sodium ortho-phenylphenate
sodium 2-biphenylate
 
Notes:
Agricultural fungicide, disinfectant, food preservative, mould inhibitor for apples
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      Product(s):
      P0202 2-Phenylphenol Sodium Salt Tetrahydrate >80.0%(T)
       
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sodium 2-phenylphenolate (Click)
CAS Number: 132-27-4Picture of molecule
ECHA EINECS - REACH Pre-Reg: 205-055-6
FDA UNII: KFV9K7N7UI
Nikkaji Web: J2.946G
MDL: MFCD00002209
Molecular Weight: 192.19269928
Formula: C12 H9 Na O
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: antimicrobial preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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JECFA Food Additive: Sodium o-Phenylphenol
GSFA Codex: Sodium ortho-phenylphenol (232)
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Physical Properties:
Appearance: white powder (est)
Assay: 97.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 282.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.002020 mm/Hg @ 25.00 °C. (est)
Flash Point: 285.00 °F. TCC ( 140.30 °C. ) (est)
logP (o/w): 2.939 (est)
Soluble in:
 water, 1000000 mg/L @ 25 °C (exp)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antimicrobial agents
preservatives
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Suppliers:
TCI AMERICA
For experimental / research use only.
2-Phenylphenol Sodium Salt Tetrahydrate >80.0%(T)
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-cat LD50  500 mg/kg
FAO Nutrition Meetings Report Series. Vol. 38A, Pg. 47, 1965.

oral-mouse LD50  683 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. Vol. 30, Pg. 54, 1979.

oral-rat LD50  656 mg/kg
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH GASTROINTESTINAL: RELAXATION (ISOLATED TISSUE)
Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. Vol. 30, Pg. 57, 1979.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antimicrobial preservatives
Recommendation for sodium ortho-phenylphenate usage levels up to:
 not for fragrance use.
 
Recommendation for sodium ortho-phenylphenate flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System: Search
Carcinogenic Potency Database: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 132-27-4
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 23675735
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 sodium 2-phenylphenolate
Chemidplus: 0000132274
EPA/NOAA CAMEO: hazardous materials
RTECS: DV7700000 for cas# 132-27-4
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References:
 sodium 2-phenylphenolate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 132-27-4
Pubchem (cid): 23675735
Pubchem (sid): 134974064
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
KEGG (GenomeNet): C19298
HMDB (The Human Metabolome Database): HMDB40464
FooDB: FDB020217
Export Tariff Code: 2907.19.8000
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 preservatives 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
(1,1'-biphenyl)-2-ol sodium salt (1:1)
(1,1'-biphenyl)-2-ol, sodium salt
[1,1'-biphenyl]-2-ol, sodium salt
[1,1'-biphenyl]-2-ol, sodium salt (1:1)
2-biphenylol sodium salt
2-biphenylol, sodium salt
2-hydroxybiphenyl sodium salt
2-hydroxydiphenyl sodium
o-phenyl phenol sodium salt
ortho-phenyl phenol sodium salt
o-phenylphenate sodium
o-phenylphenate, sodium
o-phenylphenol sodium
2-phenylphenol sodium salt
o-phenylphenol sodium salt
ortho-phenylphenol sodium salt
o-phenylphenol, sodium
 phenylphenol, sodium salt
2-phenylphenol, sodium salt
o-phenylphenol, sodium salt
 sodium (1,1'-biphenyl)-2-olate
 sodium [1,1'-biphenyl]-2-olate
 sodium 2-biphenylate
 sodium 2-biphenylolate
 sodium 2-hydroxydiphenyl
 sodium 2-phenyl phenolate
 sodium 2-phenylphenate
 sodium 2-phenylphenolate
 sodium o-phenol phenate
 sodium o-phenolphenate
 sodium o-phenyl phenate
 sodium o-phenylphenate
 sodium o-phenylphenol
 sodium o-phenylphenolate
 sodium o-phenylphenyolate
 sodium ortho-phenol phenate
 sodium ortho-phenolphenate
 sodium ortho-phenyl phenate
 sodium-2-biphenylate
 sodium-o-phenylphenate
 sodium-o-phenylphenol
 sodium, (2-biphenylyloxy)-
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Articles:
PubMed: Micronuclei and cell proliferation as early biological markers of ortho-phenylphenol-induced changes in the bladder of male F344 rats.
PubMed: Dose- and time-response studies of sodium o-phenylphenate urinary bladder carcinogenicity in rats.
PubMed: Dietary effects of ortho-phenylphenol and sodium ortho-phenylphenate on rat urothelium.
PubMed: Initiating activity of quinones in the two-stage transformation of BALB/3T3 cells.
PubMed: Genotoxic effects of the o-phenylphenol metabolites phenylhydroquinone and phenylbenzoquinone in V79 cells.
PubMed: Enhancing potential of 6 different carcinogens on multi-organ tumorigenesis after initial treatment with N-methyl-N-nitrosourea in rats.
PubMed: Sex differences in o-phenylphenol and sodium o-phenylphenate rat urinary bladder carcinogenesis: urinary metabolites and electrolytes under conditions of aciduria and alkalinuria.
PubMed: Metabolism of phenylhydroquinone by prostaglandin (H) synthase: possible implications in o-phenylphenol carcinogenesis.
PubMed: Effects of 2-phenyl-1,4-benzoquinone and 2,5-dihydroxybiphenyl on two-stage mouse skin carcinogenesis.
PubMed: Urothelial damage and tumor initiation by urinary metabolites of sodium o-phenylphenate in the urinary bladder of female rats.
PubMed: Species differences in sodium o-phenylphenate induction of urinary bladder lesions.
PubMed: Proliferative response of renal pelvic epithelium in rats to oral administration of ortho-phenylphenol, sodium ortho-phenylphenate and diphenyl.
PubMed: Correlation between the DNA damage in urinary bladder epithelium and the urinary 2-phenyl-1,4-benzoquinone levels from F344 rats fed sodium o-phenylphenate in the diet.
PubMed: Co-carcinogenic effects of NaHCO3 on o-phenylphenol-induced rat bladder carcinogenesis.
PubMed: Sodium o-phenylphenate (OPP-Na) promotes skin carcinogenesis in CD-1 female mice initiated with 7,12-dimethylbenz[a]anthracene.
PubMed: In situ freezing of the urinary bladder: a trigger of rapid development of sodium o-phenylphenate-induced urinary bladder tumors in the rat.
PubMed: DNA damage in urinary bladder epithelium of male F344 rats treated with 2-phenyl-1,4-benzoquinone, one of the non-conjugated urinary metabolites of sodium o-phenylphenate.
PubMed: Effects of pH on the carcinogenicity of o-phenylphenol and sodium o-phenylphenate in the rat urinary bladder.
PubMed: Enhancing effect of thiabendazole on urinary bladder carcinogenesis induced by sodium o-phenylphenate in F344 rats.
PubMed: Short-term screening of promoters of bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated, unilaterally ureter-ligated rats.
PubMed: Subchronic toxicity study of sodium o-phenylphenate in mice.
PubMed: Pathological analysis of the carcinogenicity of sodium o-phenylphenate and o-phenylphenol.
PubMed: Long-term toxicity and carcinogenicity study of sodium o-phenylphenate in B6C3F1 mice.
PubMed: Changes in enzyme activities in the urine and tissues of rats fed sodium o-phenylphenate.
PubMed: Altered levels of cyclic nucleotides in F344 rats fed sodium o-phenylphenate.
PubMed: Drugs, food additives and natural products as promoters in rat urinary bladder carcinogenesis.
PubMed: Promoting effect of sodium o-phenylphenate and o-phenylphenol on two-stage urinary bladder carcinogenesis in rats.
PubMed: The metabolic profile of sodium o-phenylphenate after subchronic oral administration to rats.
PubMed: Induction of tumours of the urinary system in F344 rats by dietary administration of sodium o-phenylphenate.
PubMed: A practical approach to evaluation of the germicidal efficiency of a general purpose military disinfectant.
PubMed: Factors affecting the activity of phenolic disinfectants.
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