chloramine-T
sodium chloro[(4-methylphenyl)sulfonyl]azanide
 
Notes:
None found
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sodium;chloro-(4-methylphenyl)sulfonylazanide (Click)
CAS Number: 127-65-1Picture of molecule
Other: 1576-40-5
ECHA EINECS - REACH Pre-Reg: 204-857-3
FDA UNII: 328AS34YM6
Nikkaji Web: J3.263H
Molecular Weight: 227.64495928
Formula: C7 H7 Cl N Na O2 S
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: antimicrobial agents
 
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 170.00 °C. @ 760.00 mm Hg (est)
Boiling Point: 314.30 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.000472 mm/Hg @ 25.00 °C. (est)
Flash Point: 291.00 °F. TCC ( 143.90 °C. ) (est)
logP (o/w): 2.268 (est)
Soluble in:
 water, 8.372e+004 mg/L @ 25 °C (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antimicrobial agents
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Suppliers:
Viachem
Chloramine-T
Odor: bland
Use: Tosylchloramide sodium salt (C7H7CINO2S), known commercially as Chloramine-T, is a N-chlorinated and N-deprotonated sulfonamide used as a biocide and a mild disinfectant. It is a white powder that gives unstable solutions with water. Chloramine-T is used for disinfection and as an algicide, bactericide, germicide, for parasite control, and for drinking water disinfection. It has been used in ornamental fish and aquaculture industries for many years, making it especially useful for disinfecting angling equipment before and after fishing. Chloramine-T is also used for disinfection in saunas, solariums, gyms, sport centres, kitchens, sanitary facilities, and air conditioning units. Chloramine-T is simple and safe to use, dissolves in water (warm) and immediately produces a ready-to-use, highly effective and long-lasting disinfectant solution that lasts up to eight weeks in special UV protected spray bottles.
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
parenteral-frog LDLo  200 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Pharmacology and Experimental Therapeutics. Vol. 14, Pg. 259, 1920.

parenteral-mouse LDLo  300 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Journal of Pharmacology and Experimental Therapeutics. Vol. 14, Pg. 259, 1920.

intravenous-rabbit LDLo  25 mg/kg
LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Journal of Pharmacology and Experimental Therapeutics. Vol. 14, Pg. 259, 1920.

Dermal Toxicity:
subcutaneous-guinea pig LDLo 900 mg/kg
BEHAVIORAL: EXCITEMENT BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS
Journal of Pharmacology and Experimental Therapeutics. Vol. 14, Pg. 259, 1920.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antimicrobial agents
Recommendation for chloramine-T usage levels up to:
 not for fragrance use.
 
Recommendation for chloramine-T flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
NIOSH International Chemical Safety Cards: search
NLM Hazardous Substances Data Bank: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA GENetic TOXicology: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 127-65-1
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 3641960
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 sodium;chloro-(4-methylphenyl)sulfonylazanide
Chemidplus: 0000127651
RTECS: 127-65-1
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References:
 sodium;chloro-(4-methylphenyl)sulfonylazanide
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 127-65-1
Pubchem (cid): 3641960
Pubchem (sid): 134974219
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): D02445
HMDB (The Human Metabolome Database): Search
Haz-Map: View
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 antimicrobial agents 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 benzenesulfonamide, N-chloro-4-methyl-, sodium salt (1:1)
 chloramine T
N-chloro-4-methylbenzenesulfonamide sodium salt
N-chloro-4-methylbenzenesulphonamide, sodium salt
N-chloro-p-toluenesulfonamide sodium
N-chloro-p-toluenesulfonamide sodium salt
(N-chloro-p-toluenesulfonamido)sodium
 ketjensept
 sodium chloro(tosyl)amide
 sodium chloro[(4-methylbenzene)sulfonyl]azanide
 sodium chloro[(4-methylphenyl)sulfonyl]azanide
 sodium N-chloro-p-toluenesulfonamide
 sodium p-toluenesulfonchloramide
 sodium p-toluenesulfonylchloramide
 sodium;chloro-(4-methylphenyl)sulfonylazanide
 tosyl chloramide sodium
 tosylchloramide sodium
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Articles:
PubMed: Analysis of amino acid composition in proteins of animal tissues and foods as pre-column o-phthaldialdehyde derivatives by HPLC with fluorescence detection.
PubMed: Vitamin B12[c-lactone], a biologically inactive corrinoid compound, occurs in cultured and dried lion's mane mushroom (Hericium erinaceus) fruiting bodies.
PubMed: [Determination of thiocyanate in dairy products by headspace gas chromatography].
PubMed: Effects of pearl powder extract and its fractions on fibroblast function relevant to wound repair.
PubMed: [Regulation of calculus bovis on the function of mice oral fibroblasts].
PubMed: Influence of borneol on primary mice oral fibroblasts: a penetration enhancer may be used in oral submucous fibrosis.
PubMed: Application of oxidative coupling reactions for the estimation of ritodrine hydrochloride in bulk sample and dosage forms.
PubMed: Development and validation of a gas chromatography/mass spectrometry procedure for confirmation of para-toluenesulfonamide in edible fish fillet tissue.
PubMed: Determination of residues of quaternary ammonium disinfectants in food products by liquid chromatography-tandem mass spectrometry.
PubMed: Development of radioimmunoassay for the measurement of human leptin in serum.
PubMed: Intrinsic and acquired resistance to quaternary ammonium compounds in food-related Pseudomonas spp.
PubMed: [Determination of trace iodine based on kinetic-spectrophotometry with malachite green-chloramine T system].
PubMed: Performance of a proposed determinative method for p-TSA in rainbow trout fillet tissue and bridging the proposed method with a method for total chloramine-T residues in rainbow trout fillet tissue.
PubMed: Multiresidue screen for cardiotoxins by two-dimensional thin-layer chromatography.
PubMed: Liquid chromatographic determination of para-toluenesulfonamide in edible fillet tissues from three species of fish.
PubMed: Bacillus thuringiensis delta-Endotoxin Binding Sites in Two Lepidoptera, Wiseana spp. and Epiphyas postvittana
PubMed: Fungicidal effect of 15 disinfectants against 25 fungal contaminants commonly found in bread and cheese manufacturing.
PubMed: Bronchial asthma due to sensitization to chloramine T.
PubMed: Radioimmunoassay of cholecystokinin in plasma.
PubMed: Determination of iodide and bromide by ion chromatography with post-column reaction detection.
PubMed: On-line generation of cyanogen chloride in semiautomated determination of niacin and niacinamide in food products.
PubMed: [An automated photometric method for determining niacin and niacinamide content in grain and cereals].
PubMed: Laboratory investigations on the effect of selected disinfectants on survival of the cockroaches Blattella germanica (L.).
PubMed: Determination of staphylococcal enterotoxin A in cheddar cheese produced without starter activity.
PubMed: Determination of chloramine-T in foodstuffs.
PubMed: High pressure liquid chromatographic determination of chloramine-T in food.
PubMed: Spectrodensitometric determination of chloramine-T in ice cream.
PubMed: Determination of zineb by oxidation with chloramine-T.
PubMed: Stability of 125I-labeled staphylococcal enterotoxins in solid-phase radioimmunoassay.
PubMed: Detection of chloramine T in minced meat and farinaceous foods.
PubMed: Detection of chloramine T in dairy products.
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