EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

zinc pyrithione
2-pyridinethiol, 1-oxide, zinc salt (2:1)

Supplier Sponsors

CAS Number: 13463-41-7Picture of molecule3D/inchi
Other(deleted CASRN):109702-19-4
ECHA EINECS - REACH Pre-Reg:236-671-3
Molecular Weight:317.69616000
Formula:C10 H8 N2 O2 S2 Zn
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
FCN 1169 Zinc pyrithione View - notice
FCN 1900 Zinc pyrithione View - notice
DG SANTE Food Contact Materials:zinc pyrithione
Physical Properties:
Appearance:beige fine granules (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 240.00 °C. @ 760.00 mm Hg (est)
Boiling Point: 350.20 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000091 mmHg @ 25.00 °C. (est)
Flash Point: 330.00 °F. TCC ( 165.60 °C. ) (est)
logP (o/w): -0.900 (est)
Soluble in:
 water, 4.876e+005 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antidandruff agents
antiseborrhoeic agents
hair conditioning
BOC Sciences
For experimental / research use only.
Pyrithione zinc >98%
Odor: characteristic
Use: Zinc pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.
Connect Chemicals
Zinc Pyrithione
ECSA Chemicals
Jiangyin Healthway
Zinc (Sodium,Copper) Pyrithione
New functional food ingredients
Lonza Group
Zinc Omadine™ Enhanced CP Dispersion
Odor: characteristic
Use: Zinc Omadine™ products are highly active, broad spectrum antimicrobial agents that are registered around the world for use in both personal care as well as industrial product applications. In the U.S., Zinc Omadine® products are approved for use by the EPA and allowed by the FDA. Zinc Omadine™ Enhanced CP Dispersion is a palm oil coated, 46% aqueous dispersion of Zinc Omadine™. The palm oil coating offers additional benefits, including shinier hair, weightless styling and no residue.
Lonza Group
Zinc Omadine™ Fine Particle Size (FPS) Fungicide-Algaecide Dispersion (zinc pyrithione)
Odor: characteristic
Use: Zinc OMADINE™ products are highly active, broad spectrum antimicrobial agents that are registered around the world for use in both personal care as well as industrial product applications. In the U.S., Zinc OMADINE® products are approved for use by the EPA and allowed by the FDA. Zinc OMADINE™ fungicide-algaecide is the zinc complex of pyrithione. Zinc OMADINE™ fungicide-algaecide is the active ingredient in some of the leading antidandruff shampoo products around the world, and its proven combination of efficacy and safety-in-use has made it the world's leading anti-dandruff agent for more than 30 years. Zinc OMADINE™ fungicide-algaecide is listed in the FDA Final Monograph on Dandruff and Seborrheic Dermatitis as a Category I substance (i.e. generally recognized as safe and effective). Zinc OMADINE® products are available in Industrial and Cosmetic grades, and in powder and in dispersion forms.
Sigma-Aldrich: Aldrich
For experimental / research use only.
1-Hydroxypyridine-2-thione zinc salt ∼95%
Universal Preserv-A-Chem Inc.
Universal Preserv-A-Chem Inc.
Odor: characteristic
Use: Zinc pyrithione is also used as an antibacterial treatment for household sponges, most notably by the 3M Corporation.
Universal Preserv-A-Chem Inc.
Odor: characteristic
Use: It is a preservative against bacteria, fungi, and yeast. It is useful in gels, creams, heavy lotions, and talcum powder.
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-dog LD50 600 mg/kg
Clinical Toxicology. Vol. 13, Pg. 1, 1978.

intravenous-dog LDLo 25 mg/kg
Toxicology and Applied Pharmacology. Vol. 9, Pg. 269, 1966.

oral-guinea pig LD50 > 2000 mg/kg
Toxicology and Applied Pharmacology. Vol. 7, Pg. 425, 1965.

intraperitoneal-mouse LD50 26800 ug/kg
Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1067, 1974.

oral-mouse LD50 160 mg/kg
Clinical Toxicology. Vol. 13, Pg. 1, 1978.

intravenous-rabbit LDLo 10 mg/kg
Toxicology and Applied Pharmacology. Vol. 9, Pg. 269, 1966.

oral-rat LD50 177 mg/kg
Toxicology Annual. Vol. 3, Pg. 1, 1979.

Dermal Toxicity:
subcutaneous-mouse LD50 730 mg/kg
Clinical Toxicology. Vol. 13, Pg. 1, 1978.

skin-rabbit LD50 100 mg/kg
Yakkyoku. Pharmacy. Vol. 32, Pg. 965, 1981.

Inhalation Toxicity:
inhalation-mammal (species unspecified) LC50 140 mg/m3/4H
United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-0790-1035

inhalation-rat LC50 140 mg/m3/4H
National Technical Information Service. Vol. OTS0527753-1

Safety in Use Information:
cosmetic agents
Recommendation for zinc pyrithione usage levels up to:
 not for fragrance use.
Recommendation for zinc pyrithione flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):13463-41-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :26041
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
EPA/NOAA CAMEO:hazardous materials
RTECS:ZH0950000 for cas# 13463-41-7
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:13463-41-7
Pubchem (cid):26041
Pubchem (sid):134991002
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
HMDB (The Human Metabolome Database):Search
•ecostern (ppg industries, zinc 2-pyridinethiol-1-oxide 4.8% •e paint zo (e paint), zinc 2-pyridinethiol-1-oxide 4.8% •hmf antifouling paint (sherwin-williams), zinc 2-pyridinethiol-1-oxide 6.38%, 1h-pyrrole-3-carbonitrile,4-bromo-2-(4-chlorophenyl)-5-(trifluoromethyl)- 7.28% •intersmooth 360 ecoloflex spc antifouling bea 368 dark brown (international paint), zinc 2-pyridinethiol-1-oxide 3.8%, copper(i) oxide 40.41% •islands 77 plus antifouling coating black (new nautical coatings), zinc 2-pyridinethiol-1-oxide 4.14%, copper(i) oxide 38.06% •optima activator (international paint), zinc 2-pyridinethiol-1-oxide 47.04% •pettit marine paint ultima spc antifouling paint (kop-coat), zinc 2-pyridinethiol-1-oxide 3%, copper(i) oxide 40.43% •proxel bz preservative (arch chemicals), zinc 2-pyridinethiol-1-oxide 8%, 1,2-benzisothiazolin-3-one 12% •sanitized brand pl 21-60 (sanitized inc), zinc 2-pyridinethiol-1-oxide 22.8% •sea grand prix cf-10 (chugoku marine paints), zinc 2-pyridinethiol-1-oxide 2.85%, 4,5-dichloro-2-n-octyl-3(2h)-isothiazolone 3.6% •superyacht 800 antifouling-white (international paint), zinc 2-pyridinethiol-1-oxide 3.39%, cuprous thiocyanate 16.95% •trilux 44-white (international paint), zinc 2-pyridinethiol-1-oxide 4.12%, 1h-pyrrole-3-carbonitrile,4-bromo-2-(4-chlorophenyl)-5-(trifluoromethyl)- 3.9% •ultra-fresh dw-56 biostat (thomson research), zinc 2-pyridinethiol-1-oxide 15%, thiabendazole 15% •vanquish sl 10 antimicrobial (arch chemicals), zinc 2-pyridinethiol-1-oxide 4.75%, 1,2-benzisothiazolin-3-one, 2-butyl- 4.75% •zinc omadine powder industrial microbiostat (arch chemicals), zinc 2-pyridinethiol-1-oxide 95% •zinc pyrion powder industrial microbiostat (janssen), zinc 2-pyridinethiol-1-oxide 99.6% •dhs(tm) zinc dandruff shampoo - aids in control of dandruff, seborrheic dermatitus of the scalp 2% zinc pyrithione
Potential Blenders and core components note
None Found
Potential Uses:
Occurrence (nature, food, other):note
 not found in nature
 biocut ZP
 breck one dandruff shampoo
 chemical ZPT
 head and shoulders
2-mercaptopyridine N-oxide zinc salt
2-mercaptopyridine-1-oxide zinc salt
bis[pyridine-2-thiolato-kappaS 1(oxide-kappaO)]zinc
2-pyridinethiol, 1-oxide, zinc salt (2:1)
bis(2-pyridylthio)zinc 1,1'-dioxide
 pyrithione zinc
 pyrithionum zincicum
 sebulon shampoo
 tomicide ZPT 50
 vancide ZP
 zinc bis(pyridine-2-thiolate 1-oxide)
 zinc omadine enhanced CP dispersion
 zinc omadine fine particle size (FPS) fungicide-algaecide dispersion (zinc pyrithione)
 zinc omadine general fungicide-algaecide dispersion (zinc pyrithione)
 zinc pyrithione 48-50 dispersion (cleanbio zinc)
 zinc, bis(1-(hydroxy-kappaO)-2(1H)-pyridinethionato-kappaS2)-, (T-4)-
 zinc, bis(1-hydroxy-2(1H)-pyridinethionato-O,S)-(T-4)-
 zinc, bis(1-hydroxy-2(1H)-pyridinethionato)- (8CI)
 zinc, bis(2-pyridinylthio)-, N,N'-dioxide
 zinc, bis(2-pyridylthio)-, 1,1'-dioxide
 zinc, bis(2-pyridylthio)-, N,N'-dioxide
 zincon dandruff shampoo


PubMed:Climbazole increases expression of cornified envelope proteins in primary keratinocytes.
PubMed:On the influence of the culture conditions in bacterial antifouling bioassays and biofilm properties: Shewanella algae, a case study.
PubMed:Understanding the dandruff scalp before and after treatment: an in vivo Raman spectroscopic study.
PubMed:Clinical and Biochemical Assessment of Maintenance Treatment in Chronic Recurrent Seborrheic Dermatitis: Randomized Controlled Study.
PubMed:KCNQ (Kv7) potassium channel activators as bronchodilators: combination with a β2-adrenergic agonist enhances relaxation of rat airways.
PubMed:A comparison of toxicant-induced succession for five antifouling compounds on marine periphyton in SWIFT microcosms.
PubMed:In vitro anti-Malassezia activity and potential use in anti-dandruff formulation of Asparagus racemosus.
PubMed:Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels.
PubMed:Therapeutic efficacy of anti-dandruff shampoos: a randomized clinical trial comparing products based on potentiated zinc pyrithione and zinc pyrithione/climbazole.
PubMed:Intracellular dialysis disrupts Zn2+ dynamics and enables selective detection of Zn2+ influx in brain slice preparations.
PubMed:Comparative evaluation of antimicrobials for textile applications.
PubMed:Enhanced efficacy and sensory properties of an anti-dandruff shampoo containing zinc pyrithione and climbazole.
PubMed:Assessing therapeutic effectiveness of scalp treatments for dandruff and seborrheic dermatitis, part 2: the impact of gender and ethnicity on efficacy.
PubMed:Effects of seven antifouling compounds on photosynthesis and inorganic carbon use in sugar kelp Saccharina latissima (Linnaeus).
PubMed:Dandruff/seborrhoeic dermatitis is characterized by an inflammatory genomic signature and possible immune dysfunction: transcriptional analysis of the condition and treatment effects of zinc pyrithione.
PubMed:Assessing therapeutic effectiveness of scalp treatments for dandruff and seborrheic dermatitis, part 1: a reliable and relevant method based on the adherent scalp flaking score (ASFS).
PubMed:Determination of detoxification to Daphnia magna of four pharmaceuticals and seven surfactants by activated sludge.
PubMed:Risks of using antifouling biocides in aquaculture.
PubMed:Treatment of localized psoriasis with a topical formulation of zinc pyrithione.
PubMed:Nanomolar concentrations of zinc pyrithione increase cell susceptibility to oxidative stress induced by hydrogen peroxide in rat thymocytes.
PubMed:Effects of metal pyrithione antifoulants on freshwater macrophyte Lemna gibba G3 determined by image analysis.
PubMed:Novel agents inhibit human leukemic cells.
PubMed:M channel enhancers and physiological M channel block.
PubMed:Effects of KCNQ channel modulators on the M-type potassium current in primate retinal pigment epithelium.
PubMed:Antineoplastic activity of ouabain and pyrithione zinc in acute myeloid leukemia.
PubMed:Zinc pyrithione induces ERK- and PKC-dependent necrosis distinct from TPEN-induced apoptosis in prostate cancer cells.
PubMed:Restoration of ion channel function in deafness-causing KCNQ4 mutants by synthetic channel openers.
PubMed:Zinc pyrithione inhibits yeast growth through copper influx and inactivation of iron-sulfur proteins.
PubMed:New insights on dandruff/seborrhoeic dermatitis: the role of the scalp follicular infundibulum in effective treatment strategies.
PubMed:The antifungal mechanism of action of zinc pyrithione.
PubMed:A high-content screening assay in transgenic zebrafish identifies two novel activators of fgf signaling.
PubMed:Drosophila KCNQ channel displays evolutionarily conserved electrophysiology and pharmacology with mammalian KCNQ channels.
PubMed:Zinc pyrithione salvages reperfusion injury by inhibiting NADPH oxidase activation in cardiomyocytes.
PubMed:Single-substance and mixture toxicity of five pharmaceuticals and personal care products to marine periphyton communities.
PubMed:Stress responses of human dermal fibroblasts exposed to zinc pyrithione.
PubMed:Zinc pyrithione impairs zinc homeostasis and upregulates stress response gene expression in reconstructed human epidermis.
PubMed:Acute toxicities of five commonly used antifouling booster biocides to selected subtropical and cosmopolitan marine species.
PubMed:Novel antifouling agent-zinc pyrithione: stress induction and genotoxicity to the marine mussel Mytilus galloprovincialis.
PubMed:Scalp stratum corneum histamine levels: novel sampling method reveals association with itch resolution in dandruff/seborrhoeic dermatitis treatment.
PubMed:Efficacy of a piroctone olamine/climbazol shampoo in comparison with a zinc pyrithione shampoo in subjects with moderate to severe dandruff.
PubMed:Epidermal changes associated with symptomatic resolution of dandruff: biomarkers of scalp health.
PubMed:Aminoglycosides inhibit KCNQ4 channels in cochlear outer hair cells via depletion of phosphatidylinositol(4,5)bisphosphate.
PubMed:Novel antifouling agent zinc pyrithione: determination, acute toxicity, and bioaccumulation in marine mussels (Mytilus galloprovincialis).
PubMed:Cardioprotective effect of zinc requires ErbB2 and Akt during hypoxia/reoxygenation.
PubMed:Development of a quinazoline-based chelating ligand for zinc ion and its application to validation of a zinc-ion-coordinated compound.
PubMed:Pyrithione-zinc Prevents UVB-induced Epidermal Hyperplasia by Inducing HIF-1alpha.
PubMed:DNA microarray analysis suggests that zinc pyrithione causes iron starvation to the yeast Saccharomyces cerevisiae.
PubMed:Novel antifouling agent--zinc pyrithione: short- and long-term effects on survival and reproduction of the marine polychaete Dinophilus gyrociliatus.
PubMed:Zinc pyrithione induces cellular stress signaling and apoptosis in Hep-2 cervical tumor cells: the role of mitochondria and lysosomes.
PubMed:Swimming speed alteration of Artemia sp. and Brachionus plicatilis as a sub-lethal behavioural end-point for ecotoxicological surveys.
PubMed:A bacterial biosensor for oxidative stress using the constitutively expressed redox-sensitive protein roGFP2.
PubMed:Toxicity of metal pyrithione photodegradation products to marine organisms with indirect evidence for their presence in seawater.
PubMed:The topical antimicrobial zinc pyrithione is a heat shock response inducer that causes DNA damage and PARP-dependent energy crisis in human skin cells.
PubMed:Inhibition of Candida albicans biofilm formation by antimycotics released from modified polydimethyl siloxane.
PubMed:Pyrithione and 8-hydroxyquinolines transport lead across erythrocyte membranes.
PubMed:Electrospray ionization mass spectrometric observation of ligand exchange of zinc pyrithione with amino acids.
PubMed:Pseudomonas aeruginosa PAO1 resistance to Zinc pyrithione: phenotypic changes suggest the involvement of efflux pumps.
PubMed:Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+.
PubMed:Clinical efficacies of topical agents for the treatment of seborrheic dermatitis of the scalp: a comparative study.
PubMed:Inhibition of acetylcholinesterase by metabolites of copper pyrithione (CuPT) and its possible involvement in vertebral deformity of a CuPT-exposed marine teleostean fish.
PubMed:Does tachyphylaxis occur in long-term management of scalp seborrheic dermatitis with pyrithione zinc-based treatments?
PubMed:Multidimensional risk analysis of antifouling biocides.
PubMed:Predicted concentrations of biocides from antifouling paints in Visakhapatnam Harbour.
PubMed:Flow injection analysis of zinc pyrithione in hair care products on a cobalt phthalocyanine modified screen-printed carbon electrode.
PubMed:Prediction and assessment of mixture toxicity of compounds in antifouling paints using the sea-urchin embryo-larval bioassay.
PubMed:The antidandruff efficacy of a shampoo containing piroctone olamine and salicylic acid in comparison to that of a zinc pyrithione shampoo.
PubMed:Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations.
PubMed:Synergistic toxic effects of zinc pyrithione and copper to three marine species: Implications on setting appropriate water quality criteria.
PubMed:A double-blind randomized vehicle-controlled clinical trial investigating the effect of ZnPTO dose on the scalp vs. antidandruff efficacy and antimycotic activity.
PubMed:Desensitization of chemical activation by auxiliary subunits: convergence of molecular determinants critical for augmenting KCNQ1 potassium channels.
PubMed:Combinatorial augmentation of voltage-gated KCNQ potassium channels by chemical openers.
PubMed:Surgical hand antisepsis to reduce surgical site infection.
PubMed:Time-dependent X-ray absorption spectroscopic (XAS) study on the transformation of zinc basic salt into bis(N-oxopyridine-2-thionato) zinc (II).
PubMed:Angiotensin-converting enzyme inhibitor attenuates monocyte adhesion to vascular endothelium through modulation of intracellular zinc.
PubMed:Toxicity of four antifouling biocides and their mixtures on the brine shrimp Artemia salina.
PubMed:Multicenter, open-label, non-comparative study of a combination of polytar and zinc pyrithione shampoo in the management of dandruff.
PubMed:Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants.
PubMed:Protective role of intracellular zinc in myocardial ischemia/reperfusion is associated with preservation of protein kinase C isoforms.
PubMed:Aqueous phototransformation of zinc pyrithione Degradation kinetics and byproduct identification by liquid chromatography--atmospheric pressure chemical ionisation mass spectrometry.
PubMed:In vitro antifungal efficacy of ciclopirox olamine alone and associated with zinc pyrithione compared to ketoconazole against Malassezia globosa and Malassezia restricta reference strains.
PubMed:Efficacy of a new antidandruff thermophobic foam: a randomized, controlled, investigator-blinded trial vs. ketoconazole 2% scalp fluid.
PubMed:Clinical efficacy of a new ciclopiroxolamine/zinc pyrithione shampoo in scalp seborrheic dermatitis treatment.
PubMed:Acute toxicity of pyrithione antifouling biocides and joint toxicity with copper to red sea bream (Pagrus major) and toy shrimp (Heptacarpus futilirostris).
PubMed:Improved method for the determination of zinc pyrithione in environmental water samples incorporating on-line extraction and preconcentration coupled with liquid chromatography atmospheric pressure chemical ionisation mass spectrometry.
PubMed:The interactive effects of binary mixtures of three antifouling biocides and three heavy metals against the marine algae Chaetoceros gracilis.
PubMed:Toxicity reduction of metal pyrithiones by near ultraviolet irradiation.
PubMed:Ecological effects of the insecticide imidacloprid and a pollutant from antidandruff shampoo in experimental rice fields.
PubMed:Malassezia and seborrheic dermatitis: etiology and treatment.
PubMed:Influence of light in acute toxicity bioassays of imidacloprid and zinc pyrithione to zooplankton crustaceans.
PubMed:The impact of legislation on the usage and environmental concentrations of Irgarol 1051 in UK coastal waters.
PubMed:Effects of antifouling biocides to the germination and growth of the marine macroalga, Hormosira banksii (Turner) Desicaine.
PubMed:Toxicity assessment of the antifouling compound zinc pyrithione using early developmental stages of the ascidian Ciona intestinalis.
PubMed:Environmental fate of the antifouling compound zinc pyrithione in seawater.
PubMed:The use of (14)C tracer technique to assess the functional response of zooplankton community grazing to toxic impact.
PubMed:Three etiologic facets of dandruff and seborrheic dermatitis: Malassezia fungi, sebaceous lipids, and individual sensitivity.
PubMed:A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.
PubMed:Effects on the function of three trophic levels in marine plankton communities under stress from the antifouling compound zinc pyrithione.
PubMed:[Determination of antidangdruff agent salicylic acid, zinc pyrithione, octopirox, climbazole and ketoconazole in shampoo by high performance liquid chromatography].
PubMed:Avoidance response of sediment living amphipods to zinc pyrithione as a measure of sediment toxicity.
PubMed:Unexpected effects of zinc pyrithione and imidacloprid on Japanese medaka fish (Oryzias latipes).
PubMed:Embryotoxicity of the antifouling biocide zinc pyrithione to sea urchin (Paracentrotus lividus) and mussel (Mytilus edulis).
PubMed:Pyrithiones as antifoulants: environmental fate and loss of toxicity.
PubMed:A unique water optional health care personnel handwash provides antimicrobial persistence and residual effects while decreasing the need for additional products.
PubMed:Zinc pyrithione induces apoptosis and increases expression of Bim.
PubMed:Pustular psoriasis and the Kobner phenomenon caused by allergic contact dermatitis from zinc pyrithione-containing shampoo.
PubMed:Zinc pyrithione in alcohol-based products for skin antisepsis: persistence of antimicrobial effects.
PubMed:Gold complexes inhibit mitochondrial thioredoxin reductase: consequences on mitochondrial functions.
PubMed:New biocide-free anti-fouling paints are toxic.
PubMed:Seasonal variations in the effect of zinc pyrithione and copper pyrithione on pelagic phytoplankton communities.
PubMed:Improving antifungal activity of zinc pyrithione through particle coating technology.
PubMed:Indirect estimation of degradation time for zinc pyrithione and copper pyrithione in seawater.
PubMed:Effects of zinc pyrithione and copper pyrithione on microbial community function and structure in sediments.
PubMed:Worldwide occurrence and effects of antifouling paint booster biocides in the aquatic environment: a review.
PubMed:The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial.
PubMed:The hair strand test - a new method for testing antifungal effects of antidandruff preparations.
PubMed:The use of 0.25% zinc pyrithione spray does not enhance the efficacy of clobetasol propionate 0.05% foam in the treatment of psoriasis.
PubMed:Increased scalp skin lipids in response to antidandruff treatment containing zinc pyrithione.
PubMed:A multicenter randomized trial of ketoconazole 2% and zinc pyrithione 1% shampoos in severe dandruff and seborrheic dermatitis.
PubMed:Effects of new antifouling compounds on the development of sea urchin.
PubMed:Toxicity evaluation of new antifouling compounds using suspension-cultured fish cells.
PubMed:Antimicrobial susceptibility changes and T-OMP shifts in pyrithione-passaged planktonic cultures of Pseudomonas aeruginosa PAO1.
PubMed:Dandruff has an altered stratum corneum ultrastructure that is improved with zinc pyrithione shampoo.
PubMed:Management of seborrheic dermatitis and pityriasis versicolor.
PubMed:Evaluation of safety and efficacy of ketoconazole 2% and zinc pyrithione 1% shampoo in patients with moderate to severe dandruff--a postmarketing study.
PubMed:Analysis of waterborne paints by gas chromatography-mass spectrometry with a temperature-programmable pyrolyzer.
PubMed:Histopathology of psoriasis treated with zinc pyrithione.
PubMed:Histopathology of psoriasis treated with zinc pyrithione.
PubMed:Treatment of seborrheic dermatitis.
PubMed:Pyrithiones as antifoulants: Environmental chemistry and preliminary risk assessment.
PubMed:Anecdotal therapies.
PubMed:Embryotoxicity of zinc pyrithione, an antidandruff chemical, in fish.
PubMed:Skin Cap analysis in Spain.
PubMed:Skin Cap and corticosteroids.
PubMed:Pustular psoriasis and hepatotoxicity associated with use of Skin Cap spray.
PubMed:Editorial comment on Skin Cap.
PubMed:Skin Cap: what have we learned, and when did we learn it?
PubMed:Immediacy is both a liability and an asset of the Internet.
PubMed:Determination of the antifouling agent zinc pyrithione in water samples by copper chelate formation and high-performance liquid chromatography-atmospheric pressure chemical ionisation mass spectrometry.
PubMed:A novel assay for the distribution of pyrithione biocides in bacterial cells.
PubMed:Pyrithione biocides as inhibitors of bacterial ATP synthesis.
PubMed:Pyrithione biocide interactions with bacterial phospholipid head groups.
PubMed:[The "Antipsoriatic" Skin-Cap contains a non-declared potent corticosteroid].
PubMed:[On "Skin-Cap"].
PubMed:Allergic contact dermatitis caused by zinc pyrithione associated with pustular psoriasis.
PubMed:Prolonged effects of antidandruff shampoos - time to recurrence of Malassezia ovalis colonization of skin.
PubMed:The highly effective use of topical zinc pyrithione in the treatment of psoriasis: a case report.
PubMed:Malassezia furfur: a fungus belonging to the physiological skin flora and its relevance in skin disorders.
PubMed:Toxicity of potential irritants in mammalian cells in vitro.
PubMed:In vitro susceptibility of Malassezia furfur.
PubMed:Mechanism of pyrithione-induced membrane depolarization in Neurospora crassa.
PubMed:Allergic contact dermatitis from zinc pyrithione.
PubMed:Seborrheic dermatitis.
PubMed:Positive patch tests to zinc pyrithione.
PubMed:Seborrhoeic dermatitis and Pityrosporum yeasts.
PubMed:Effects of lipophilic complex formation on the disposition of nickel in experimental animals.
PubMed:Evaluation de l'activité antifongique de deux dérivés et test d'innocuitéin vivo de shampooings à visée antipelliculaire ainsi formulés.
PubMed:Evaluation of the genotoxic potential of zinc pyrithione in the Salmonella mutagenicity (Ames) assay, CHO/HGPRT gene mutation assay and mouse micronucleus assay.
PubMed:Interspecies variations in response to topical application of selected zinc compounds.
PubMed:The in vitro antifungal activity of ketoconazole, zinc pyrithione, and selenium sulfide against Pityrosporum and their efficacy as a shampoo in the treatment of experimental pityrosporosis in guinea pigs.
PubMed:High-performance liquid chromatographic determination of zinc pyrithione in antidandruff preparations based on copper chelate formation.
PubMed:ZPT-related distal axonopathy: behavioral and electrophysiologic correlates in rats.
PubMed:[1% econazole hair-shampoo in the treatment of pityriasis capitis; a comparative study versus zinc-pyrithione shampoo].
PubMed:Dermatitis from zinc pyrithione.
PubMed:[Bactericidal activity of disinfectants against certain bacterial strains of S. aureus].
PubMed:Determination of zinc pyrithione in cosmetic products by high-performance liquid chromatography with pre-labelling.
PubMed:Effect of zinc pyridinethione on the tissue disposition of nickel and cadmium in mice.
PubMed:Chelating drugs and zinc.
PubMed:Current treatment of cutaneous Pityrosporum and Candida-infections.
PubMed:The dissolution rate of zinc pyrithione.
PubMed:The effects of a shampoo containing zinc pyrithione on the control of dandruff.
PubMed:The effect and mode of action of zinc pyrithione on cell growth. II. In vivo studies.
PubMed:Effect of zinc pyrithione on mitotic activity in normal human skin.
PubMed:Zinc pyrithione (Zinc Omadine) allergy.
PubMed:The effect and mode of action of zinc pyrithione on cell growth. I. In vitro studies.
PubMed:[Treatment of pityriasis versicolor].
PubMed:Allergic contact dermatitis to zinc pyrithione.
PubMed:Analysis of zinc pyrithione in shampoos by reversed-phase high-performance liquid chromatography.
PubMed:Evaluation of the ability of d-penicillamine to protect rats against the neurotoxicity induced by zinc pyridinethione, acrylamide, 2,5-hexanedione and p-bromophenylacetylurea.
PubMed:The comparative toxic effects of proprietary antidandruff, adult and baby shampoos on rabbit ileum.
PubMed:In vivo procedures for assessment of hair greasiness.
PubMed:Double-blind comparison of a zinc pyrithione shampoo and its shampoo base in the treatment of tinea versicolor.
PubMed:Abnormalities of axonal transport: are they a cause of peripheral nerve disease?
PubMed:[N1-metal sulfa drugs and zincpolyanemine and its derivatives in prevention of burn wound sepsis].
PubMed:Zinc pyridinethione: serum metabolites of zinc pyridinethione in rabbits, rats, monkeys, and dogs after oral dosing.
PubMed:Antifungal activity of dermatological shampoos.
PubMed:The inhibitory effect of zinc pyrithione on the epidermal proliferation of animal skins.
PubMed:A randomized, controlled clinical trial of four anti-dandruff shampoos.
PubMed:Zinc pyridinethione: urinary metabolites of zinc pyridinethione in rabbits, rats, monkeys, and dogs after oral dosing.
PubMed:Contact allergic sensitivity to zinc pyrithione followed by the photosensitivity dermatitis and actinic reticuloid syndrome.
PubMed:An open trial of the effect of a zinc pyrithione shampoo in tinea versicolor.
PubMed:Effects of pyrithiones and surfactants on zinc and enzyme levels in rabbits.
PubMed:Axoplasmic transport in zinc pyridinethione neuropathy: evidence for an abnormality in distal turn-around.
PubMed:Seborrhoeic dermatitis of the scalp treated with a tar/zinc pyrithione shampoo.
PubMed:An evaluation of the antipityrosporum properties of zinc pyrithione on hair and skin.
PubMed:Acute toxicity of Zinc pyrithione to human skin cells in vitro.
PubMed:Neurological, microscopic and enzyme-histochemical assessment of zinc pyrithione toxicity.
PubMed:Reproduction and teratology studies of zinc pyrithione administered orally or topically to rats and rabbits.
PubMed:Contact dermatitis from zinc pyrithione, an antidandruff agent.
PubMed:Disposition of zinc pyrithione in the rat.
PubMed:Sural nerve conduction study in the rat: a new technique for studying experimental neuropathies.
PubMed:Zinc pyrithione and peripheral neuritis.
PubMed:Preliminary neurological evaluation of generalized weakness in zinc pyrithione-treated rats.
PubMed:Teratologic evaluation of dermally applied zinc pyrithione on swine.
PubMed:A percutaneous teratology study of zinc pyrithione in rabbits.
PubMed:Anti-seborrhoeic qualities of zinc pyrithione in a cream vehicle. II. Safety evaluation.
PubMed:The anti-seborrheic qualities of zinc pyrithione (zinc pyridine-2-thiol-1-oxide) in a cream vehicle. 1. A preliminary report.
ingredient of commercial anti-dandruff shampoos; there is controversy over whether this is an ingredient of the otc drug skin cap.
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