EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

chloridazon
5-amino-4-chloro-2-phenylpyridazinone

Supplier Sponsors

CAS Number: 1698-60-8Picture of molecule3D/inchi
Other(deleted CASRN):58858-18-7
ECHA EINECS - REACH Pre-Reg:216-920-2
FDA UNII: 26X5RK7X7W
Nikkaji Web:J1.775B
Beilstein Number:0397241
MDL:MFCD00055402
XlogP3-AA:0.80 (est)
Molecular Weight:221.64596000
Formula:C10 H8 Cl N3 O
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:herbicides / pesticides
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 205.00 °C. @ 760.00 mm Hg
logP (o/w): 1.140
Soluble in:
 water, 400 mg/L @ 20 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Chloridazon > 95%
Odor: characteristic
Use: Herbicide, active by perturbing cell membranes
Carbosynth
For experimental / research use only.
Chloridazon
Santa Cruz Biotechnology
For experimental / research use only.
Chloridazon
Sigma-Aldrich
For experimental / research use only.
Chloridazon PESTANAL®, analytical standard
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-guinea pig LD50 493 mg/kg
Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 17, Pg. S171, 1992.

unreported-mammal (species unspecified) LD50 2000 mg/kg
Agrokhimiya. Agricultural Chemistry. Vol. (5), Pg. 142, 1977.

intraperitoneal-mouse LD50 235 mg/kg
Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 17, Pg. S171, 1992.

oral-mouse LD50 598 mg/kg
Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 17, Pg. S171, 1992.

oral-rabbit LD50 2000 mg/kg
BEHAVIORAL: TREMOR BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 23(8), Pg. 48, 1979.

intraperitoneal-rat LD50 194 mg/kg
Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 17, Pg. S171, 1992.

oral-rat LD50 647 mg/kg
Fundamental and Applied Toxicology. Vol. 7, Pg. 299, 1986.

Dermal Toxicity:
subcutaneous-mouse LD50 1205 mg/kg
Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 17, Pg. S171, 1992.

skin-rabbit LD50 2500 mg/kg
"Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A080, Pg. 1985

skin-rat LD50 > 5000 mg/kg
Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 17, Pg. S171, 1992.

subcutaneous-rat LD50 1410 mg/kg
Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. Vol. 17, Pg. S171, 1992.

Inhalation Toxicity:
inhalation-rat LC50 > 30800 mg/m3/4
"Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A080, Pg. 1985
 
Safety in Use Information:
Category:
herbicides / pesticides
Recommendation for chloridazon usage levels up to:
 not for fragrance use.
 
Recommendation for chloridazon flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Retrospective analysis of the immunotoxic effects of plant protection products as reported in the Draft Assessment Reports for their peer review at EU level
View page or View pdf

Review of the existing maximum residue levels for chloridazon according to Article 12 of Regulation (EC) No 396/2005
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):1698-60-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :15546
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
5-amino-4-chloro-2-phenylpyridazin-3-one
Chemidplus:0001698608
RTECS:UR6125000 for cas# 1698-60-8
 
References:
 5-amino-4-chloro-2-phenylpyridazin-3-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):15546
Pubchem (sid):134979352
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C18570
HMDB (The Human Metabolome Database):Search
ChemSpider:View
Wikipedia:View
Wikipedia2:View2
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
5-amino-4-chloro-2-phenyl-3-pyridazinone
5-amino-4-chloro-2-phenylpyridazin-3-one
5-amino-4-chloro-2-phenylpyridazin-3(2H)-one
5-amino-4-chloro-2-phenylpyridazinone
5-amino-4-chloro-2,3-dihydro-3-oxo-2-phenylpyridazine
 BAS 1191611
 BAS 13033
 burex
 chloridazone
 clorizol
 curbetan
1-fenyl-4-amino-5-chlor-6-pyridazinon
 phenosane
1-phenyl-4-amino-5-chloropyridaz-6-one
1-phenyl-4-amino-5-chloropyridazin-6-one
1-phenyl-4-amino-5-chlorpyridaz-6-one
1-phenyl-4-amino-5-chlorpyridazon-(6)
 pyramin RB
 pyramine
 pyrazon
 pyrazone
 pyrazonl
3(2H)-pyridazinone, 5-amino-4-chloro-2-phenyl-
 suzon
 

Articles:

PubMed:Assessment of the genotoxic potential along the Danube River by application of the comet assay on haemocytes of freshwater mussels: The Joint Danube Survey 3.
PubMed:Various effects of the photosystem II--inhibiting herbicides on 5-n-alkylresorcinol accumulation in rye seedlings.
PubMed:Induction time of Fe-SOD synthesis and activity determine different tolerance of two Desmodesmus (green algae) strains to chloridazon: a study with synchronized cultures.
PubMed:Can damselfly larvae (Ischnura elegans) be used as bioindicators of sublethal effects of environmental contamination?
PubMed:Sorption of polar herbicides and herbicide metabolites by biochar-amended soil.
PubMed:Bentonite and anthracite in alginate-based controlled release formulations to reduce leaching of chloridazon and metribuzin in a calcareous soil.
PubMed:Liquid-solid sample preparation followed by headspace solid-phase microextraction determination of multiclass pesticides in soil.
PubMed:Destruction of halogen-containing pesticides by means of detonation combustion.
PubMed:Phytotoxicity and antioxidative enzymes of green microalga (Desmodesmus subspicatus) and duckweed (Lemna minor) exposed to herbicides MCPA, chloridazon and their mixtures.
PubMed:Reduction of matrix effects and improvement of sensitivity during determination of two chloridazon degradation products in aqueous matrices by using UPLC-ESI-MS/MS.
PubMed:Non-targeted analysis of wastewater treatment plant effluents by high performance liquid chromatography-time slice-solid phase extraction-nuclear magnetic resonance/time-of-flight-mass spectrometry.
PubMed:Studies on the photo-catalytic activity of semiconductor nanostructures and their gold core-shell on the photodegradation of malathion.
PubMed:Time- and dose-dependent induction of HSP70 in Lemna minor exposed to different environmental stressors.
PubMed:Phenylobacterium muchangponense sp. nov., isolated from beach soil, and emended description of the genus Phenylobacterium.
PubMed:The experimental and theoretical QM/MM study of interaction of chloridazon herbicide with ds-DNA.
PubMed:Development of analytical strategies using U-HPLC-MS/MS and LC-ToF-MS for the quantification of micropollutants in marine organisms.
PubMed:Assessing exposure to transformation products of soil-applied organic contaminants in surface water: comparison of model predictions and field data.
PubMed:Pan-European survey on the occurrence of selected polar organic persistent pollutants in ground water.
PubMed:Prevention of chloridazon and metribuzin pollution using lignin-based formulations.
PubMed:A direct LC/MS/MS method for the determination of ciclopirox penetration across human nail plate in in vitro penetration studies.
PubMed:Assessment of heavy metal and pesticide levels in soil and plant products from agricultural area of Belgrade, Serbia.
PubMed:Environmental occurrence and degradation of the herbicide n-chloridazon.
PubMed:Adsorption of chloridazon from aqueous solution on modified kerolite-rich materials.
PubMed:Modifying sorbents in controlled release formulations to prevent herbicides pollution.
PubMed:Metamitron-resistant Chenopodium album from sugar beet: cross-resistance profile.
PubMed:Individual and combined effect of anthracene, cadmium, and chloridazone on growth and activity of SOD izoformes in three Scenedesmus species.
PubMed:[A new species of the genus Phenylobacterium for the degradation of LAS (linear alkylbenzene sulfonate)].
PubMed:Adsorption of chloridazon from aqueous solution on heat and acid treated sepiolites.
PubMed:Wet deposition of pesticides and nitrophenols at two sites in Denmark: measurements and contributions from regional sources.
PubMed:Effects of addition of straw, chitin and manure to new or recycled biofilters on their pesticides retention and degradation properties.
PubMed:Electrochemical reduction of chloridazon at mercury electrodes, and its analytical application.
PubMed:A study on the behaviour of pesticides and their transformation products in the Scheldt estuary using liquid chromatography-electrospray tandem mass spectrometry.
PubMed:Effect of chloridazone on the animal organism.
PubMed:Ultra-trace-level determination of polar pesticides and their transformation products in surface and estuarine water samples using column liquid chromatography-electrospray tandem mass spectrometry.
PubMed:The organochlorine herbicide chloridazon interacts with cell membranes.
PubMed:Cytogenetic effects of the herbicide chloridazon in cultured sheep lymphocytes.
PubMed:Acute oral toxicity of the herbicide BUREX EKO in pheasants.
PubMed:Rapid extraction and capillary gas chromatography for diazine herbicides in human body fluids.
PubMed:Dibenzofuran 4,4a-dioxygenase from Sphingomonas sp. strain RW1: angular dioxygenation by a three-component enzyme system.
PubMed:[Phenazon metabolism in children with liver diseases].
PubMed:[Effectiveness of introducing individual protection measures for workers in the phenazone industry].
PubMed:Acute toxicity of pesticides in adult and weanling rats.
PubMed:[Physical, chemical and biological study of dust from large-scale pig farms].
PubMed:[Occurrence of drug reactions].
PubMed:[Experimental study of the gonadotoxic action of 1-phenyl-4-amino-5-chloropyridazole-6].
PubMed:Purification of arogenate dehydrogenase from Phenylobacterium immobile.
PubMed:[Decomposition and stabilization of drugs. XX. Photodecomposition and stabilization of dipyridamol].
PubMed:Chloridazon-catechol dioxygenases, a distinct group of meta-cleaving enzymes.
PubMed:The lipopolysaccharide of a chloridazon-degrading bacterium.
PubMed:Serological studies on chloridazon-degrading bacteria.
PubMed:Allergic contact dermatitis to chloridazon.
PubMed:A novel non-heme iron-containing dioxygenase. Chloridazon-catechol dioxygenase from Phenylobacterium immobilis DSM 1986.
PubMed:Determination of pyrazon residues in water by reversed phase high performance liquid chromatography.
PubMed:Influence of pyramin and venzar on some metabolic products of Azotobacter chroococcum.
PubMed:Bacterial degradation of aminopyrine.
PubMed:[Degradation of L-phenylalanine and of aromatic carboxylic acids by chloridazon-degrading bacteria. Combination of side chain degradation and dioxygenase pathway].
PubMed:Bacterial conversion of phenylalanine and aromatic carboxylic acids into dihydrodiols.
PubMed:Acute toxicity testing of some herbicides-, alkaloids-, and antibiotics-metabolizing soil bacteria in the rat.
PubMed:Herbicidal effect on some metabolic processes of Azotobacter chroococcum.
PubMed:Interactions of Mycelia sterilia G-1 with venzar and pyramin.
PubMed:Herbicidal treatments for control of Papaver somniferum L.
PubMed:Influence of selected pesticides on the microbial degradation of 14C-triallate and 14C-diallate in soil.
PubMed:[Degradation and biosynthesis of L-phenylalanine by chloridazon-degrading bacteria].
PubMed:[Preparation of a chloridazon metabolite by use of immobilized chloridazon-dihydrodiol dehydrogenase. Some properties of the immobilized enzyme].
PubMed:[Purification and properties of two chloridazondihydrodiol dehydrogenases from chloridazon degrading bacteria].
PubMed:[What does conservative therapy of "idiopathic" facial paresis accomplish?].
PubMed:[Degradation of antipyrin by pyrazon-degrading bacteria (author's transl)].
PubMed:[Catechol 2,3-dioxygenase from pyrazon-degrading bacteria (author's transl)].
PubMed:Purification and properties of pyrazon dioxygenase from pyrazon-degrading bacteria.
PubMed:[Enzymatic formationof 4-hydroxy-2-oxovalerate using pyrazon-degrading bacteria (author's transl)].
PubMed:[Enzymatic formation of a cis,cis-muconic acid derivative using pyrazon-degrading bacteria (author's transl)].
PubMed:Fate of pyrazon in a model ecosystem.
PubMed:Bacterial hydroxylation of pyrazon compounds.
PubMed:[Isolation and characterization of bacteria, growing on pyrazon].
PubMed:[Not Available].
PubMed:THE ROLE OF PYRAZON IN REACTIONS IN TUBERCULOID LEPROSY.
PubMed:A study of the yeast fermentation method for the determination of thiamine and pyramin.
PubMed:Relation between urinary excretion of thiamine and pyramin (the pyrimidine-like component of thiamine).
PubMed:The urinary excretion of thiamine, pyramin (the pyrimidine-like component of thiamine) and riboflavin by man in semistarvation.
 
Notes:
None found
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