EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

vitamin A acetate
acetic acid, retinyl ester

Supplier Sponsors

CAS Number: 127-47-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:204-844-2
FDA UNII: 3LE3D9D6OY
Nikkaji Web:J34.628D
Beilstein Number:1915439
MDL:MFCD00019413
XlogP3:6.30 (est)
Molecular Weight:328.49544000
Formula:C22 H32 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:nutrient supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
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Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1930 Vitamin A acetate View - review
FDA Mainterm (SATF):127-47-9 ; VITAMIN A ACETATE
FDA Regulation:
FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1930 Vitamin A.
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 0.0003555 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
AIDP
Vitamin A Palmitate Retinol 250,000 IU/g
American International Chemical, LLC.
Vitamin A Acetate
BASF
Dry Vitamin A Acetate
BOC Sciences
For experimental / research use only.
VITAMIN A ACETATE >98%
Charkit Chemical
VITAMIN A ACETATE 500
Farbest-Tallman Foods
ZMC Vitamin A Acetate 325,000 IU/gm CWS Gelatin-Free
Flavor: bland
This product is used fortifying powdered products such as infant formulas, dietetic foods and dairy products.
Farbest-Tallman Foods
ZMC Vitamin A Acetate 500,000 IU/gm TAB
Flavor: bland
It is used as a Vitamin A source for dietary supplements including tablet and hard-shell capsule preparations.
Glentham Life Sciences
Vitamin A acetate
Indis NV
For experimental / research use only.
Vitamin A Acetate
Jiangyin Healthway
Vitamin A Acetate
New functional food ingredients
Maypro Industries
Vitamin A Acetate
Penta International
VITAMIN A ACETATE
Qingdao Dacon Trading
Vitamin A Acetate
Santa Cruz Biotechnology
For experimental / research use only.
Retinyl acetate
Sigma-Aldrich: Sigma
For experimental / research use only.
Retinyl acetate synthetic, crystalline solid or supercooled liquid
sds
Zanos
Vitamin A 325.000 I.U./g CWS-A
Zanos
Vitamin A 325.000 I.U./g SD CWS-S
Zanos
Vitamin A 500.000 I.U./g SD CWS-A
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 4100 mg/kg
Journal of the American Academy of Dermatology. Vol. 6, Pg. 652, 1982.

intravenous-mouse LD50 432 mg/kg
United States Patent Document. Vol. #3878202

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
nutrient supplements
Recommendation for vitamin A acetate usage levels up to:
 not for fragrance use.
 
Recommendation for vitamin A acetate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):127-47-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :638034
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] acetate
Chemidplus:0000127479
RTECS:VH6825000 for cas# 127-47-9
 
References:
 [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] acetate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:127-47-9
Pubchem (cid):638034
Pubchem (sid):134974060
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D01621
HMDB (The Human Metabolome Database):HMDB35185
FooDB:FDB013829
FDA Listing of Food Additive Status:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 acetic acid, retinyl ester
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl acetate
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetr aenyl acetate
[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] acetate
all-trans-retinol acetate
 retinyl acetate
all-trans-retinyl acetate
all-trans-retinylacetate
 vitamin A acetate
all-trans-vitamin A acetate
 

Articles:

PubMed:Determination of vitamins A and E in infant formula and adult/pediatric nutritional formula by HPLC with UV and fluorescence detection: First Action 2012.09.
PubMed:Triple-fortified rice containing vitamin A reduced marginal vitamin A deficiency and increased vitamin A liver stores in school-aged Thai children.
PubMed:Simultaneous determination of 13-cis and all-trans vitamin A palmitate (retinyl palmitate), vitamin A acetate (retinyl acetate), and total vitamin E (alpha-tocopherol and DL-alpha-tocopherol acetate) in infant formula and adult nutritionals by normal phase HPLC: first action 2012.10.
PubMed:[Effects of vitamin A supplementation on nutritional status of iron in healthy adults].
PubMed:β-Carotene in Golden Rice is as good as β-carotene in oil at providing vitamin A to children.
PubMed:Safety evaluation of vitamin A in growing dogs.
PubMed:Cloning, expression and characterization of a lipase gene from the Candida antarctica ZJB09193 and its application in biosynthesis of vitamin A esters.
PubMed:The effect of food preparation on the bioavailability of carotenoids from carrots using intrinsic labelling.
PubMed:UVA photoirradiation of anhydroretinol--formation of singlet oxygen and superoxide.
PubMed:Vitamin A equivalence of spirulina beta-carotene in Chinese adults as assessed by using a stable-isotope reference method.
PubMed:beta-Cryptoxanthin from supplements or carotenoid-enhanced maize maintains liver vitamin A in Mongolian gerbils ( Meriones unguiculatus) better than or equal to beta-carotene supplements.
PubMed:[Vitamin A equivalence of spinach beta-carotene in human body].
PubMed:Use of metabolic stimulators and inhibitors for enhanced production of beta-carotene and lycopene by Blakeslea trispora NRRL 2895 and 2896.
PubMed:Diets rich in polyphenols and vitamin A inhibit the development of type I autoimmune diabetes in nonobese diabetic mice.
PubMed:Interactions of human serum albumin with retinoic acid, retinal and retinyl acetate.
PubMed:Photodecomposition and phototoxicity of natural retinoids.
PubMed:Spinach or carrots can supply significant amounts of vitamin A as assessed by feeding with intrinsically deuterated vegetables.
PubMed:Photoreaction, phototoxicity, and photocarcinogenicity of retinoids.
PubMed:Photodecomposition of retinyl palmitate in ethanol by UVA light-formation of photodecomposition products, reactive oxygen species, and lipid peroxides.
PubMed:Use of the deuterated-retinol-dilution technique to monitor the vitamin A status of Nicaraguan schoolchildren 1 y after initiation of the Nicaraguan national program of sugar fortification with vitamin A.
PubMed:Rapid determination by reversed-phase high-performance liquid chromatography of Vitamins A and E in infant formulas.
PubMed:Mechanisms of TCDD-induced abnormalities and embryo lethality in white leghorn chickens.
PubMed:Teratogenic effects of chronic ingestion of high levels of vitamin A in cats.
PubMed:[Evaluation on intestinal and whole-body conversion of beta-carotene to vitamin A in Chinese adults using a stable isotope reference method].
PubMed:Simultaneous determination of vitamin A and beta-carotene in dietary supplements by liquid chromatography.
PubMed:Determination of liposoluble vitamins in cooked meals, milk and milk products by liquid chromatography.
PubMed:Alpha- and beta-carotene from a commercial puree are more bioavailable to humans than from boiled-mashed carrots, as determined using an extrinsic stable isotope reference method.
PubMed:Bioavailability and antioxidant activity of some food supplements in men and women using the D-Roms test as a marker of oxidative stress.
PubMed:A novel extrinsic reference method for assessing the vitamin A value of plant foods.
PubMed:Influence of vitamin A status on the regulation of uridine (5'-)diphosphate-glucuronosyltransferase (UGT) 1A1 and UGT1A6 expression by L-triiodothyronine.
PubMed:On-line supercritical fluid extraction/enzymatic hydrolysis of vitamin a esters: a new simplified approach for the determination of vitamins a and e in food.
PubMed:A fortifier comprising protein, vitamins, and calcium-glycerophosphate for preterm human milk.
PubMed:Bioavailability trials of beta-carotene from fresh and dehydrated drumstick leaves (Moringa oleifera) in a rat model.
PubMed:Dietary vitamin A modulates the concentrations of RRR-alpha-tocopherol in plasma lipoproteins from calves fed milk replacer.
PubMed:Estimation of the dietary vitamin A requirement of juvenile grass shrimp, Penaeus monodon.
PubMed:Antimutagenic effects and possible mechanisms of action of vitamins and related compounds against genotoxic heterocyclic amines from cooked food.
PubMed:Bioavailability of carotenoids in human subjects.
PubMed:Effect of reduced body weight gain on the evaluation of chemopreventive agents in the methylnitrosourea-induced mammary cancer model.
PubMed:Effect of vitamin A on the oxidative stability of broiler meat during storage: lack of interactions with vitamin E.
PubMed:Binding of retinoids to beta-lactoglobulin isolated by bioselective adsorption.
PubMed:Suppressive effects of retinoids, carotenoids and antioxidant vitamins on heterocyclic amine-induced umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002).
PubMed:Interactions in indices of vitamin A, zinc and copper status when these nutrients are fed to rats at adequate and increased levels.
PubMed:Effect of retinyl acetate, ascorbic acid and tocopherol supplementation of the feed on egg vitamin A content in Japanese quail.
PubMed:Pigment cholelithiasis induced by vitamin A and its prevention by butylated hydroxytoluene.
PubMed:Strain variation in vitamin A (retinol) status of streptozotocin-induced diabetic rats.
PubMed:Consumption of excess vitamin A, but not excess beta-carotene, causes accumulation of retinol that exceeds the binding capacity of cellular retinol-binding protein, type II in rat intestine.
PubMed:The effect of excessive dietary vitamin A on performance and vitamin E status in swine fed diets varying in dietary vitamin E.
PubMed:Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat.
PubMed:Glucuronidation of all-trans-retinoic acid in liposomal membranes.
PubMed:The influence of dietary levels of vitamin A and fat on colon cancer.
PubMed:Effects of dietary retinyl acetate on the promotion of hepatic enzyme-altered foci by polybrominated biphenyls in initiated rats.
PubMed:Modification of retinyl acetate toxicity in rats by coadministration of menhaden oil.
PubMed:Relationship of vitamin A and vitamin E intake to fasting plasma retinol, retinol-binding protein, retinyl esters, carotene, alpha-tocopherol, and cholesterol among elderly people and young adults: increased plasma retinyl esters among vitamin A-supplement users.
PubMed:Retinyl acetate inhibits estrogen-induced mammary carcinogenesis in female ACI rats.
PubMed:Effects of simultaneous treatment with various chemicals on BHA-induced development of rat forestomach hyperplasia--complete inhibition by diethylmaleate in a 5-week feeding study.
PubMed:Zinc-vitamin A interaction in pregnant and fetal rats: supplemental vitamin A does not prevent zinc-deficiency-induced teratogenesis.
PubMed:Effect of moderate vitamin A supplementation and lack of dietary vitamin A on the development of mammary tumors in female rats treated with low carcinogenic dose levels of 7,12-dimethylbenz(a)anthracene.
PubMed:Effects of vitamin A on cyclophosphamide mutagenicity in vitro (Ames test) and in vivo (mouse micronucleus test).
PubMed:Fat and vitamin A stability in the presence of Ronoxan A and other antioxidants.
PubMed:Localization of tritiated vitamin A in lymph nodes of the mouse: an autoradiographic study of vitamin A-storing cells.
PubMed:Vitamin A - application technology.
PubMed:Hypervitaminosis A combined with calcium deficiency in rats.
PubMed:Studies on urinary arylsulphatase activity in vitamin A deficient rats.
PubMed:Influence of excess vitamin E on vitamin A toxicity in rats.
PubMed:Polarography of conjugated unsaturated lipids.
 
Notes:
Dietary supplement, permitted in infant formulas
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