaltose or sodium iron ethylenediaminetetraacetic acid (NaFeEDTA), results in a substantial increase of non-transferrin-bound iron in healthy iron-adequate men.
PubMed:Mixture of ferric sodium ethylenediaminetetraacetate (NaFeEDTA) and ferrous sulfate: an effective iron fortificant for complementary foods for young Chinese children.
PubMed:Effect of iron-fortified foods on hematologic and biological outcomes: systematic review of randomized controlled trials.
PubMed:[Iron and zinc in vitro potential availability in an infant diet with fortified bread with different iron sources or with the addition of different iron absorption promoters].
PubMed:Equivalent effects on fecal reactive oxygen species generation with oral supplementation of three iron compounds: ferrous sulfate, sodium iron EDTA and iron polymaltose.
PubMed:Moderate NaFeEDTA and ferrous sulfate supplementation can improve both hematologic status and oxidative stress in anemic pregnant women.
PubMed:Fortifying complementary foods with NaFeEDTA--considerations for developing countries.
PubMed:Development of fortified biscuit using NaFeEDTA.
PubMed:Fortification iron as ferrous sulfate plus ascorbic acid is more rapidly absorbed than as sodium iron EDTA but neither increases serum nontransferrin-bound iron in women.
PubMed:Random serial sampling to evaluate efficacy of iron fortification: a randomized controlled trial of margarine fortification with ferric pyrophosphate or sodium iron edetate.
PubMed:Comparative study of efficacy, tolerability and compliance of oral iron preparations (iron edetae, iron polymatose complex) and intramuscular iron sorbitol in iron deficiency anaemia in children.
PubMed:Oral supplementation with NaFeEDTA reduces blood lead in postmenopausal but not premenopausal Korean women with anemia.
PubMed:Effect of sodium iron ethylenediaminetetra-acetate (NaFeEDTA) on haemoglobin and serum ferritin in iron-deficient populations: a systematic review and meta-analysis of randomised and quasi-randomised controlled trials.
PubMed:Fortifying brown bread with sodium iron EDTA, ferrous fumarate, or electrolytic iron does not affect iron status in South African schoolchildren.
PubMed:A randomised double-blind study comparing sodium feredetate with ferrous fumarate in anaemia in pregnancy.
PubMed:Tissue iron distribution and urinary mineral excretion vary depending on the form of iron (FeSO4 or NaFeEDTA) and the route of administration (oral or subcutaneous) in rats given high doses of iron.
PubMed:Effects of various iron fortificants on sensory acceptability and shelf-life stability of instant noodles.
PubMed:Efficacy of iron-fortified whole maize flour on iron status of schoolchildren in Kenya: a randomised controlled trial.
PubMed:Iron dissociates from the NaFeEDTA complex prior to or during intestinal absorption in rats.
PubMed:Iron uptake by Caco-2 cells from NaFeEDTA and FeSO4: Effects of ascorbic acid, pH, and a Fe(II) chelating agent.
PubMed:Sodium iron (III) ethylenediaminetetraacetic acid synthesis to reduce iron deficiency globally.
PubMed:[Determination of sodium iron (III) ethylenediaminetetraacetate in iron-fortified soy sauce by reversed-phase ion-pair high performance liquid chromatography].
PubMed:[Capillary zone electrophoretic determination of NaFeEDTA in iron fortified soy sauce].
PubMed:Studies on the effectiveness of NaFeEDTA-fortified soy sauce in controlling iron deficiency: a population-based intervention trial.
PubMed:Increased osmolality of breast milk with therapeutic additives.
PubMed:Alkaline anaerobic respiration: isolation and characterization of a novel alkaliphilic and metal-reducing bacterium.
PubMed:[Study on the effect of NaFeEDTA on preventing lead poisoning in rats and its impact on zinc, copper].
PubMed:Iron absorption from fish sauce and soy sauce fortified with sodium iron EDTA.
PubMed:Acute toxicity of carbonyl iron and sodium iron EDTA compared with ferrous sulfate in young rats.
PubMed:The effect of different iron fortificants on iron absorption from iron-fortified rice.
PubMed:Photodegradation of ethylenediaminetetraacetic acid (EDTA) and ethylenediamine disuccinic acid (EDDS) within natural UV radiation range.
PubMed:The effect of change in pH on the solubility of iron bis-glycinate chelate and other iron compounds.
PubMed:Overexpression of EC-SOD suppresses endothelial-cell-mediated LDL oxidation.
PubMed:Disposition, accumulation and toxicity of iron fed as iron (II) sulfate or as sodium iron EDTA in rats.
PubMed:Absorption of iron from unmodified maize and genetically altered, low-phytate maize fortified with ferrous sulfate or sodium iron EDTA.
PubMed:Safety assessment of iron EDTA [sodium iron (Fe(3+)) ethylenediaminetetraacetic acid]: summary of toxicological, fortification and exposure data.
PubMed:Genotoxicity of iron compounds in Salmonella typhimurium and L5178Y mouse lymphoma cells.
PubMed:Sodium iron EDTA [NaFe(III)EDTA] as a food fortificant does not influence absorption and urinary excretion of manganese in healthy adults.
PubMed:Short communication: the use of sodium ironedetate (Sytron) as an MRI rectal contrast agent.
PubMed:Fortification of sugar with iron sodium ethylenediaminotetraacetate (FeNaEDTA) improves iron status in semirural Guatemalan populations.
PubMed:Iron from complex salts and its bioavailability to rats.
PubMed:Fractionation of liver microsomes with polyethylene glycol and purification of NADH-cytochrome b5 oxidoreductase and cytochrome b5.
PubMed:Synthesis and iron(III) binding properties of 3-hydroxypyrid-4-ones derived from kojic acid.
PubMed:Sodium iron EDTA [NaFe(III)EDTA] as a food fortificant: the effect on the absorption and retention of zinc and calcium in women.
PubMed:Peroxynitrite inhibition of oxygen consumption and sodium transport in alveolar type II cells.
PubMed:Toxicological profile, current use, and regulatory issues on EDTA compounds for assessing use of sodium iron EDTA for food fortification.
PubMed:Degradation of the Ferric Chelate of EDTA by a Pure Culture of an Agrobacterium sp.
PubMed:Application of a long-term enhanced xanthine oxidase-induced luminescence in solid-phase immunoassays.
PubMed:Kinetics and mechanism of electron transfer between meso-tetra sulphonated phenyl porphyrin iron(III)-apomyoglobin and Fe(EDTA)2- complexes.
PubMed:Iron stimulation of free radical-mediated porphyrinogen oxidation by hepatic and renal mitochondria.
PubMed:Photosensitization by antitumor agents, 4. Anthrapyrazole-photosensitized formation of single strand-breaks in DNA.
PubMed:Hydroxyl radicals are not involved in NADPH dependent microsomal lipid peroxidation.
PubMed:Iron deficiency in the tropics.
PubMed:Ironstrene (ferric sodium edetate) treatment of anaemic infants.
PubMed:Aerobic photodegradation of X(N) chelates of (ethylenedinitrilo)tetraacetic acid (EDTA): implications for natural waters.
PubMed:A comparative study of iron absorption and utilization following ferrous sulphate and sodium ironedetate ("Sytron").
PubMed:Ferric sodium EDTA; clinical experience with infants and young children suffering from anaemia; preliminary report.
 
Notes:
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