trisodium nitrilotriacetate
glycine, N,N-bis(carboxymethyl)-, sodium salt (1:3)
 
Notes:
a derivative of acetic acid, n(ch2cooh)3. it is a complexing (sequestering) agent that forms stable complexes with zn2+. (from miall's dictionary of chemistry, 5th ed.) Used as a food additive [EAFUS]
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trisodium 2-[bis(2-oxido-2-oxoethyl)amino]acetate (Click)
CAS Number: 5064-31-3Picture of molecule
ECHA EINECS - REACH Pre-Reg: 225-768-6
FDA UNII: E3C8R2M0XD
Nikkaji Web: J122.457C
MDL: MFCD00064231
Molecular Weight: 257.08532784
Formula: C6 H6 N Na3 O6
NMR Predictor: Predict (works with chrome or firefox)
Category: boiler water additives used in the preparation of steam that will contact food
 
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FDA Mainterm: TRISODIUM NITRILOTRIACETATE
FDA Regulation:
FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart D--Specific Usage Additives
Sec. 173.310 Boiler water additives.
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Physical Properties:
Food Chemicals Codex Listed: No
Boiling Point: 498.20 °C. @ 760.00 mm Hg (est)
Flash Point: 491.00 °F. TCC ( 255.10 °C. ) (est)
logP (o/w): -1.764 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: chelating agents
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Suppliers:
American International Chemical
Dabeersen 217C Nitrilotriacetic Acid Triosodium Salt
American International Chemical
Dabeersen 217L Nitrilotriacetic Acid Triosodium Salt, Aqueous Solution-NTA
Dow Chemical
VERSENE NTA Chelating Agent
Santa Cruz Biotechnology
For experimental / research use only.
Nitrilotriacetic acid trisodium salt ≥99%
Sigma-Aldrich: Sigma
For experimental / research use only.
Nitrilotriacetic acid trisodium salt, Sigma Grade, ≥98%
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  1100 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING
Toxicology and Applied Pharmacology. Vol. 18, Pg. 398, 1971.

intraperitoneal-rat LD50  254 mg/kg
Toxicology and Applied Pharmacology. Vol. 18, Pg. 398, 1971.

oral-mouse LD50  681 mg/kg
National Cancer Institute by Litton Bionetics, Inc. Vol. NCI-E-C-72-3252, Pg. 1973

oral-dog LD50  > 5000 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING
Toxicology and Applied Pharmacology. Vol. 18, Pg. 398, 1971.

oral-mouse LD50  681 mg/kg
Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. Vol. NCI-E-C-72-3252, Pg. 1973

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: boiler water additives used in the preparation of steam that will contact food
Recommendation for trisodium nitrilotriacetate usage levels up to:
 not for fragrance use.
 
Recommendation for trisodium nitrilotriacetate flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ECHA (ESR): View
NIOSH International Chemical Safety Cards: search
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 5064-31-3
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 21152
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 trisodium 2-[bis(2-oxido-2-oxoethyl)amino]acetate
Chemidplus: 0005064313
RTECS: 5064-31-3
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References:
 trisodium 2-[bis(2-oxido-2-oxoethyl)amino]acetate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 5064-31-3
Pubchem (cid): 21152
Pubchem (sid): 134984529
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
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FooDB: FDB010423
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Formulations/Preparations:
available commercially as pure solid or as a solution in water.
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 chelating agents 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 acetic acid, nitrilotri-, trisodium salt
N,N-bis(carboxymethyl)glycine, trisodium salt
 dabeersen 217C nitrilotriacetic acid triosodium salt
 dabeersen 217L nitrilotriacetic acid triosodium salt, aqueous solution-NTA
 glycine, N,N-bis(carboxymethyl)-, sodium salt (1:3)
 glycine, N,N-bis(carboxymethyl)-, trisodium salt
 hampshire NTA
 nitrilotriacetate trisodium salt
 nitrilotriacetic acid trisodium
 nitrilotriacetic acid trisodium salt
 nitrilotriacetic acid, trisodium salt
 NTA trisodium salt
monosodium nitrilotriacetate
 syntron A
 trisodium 2-[bis(2-oxido-2-oxoethyl)amino]acetate
 trisodium 2,2',2''-nitrilotriacetate
 trisodium aminotriacetate
 trisodium N,N-bis(carboxymethyl)glycinate
 trisodium nitrilotriacetate
 trisodium NTA
 versene NTA chelating agent
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Articles:
PubMed: Effect of methimazole on rat renal carcinogenesis induced by N-ethyl-N-hydroxyethylnitrosamine.
PubMed: Possible application to medium-term organ bioassays for renal carcinogenesis modifiers in rats treated with N-ethyl-N-hydroxyethylnitrosamine and unilateral nephrectomy.
PubMed: Differential effects of renal carcinogens and tumor promoters on growth promotion and inhibition of gap junctional communication in two rat renal epithelial cell lines.
PubMed: Monoclonal antibody against rat renal cell tumor-associated antigen as a new tool for the analysis of renal tumorigenesis.
PubMed: Inhibition of gap-junctional intercellular communication between Chinese hamster lung fibroblasts by di(2-ethylhexyl) phthalate (DEHP) and trisodium nitrilotriacetate monohydrate (NTA).
PubMed: Effects of trisodium nitrilotriacetate monohydrate, nitrilotriacetic acid and ammonium chloride on urinary bladder carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl) nitrosamine.
PubMed: Effect of N-nitroso-n-butyl-(4-hydroxybutyl)amine exposure on the changes in mineral disposition caused by trisodium nitrilotriacetate.
PubMed: Promoting effect of trisodium nitrilotriacetate monohydrate on urinary bladder carcinogenesis in rats.
PubMed: Dose-dependent promoting effect of trisodium nitrilotriacetate monohydrate on urinary bladder carcinogenesis in Wistar rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
PubMed: Dose-related effect of trisodium nitrilotriacetate monohydrate on renal tumorigenesis initiated with N-ethyl-N-hydroxyethylnitrosamine in rats.
PubMed: Trisodium nitriloacetate monohydrate: promoting effect in urinary bladder carcinogenesis in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
PubMed: Renal pelvic and ureteral dilatation in male rats ingesting trisodium nitrilotriacetate.
PubMed: Trisodium nitrilotriacetate monohydrate: promoting effects on the development of renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine.
PubMed: The pathogenesis of renal cortical tumours in rats fed 2% trisodium nitrilotriacetate monohydrate.
PubMed: Short-term effects of dietary nitrilotriacetic acid in the male Charles River rat kidney.
PubMed: The effect of chronic administration of trisodium nitrilotriacetate (Na3NTA) on the haversian remodelling system in dogs.
PubMed: Comparisons of response of Fischer-344 and Charles River rats to 1.5% nitrilotriacetic acid and 2% trisodium nitrilotriacetate, monohydrate.
PubMed: Subacute oral toxicity of trisodium nitrilotriacetate (Na3NTA) in dogs.
PubMed: Effect of trisodium nitrilotriacetate (Na 3 NTA) on the metabolism of selected metal ions.
PubMed: Effects of trisodium nitrilotriacetate, trisodium citrate and a trisodium nitrilotriacetate-ferric chloride mixture on cadmium and methyl mercury toxicity and teratogenesis in rats.
PubMed: Effects of trisodium nitrilotriacetate on cadmium and methyl mercury toxicity and teratogenicity in rats.
PubMed: Trisodium nitrilotriacetate in drinking water. Metabolic and renal effects in rats.
PubMed: Two-year rat feeding study with trisodium nitrilotriacetate and its calcium chelate.
PubMed: Reproduction and teratology studies of trisodium nitrilotriacetate in rats and rabbits.
PubMed: Toxicity evaluation of trisodium nitrilotriacetate.
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