EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes


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CAS Number: 3380-34-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:222-182-2
Nikkaji Web:J7.727E
Beilstein Number:0605448
XlogP3-AA:5.00 (est)
Molecular Weight:289.54219000
Formula:C12 H7 Cl3 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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US Patents:Search
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Pubchem Patents:Search
DG SANTE Food Contact Materials:2,4,4'-trichloro-2'-hydroxydiphenylether
Physical Properties:
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 54.00 to 58.00 °C. @ 760.00 mm Hg
Boiling Point: 344.00 to 345.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000032 mmHg @ 25.00 °C. (est)
Flash Point: 324.00 °F. TCC ( 162.20 °C. ) (est)
logP (o/w): 4.760
Soluble in:
 water, 10 mg/L @ 20 °C (exp)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: deodorants
BOC Sciences
For experimental / research use only.
Irgasan (Triclosan) ≥98.0%
Odor: characteristic
Use: Triclosan is an antimicrobial agents found in many soaps and detergents, binds to bacterial ENR enzyme. Used as bacteriostat and preservative for cosmetic and detergent compositions. Antiseptic, disinfectant.
Charkit Chemical
ECSA Chemicals
Glentham Life Sciences
Jiangyin Healthway
New functional food ingredients
Kingyoung Bio Technical
Kraft Chemical
Triclosan USP
Nakoda Chemicals
Santa Cruz Biotechnology
For experimental / research use only.
Shiva Chemicals and Pharmaceuticals
Sigma-Aldrich: Aldrich
For experimental / research use only.
5-Chloro-2-(2,4-dichlorophenoxy)phenol 97%
Vigon International
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 3700 mg/kg
"Pesticides Symposia; Collection of Papers Presented at the Sixth & Seventh Inter-American Conferences on Toxicology and Occupational Medicine, Miami, FL," Miami, FL, J.L. Halos, 1968-70Vol. 6, Pg. 245, 1968/1970.

oral-mouse LD50 4530 mg/kg
"Pesticides Symposia; Collection of Papers Presented at the Sixth & Seventh Inter-American Conferences on Toxicology and Occupational Medicine, Miami, FL," Miami, FL, J.L. Halos, 1968-70Vol. 6, Pg. 245, 1968/1970.

intraperitoneal-mouse LD50 84 mg/kg
Yakkyoku. Pharmacy. Vol. 28, Pg. 985, 1977.

intraperitoneal-rat LD50 89 mg/kg
Yakkyoku. Pharmacy. Vol. 28, Pg. 985, 1977.

intravenous-rat LD50 29 mg/kg
Industrial Medicine and Surgery. Vol. 38, Pg. 64, 1969.

Dermal Toxicity:
skin-rabbit LD50 9300 mg/kg
Industrial Medicine and Surgery. Vol. 38, Pg. 64, 1969.

subcutaneous-mouse LD50 3800 mg/kg
Yakkyoku. Pharmacy. Vol. 28, Pg. 985, 1977.

subcutaneous-rat LD50 3900 mg/kg
Yakkyoku. Pharmacy. Vol. 28, Pg. 985, 1977.

Inhalation Toxicity:
Not determined
Safety in Use Information:
Recommendation for triclosan usage levels up to:
 not for fragrance use.
Recommendation for triclosan flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to a 3rd list of substances for food contact materials
View page or View pdf

EPI System: View
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):3380-34-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5564
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:3380-34-5
Pubchem (cid):5564
Pubchem (sid):134982808
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
KEGG (GenomeNet):C12059
HMDB (The Human Metabolome Database):Search
•trade names: aquasept, gamophen, irgasan dp 300, sapoderm, ster-zac •vinyzene dp 7000 (rohm and haas company): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 99%. •vinyzene sb-30 (rohm and haas company): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 10%. •sanitized brand t96-21 (sanitized inc.): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 10%. •sanitized brand pla (sanitized inc.): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 99.9%. •waste minders with stangard4 (s.c. johnson & son inc.): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- .06%. •microbanish r (troy chemical corp): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 99%. •vikol thp (vikon chemical company, inc.): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 2%. •ultrafresh 300 dd nonionic (thomas research associates): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 1.6%, bis(tributyltin) oxide 1.06%. •ultra fresh nm (thomas research associates): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 3%. •ultra fresh nm-100 (thomas research associates): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 99%. •ultra-fresh ft-7 (thomas research associates): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 1%, octhilinone 6.1%. •microban additive "b" (microban products company): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 99%. •viv-20 (triclosan) (microban products company): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 99.9%. •aerisguard bioactive coil treatment (aeris environmental ltd): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- .69%. •invasan am 110 us (huntsman international, llc): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 10%. •superclear t100 (pulcra chemicals, llc): phenol, 5-chloro-2-(2,4-dichlorophenoxy)- 99.9%.
Potential Blenders and core components note
None Found
Potential Uses:
Occurrence (nature, food, other):note
 not found in nature
 ether, 2'-hydroxy-2,4,4'-trichlorodiphenyl
2-hydroxy-2',4,4'-trichlorodiphenyl ether
 microban B
 phenol, 5-chloro-2-(2,4-dichlorophenoxy)-
 symguard CD
2,4,4'-trichloro-2'-hydroxy diphenyl ether
2,4,4'-trichloro-2'-hydroxydiphenyl ether


PubMed:Determination of plaque viability following a single brushing with commercial toothpastes.
PubMed:Comparison of the short-term antiplaque/antibacterial efficacy of two commercial dentifrices.
PubMed:The technology behind Colgate Total Advanced Fresh.
PubMed:A model for studying the effects of mouthrinses on de novo plaque formation.
PubMed:Development of a multianalyte method based on micro-matrix-solid-phase dispersion for the analysis of fragrance allergens and preservatives in personal care products.
PubMed:News, views, & reviews. Update on antibacterial soaps: the FDA takes a second look at triclosans.
PubMed:Quantitative microbial risk assessment of antibacterial hand hygiene products on risk of shigellosis.
PubMed:Development of a multi-preservative method based on solid-phase microextraction-gas chromatography-tandem mass spectrometry for cosmetic analysis.
PubMed:Triclosan Induced Aminoglycoside-Tolerant Listeria monocytogenes Isolates can appear as Small-Colony Variants.
PubMed:Assessment of toxic effects of triclosan on the terrestrial snail (Achatina fulica).
PubMed:Urinary concentrations of environmental phenols in pregnant women in a pilot study of the National Children's Study.
PubMed:Reliability of triclosan measures in repeated urine samples from Norwegian pregnant women.
PubMed:Uptake and accumulation of antimicrobials, triclocarban and triclosan, by food crops in a hydroponic system.
PubMed:Identification of plant metabolites of environmental contaminants by UPLC-QToF-MS: the in vitro metabolism of triclosan in horseradish.
PubMed:FDA pushes makers of antimicrobial soap to prove safety and effectiveness.
PubMed:Fate and uptake of pharmaceuticals in soil-plant systems.
PubMed:Triclocarban, triclosan and its transformation product methyl triclosan in native earthworm species four years after a commercial-scale biosolids application.
PubMed:Widespread occurrence of bisphenol A diglycidyl ethers, p-hydroxybenzoic acid esters (parabens), benzophenone type-UV filters, triclosan, and triclocarban in human urine from Athens, Greece.
PubMed:Analysis of triclosan-selected Salmonella enterica mutants of eight serovars revealed increased aminoglycoside susceptibility and reduced growth rates.
PubMed:Analytical performance of two miniaturised extraction methods for triclosan and methyltriclosan, in fish roe and surimi samples.
PubMed:Transcriptomic analysis of triclosan-susceptible and -tolerant Escherichia coli O157:H19 in response to triclosan exposure.
PubMed:Biocide and copper tolerance in enterococci from different sources.
PubMed:Structure-activity relationships of 44 halogenated compounds for iodotyrosine deiodinase-inhibitory activity.
PubMed:Comparative uptake and translocation of pharmaceutical and personal care products (PPCPs) by common vegetables.
PubMed:Bioconcentration of triclosan and methyl-triclosan in marine mussels (Mytilus galloprovincialis) under laboratory conditions and in metropolitan waters of Gulf St Vincent, South Australia.
PubMed:Oregano essential oil as an antimicrobial additive to detergent for hand washing and food contact surface cleaning.
PubMed:Triclosan exposure reduces thyroxine levels in pregnant and lactating rat dams and in directly exposed offspring.
PubMed:Foliar sorption of emerging and priority contaminants under controlled conditions.
PubMed:Small colony variants (SCVs) of Staphylococcus aureus--a bacterial survival strategy.
PubMed:Antibacterial electrospun poly(lactic acid) (PLA) nanofibrous webs incorporating triclosan/cyclodextrin inclusion complexes.
PubMed:Comparative analysis of the susceptibility to triclosan and three other biocides of avian Salmonella enterica isolates collected 1979 through 1994 and 2004 through 2010.
PubMed:Combined treatments of enterocin AS-48 with biocides to improve the inactivation of methicillin-sensitive and methicillin-resistant Staphylococcus aureus planktonic and sessile cells.
PubMed:Assessment of the susceptibility of lactic acid bacteria to biocides.
PubMed:Comparison of degradation between indigenous and spiked bisphenol A and triclosan in a biosolids amended soil.
PubMed:Triclosan blocks MMP-13 expression in hormone-stimulated osteoblasts.
PubMed:Proteomic and phenotypic analysis of triclosan tolerant verocytotoxigenic Escherichia coli O157:H19.
PubMed:Development of antimicrobial resistance in Campylobacter jejuni and Campylobacter coli adapted to biocides.
PubMed:Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2012.
PubMed:How dirty are the dirty dozen ingredients in cosmetics?
PubMed:Effects of efflux-pump inducers and genetic variation of the multidrug transporter cmeB in biocide resistance of Campylobacter jejuni and Campylobacter coli.
PubMed:Triclosan exposure and allergic sensitization in Norwegian children.
PubMed:Metabolization of the bacteriostatic agent triclosan in edible plants and its consequences for plant uptake assessment.
PubMed:Slow O-demethylation of methyl triclosan to triclosan, which is rapidly glucuronidated and sulfonated in channel catfish liver and intestine.
PubMed:Uptake of galaxolide, tonalide, and triclosan by carrot, barley, and meadow fescue plants.
PubMed:Toxicity and bioaccumulation of biosolids-borne triclosan in food crops.
PubMed:Triple bioaffinity mass spectrometry concept for thyroid transporter ligands.
PubMed:Cytotoxicity and inhibitory effects of low-concentration triclosan on adipogenic differentiation of human mesenchymal stem cells.
PubMed:Urinary levels of triclosan and parabens are associated with aeroallergen and food sensitization.
PubMed:Comparative proteomic analysis of Salmonella tolerance to the biocide active agent triclosan.
PubMed:Efficacy of biocides used in the modern food industry to control salmonella enterica, and links between biocide tolerance and resistance to clinically relevant antimicrobial compounds.
PubMed:Transfer of Salmonella Enteritidis to four types of surfaces after cleaning procedures and cross-contamination to tomatoes.
PubMed:Involvement of efflux mechanisms in biocide resistance of Campylobacter jejuni and Campylobacter coli.
PubMed:Nitrate causes a dose-dependent augmentation of nitric oxide status in healthy women.
PubMed:An expert panel report of a proposed scientific model demonstrating the effectiveness of antibacterial handwash products.
PubMed:Pharmaceutical and personal care products in groundwater, subsurface drainage, soil, and wheat grain, following a high single application of municipal biosolids to a field.
PubMed:Miniaturized extraction methods of triclosan from aqueous and fish roe samples. Bioconcentration studies in zebrafish larvae (Danio rerio).
PubMed:Uptake of organic emergent contaminants in spath and lettuce: an in vitro experiment.
PubMed:Effect of enterocin AS-48 in combination with biocides on planktonic and sessile Listeria monocytogenes.
PubMed:Review of risk from potential emerging contaminants in UK groundwater.
PubMed:Field dissipation of 4-nonylphenol, 4-t-octylphenol, triclosan and bisphenol A following land application of biosolids.
PubMed:Emerging pollutants in sewage, surface and drinking water in Galicia (NW Spain).
PubMed:A meta-analysis of the published literature on the effectiveness of antimicrobial soaps.
PubMed:Sensitivity analysis for the SimpleTreat model to simulate fate of chemicals in sewage treatment plants.
PubMed:Determination of preservative and antimicrobial compounds in fish from Manila Bay, Philippines using ultra high performance liquid chromatography tandem mass spectrometry, and assessment of human dietary exposure.
PubMed:4-Nonylphenol, bisphenol-A and triclosan levels in human urine of children and students in China, and the effects of drinking these bottled materials on the levels.
PubMed:Sublethal triclosan exposure decreases susceptibility to gentamicin and other aminoglycosides in Listeria monocytogenes.
PubMed:Degradation of 4-nonylphenol, 4-t-octylphenol, bisphenol A and triclosan following biosolids addition to soil under laboratory conditions.
PubMed:In vitro interaction between fluconazole and triclosan against clinical isolates of fluconazole-resistant Candida albicans determined by different methods.
PubMed:Inappropriate use of D-values for determining biocidal activity of various antimicrobials.
PubMed:Effect of active packaging incorporated with triclosan on bacteria adhesion.
PubMed:Uptake of 17α-ethynylestradiol and triclosan in pinto bean, Phaseolus vulgaris.
PubMed:Simultaneous determination of 20 pharmacologically active substances in cow's milk, goat's milk, and human breast milk by gas chromatography-mass spectrometry.
PubMed:Assessment of the antibacterial activity of a triclosan-containing cutting board.
PubMed:Listeria monocytogenes and Salmonella enterica enteritidis biofilms susceptibility to different disinfectants and stress-response and virulence gene expression of surviving cells.
PubMed:Effectiveness of triclosan in the management of radiation-induced oral mucositis: a randomized clinical trial.
PubMed:Characterization of Salmonella enterica isolates from turkeys in commercial processing plants for resistance to antibiotics, disinfectants, and a growth promoter.
PubMed:Salmonella enterica Enteritidis biofilm formation and viability on regular and triclosan-impregnated bench cover materials.
PubMed:Comparative efficacy of seven hand sanitizers against murine norovirus, feline calicivirus, and GII.4 norovirus.
PubMed:Selected personal care products and endocrine disruptors in biosolids: an Australia-wide survey.
PubMed:A review of personal care products in the aquatic environment: environmental concentrations and toxicity.
PubMed:Fully automated determination of parabens, triclosan and methyl triclosan in wastewater by microextraction by packed sorbents and gas chromatography-mass spectrometry.
PubMed:Occurrence, efficacy, metabolism, and toxicity of triclosan.
PubMed:Probabilistic risk evaluation for triclosan in surface water, sediments, and aquatic biota tissues.
PubMed:Review of 'emerging' organic contaminants in biosolids and assessment of international research priorities for the agricultural use of biosolids.
PubMed:In-sample acetylation-non-porous membrane-assisted liquid-liquid extraction for the determination of parabens and triclosan in water samples.
PubMed:Immunosuppressive effects of triclosan, nonylphenol, and DDT on human natural killer cells in vitro.
PubMed:The synergistic activity of triclosan and ciprofloxacin on biofilms of Salmonella Typhimurium.
PubMed:Electrochemical sensor for rapid detection of triclosan using a multiwall carbon nanotube film.
PubMed:Organic contaminants in sewage sludge (biosolids) and their significance for agricultural recycling.
PubMed:Impact of biosolids on the persistence and dissipation pathways of triclosan and triclocarban in an agricultural soil.
PubMed:Assessment of human exposure to Bisphenol-A, Triclosan and Tetrabromobisphenol-A through indoor dust intake in Belgium.
PubMed:Runoff of pharmaceuticals and personal care products following application of dewatered municipal biosolids to an agricultural field.
PubMed:Adsorption and degradation of triclosan and triclocarban in soils and biosolids-amended soils.
PubMed:Simultaneous determination of parabens, triclosan and triclocarban in water by liquid chromatography/electrospray ionisation tandem mass spectrometry.
PubMed:Pharmaceutical and personal care products in tile drainage following surface spreading and injection of dewatered municipal biosolids to an agricultural field.
PubMed:Association of triclosan to casein proteins through solvent-mediated high-pressure homogenization.
PubMed:Development of triclosan and antibiotic resistance in Salmonella enterica serovar Typhimurium.
PubMed:An ecological risk assessment for triclosan in the terrestrial environment.
PubMed:Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1.
PubMed:Automated on-line column-switching HPLC-MS/MS method with peak focusing for measuring parabens, triclosan, and other environmental phenols in human milk.
PubMed:Determinations and residual characteristics of triclosan in household food detergents of Taiwan.
PubMed:Pharmaceutical and personal care products in tile drainage following land application of municipal biosolids.
PubMed:Polychlorinated dibenzo-p-dioxins and dibenzofurans pollution in China: sources, environmental levels and potential human health impacts.
PubMed:Snail bioaccumulation of triclocarban, triclosan, and methyltriclosan in a North Texas, USA, stream affected by wastewater treatment plant runoff.
PubMed:Runoff of pharmaceuticals and personal care products following application of biosolids to an agricultural field.
PubMed:Simplified sample preparation method for triclosan and methyltriclosan determination in biota and foodstuff samples.
PubMed:Antibiotic and disinfectant susceptibility profiles of vancomycin-resistant Enterococcus faecium (VRE) isolated from community wastewater in Texas.
PubMed:Individual and mixture effects of selected pharmaceuticals and personal care products on the marine phytoplankton species Dunaliella tertiolecta.
PubMed:Antimicrobial susceptibility of Listeria monocytogenes from food products.
PubMed:Measurement of triclosan in water using a magnetic particle enzyme immunoassay.
PubMed:Effect of triclosan on Salmonella typhimurium at different growth stages and in biofilms.
PubMed:Efflux pump activity in fluoroquinolone and tetracycline resistant Salmonella and E. coli implicated in reduced susceptibility to household antimicrobial cleaning agents.
PubMed:Risk assessment of triclosan [Irgasan] in human breast milk.
PubMed:Triclosan and antimicrobial resistance in bacteria: an overview.
PubMed:Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase.
PubMed:Evaluation of the antibacterial effect of a triclosan-containing floor used in the food industry.
PubMed:Environmental oestrogens, cosmetics and breast cancer.
PubMed:Inhibition of sulfotransferases by xenobiotics.
PubMed:Assessment of benefits from use of antimicrobial hand products: reduction in risk from handling ground beef.
PubMed:A unique water optional health care personnel handwash provides antimicrobial persistence and residual effects while decreasing the need for additional products.
PubMed:Possible associations between Salmonella persistence in poultry houses and resistance to commonly used disinfectants and a putative role of mar.
PubMed:Inhibition of fatty acid synthase prevents preadipocyte differentiation.
PubMed:Determination of triclosan in foodstuffs.
PubMed:Effect of triclosan or a phenolic farm disinfectant on the selection of antibiotic-resistant Salmonella enterica.
PubMed:The effect of a toothpaste containing 2% zinc citrate/0.3% Triclosan on the glycolysis of plaque bacteria ex vivo after food intake.
PubMed:The effect of a 2% zinc citrate, 0.3% Triclosan dentifrice on plaque acid production following consumption of a snackfood.
PubMed:Plaque antibacterial levels following controlled food intake and use of a toothpaste containing 2% zinc citrate and 0.3% Triclosan.
PubMed:Effects of three pharmaceutical and personal care products on natural freshwater algal assemblages.
PubMed:Antimicrobial food packaging in meat industry.
PubMed:Effectiveness of some recent antimicrobial packaging concepts.
PubMed:[Can disinfectants contribute to antibiotic resistance?].
PubMed:The comparative anticaries efficacy of a dentifrice containing 0.3% triclosan and 2.0% copolymer in a 0.243% sodium fluoride/silica base and a dentifrice containing 0.243% sodium fluoride/silica base: a two-year coronal caries clinical trial on adults in Israel.
PubMed:Determination of phenolic disinfectant agents in commercial formulations by liquid chromatography.
PubMed:A method of assessing the efficacy of hand sanitizers: use of real soil encountered in the food service industry.
PubMed:Percutaneous penetration and dermal metabolism of triclosan (2,4, 4'-trichloro-2'-hydroxydiphenyl ether).
PubMed:The influence of specific foods and oral hygiene on the microflora of fissures and smooth surfaces of molar teeth: A 5-day study.
PubMed:The effectiveness of triclosan-incorporated plastic against bacteria on beef surfaces.
PubMed:[Analysis of components in natural food additive "grapefruit seed extract" by HPLC and LC/MS].
PubMed:Dietary staining in vitro by mouthrinses as a comparative measure of antiseptic activity and predictor of staining in vivo.
PubMed:Evaluation of the skin disinfecting activity and cumulative effect of chlorhexidine and triclosan handwash preparations on hands artificially contaminated with Serratia marcescens.
a diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. it has some bacteriostatic and fungistatic action.
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