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brompheniramine maleate
2-pyridinepropanamine, g-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1)

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CAS Number: 980-71-2Picture of molecule3D/inchi
Other(deleted CASRN):32865-01-3
FDA UNII: IXA7C9ZN03
MDL:MFCD00057367
Molecular Weight:435.31811000
Formula:C20 H23 Br N2 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 403.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000001 mmHg @ 25.00 °C. (est)
Flash Point: 388.00 °F. TCC ( 197.50 °C. ) (est)
logP (o/w): 3.565 (est)
Soluble in:
 water, 2.639e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
American International Chemical, LLC.
Brompheniramine Maleate
BOC Sciences
For experimental / research use only.
Brompheniramine hydrogen maleate >98%
Odor: characteristic
Use: Brompheniramine hydrogen maleate is a histamine H1 receptors antagonist.
Glentham Life Sciences
Bromopheniramine maleate
Santa Cruz Biotechnology
For experimental / research use only.
Brompheniramine Maleate ≥98%
Sigma-Aldrich
For experimental / research use only.
(±)-Brompheniramine maleate salt
TCI AMERICA
For experimental / research use only.
Brompheniramine Maleate >98.0%(HPLC)(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50 76 mg/kg
"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 19, 1969.

oral-rat LD50 318 mg/kg
"Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 19, 1969.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for brompheniramine maleate usage levels up to:
 not for fragrance use.
 
Recommendation for brompheniramine maleate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):980-71-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5281067
National Institute of Allergy and Infectious Diseases:Data
3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine;(Z)-but-2-enedioic acid
Chemidplus:0000980712
RTECS:US4025000 for cas# 980-71-2
 
References:
 3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine;(Z)-but-2-enedioic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5281067
Pubchem (sid):135049025
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D00663
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.39.4100
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 allent
2-(p-bromo-a-(2-(dimethylamino)ethyl)benzyl)pyridine maleate
2-(p-bromo-a-(2-(dimethylamino)ethyl)benzyl)pyridine maleate (1:1)
2-(p-bromo-a-(2-dimethylaminoethyl)benzyl)pyridine maleate
(±)-2-[p-bromo-a-(2-dimethylaminoethyl)benzyl]pyridine maleate
1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane maleate
3-(p-bromophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine maleate
3-(4-bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine maleate
3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine (2Z)-but-2-enedioate
3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine (2Z)-but-2-enedioate (1:1)
3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine maleate
3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine
3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine (2Z)-but-2-enedioate
3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine;(Z)-but-2-enedioic acid
(2Z)-but-2-endisäure--3-(4-bromphenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amin(1:1)
 dexchlorpheniramine maleate
 dimetane
 dimetapp allergy
 dimetapp cold & flu
 dimetapp DM
 drauxin
 ebalin
 gammistin
 ilvin maleate
 lodrane LD
 parabromodylamine maleate
2-pyridinepropanamine, g-(4-bromophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1)
 rolabromophen
 spentane
 veltane
 

Articles:

PubMed:Combined use of ionic liquid and hydroxypropyl-β-cyclodextrin for the enantioseparation of ten drugs by capillary electrophoresis.
PubMed:Combined use of ionic liquid and β-CD for enantioseparation of 12 pharmaceuticals using CE.
PubMed:Tannate complexes of antihistaminic drug: sustained release and taste masking approaches.
PubMed:Chemical stability of brompheniramine maleate in an oral liquid dosage form.
PubMed:The effect of achiral calixarenes on chiral separation of propranolol-HCl and brompheniramine maleate in capillary electrophoresis using cyclodextrin as chiral selector.
PubMed:Development of a validated capillary electrophoresis method for enantiomeric purity testing of dexchlorpheniramine maleate.
PubMed:Brompheniramine maleate: a double-blind, placebo-controlled comparison with terfenadine for symptoms of allergic rhinitis.
PubMed:Efficacy of brompheniramine maleate for the treatment of rhinovirus colds.
PubMed:Is an antihistamine-decongestant combination effective in temporarily relieving symptoms of the common cold in preschool children?
PubMed:Withdrawal symptoms after discontinuation of long-acting brompheniramine maleate.
PubMed:Mast-cell histamine is angiogenic through receptors for histamine1 and histamine2.
PubMed:Effect of food on bioavailability of pseudoephedrine and brompheniramine administered from a gastrointestinal therapeutic system.
PubMed:Nasal pharmacodynamics of brompheniramine in perennial rhinitis.
PubMed:Terfenadine and brompheniramine maleate in urticaria and dermographism.
PubMed:A placebo-controlled comparative study of sustained-release brompheniramine maleate against clemastine fumarate in the treatment of chronic urticaria.
PubMed:X-ray powder diffraction data for selected drugs: furosemide, hydrochlorothiazide, naproxen, naproxen sodium, propranolol hydrochloride, and the halopheniramine maleates.
PubMed:Adverse effects of brompheniramine on pulmonary function in a subset of asthmatic children.
PubMed:Acute otitis media in children: are decongestants or antihistamines necessary?
PubMed:Differences in performance impairment due to brompheniramine maleate as a function of the sustained-release system.
PubMed:Facial dyskinesia from overdose of an antihistamine.
PubMed:Prevention and treatment of serous otitis media with an oral antihistamine. A double-blind study in pediatric practice.
PubMed:Negative middle ear pressure and hearing thresholds in secretory otitis media. A double-blind crossover study with Lunerin.
PubMed:Ion-pair reversed-phase high-pressure liquid chromatography of cough-cold syrups I: pseudoephedrine hydrochloride, brompheniramine maleate, and dextromethorphan hydrobromide.
PubMed:Effect of the antihistamines, brompheniramine maleate and triprolidine hydrochloride, on performance in man.
PubMed:Semiautomated method for the analysis of formulations of chlorpheniramine maleate and brompheniramine maleate.
PubMed:Quantitative determinations of two decongestants and an antihistamine in combination using paired ion high-pressure liquid chromatography.
PubMed:Quantitative determination of four antihistamines in combination by high-pressure liquid chromatography.
PubMed:Hemolysis of erythrocytes by primary pharmacologic agents, part 2: influence of the vehicle.
PubMed:Aggregation of antihistamines in aqueous solution: effect of counterions on self-association of pyridine derivatives.
PubMed:Treatment of children with perennial rhinitis with brompheniraminemaleate and phenylpropanolaminehydrochloride (lunerin mite)
PubMed:Crystal structure of dl-brompheniramine maleate (1-(p-bromophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine maleate).
PubMed:Effect of glycopyrrolate and brompheniramine maleate on the recurrence rate of duodenal ulcer.
PubMed:A clinical trial of brompheniramine maleate in chronic urticaria.
PubMed:BROMPHENIRAMINE maleate.
 
Notes:
histamine h1 antagonist used in treatment of allergies, rhinitis, and urticaria.
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