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bromhexine hydrochloride
2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline hydrochloride (1:1)

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Name:2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline;hydrochloride
CAS Number: 611-75-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:210-280-8
FDA UNII: YC2ZOM3Z8V
Beilstein Number:4848376
MDL:MFCD00056626
Molecular Weight:412.59537000
Formula:C14 H21 Br2 Cl N2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 441.50 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000000 mmHg @ 25.00 °C. (est)
Flash Point: 429.00 °F. TCC ( 220.80 °C. ) (est)
logP (o/w): 5.081 (est)
Soluble in:
 water, 5.346 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Bromhexine Hydrochloride >98%
Glentham Life Sciences
Bromhexine hydrochloride
Santa Cruz Biotechnology
For experimental / research use only.
Bromhexine Hydrochloride
Sigma-Aldrich: Aldrich
For experimental / research use only.
Bromhexine Hydrochloride ≥98.0% (AT)
sds
TCI AMERICA
For experimental / research use only.
Bromhexine Hydrochloride
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 2210 mg/kg
Gendai no Rinsho. Vol. 3, Pg. 259, 1969.

intravenous-mouse LD50 44 mg/kg
Gendai no Rinsho. Vol. 3, Pg. 259, 1969.

oral-mouse LD50 3000 mg/kg
Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriums-diagnostik. Vol. 109, Pg. 385, 1970.

oral-rabbit LD50 10000 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION CARDIAC: OTHER CHANGES
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 163, Pg. 284, 1966.

intraperitoneal-rat LD50 1680 mg/kg
BEHAVIORAL: TREMOR SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA
Gendai no Rinsho. Vol. 3, Pg. 259, 1969.

oral-rat LD50 6000 mg/kg
BEHAVIORAL: TREMOR SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: ATAXIA
Gendai no Rinsho. Vol. 3, Pg. 259, 1969.

Dermal Toxicity:
subcutaneous-mouse LD50 > 14000 mg/kg
Drugs in Japan Vol. 6, Pg. 737, 1982.

subcutaneous-rat LD50 > 14000 mg/kg
Yakkyoku. Pharmacy. Vol. 35(1), Pg. -, 1984.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for bromhexine hydrochloride usage levels up to:
 not for fragrance use.
 
Recommendation for bromhexine hydrochloride flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5702220
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline;hydrochloride
Chemidplus:0000611756
RTECS:XS9950000 for cas# 611-75-6
 
References:
 2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline;hydrochloride
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5702220
Pubchem (sid):135048886
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D01778
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2921.59.8090
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
2-amino-3,5-dibromo-N-cyclohexyl-N-methylbenzenemethanamine monohydrochloride
2-amino-3,5-dibromo-N-cyclohexyl-N-methylbenzylamine hydrochloride
[(2-amino-3,5-dibromophenyl)methyl]cyclohexylmethylamine, chloride
2-amino-N-cyclohexyl-3,5-dibromo-N-methylbenzylamine hydrochloride
 benzenemethanamine, 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl-, hydrochloride (1:1)
 benzenemethanamine, 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl-, monohydrochloride
 benzylamine, 2-amino-N-cyclohexyl-3,5-dibromo-N-methyl-, hydrochloride
 bisolvon
 bromhexine chloride
 bromhexine HCl
 bromhexinehydrochloride
 bromohexine HCl
 bromohexine hydrochloride
N-cyclohexyl-N-methyl-(2-amino-3,5-dibromobenzyl)ammonium chloride
2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline;hydrochloride
2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline hydrochloride (1:1)
3,5-dibromo-Na-cyclohexyl-Na-methyltoluene-a,2-diamine Hydrochloride
 

Articles:

PubMed:Extractive determination of ephedrine hydrochloride and bromhexine hydrochloride in pure solutions, pharmaceutical dosage form and urine samples.
PubMed:Investigation of internal structure of fine granules by microtomography using synchrotron X-ray radiation.
PubMed:On the formation of bromhexine impurity E and its chromatographic behaviour.
PubMed:Solubility and solution stability studies of different amino acid prodrugs of bromhexine.
PubMed:Stability-indicating HPLC Method for Simultaneous Determination of Terbutaline Sulphate, Bromhexine Hydrochloride and Guaifenesin.
PubMed:[Treatment of acute exacerbation of the obstructive pulmonary disease with hospitalization at an intensive care unit].
PubMed:Cyclodextrins: Efficient biocompatible solubilizing excipients for bromhexine liquid and semi-solid drug delivery systems.
PubMed:Effect of drug content and agglomerate size on tabletability and drug release characteristics of bromhexine hydrochloridetalc agglomerates prepared by crystallo-co-agglomeration.
PubMed:Simultaneous determination of salbutamol sulphate and bromhexine hydrochloride in tablets by reverse phase liquid chromatography.
PubMed:Recent developments in the treatment of alcoholic chronic pancreatitis.
PubMed:Bioequivalence study of bromhexine by liquid chromatography-electrospray ionization-mass spectrometry after oral administration of bromhexine hydrochloride tablets.
PubMed:Chemiluminescence determination of bromhexine hydrochloride with morin as chemiluminescent reagent.
PubMed:Design and evaluation of deformable talc agglomerates prepared by crystallo-co-agglomeration technique for generating heterogeneous matrix.
PubMed:Simultaneous determination of salbutamol sulphate, bromhexine hydrochloride and etofylline in pharmaceutical formulations with the use of four rapid derivative spectrophotometric methods.
PubMed:Development and validation of chemometrics-assisted spectrophotometric and liquid chromatographic methods for the simultaneous determination of two multicomponent mixtures containing bronchodilator drugs.
PubMed:Effect of bromhexine hydrochloride therapy for alcoholic chronic pancreatitis.
PubMed:A pilot study of aerosolized N-acetylcysteine for idiopathic pulmonary fibrosis.
PubMed:Simultaneous determination of ingredients in a cold medicine by cyclodextrin-modified microemulsion electrokinetic chromatography.
PubMed:Mediastinal pancreatic pseudocyst caused by obstruction of the pancreatic duct was eliminated by bromhexine hydrochloride.
PubMed:Treatment of gingival overgrowth induced by manidipine administration. A case report.
PubMed:Solubilization of bromhexine hydrochloride in aqueous lecithin dispersions. Physicochemical characterization of interactions between drug and carrier.
PubMed:Sjögren syndrome associated with multiple myeloma of the IgA κ-type.
PubMed:Bromhexine hydrochloride eliminates protein plugs and relieves attacks of pancreatitis.
PubMed:Simultaneous determination of bromhexine hydrochloride and methyl and propyl p-hydroxybenzoate and determination of dextromethorphan hydrobromide in cough-cold syrup by high-performance liquid chromatography.
PubMed:Improvement of some pharmaceutical properties of drugs by cyclodextrin complexation. 3. Bromhexine hydrochloride.
PubMed:[Experimental studies on the influence of selected preparations on secretion of tear fluid. II: Light and transmission electron microscopy].
PubMed:[Experimental studies on the influence of selected preparations on secretion of tear fluid. I. Schirmer test I and lysozyme test].
PubMed:Automatic determination of amylocaine and bromhexine by atomic absorption spectrometry.
PubMed:Bromhexine plus oxytetracycline: the effect of combined administration upon the rheological properties of mucus from the mini-pig.
PubMed:Predisposition to uterine microbial contamination in the guinea-pig following administration of mucolytic drugs and steroid hormones.
PubMed:[Experimental investigations on the influence of bromhexine hydrochloride on the excretion of lacrimal fluid].
PubMed:The effect of bromhexine hydrochloride on the viscoelastic properties of mucus from the mini-pig.
PubMed:[Simultaneous determination of three components in compound clorprenaline tablet by using the derivative-complementary tristimulus method].
PubMed:Lack of detectable DNA alkylation for bromhexine in man.
PubMed:The effects of bromhexine hydrochloride and S-carboxymethyl-L-cysteine on guinea-pig uterine microflora.
PubMed:The negative effects of mucolytics in otitis media with effusion.
PubMed:Gas-liquid chromatographic and ion-pair high-performance liquid chromatographic determination of pseudoephedrine hydrochloride and bromhexine hydrochloride in pharmaceuticals.
PubMed:[Application of second derivative spectrometry to the determination of bromhexine hydrochloride and spectrophotometry to the determination of dyphylline in compound preparations].
PubMed:Bromhexine in the treatment of otitis media with effusion.
PubMed:Spectrophotometric determination of bromhexine hydrochloride in pharmaceutical preparations.
PubMed:[Pharmacological effects of brovanexine hydrochloride (BR-222) on the respiratory tract system, particularly on the respiratory tract fluid, mucociliary transport and cough].
PubMed:Effect of expectorants on relaxation behavior of sputum viscoelasticity in vivo.
PubMed:Bioavailability of bromhexine tablets and preliminary pharmacokinetics in humans.
PubMed:[Incompatibility of cefotiam dihydrochloride in parenteral preparation by high-performance liquid chromatography].
PubMed:Bromhexine for otitis media with effusion.
PubMed:Pharmacokinetics of bromhexine in the dog.
PubMed:Bromhexine hydrochloride in chronic secretory otitis media--a clinical trial.
 
Notes:
a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (from martindale, the extra pharmacopoeia, 30th ed, p744)
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