sodium citrate anhydrous
citric acid trisodium salt
 
Notes:
a key intermediate in metabolism. it is an acid compound found in citrus fruits. the salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.
  • ECSA Chemicals
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      Product(s):
      Trisodium Citrate
       
  • M&U International
    • M&U International LLC
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      Meeting customers increasing demands at home as well as abroad.
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      A0232 SODIUM CITRATE, Kosher
       
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trisodium 2-hydroxypropane-1,2,3-tricarboxylate (Click)
CAS Number: 68-04-2Picture of molecule
ECHA EINECS - REACH Pre-Reg: 200-675-3
FDA UNII: RS7A450LGA
Nikkaji Web: J1.168A
Molecular Weight: 258.06955784
Formula: C6 H5 Na3 O7
NMR Predictor: Predict (works with chrome or firefox)
Category: preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
184.1751 Sodium citrate View-review
EU SANCO Sodium citrates View-review
JECFA Food Additive: Trisodium Citrate
GSFA Codex: Trisodium citrate (331(iii))
FDA Mainterm: TRISODIUM CITRATE
FDA Regulation:
FDA PART 131 -- MILK AND CREAM
Subpart B--Requirements for Specific Standardized Milk and Cream
Sec. 131.111 Acidified milk.


FDA PART 131 -- MILK AND CREAM
Subpart B--Requirements for Specific Standardized Milk and Cream
Sec. 131.112 Cultured milk.


FDA PART 131 -- MILK AND CREAM
Subpart B--Requirements for Specific Standardized Milk and Cream
Sec. 131.160 Sour cream.


FDA PART 131 -- MILK AND CREAM


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.169 Pasteurized process cheese.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.173 Pasteurized process cheese food.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.179 Pasteurized process cheese spread.


FDA PART 150 -- FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products
Sec. 150.141 Artificially sweetened fruit jelly.


FDA PART 150 -- FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products
Sec. 150.161 Artificially sweetened fruit preserves and jams.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.300 Resinous and polymeric coatings.


FDA PART 179 -- IRRADIATION IN THE PRODUCTION, PROCESSING AND HANDLING OF FOOD
Subpart C--Packaging Materials for Irradiated Foods
Sec. 179.45 Packaging materials for use during the irradiation of prepackaged foods.


FDA PART 181 -- PRIOR-SANCTIONED FOOD INGREDIENTS
Subpart B--Specific Prior-Sanctioned Food Ingredients
Sec. 181.29 Stabilizers.


FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1751 Sodium citrate.
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Physical Properties:
Appearance: white crystalline powder (est)
Assay: 99.00 to 100.00 % 
Food Chemicals Codex Listed: No
logP (o/w): -0.280 (est)
Soluble in:
 water, 1.2e+005 mg/L @ 25 °C (est)
 water, 4.34E+05 mg/L @ C (exp)
Insoluble in:
 alcohol
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Organoleptic Properties:
Odor Strength: none
Odor Description:
at 100.00 %. 
odorless
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: buffering agents
chelating agents
masking agents
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Suppliers:
ADM
Sodium Citrate Anhydrous Powder
Odor: odorless
Use: Sodium Citrate Anhydrous is derived from citric acid and is available in either free-flowing colorless granular, fine granular or powder forms. It is odorless and freely soluble in water, but insoluble in alcohol. Storage at room temperature in tightly sealed containers is recommended. Sodium citrate dihydrate is the most broadly used emulsifying salt in sliced processed cheese products. It is commonly used as a buffering agent in combination with citric acid to provide precise pH control required in many food and beverage applications. In meat products it is used as an anticoagulant of fresh livestock blood and as a curing accelerator. The detergent-building and rapid biodegradability characteristics of sodium citrate enable its use as an environmentally acceptable phosphate substitute in a large variety of household cleaning products.
ADM
Sodium Citrate Anhydrous, USP/FCC
Atlantic Chemicals
Trisodium Citrate
ECSA Chemicals
Trisodium Citrate
Company Profile
Graham Chemical
Sodium Citrate
Jungbunzlauer Suisse
Trisodium Citrate Anhydrous
Flavor: characteristic
Trisodium citrate is a tribasic salt of citric acid. It is produced by complete neutralisation of citric acid with high purity sodium hydroxide or carbonate and subsequent crystallisation and dehydration. The common hydrate form, trisodium citrate dihydrate, is widely used in foods, beverages and various technical applications mainly as buffering, sequestering or emulsifying agent, whereas the anhydrous form finds its uses in particular applications such as water sensitive dry blends and instant beverages, surfactants, fragrances as well as in tablets and OTC products. Jungbunzlauer trisodium citrate anhydrous is manufactured from trisodium citrate dihydrate. Water molecules of the dihydrate crystals are removed by a patented process without destroying the original crystal matrix. The resulting crystals have a porous matrix that can be used as a carrier for inorganic and/or organic substances, especially after being impregnated with liquids. Further, due to the absence of water, the product is not prone to caking. Trisodium citrate anhydrous is also used in applications where excess water is not desired.
M&U International
SODIUM CITRATE, Kosher
Penta International
SODIUM CITRATE ANHYDROUS GRANULAR, Kosher
Penta International
SODIUM CITRATE ANHYDROUS POWDER, Kosher
Penta International
TRISODIUM CITRATE
Sigma-Aldrich
For experimental / research use only.
Citric acid trisodium salt ≥98% (GC), anhydrous
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50  1548 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.

intravenous-rabbit LD50  449 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.

intravenous-mouse LD50  170 mg/kg
LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.

intraperitoneal-mouse LD50  1364 mg/kg
LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: preservatives
Recommendation for sodium citrate anhydrous usage levels up to:
 not for fragrance use.
 
Recommendation for sodium citrate anhydrous flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
NIOSH International Chemical Safety Cards: search
NLM Hazardous Substances Data Bank: Search
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AIDS Citations: Search
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NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 68-04-2
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 6224
National Institute of Allergy and Infectious Diseases: Data
 trisodium 2-hydroxypropane-1,2,3-tricarboxylate
Chemidplus: 0000068042
RTECS: 68-04-2
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References:
 trisodium 2-hydroxypropane-1,2,3-tricarboxylate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 68-04-2
Pubchem (cid): 6224
Pubchem (sid): 134971042
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
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tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
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KEGG (GenomeNet): D05855
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Formulations/Preparations:
•sodium citrate is an ingredient in anticoagulant citrate dextrose solution usp; anticoagulant citrate phosphate dextrose solution usp; & sodium citrate & citric acid solution usp. •grades: highest purity, medicinal; pure, commercial, cp; usp; fcc. dihydrate
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 buffering agents 
 chelating agents 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 citric acid trisodium salt
2-hydroxy-1,2,3-propane tricarboxylic acid trisodium salt anhydrous
 natrocitral
 trisodium 2-hydroxy-1,2,3-propane tricarboxylate
 trisodium 2-hydroxypropane-1,2,3-tricarboxylate
 trisodium citrate
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Articles:
PubMed: Effect of increasing the protein-to-fat ratio and reducing fat content on the chemical and physical properties of processed cheese product.
PubMed: Development of a multi-mycotoxin analysis in beer-based drinks by a modified QuEChERS method and ultra-high-performance liquid chromatography coupled with tandem mass spectrometry.
PubMed: A multipathogen selective enrichment broth for simultaneous growth of Salmonella spp., Vibrio parahaemolyticus, and Vibrio cholerae.
PubMed: Casein peptization, functional properties, and sensory acceptance of processed cheese spreads made with different emulsifying salts.
PubMed: Rheological enhancement of mechanically activated alpha-tricalcium phosphate cements.
PubMed: Factors influencing calcium phosphate cement shelf-life.
PubMed: Ionic modification of calcium phosphate cement viscosity. Part II: hypodermic injection and strength improvement of brushite cement.
PubMed: Ionic modification of calcium phosphate cement viscosity. Part I: hypodermic injection and strength improvement of apatite cement.
PubMed: Effect of sodium citrate on structure-function relationships of Cheddar cheese.
PubMed: Effective inhibition of mannitol crystallization in frozen solutions by sodium chloride.
PubMed: Chemical stability of an ester prodrug of a glycoprotein IIb/IIIa receptor antagonist in solid dosage forms.
PubMed: The effects of a single evening dose of alkaline citrate on urine composition and calcium stone formation.
PubMed: The adsorption of 99mTc(Sn)-diphosphonate complexes on tri-calciumphosphate: the influence of preparation conditions, ligand-type, incubation media and adsorption conditions. The reversibility of the adsorption.
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