EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

rutin
3,3',4',5,5',7-hexahydroxyflavone (6-O-alpha-L-rhamnosyl-beta-D-glucoside)

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Name:2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychrome
CAS Number: 153-18-4Picture of molecule3D/inchi
Other:115888-40-9
ECHA EINECS - REACH Pre-Reg:205-814-1
FDA UNII:5G06TVY3R7
Nikkaji Web:J818D
Beilstein Number:0075455
MDL:MFCD01319140
XlogP3-AA:-1.30 (est)
Molecular Weight:610.52330000
Formula:C27 H30 O16
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:special dietary and nutritional additives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm: RUTIN
 
Physical Properties:
Appearance:pale yellow to amber powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 125.00 °C. @ 760.00 mm Hg
logP (o/w): -2.020 (est)
Soluble in:
 water, 125 mg/L @ 25 °C (exp)
 water, 2.756e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antioxidants
hair conditioning
skin conditioning
 
Suppliers:
Aceto
Rutin
AIDP
Rutin 95.0%-101.5%
Amax Nutrasource
Rutin 95%
AuNutra® Industries
Rutin P.E.
BOC Sciences
For experimental / research use only.
Rutin
Coompo
For experimental / research use only.
Rutin from Plants ≥96%
Odor: characteristic
Use: Rutin has been shown to inhibit in vitro the vascular endothelial growth factor in subtoxic concentrations, so acts as an inhibitor of angiogenesis. This finding can be potentially relevant for the control of some cancers. Rutin inhibits platelet aggregation, as well as decreases capillary permeability, making the blood thinner and improving circulation. Rutin shows anti-inflammatory activity in some animal and in vitro models. Rutin inhibits aldose reductase activity. Aldose reductase is an enzyme normally present in the eye and elsewhere in the body. It helps change glucose into the sugar alcohol sorbitol. Recent studies show rutin could help prevent blood clots, so could be used to treat patients at risk of heart attacks and strokes. Some evidence also shows rutin can be used to treat hemorrhoids, varicosis, and microangiopathy. Rutin is important because it strengthens capillaries and can help people who bruise or bleed easily. Studies have demonstrated that rutin can help to stop venous edema, that is an early sign of chronic venous disease of the leg. Rutin is also an antioxidant; compared to quercetin, acacetin, morin, hispidulin, hesperidin, and naringin, it was found to be the strongest. However, in other trials, the effects of rutin were lower or negligible compared to those of quercetin. Rutin has also the property to chelate metal ions, such as iron, thereby reducing the Fenton reaction.
ExtraSynthese
For experimental / research use only.
Rutin (HPLC) ≥99%
Jiangyin Healthway
Rutin
New functional food ingredients
Maypro Industries
Rutin
Pangaea Sciences
Rutin NF
Penta International
RUTIN USP/NF
Qingdao Dacon Trading
Rutin
Sigma-Aldrich: Sigma
For experimental / research use only.
Rutin hydrate ≥94% (HPLC), powder
Sinoway Industrial
For experimental / research use only.
Troxerutin
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50 2000 mg/kg
Eksperimentalna Meditsina i Morfologiya. Vol. 19, Pg. 207, 1980.

intravenous-mouse LD50 950 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 39, Pg. 556, 1950.

intraperitoneal-mouse LD50 200 mg/kg
National Technical Information Service. Vol. AD277-689

intraperitoneal-guinea pig LD50 2000 mg/kg
Eksperimentalna Meditsina i Morfologiya. Vol. 19, Pg. 207, 1980.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: special dietary and nutritional additives
Recommendation for rutin usage levels up to:
 not for fragrance use.
 
Recommendation for rutin flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the substantiation of a health claim related to a combination of diosmin, troxerutin and hesperidin and maintenance of normal venous tone pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf

Scientific Opinion on the substantiation of a health claim related to a combination of diosmin, troxerutin and hesperidin and maintenance of normal venous-capillary permeability pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):153-18-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5280805
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychrome
Chemidplus:0000153184
 
References:
 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychrome
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:153-18-4
Pubchem (cid):5280805
Pubchem (sid):134973934
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
KEGG (GenomeNet):C05625
HMDB (The Human Metabolome Database):HMDB03249
FooDB:FDB002536
Household Products:Search
VCF-Online:VCF Volatile Compounds in Food
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 anise seed
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 anise star anise fruit
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 anise star anise plant
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 apple fruit
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 apple fruit juice
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 apple leaf
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 apple pericarp
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 apple plant
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 apricot fruit
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 apricot leaf
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 asparagus root
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 banana fruit
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 basil leaf
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 bay laurel leaf
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 bean black bean shoot
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 bean mung bean sprout
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 bilberry leaf
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 blueberry plant
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 broccoli asparagus broccoli leaf
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 brussel sprout shoot
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 buckwheat flower
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 buckwheat leaf
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 buckwheat petiole
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 buckwheat plant
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 buckwheat seed
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 buckwheat stem
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 buckwheat testa
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 cacao leaf
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 cantaloupe plant
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 caper flower
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 caper shoot
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 carpobrotus edulis
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 cayenne fruit
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 celery shoot
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 chamomile garden chamomile plant
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 chamomile sweet false chamomile flower
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 cherry sour cherry plant
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 chicory leaf
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 chicory seed
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 coriander fruit
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 coriander shoot
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 cotton plant
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 currant black currant fruit
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 currant black currant fruit juice
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 currant black currant leaf
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 date palm pollen
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 dill leaf
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 dill plant
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 elder black elder flower
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 elder black elder leaf
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 fennel seed
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 fenugreek leaf
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 fig fruit
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 fig leaf
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 garlic plant
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 ginkgo biloba
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 ginkgo biloba leaf
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 ginkgo biloba plant
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 grape leaf
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 horseradish leaf
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 lemon fruit
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 lemon leaf
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 lemongrass leaf
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 loquat leaf
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 lotus indian lotus embryo
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 marjoram shoot
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 mugwort plant
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 olive pericarp
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 onion bulb
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 orange leaf
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 orange pericarp
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 oregano plant
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 parsley leaf
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 parsley shoot
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 parsnip leaf
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 parsnip plant
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 peach fruit
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 peanut plant
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 pear plant
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 pepper bell pepper fruit
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 pepper black pepper fruit
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 peppermint plant
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 pigweed plant
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 pomegranate fruit
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 pomegranate fruit juice
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 pomegranate leaf
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 pomegranate plant
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 potato flower
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 potato shoot
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 raspberry red raspberry plant
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 rhubarb leaf
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 rhubarb plant
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 rue
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 sorrel garden sorrel leaf
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 soybean shoot
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 spinach leaf
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 spinach shoot
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 tarragon leaf
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 tarragon shoot
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 tea leaf
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 tomato fruit
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 tomato leaf
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 watercress shoot
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 watermelon seed
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Synonyms:
4H-1-benzopyran-4-one, 3-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-
4H-1-benzopyran-4-one, 3-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]-oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-
 birutan
 c.i. 75730
 ci 75730
3-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
3-[[6-O-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-mannopyranoside
 glucopyranoside, quercetin-3 6-O-(6-deoxy-alpha-L-mannopyranosyl)-, beta-D-
 glucopyranoside, quercetin-3 6-O-alpha-L-rhamnopyranosyl-, beta-D
3,3',4',5,5',7-hexahydroxyflavone (6-O-alpha-L-rhamnosyl-beta-D-glucoside)
 myrticolorin
 osyritrin
3,3',4',5,7-pentahydroxyflavone-3-rutinoside
 quercetin 3-O-[beta-L-rhamnosyl-(1->6)-beta-D-glucoside]
 quercetin 3-O-beta-delta-rutinoside
 quercetin 3-O-rutinoside
 quercetin 3-rutinoside
 quercetin, 3-(6-0-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside)
 quercetin, 3-(6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside)
 quercetin, 3-(6-O-alpha-L-rhamnopyranosyl-beta-D-glucopyranoside)
3-rhamnoglucosyl quercetin
 rutin trihydrate
3-rutinosyl quercetin
 rutoside
 sophorin
 troxerutin
 venoruton
 violaquercitrin
 vitamin P
 

Articles:

PubMed:Investigation of the chemical compositions in tobacco of different origins and maturities at harvest by GC-MS and HPLC-PDA-QTOF-MS.
J-Stage:Effects of Various Asparagus Production Methods on Rutin and Protodioscin Contents in Spears and Cladophylls
PubMed:Metabolomic profiling and sensorial quality of 'Golden Delicious', 'Liberty', 'Santana', and 'Topaz' apples grown using organic and integrated production systems.
PubMed:Identification of tartary buckwheat tea aroma compounds with gas chromatography-mass spectrometry.
PubMed:Hesperidin, a flavone glycoside, as mediator of neuronal survival.
PubMed:Identification and quantification of free radical scavengers in Pu-erh tea by HPLC-DAD-MS coupled online with 2,2'-Azinobis(3-ethylbenzthiazolinesulfonic acid) diammonium salt assay.
PubMed:Influence of cooking process on phenolic marker compounds of vegetables.
PubMed:Researching on new species of "Mate": Ilex brevicuspis: phytochemical and pharmacology study.
PubMed:Evaluation of extracts and isolated fraction from Capparis spinosa L. buds as an antioxidant source.
PubMed:[Membrane stabilizing effect of medicinal substances used for the treatment of chronic venous insufficiency].
 
Notes:
a flavonol glycoside found in many plants, including buckwheat; tobacco; forsythia; hydrangea; viola, etc. it has been used therapeutically to decrease capillary fragility. First isol. from Ruta graveolens (rue). Bioflavanoid
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