lactitol
4-O-beta-D-galactopyranosyl-D-glucitol
 
Notes:
Artificial sweetener used in foods. Sweetness 0.4 x sucrose Lactitol is a sugar alcohol used as a replacement bulk sweetener for low calorie foods with approximately 40% of the sweetness of sugar. Lactitol is produced by two manufacturers, Danisco and Purac Biochem.
  • Jiangyin Healthway
    • Jiangyin Healthway International Trade Co.
      Independent Ingredients Supplier
      We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
      Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals.
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      Product(s):
      HLCFD-195 Lactitol
       
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(2S,3R,4R,5R)-4-[(2S,3R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,5,6-pentol (Click)
CAS Number: 585-86-4Picture of molecule
ECHA EINECS - REACH Pre-Reg: 209-813-7
FDA UNII: L2B0WJF7ZY
XlogP3-AA: -5.20 (est)
Molecular Weight: 344.31448000
Formula: C12 H24 O11
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: sweeteners, texturisers
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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JECFA Food Additive: Lactitol
GSFA Codex: Lactitol (966)
DG SANTE Food Additives: lactitol
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Physical Properties:
Appearance: white crystalline powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 146.00 °C. @ 760.00 mm Hg
Boiling Point: 788.53 °C. @ 760.00 mm Hg (est)
Flash Point: 807.00 °F. TCC ( 430.70 °C. ) (est)
logP (o/w): -4.679 (est)
Soluble in:
 water, 667000 mg/L @ 25 °C (exp)
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Organoleptic Properties:
 sweet  
Taste Description:
sweet
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: humectants
skin conditioning
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Suppliers:
BOC Sciences
For experimental / research use only.
Lactitol
Carbosynth
For experimental / research use only.
Lactitol anhydrous
Jiangyin Healthway
Lactitol
New functional food ingredients
Universal Preserv-A-Chem Inc.
LACTITOL MFP (POWDER)
Odor: characteristic
Use: Is a polyhydric alcohol (polyol) derived from lactose by catalytic hydrogenation. It is 30-40% as sweet as sucrose. It has a taste profile and solutbility that is comparable to sugar. Uses include bakery products, chewing gums, and tablets.
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: sweeteners, texturisers
Recommendation for lactitol usage levels up to:
 not for fragrance use.
 
Recommendation for lactitol flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Lactitol and the maintenance of normal defecation: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
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Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 91476
National Institute of Allergy and Infectious Diseases: Data
 (2S,3R,4R,5R)-4-[(2S,3R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,5,6-pentol
Chemidplus: 0000585864
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References:
 (2S,3R,4R,5R)-4-[(2S,3R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,5,6-pentol
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 91476
Pubchem (sid): 135048765
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): HMDB40937
FooDB: FDB020779
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 humectants 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
4-O-beta-D-galactopyranosyl-D-glucitol
4-O-beta-dextro-galactopyranosyl-dextro-glucitol
D-glucitol, 4-O-beta-D-galactopyranosyl-
 lactitolum
 lactobiosit
(2S,3R,4R,5R)-4-[(2S,3R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,5,6-pentol
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Articles:
PubMed: [Determination of alditols in foods by ion chromatography-mass spectrometry].
J-Stage: Preparation of D-Gulose from Disaccharide Lactitol Using Microbial and Chemical Methods
PubMed: [Prevention of hepatic encephalopathy.]
PubMed: Potential intakes of total polyols based on UK usage survey data.
PubMed: [Determination of alditols in wine by gas chromatography-mass spectrometry after acetate derivatization].
PubMed: Insight into the molecular properties of Chitlac, a chitosan derivative for tissue engineering.
PubMed: Cochrane Review: Osmotic and stimulant laxatives for the management of childhood constipation (Review).
PubMed: Disaccharides in the treatment of hepatic encephalopathy.
PubMed: Preparation of D-gulose from disaccharide lactitol using microbial and chemical methods.
PubMed: Lactulose, rifaximin or branched chain amino acids for hepatic encephalopathy: what is the evidence?
PubMed: Effect of feeding a selected combination of galacto-oligosaccharides and a strain of Bifidobacterium pseudocatenulatum on the intestinal microbiota of cats.
PubMed: Antioxidant protective effects of lactitol against endotoxemia in patients with chronic viral hepatitis.
PubMed: [Influence of lactitol and lactulose on adhesion properties of Bacillus subtilis probiotic strains].
PubMed: Combination therapy for the treatment and prevention of hepatic encephalopathy.
PubMed: Intestinal permeability and fecal eosinophil-derived neurotoxin are the best diagnosis tools for digestive non-IgE-mediated cow's milk allergy in toddlers.
PubMed: Transcriptional analysis of prebiotic uptake and catabolism by Lactobacillus acidophilus NCFM.
PubMed: Factors related to quality of life in patients with cirrhosis and ascites: relevance of serum sodium concentration and leg edema.
PubMed: Osmotic and stimulant laxatives for the management of childhood constipation.
PubMed: Freeze-thaw stability of duck surimi-like materials with different cryoprotectants added.
PubMed: Improved bioavailability of inhibitors of Trypanosoma cruzi trans-sialidase: PEGylation of lactose analogs with multiarm polyethyleneglycol.
PubMed: Biological activity of SE-10, granulated powder of Sasa senanensis Rehder leaf extract.
PubMed: [Hepatic encephalopathy and liver transplantation].
PubMed: Culture media for differential isolation of Lactobacillus casei Shirota from oral samples.
PubMed: Prolonging the viability of Lactobacillus plantarum through the addition of prebiotics into the medium.
PubMed: [Diagnostics and treatment of hepatic encephalopathy].
PubMed: Transcriptional and functional analysis of galactooligosaccharide uptake by lacS in Lactobacillus acidophilus.
PubMed: Gut microbiota of healthy elderly NSAID users is selectively modified with the administration of Lactobacillus acidophilus NCFM and lactitol.
PubMed: The effect of alternative sweeteners on batter rheology and cake properties.
PubMed: Proteome reference map of Lactobacillus acidophilus NCFM and quantitative proteomics towards understanding the prebiotic action of lactitol.
PubMed: Lactitol or lactulose in the treatment of chronic constipation: result of a systematic.
PubMed: Differences between reversible (self-association) and irreversible aggregation of rHuG-CSF in carbohydrate and polyol formulations.
PubMed: Current and emerging strategies for treating hepatic encephalopathy.
PubMed: Synthesis of PEGylated lactose analogs for inhibition studies on T.cruzi trans-sialidase.
PubMed: Pharmacotherapy for hepatic encephalopathy.
PubMed: Xylo-oligosaccharides and lactitol promote the growth of Bifidobacterium lactis and Lactobacillus species in pure cultures.
PubMed: Synbiotic effects of lactitol and Lactobacillus acidophilus NCFM™ in a semi-continuous colon fermentation model.
PubMed: Identification of a dehydrogenase required for lactose metabolism in Caulobacter crescentus.
PubMed: Freeze-drying of proteins with glass-forming oligosaccharide-derived sugar alcohols.
PubMed: Constipation in adults.
PubMed: Recombinant human granulocyte colony stimulating factor pre-screening and screening of stabilizing carbohydrates and polyols.
PubMed: Multivalent catanionic GalCer analogs derived from first generation dendrimeric phosphonic acids.
PubMed: Current trends in the treatment of hepatic encephalopathy.
PubMed: [Elderly hereditary hemorrhagic telangiectasia female with portosystemic encephalopathy].
PubMed: [Prebiotic lactitol as a component of biopreparation from aerobic bacilli].
PubMed: Polyols as filler-binders for disintegrating tablets prepared by direct compaction.
PubMed: Treatment of minimal hepatic encephalopathy.
PubMed: Rifaximin for the treatment of hepatic encephalopathy.
PubMed: Influence of a combination of Lactobacillus acidophilus NCFM and lactitol on healthy elderly: intestinal and immune parameters.
PubMed: [Influence of the bifidobacteria and lactitol containing products on lypoperoxidation processes and intestinal microflora].
PubMed: Intestinal metabolism of weaned piglets fed a typical United States or European diet with or without supplementation of tributyrin and lactitol.
PubMed: Characteristic fragmentation patterns of the trimethylsilyl and trimethylsilyl-oxime derivatives of various saccharides as obtained by gas chromatography coupled to ion-trap mass spectrometry.
PubMed: A study of the properties of tablets from the mixtures of directly compressible starch and directly compressible lactitol.
PubMed: The cost-effectiveness and budget impact of competing therapies in hepatic encephalopathy - a decision analysis.
PubMed: [A case of recurrent pneumatosis cystoides intestinalis associated with recurrent pneumoperitoneum].
PubMed: The treatment of hepatic encephalopathy.
PubMed: The trans-sialidase from Trypanosoma cruzi efficiently transfers alpha-(2-->3)-linked N-glycolylneuraminic acid to terminal beta-galactosyl units.
PubMed: Effects of low doses of lactitol on faecal microflora, pH, short chain fatty acids and gastrointestinal symptomology.
PubMed: Adverse gastrointestinal effects of arginine and related amino acids.
PubMed: Threshold for transitory diarrhea induced by ingestion of xylitol and lactitol in young male and female adults.
PubMed: Characterization of the bga1-encoded glycoside hydrolase family 35 beta-galactosidase of Hypocrea jecorina with galacto-beta-D-galactanase activity.
PubMed: Anemia impairs small intestinal absorption measured by intestinal permeability in children.
PubMed: Suppressive effect of partially hydrolyzed guar gum on transitory diarrhea induced by ingestion of maltitol and lactitol in healthy humans.
PubMed: Constipation in adults.
PubMed: Effects of lactitol on intestinal microflora and plasma endotoxin in patients with chronic viral hepatitis.
PubMed: Bifidobacterium lactis Bb-12 and Lactobacillus salivarius UCC500 modify carboxylic acid formation in the hindgut of rats given pectin, inulin, and lactitol.
PubMed: Direct simultaneous determination of eight sweeteners in foods by capillary isotachophoresis.
PubMed: The trans-sialidase from Trypanosoma cruzi triggers apoptosis by target cell sialylation.
PubMed: Molecular mobility and dynamic site heterogeneity in amorphous lactose and lactitol from erythrosin B phosphorescence.
PubMed: Prevention of first overt episode of hepatic encephalopathy after TIPS: no easy task.
PubMed: Carbohydrate preference, acid tolerance and bile tolerance in five strains of Bifidobacterium.
PubMed: [The diagnostics and therapy of hepatic encephalopathy. Recommendations of of the working group on portal hypertension in the Czech Hepatology Society and the J. E. Purkinje Czech Medical Society].
PubMed: Management of hepatic encephalopathy: focus on antibiotic therapy.
PubMed: Cyclic treatment of chronic hepatic encephalopathy with rifaximin. Results of a double-blind clinical study.
PubMed: Short-chain fatty acid formation in the hindgut of rats fed oligosaccharides varying in monomeric composition, degree of polymerisation and solubility.
PubMed: Attenuated response of the serum triglyceride concentration to ingestion of a chocolate containing polydextrose and lactitol in place of sugar.
PubMed: [Intestinal function tests].
PubMed: Dietary lactitol fermentation increases circulating peptide YY and glucagon-like peptide-1 in rats and humans.
PubMed: Maximum permissive dosage of lactose and lactitol for transitory diarrhea, and utilizable capacity for lactose in Japanese female adults.
PubMed: Rifaximin, a nonabsorbed oral antibiotic, in the treatment of hepatic encephalopathy: antimicrobial activity, efficacy, and safety.
PubMed: Pharmacological prophylaxis of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt: a randomized controlled study.
PubMed: [Pneumatosis intestinalis in 9 children with an oncologic disease].
PubMed: [Nonabsorbable disaccharides for the treatment of hepatic encephalopathy--a systemic review of randomized clinical trials--a secondary publication].
PubMed: Constipation in adults.
PubMed: Review: lactulose or lactitol may improve hepatic encephalopathy but may be less effective than antibiotics.
PubMed: alpha-2,3-sialyllactitol is a donor substrate for Trypanosoma cruzi trans-sialidase.
PubMed: Effect of sugar alcohols on gut function and body composition in normal and cecectomized rats.
PubMed: Polydextrose, lactitol, and fructo-oligosaccharide fermentation by colonic bacteria in a three-stage continuous culture system.
PubMed: Oxalate degradation by intestinal lactic acid bacteria in dogs and cats.
PubMed: Combination of polydextrose and lactitol affects microbial ecosystem and immune responses in rat gastrointestinal tract.
PubMed: Effects of hyperosmolar agents--lactulose, lactitol, sodium phosphate and polyethylene glycol--on cecal coliform bacteria during traditional bowel cleansing: an experimental study in rats.
PubMed: Sugar alcohols: what is the evidence for caries-preventive and caries-therapeutic effects?
PubMed: Nonabsorbable disaccharides for hepatic encephalopathy.
PubMed: Lactose derivatives are inhibitors of Trypanosoma cruzi trans-sialidase activity toward conventional substrates in vitro and in vivo.
PubMed: Antagonistic activity of lactic acid bacteria as probiotics against selected bacteria of the Enterobaceriacae family in the presence of polyols and their galactosyl derivatives.
PubMed: Non-absorbable disaccharides for hepatic encephalopathy: systematic review of randomised trials.
PubMed: Health potential of polyols as sugar replacers, with emphasis on low glycaemic properties.
PubMed: [Compressibility of directly compressed forms of lactitol].
PubMed: Effects of lactulose and lactitol on coliform bacteria and bacterial translocation in the caecum during 72-h starvation in rats.
PubMed: Chemoenzymatically synthesized glycoconjugate polymers.
PubMed: Comparison of rifaximin and lactitol in the treatment of acute hepatic encephalopathy: results of a randomized, double-blind, double-dummy, controlled clinical trial.
PubMed: Interaction of methylparaben preservative with selected sugars and sugar alcohols.
PubMed: Sugar alcohols enhance calcium transport from rat small and large intestine epithelium in vitro.
PubMed: [Determination of lactitol in mice serum by high performance liquid chromatography].
PubMed: Tributyrin and lactitol synergistically enhanced the trophic status of the intestinal mucosa and reduced histamine levels in the gut of nursery pigs.
PubMed: AtFXG1, an Arabidopsis gene encoding alpha-L-fucosidase active against fucosylated xyloglucan oligosaccharides.
PubMed: Structural changes in natural actomyosin and surimi from ling cod (Ophiodon elongatus) during frozen storage in the absence or presence of cryoprotectants.
PubMed: Intestinal permeability in children: variation with age and reliability in the diagnosis of cow's milk allergy.
PubMed: Mechanism and characteristics of protein release from lactitol-based cross-linked hydrogel.
PubMed: Lactitol-based poly(ether polyol) hydrogels for controlled release chemical and drug delivery systems.
PubMed: What clients need to know about sugar replacers.
PubMed: Relationship between conformational stability and lyophilization-induced structural changes in chymotrypsin.
PubMed: Lactitol tolerance in healthy Thai adults.
PubMed: A computer-controlled system to simulate conditions of the large intestine with peristaltic mixing, water absorption and absorption of fermentation products.
PubMed: Enhancement of the foaming properties of protein dried in the presence of trehalose.
PubMed: Determination of maltitol, isomaltitol, and lactitol by high-pH anion-exchange chromatography with pulsed amperometric detection.
PubMed: Effect of lactitol on blood ammonia response to oral glutamine challenge in cirrhotic patients: evidence for an effect of nonabsorbable disaccharides on small intestine ammonia generation.
PubMed: [Allergy to protein hydrolysates. Report of 30 cases].
PubMed: Survival of a probiotic, Lactobacillus casei strain Shirota, in the gastrointestinal tract: selective isolation from faeces and identification using monoclonal antibodies.
PubMed: Comparative gastrointestinal tolerance of sucrose, lactitol, or D-tagatose in chocolate.
PubMed: The effect of lactose derivatives on intestinal lactic acid bacteria.
PubMed: Small intestinal transit and digestibility of lactitol in Wistar rats.
PubMed: Beneficial effect of carbohydrate maldigestion induced by a disaccharidase inhibitor (AO-128) in the treatment of chronic portal-systemic encephalopathy. A double-blind, randomized, controlled trial.
PubMed: Development of a biosensor for monitoring of glycerol during alcoholic fermentation.
PubMed: Influence of the substrate on the reproducibility of the hydrogen breath test to measure the orocecal transit time.
PubMed: Altered colonic environment, a possible predisposition to colorectal cancer and colonic inflammatory bowel disease: rationale of dietary manipulation with emphasis on disaccharides.
PubMed: Flow-injection detector incorporating a screen-printed disposable amperometric biosensor for monitoring organophosphate pesticides.
PubMed: Metabolic response to lactitol and xylitol in healthy men.
PubMed: Effects of lactitol-oligosaccharides on calcium and magnesium absorption in rats.
PubMed: Lack of evidence for sialidase activity in Helicobacter pylori.
PubMed: A short-term plaque study using Lactitol as a non-sugar sweetener.
PubMed: Systematic review of the effectiveness of laxatives in the elderly.
PubMed: Faecal steroids and colorectal carcinogenesis.
PubMed: Effects of lactulose and lactitol on colonic microflora and enzymatic activity.
PubMed: The treatment of chronic constipation in adults. A systematic review.
PubMed: Bacterial translocation in the course of acute pancreatitis: beneficial role of nonabsorbable antibiotics and lactitol enemas.
PubMed: Sialidase activity in nuclear membranes of rat brain.
PubMed: Fermentable carbohydrate modulates postprandial enteroglucagon and gastrin release in rats.
PubMed: [Lactilol (Importal, 10g in powder made by ZYMA) in the treatment of portal systemic encephalopathy].
PubMed: Fermentable carbohydrates elevate plasma enteroglucagon but high viscosity is also necessary to stimulate small bowel mucosal cell proliferation in rats.
PubMed: [Study of early postoperative lactitol versus paraffin following anal surgery in 110 adult patients].
PubMed: Dose-related gastrointestinal response to the ingestion of either isomalt, lactitol or maltitol in milk chocolate.
PubMed: Lactitol enhances short-chain fatty acid and gas production by swine cecal microflora to a greater extent when fermenting low rather than high fiber diets.
PubMed: Commercial utilization of minor milk components in the health and food industries.
PubMed: Impact of polyunsaturated fatty acids on human colonic bacterial metabolism: an in vitro and in vivo study.
PubMed: The mechanism of lactitol (NS-4) in inducing adrenomedullary proliferative lesion in rats.
PubMed: [Effects of lactitol on fecal bacterial flora in patients with liver cirrhosis and hepatic encephalopathy].
PubMed: A review of drug-induced Leydig cell hyperplasia and neoplasia in the rat and some comparisons with man.
PubMed: Effects of lactitol [correction of lactilol] on hepatic encephalopathy and plasma amino-acid imbalance.
PubMed: [Ameliorating effect of lactitol on experimental hepatic encephalopathy in Eck fistula dogs].
PubMed: [The effect of lactitol (NS-4) on the concentrations of ammonia and amino acids in blood and cerebrospinal fluid in Eck fistula (portacaval-shunted) dogs].
PubMed: Colonic transit times and the effect of lactulose or lactitol in hospitalized patients.
PubMed: [Lactitol in chronic idiopathic constipation in children].
PubMed: Mechanism for lowering blood ammonia levels by lactitol.
PubMed: Age and laxative use in hospitalized patients. A report of the "Gruppo Italiano di Farmacovigilanza nell'Anziano--GIFA".
PubMed: [Effect of lactitol (NS-4) on the increase in blood and brain ammonia concentration and on coma in newly developed rat models of hepatic coma].
PubMed: [Lactitol suppresses the disturbance of consciousness caused by experimentally induced hepatic encephalopathy in rats: an EEG study].
PubMed: Effects of lactitol-oligosaccharides on the intestinal microflora in rats.
PubMed: Treatment of porto-systemic encephalopathy with lactitol verus lactulose: a randomized controlled study.
PubMed: Bitterness of sweeteners as a function of concentration.
PubMed: Effects of long-term administration of low-dose lactitol in patients with cirrhosis but without overt encephalopathy.
PubMed: [Antigenicity study on lactitol (NS-4)].
PubMed: [Mutagenicity studies of lactitol (NS-4)].
PubMed: [Reproductive and developmental toxicity studies of lactitol (NS-4) (4)--Perinatal and postnatal study in rats by oral administration].
PubMed: [Reproductive and developmental toxicity studies of lactitol (NS-4) (3)--Teratogenicity study in rabbits by oral administration].
PubMed: [Reproductive and developmental toxicity studies of lactitol (NS-4) (2)--Teratogenicity study in rats by oral administration].
PubMed: [Reproductive and developmental toxicity studies of lactitol (NS-4) (1)--Fertility study in rats by oral administration].
PubMed: [52-week oral toxicity study of lactitol (NS-4) in dogs followed by 9-week recovery test].
PubMed: [52-week oral toxicity study of lactitol (NS-4) in rats followed by 9-week recovery test].
PubMed: [13-week oral toxicity study of lactitol (NS-4) in dogs followed by 4-week recovery test].
PubMed: [13-week oral toxicity study of lactitol (NS-4) in rats followed by 5-week recovery test].
PubMed: [Single dose toxicity study of lactitol (NS-4) in dogs].
PubMed: [Single dose toxicity studies of lactitol (NS-4) in mice and rats].
PubMed: Silyl protection in the solid-phase synthesis of N-linked glycopeptides. Preparation of glycosylated fluorogenic substrates for subtilisins.
PubMed: Molecular dynamics simulation and NMR study of a blood group H trisaccharide.
PubMed: Fast atom bombardment mass spectrometry of N-acetylated neoglycolipids of the 1-deoxy-1-phosphatidylethanolamino-lactitol-type.
PubMed: Clinical caries studies with polyalcohols. A literature review.
PubMed: Possible role of myelin-associated neuraminidase in membrane adhesion.
PubMed: Hepatic encephalopathy.
PubMed: [Lactulose and its derivatives--treatment of hepatic encephalopathy and other possible indications for its use].
PubMed: [Nutrition and malnutrition in hepatic cirrhosis].
PubMed: 'Determination' of sugar alcohol and Polydextrose absorption in humans by the breath hydrogen (H2) technique: the stoichiometry of hydrogen production and the interaction between carbohydrates assessed in vivo and in vitro.
PubMed: Lactitol in treatment of chronic hepatic encephalopathy. A meta-analysis.
PubMed: Efficacy of sweeteners and sugar substitutes in caries prevention.
PubMed: Metabolism of erythritol in humans: comparison with glucose and lactitol.
PubMed: [The effect of oligosaccharides on piglets].
PubMed: Mucin degradation in the human colon: production of sialidase, sialate O-acetylesterase, N-acetylneuraminate lyase, arylesterase, and glycosulfatase activities by strains of fecal bacteria.
PubMed: The effect of lactulose and lactitol administration on fecal fat excretion in patients with liver cirrhosis.
PubMed: Crystal structure of lactitol (4-O-beta-D-galactopyranosyl-D-glucitol) trihydrate.
PubMed: Formation of oligosaccharides from lactitol by Aspergillus oryzae beta-D-galactosidase.
PubMed: [The effects of lactitol in the treatment of intestinal stasis in childhood].
PubMed: Quantitative assessment of lipoprotein metabolism by positron emission tomography with an 18F-containing residualizing label.
PubMed: 1-Deoxy-1-phosphatidylethanolamino-lactitol-type neoglycolipids serve as acceptors for sialyltransferases from rat liver golgi vesicles.
PubMed: Lactitol or lactulose in the treatment of chronic hepatic encephalopathy: results of a meta-analysis.
PubMed: Neuraminidase activities in oligodendroglial cells of the rat brain.
PubMed: Crystal structure of lactitol (4-O-beta-D-galactopyranosyl-D-glucitol) dihydrate.
PubMed: Crystal structure of lactitol (4-O-beta-D-galactopyranosyl-D-glucitol).
PubMed: [Reproducibility of orocecal transit time and hydrogen production measured by breath tests].
PubMed: [How is bowel function? Satellite symposium at the 19th Congress of the Society of Gastroenterology, 25-26 October 1991].
PubMed: Sex and age dependence of rat kidney sialidase.
PubMed: [A clinical comparative study of crystalline pure lactulose and powder pure lactitol in portasystemic encephalopathy of cirrhotic patients].
PubMed: [Lactitol in the treatment of constipation in the adult. Open, non-comparative study of its efficacy and its clinical and biological tolerance].
PubMed: [Portosystemic encephalopathy].
PubMed: [Clinical tolerance, intestinal absorption, and energy value of four sugar alcohols taken on an empty stomach].
PubMed: Structure of lactitol (4-O-beta-D-galactopyranosyl-D-glucitol) monohydrate: and artificial sweetener.
PubMed: Effects of lactulose and lactitol on protein digestion and metabolism in conventional and germ free animal models: relevance of the results to their use in the treatment of portosystemic encephalopathy.
PubMed: First and second generation non absorbable disaccharides in the treatment of hepatic encephalopathy.
PubMed: Lactitol in the treatment of chronic hepatic encephalopathy--a randomized cross-over comparison with lactulose.
PubMed: Effect of lactitol and lactulose administration on the fecal flora in cirrhotic patients.
PubMed: Nonabsorbable disaccharides plus neomycin in hepatic encephalopathy: do they enhance each other?
PubMed: [Sodium benzoate in portal-systemic-encephalopathy-induced blood ammonia normalization and clinical improvement. Interim report of a double-blind multicenter trial].
PubMed: [Current possibilities in the therapy of hepatic encephalopathy].
PubMed: Lactulose inhibits endotoxin induced tumour necrosis factor production by monocytes. An in vitro study.
PubMed: Hydrogen excretion after ingestion of five different sugar alcohols and lactulose.
PubMed: Lactitol in prevention of recurrent episodes of hepatic encephalopathy in cirrhotic patients with portal-systemic shunt.
PubMed: [Lactitol and neomycin: monotherapy or combined therapy in the prevention and treatment of hepatic encephalopathy?].
PubMed: Lactitol and lactulose for the treatment of subclinical hepatic encephalopathy in cirrhotic patients. A randomised, cross-over study.
PubMed: Latest state of research on lactitol and dental caries.
PubMed: Effect of absorbable and nonabsorbable sugars on intestinal calcium absorption in humans.
PubMed: Dental and metabolic effects of lactitol in the diet of laboratory rats.
PubMed: Effect of one month of lactitol treatment on calcium metabolism in man.
PubMed: Studies of the dental properties of lactitol compared with five other bulk sweeteners in vitro.
PubMed: [Dose-response curve and preliminary clinical study of a laxative, lactilol].
PubMed: Assimilation of lactitol, an 'unabsorbed' disaccharide in the normal human colon.
PubMed: Lactitol vs. lactulose in the treatment of chronic recurrent portal-systemic encephalopathy.
PubMed: Alteration in sialidase and other glycosidase activities in the kidney of spontaneously hypertensive rats: persistence after preventive treatment with hydralazine.
PubMed: A trial of lactitol in sweets and its effects on human dental plaque.
PubMed: Influence of the disaccharide lactitol on intestinal absorption and body retention of calcium in rats.
PubMed: Treatment of chronic constipation with lactitol sweetened yoghurt supplemented with guar gum and wheat bran in elderly hospital in-patients.
PubMed: [Study of the laxative effect of Lactitol as opposed to lactulose in an open, randomized comparative study].
PubMed: Dietary lactitol elevates liver cholesterol in rats.
PubMed: Lactitol: gastrointestinal absorption and effect on blood lactate in healthy volunteers and patients with cirrhosis.
PubMed: The influence of food additives and related materials on lower bowel structure and function.
PubMed: Lactitol, a second-generation disaccharide for treatment of chronic portal-systemic encephalopathy. A double-blind, crossover, randomized clinical trial.
PubMed: Lactitol, lactulose, and blood ammonia.
PubMed: Lactitol vs. lactulose in the treatment of acute hepatic encephalopathy in cirrhotic patients: a double-blind, randomized trial.
PubMed: Lactitol, lactulose, and blood ammonia.
PubMed: Hydrolysis of lactitol, maltitol and Palatinit by human intestinal biopsies.
PubMed: Lactitol.
PubMed: Acidifying enemas (lactitol and lactose) vs. nonacidifying enemas (tap water) to treat acute portal-systemic encephalopathy: a double-blind, randomized clinical trial.
PubMed: Lactitol versus lactulose in the treatment of acute portal systemic encephalopathy (PSE). A controlled trial.
PubMed: Lactitol versus lactulose in the treatment of chronic hepatic encephalopathy. A double-blind, randomised, cross-over study.
PubMed: Comparative modes of action of lactitol and lactulose in the treatment of hepatic encephalopathy.
PubMed: Lactitol, a new hydrogenated lactose derivative: intestinal absorption and laxative threshold in normal human subjects.
PubMed: The elderberry (Sambucus nigra L.) bark lectin recognizes the Neu5Ac(alpha 2-6)Gal/GalNAc sequence.
PubMed: Energy balances of eight volunteers fed on diets supplemented with either lactitol or saccharose.
PubMed: Further characterization of a myelin-associated neuraminidase: properties and substrate specificity.
PubMed: [The effect of lactitol on the production of expired hydrogen in normal subjects].
PubMed: Cariogenicity of lactitol in program-fed rats.
PubMed: 125I-glycoconjugate labels for identifying sites of protein catabolism in vivo: effect of structure and chemistry of coupling to protein on label entrapment in cells after protein degradation.
PubMed: Lactitol in the treatment of chronic hepatic encephalopathy: an open comparison with lactulose.
PubMed: The effect of sweeteners on acid production in plaque.
PubMed: Enzootic and epizootic adrenal medullary proliferative disease of rats: influence of dietary factors which affect calcium absorption.
PubMed: Metabolism of sialic acids from exogenously administered sialyllactose and mucin in mouse and rat.
PubMed: Studies on kidney sialidase in normal and diabetic rats.
PubMed: Neuraminidase activity: a biochemical marker to distinguish Streptococcus mitis from Streptococcus sanguis.
PubMed: Lysosomal sialidase deficiency in sialidosis with partial beta-galactosidase deficiency.
PubMed: [1st use of lactitol in the treatment of porto-systemic encephalopathy].
PubMed: Mucolipidosis I: studies of sialidase activity and a prenatal diagnosis.
PubMed: Food additives derived from lactose: lactitol and lactitol palmitate.
PubMed: beta-D-Galactoside transport in Escherichia coli: substrate recognition.
PubMed: [Lactic acid production from sugar alcohol, maltitol and lactitol, in human whole saliva].
PubMed: [pH analysis of the bacterial fermentation of sugar alcohol, maltitol and lactitol, in human whole saliva].
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