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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 648.00 to 649.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 440.00 °F. TCC ( 226.40 °C. ) (est)
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| logP (o/w): | 5.744 (est) |
| Soluble in: |
| | alcohol | | | water, 0.000451 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for gamma-mangostin usage levels up to: | | | not for fragrance use.
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| Recommendation for gamma-mangostin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 1,3,6,7-tetrahydroxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5464078 |
| Pubchem (sid): | 135021472 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| g- | mangosin | | 2,8-bis(3- | methyl-2-butenyl)-1,3,6,7-tetrahydroxy-9H-xanthen-9-one | | 1,3,6,7- | tetrahydroxy-2,5-bis(3-methyl-2-butenyl)-9H-xanthen-9-one | | 1,3,6,7- | tetrahydroxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one | | 1,3,6,7- | tetrahydroxy-2,8-bis(3-methylbut-2-enyl)-9H-xanthen-9-one | | 1,3,6,7- | tetrahydroxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one | | 9H- | xanthen-9-one, 1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-buten-1-yl)- | | 9H- | xanthen-9-one, 1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-butenyl)- |
Articles:
| PubMed:Prenylated xanthones from mangosteen as promising cholinesterase inhibitors and their molecular docking studies. |
| PubMed:Cytotoxic prenylated xanthones from the pericarps of Garcinia mangostana. |
| PubMed:Rapid identification of cholinesterase inhibitors from the seedcases of mangosteen using an enzyme affinity assay. |
| PubMed:γ-Mangostin from Garcinia mangostana pericarps as a dual agonist that activates Both PPARα and PPARδ. |
| PubMed:Altered mRNA expression related to the apoptotic effect of three xanthones on human melanoma SK-MEL-28 cell line. |
| PubMed:Antitumour and free radical scavenging effects of γ-mangostin isolated from Garcinia mangostana pericarps against hepatocellular carcinoma cell. |
| PubMed:Antileptospiral activity of xanthones from Garcinia mangostana and synergy of gamma-mangostin with penicillin G. |
| PubMed:Pharmacokinetic properties of pure xanthones in comparison to a mangosteen fruit extract in rats. |
| PubMed:Distribution of major xanthones in the pericarp, aril, and yellow gum of mangosteen (Garcinia mangostana linn.) fruit and their contribution to antioxidative activity. |
| PubMed:Mechanisms of vasorelaxation to gamma-mangostin in the rat aorta. |
| PubMed:Inhibition of human aldose reductase-like protein (AKR1B10) by α- and γ-mangostins, major components of pericarps of mangosteen. |
| PubMed:New "hyphenated" CPC-HPLC-DAD-MS strategy for simultaneous isolation, analysis and identification of phytochemicals: application to xanthones from Garcinia mangostana. |
| PubMed:Mangosteen xanthones mitigate ovalbumin-induced airway inflammation in a mouse model of asthma. |
| PubMed:In vitro and in vivo anti-colon cancer effects of Garcinia mangostana xanthones extract. |
| PubMed:Inflammation-related disorders in the tryptophan catabolite pathway in depression and somatization. |
| PubMed:Investigation of biological activities of dichloromethane and ethyl acetate fractions of Platonia insignis Mart. seed. |
| PubMed:Gamma-mangostin, a micronutrient of mangosteen fruit, induces apoptosis in human colon cancer cells. |
| PubMed:Antibacterial activity of xanthones from Garcinia mangostana (L.) and their structure-activity relationship studies. |
| PubMed:Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adults. |
| PubMed:Antifibrotic constituents from Garcinia mangostana. |
| PubMed:Combined microwave-assisted extraction and high-speed counter-current chromatography for separation and purification of xanthones from Garcinia mangostana. |
| PubMed:Cytotoxic effect of xanthones from pericarp of the tropical fruit mangosteen (Garcinia mangostana Linn.) on human melanoma cells. |
| PubMed:γ-Mangostin increases serotonin 2A/2C, muscarinic, histamine and bradykinin receptor mRNA expression. |
| PubMed:Apoptotic effects of γ-mangostin from the fruit hull of Garcinia mangostana on human malignant glioma cells. |
| PubMed:A new prenylated xanthone from Garcinia xipshuanbannaensis Y.H. Li. |
| PubMed:Preparative separation of major xanthones from mangosteen pericarp using high-performance centrifugal partition chromatography. |
| PubMed:Xanthones from mangosteen inhibit inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media. |
| PubMed:New medicinal properties of mangostins: analgesic activity and pharmacological characterization of active ingredients from the fruit hull of Garcinia mangostana L. |
| PubMed:Panaxanthone isolated from pericarp of Garcinia mangostana L. suppresses tumor growth and metastasis of a mouse model of mammary cancer. |
| PubMed:Bioaccessibility, biotransformation, and transport of alpha-mangostin from Garcinia mangostana (Mangosteen) using simulated digestion and Caco-2 human intestinal cells. |
| PubMed:Xanthones from mangosteen prevent lipopolysaccharide-mediated inflammation and insulin resistance in primary cultures of human adipocytes. |
| PubMed:Anti-cancer effects of xanthones from pericarps of mangosteen. |
| PubMed:Effects of compounds from Garcinia mangostana on inflammatory mediators in RAW264.7 macrophage cells. |
| PubMed:Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity. |
| PubMed:Garcinia mangostana: a source of potential anti-cancer lead compounds against CEM-SS cell line. |
| PubMed:Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation. |
| PubMed:Anti-inflammatory activity of mangostins from Garcinia mangostana. |
| PubMed:Xanthones with quinone reductase-inducing activity from the fruits of Garcinia mangostana (Mangosteen). |
| PubMed:Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen). |
| PubMed:Garcinone B reduces prostaglandin E2 release and NF-kappaB-mediated transcription in C6 rat glioma cells. |
| PubMed:Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells. |
| PubMed:A geranylated biphenyl derivative from Garcinia malvgostana. |
| PubMed:Antimalarial xanthones from Calophyllum caledonicum and Garcinia vieillardii. |
| PubMed:gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells. |
| PubMed:Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells. |
| PubMed:Inhibition of eukaryote protein kinases and of a cyclic nucleotide-binding phosphatase by prenylated xanthones. |
| PubMed:Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha-methyltryptamine-induced head-twitch responses of mice. |
| PubMed:[Novel types of receptor antagonists from the medicinal plant Garcinia mangostana]. |
| PubMed:Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist. |
| PubMed:Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana. |
| PubMed:Active constituents against HIV-1 protease from Garcinia mangostana. |
| PubMed:Inhibition of wheat embryo calcium-dependent protein kinase and other kinases by mangostin and gamma-mangostin. |
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3D/inchi