rutin
3,3',4',5,5',7-hexahydroxyflavone (6-O-alpha-L-rhamnosyl-beta-D-glucoside)
 
Notes:
a flavonol glycoside found in many plants, including buckwheat; tobacco; forsythia; hydrangea; viola, etc. it has been used therapeutically to decrease capillary fragility. First isol. from Ruta graveolens (rue). Bioflavanoid
  • Jiangyin Healthway
    • Jiangyin Healthway International Trade Co.
      Independent Ingredients Supplier
      We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
      Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals.
      Email: Info
      Email: Sales
      Voice: 86-510-86023169
      Fax: 86-510-86023170
      Mobile0086-13093133011
      Services
      Biochemical
      Natural Food Colour
      New functional food ingredients
      Product(s):
      130294 Rutin
       
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      Product(s):
      18-95000 RUTIN USP/NF
       
Synonyms   Articles   Notes   Search
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychrome (Click)
CAS Number: 153-18-4Picture of molecule
Other: 115888-40-9
ECHA EINECS - REACH Pre-Reg: 205-814-1
FDA UNII: 5G06TVY3R7
Nikkaji Web: J818D
Beilstein Number: 0075455
MDL: MFCD01319140
XlogP3-AA: -1.30 (est)
Molecular Weight: 610.52330000
Formula: C27 H30 O16
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: special dietary and nutritional additives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
FDA Mainterm: RUTIN
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Physical Properties:
Appearance: pale yellow to amber powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 125.00 °C. @ 760.00 mm Hg
logP (o/w): -2.020 (est)
Soluble in:
 water, 125 mg/L @ 25 °C (exp)
 water, 2.756e+004 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
hair conditioning
skin conditioning
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Suppliers:
Aceto
Rutin
AIDP
Rutin 95.0%-101.5%
Amax Nutrasource
Rutin 95%
AuNutra® Industries
Rutin P.E.
BOC Sciences
For experimental / research use only.
Rutin
Coompo
For experimental / research use only.
Rutin from Plants ≥96%
Odor: characteristic
Use: Rutin has been shown to inhibit in vitro the vascular endothelial growth factor in subtoxic concentrations, so acts as an inhibitor of angiogenesis. This finding can be potentially relevant for the control of some cancers. Rutin inhibits platelet aggregation, as well as decreases capillary permeability, making the blood thinner and improving circulation. Rutin shows anti-inflammatory activity in some animal and in vitro models. Rutin inhibits aldose reductase activity. Aldose reductase is an enzyme normally present in the eye and elsewhere in the body. It helps change glucose into the sugar alcohol sorbitol. Recent studies show rutin could help prevent blood clots, so could be used to treat patients at risk of heart attacks and strokes. Some evidence also shows rutin can be used to treat hemorrhoids, varicosis, and microangiopathy. Rutin is important because it strengthens capillaries and can help people who bruise or bleed easily. Studies have demonstrated that rutin can help to stop venous edema, that is an early sign of chronic venous disease of the leg. Rutin is also an antioxidant; compared to quercetin, acacetin, morin, hispidulin, hesperidin, and naringin, it was found to be the strongest. However, in other trials, the effects of rutin were lower or negligible compared to those of quercetin. Rutin has also the property to chelate metal ions, such as iron, thereby reducing the Fenton reaction.
ExtraSynthese
For experimental / research use only.
Rutin (HPLC) ≥99%
Jiangyin Healthway
Rutin
New functional food ingredients
Maypro Industries
Rutin
Pangaea Sciences
Rutin NF
Penta International
RUTIN USP/NF
Qingdao Dacon Trading
Rutin
Sigma-Aldrich: Sigma
For experimental / research use only.
Rutin hydrate ≥94% (HPLC), powder
Sinoway Industrial
For experimental / research use only.
Troxerutin
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50  2000 mg/kg
Eksperimentalna Meditsina i Morfologiya. Vol. 19, Pg. 207, 1980.

intravenous-mouse LD50  950 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 556, 1950.

intraperitoneal-mouse LD50  200 mg/kg
National Technical Information Service. Vol. AD277-689

intraperitoneal-guinea pig LD50  2000 mg/kg
Eksperimentalna Meditsina i Morfologiya. Vol. 19, Pg. 207, 1980.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: special dietary and nutritional additives
Recommendation for rutin usage levels up to:
 not for fragrance use.
 
Recommendation for rutin flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on the substantiation of a health claim related to a combination of diosmin, troxerutin and hesperidin and maintenance of normal venous tone pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf
Scientific Opinion on the substantiation of a health claim related to a combination of diosmin, troxerutin and hesperidin and maintenance of normal venous-capillary permeability pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Carcinogenic Potency Database: Search
EPA GENetic TOXicology: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 153-18-4
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 5280805
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychrome
Chemidplus: 0000153184
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References:
 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychrome
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 153-18-4
Pubchem (cid): 5280805
Pubchem (sid): 134973934
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEBI: View
CHEMBL: View
Golm Metabolome Database: Search
KEGG (GenomeNet): C05625
HMDB (The Human Metabolome Database): HMDB03249
FooDB: FDB002536
Household Products: Search
VCF-Online: VCF Volatile Compounds in Food
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
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 currant black currant leaf
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 date palm pollen
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 dill leaf
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 dill plant
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 elder black elder flower
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 elder black elder leaf
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 fennel seed
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 fenugreek leaf
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 fig fruit
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 fig leaf
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 grape leaf
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 lemon fruit
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 lemon leaf
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 loquat leaf
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 lotus indian lotus embryo
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 marjoram shoot
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 mugwort plant
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 olive pericarp
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 onion bulb
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 orange leaf
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 orange pericarp
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 oregano plant
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 parsley leaf
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 parsley shoot
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 parsnip leaf
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 parsnip plant
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 peach fruit
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 peanut plant
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 pear plant
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 pepper bell pepper fruit
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 pepper black pepper fruit
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 peppermint plant
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 pigweed plant
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 pomegranate fruit
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 pomegranate fruit juice
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 pomegranate leaf
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 pomegranate plant
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 potato flower
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 potato shoot
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 raspberry red raspberry plant
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 rhubarb leaf
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 rhubarb plant
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 rue
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 sorrel garden sorrel leaf
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 soybean shoot
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 spinach leaf
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 spinach shoot
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 tarragon leaf
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 tarragon shoot
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 tea leaf
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 tomato fruit
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 tomato leaf
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 watercress shoot
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 watermelon seed
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Synonyms:
4H-1-benzopyran-4-one, 3-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-
4H-1-benzopyran-4-one, 3-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]-oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-
 birutan
 c.i. 75730
 ci 75730
3-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
3-[[6-O-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-mannopyranoside
 glucopyranoside, quercetin-3 6-O-(6-deoxy-alpha-L-mannopyranosyl)-, beta-D-
 glucopyranoside, quercetin-3 6-O-alpha-L-rhamnopyranosyl-, beta-D
3,3',4',5,5',7-hexahydroxyflavone (6-O-alpha-L-rhamnosyl-beta-D-glucoside)
 myrticolorin
 osyritrin
3,3',4',5,7-pentahydroxyflavone-3-rutinoside
 quercetin 3-O-[beta-L-rhamnosyl-(1->6)-beta-D-glucoside]
 quercetin 3-O-beta-delta-rutinoside
 quercetin 3-O-rutinoside
 quercetin 3-rutinoside
 quercetin, 3-(6-0-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside)
 quercetin, 3-(6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside)
 quercetin, 3-(6-O-alpha-L-rhamnopyranosyl-beta-D-glucopyranoside)
3-rhamnoglucosyl quercetin
 rutin trihydrate
3-rutinosyl quercetin
 rutoside
 sophorin
 troxerutin
 venoruton
 violaquercitrin
 vitamin P
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Articles:
PubMed: Investigation of the chemical compositions in tobacco of different origins and maturities at harvest by GC-MS and HPLC-PDA-QTOF-MS.
J-Stage: Effects of Various Asparagus Production Methods on Rutin and Protodioscin Contents in Spears and Cladophylls
PubMed: Metabolomic profiling and sensorial quality of 'Golden Delicious', 'Liberty', 'Santana', and 'Topaz' apples grown using organic and integrated production systems.
PubMed: Identification of tartary buckwheat tea aroma compounds with gas chromatography-mass spectrometry.
PubMed: Hesperidin, a flavone glycoside, as mediator of neuronal survival.
PubMed: Identification and quantification of free radical scavengers in Pu-erh tea by HPLC-DAD-MS coupled online with 2,2'-Azinobis(3-ethylbenzthiazolinesulfonic acid) diammonium salt assay.
PubMed: Influence of cooking process on phenolic marker compounds of vegetables.
PubMed: Researching on new species of "Mate": Ilex brevicuspis: phytochemical and pharmacology study.
PubMed: Evaluation of extracts and isolated fraction from Capparis spinosa L. buds as an antioxidant source.
PubMed: [Membrane stabilizing effect of medicinal substances used for the treatment of chronic venous insufficiency].
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