EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

laureth-10
poly(oxy-1,2-ethanediyl), .alpha.-dodecyl-.omega.-hydroxy- (10 mol EO average molar ratio)

Supplier Sponsors

CAS Number: 6540-99-4Picture of molecule3D/inchi
FDA UNII: Search
Nikkaji Web:J740.903F
XlogP3:3.80 (est)
Molecular Weight:626.86922000
Formula:C32 H66 O11
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
CAS Number: 9002-92-0Picture of molecule3D/inchi
Other(deleted CASRN):101008-55-3
ECHA ELINCS - REACH Pre-Reg:500-002-6
FDA UNII: 89TKQ5R54
Nikkaji Web:J92.963H
XlogP3:5.10 (est)
Formula:(C2 H4 O)mult-C12 H26 O
NMR Predictor:Predict (works with chrome, Edge or firefox)
Also(can) Contains:ethoxylated C10-16 alcohols
Category:emulsifiers, surfactants
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 645.10 °C. @ 760.00 mm Hg (est)
Flash Point: 651.00 °F. TCC ( 344.00 °C. ) (est)
logP (o/w): 1.820 (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: surfactants
surfactant - emulsifying
 
Suppliers:
BOC Sciences
For experimental / research use only.
Decaethylene Glycol Monodecyl Ether pH (1%, solution):3.0
Universal Preserv-A-Chem Inc.
Laureth-10
Odor: characteristic
Use: In cosmetics and personal care products, the laureth ingredients are used in the formulation of a variety of bath, eye, facial, hair, cleansing and sunscreen products. They are also used in cuticle softeners, deodorants and moisturizing products.
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-guinea pig LD50 38 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) KIDNEY, URETER, AND BLADDER: HEMATURIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 162, 1957.

oral-guinea pig LD50 384 mg/kg
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 162, 1957.

intraperitoneal-mouse LD50 160 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.

intraperitoneal-mouse LD50 160 mg/kg
Drugs in Japan Vol. -, Pg. 1300, 1995.

intravenous-mouse LD50 100 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.

intravenous-mouse LD50 100 mg/kg
Toxicology and Applied Pharmacology. Vol. 7, Pg. 206, 1965.

oral-mouse LD50 1170 mg/kg
Toxicology and Applied Pharmacology. Vol. 2, Pg. 133, 1960.

oral-mouse LD50 1170 mg/kg
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 162, 1957.

oral-mouse LD50 3500 mg/kg
American Perfumer and Cosmetics. Vol. 77, Pg. 35, 1962.

oral-mouse LD50 4940 mg/kg
American Perfumer and Cosmetics. Vol. 77, Pg. 35, 1962.

intratracheal-rabbit LD50 > 15 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 78, 1976.

intravenous-rabbit LD50 36 mg/kg
KIDNEY, URETER, AND BLADDER: HEMATURIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 162, 1957.

parenteral-rabbit LD50 > 75 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 78, 1976.

intraperitoneal-rat LD50 125 mg/kg
GASTROINTESTINAL: OTHER CHANGES
Food and Cosmetics Toxicology. Vol. 8, Pg. 125, 1970.

intravenous-rat LD50 27 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.

intravenous-rat LD50 27 mg/kg
Drugs in Japan Vol. -, Pg. 1300, 1995.

intravenous-rat LD50 390 mg/kg
Toxicology and Applied Pharmacology. Vol. 2, Pg. 133, 1960.

oral-rat LD50 1000 mg/kg
LIVER: FATTY LIVER DEGERATION GASTROINTESTINAL: OTHER CHANGES GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Food and Cosmetics Toxicology. Vol. 8, Pg. 125, 1970.

oral-rat LD50 4150 mg/kg
Toxicology and Applied Pharmacology. Vol. 2, Pg. 133, 1960.

oral-rat LD50 8600 mg/kg
Soap, Perfumery & Cosmetics. Vol. 38, Pg. 47, 1965.

Dermal Toxicity:
subcutaneous-mouse LD50 792 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.

subcutaneous-mouse LD50 792300 ug/kg
Drugs in Japan Vol. -, Pg. 1300, 1995.

subcutaneous-rat LD50 953 mg/kg
Drugs in Japan Vol. -, Pg. 1300, 1995.

subcutaneous-rat LD50 954 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
emulsifiers, surfactants
Recommendation for laureth-10 usage levels up to:
 not for fragrance use.
 
Recommendation for laureth-10 flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):6540-99-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :145870
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
2-[2-[2-[2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Chemidplus:0006540994
2-dodecoxyethanol (peg-10)
Chemidplus:0009002920
EPA/NOAA CAMEO:hazardous materials
 
References:
 2-[2-[2-[2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:6540-99-4
Pubchem (cid):145870
Pubchem (sid):135102162
 2-dodecoxyethanol (peg-10)
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:9002-92-0
Pubchem (cid):24750
Pubchem (sid):134991393
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D01539
HMDB (The Human Metabolome Database):Search
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 britex L 100
2-dodecoxyethanol (peg-10)
 peg-10 lauryl ether
 poly(oxy-1,2-ethanediyl), .alpha.-dodecyl-.omega.-hydroxy- (10 mol EO average molar ratio)
 polyethylene glycol (10) lauryl ether
 polyethylene glycol (10) monolauryl ether
 polyoxyethylene (10) lauryl ether
 polyoxyethylene (10) monolauryl ether
 
 
Notes:
polyethylene glycol monododecyl ether (average polymer n=9).
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