propylene glycol laurate
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2-hydroxypropyl dodecanoate (Click)
CAS Number: 27194-74-7
ECHA EC Number: 248-315-4
FDA UNII: 668Z5835Z3
XlogP3-AA: 5.00 (est)
Molecular Weight: 258.40170000
Formula: C15 H30 O3
NMR Predictor: Predict
2-hydroxypropyl dodecanoate (Click)
CAS Number: 142-55-2
ECHA EC Number: 205-542-3
FDA UNII: M4AW13H75T
XlogP3-AA: 5.00 (est)
Molecular Weight: 258.40170000
Formula: C15 H30 O3
NMR Predictor: Predict
Category: surfactant, skin conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
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Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
IBM Patents: Obtain
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 92.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 361.00 to  364.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.000001 mm/Hg @ 25.00 °C. (est)
Flash Point: 283.00 °F. TCC ( 139.30 °C. ) (est)
logP (o/w): 4.925 (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: skin conditioning
surfactants
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Suppliers:
ABITEC
Capmul PG-12 EP/NF
Alzo International
Dermol PGML
Gattefosse
Emulfree® P
Odor: characteristic
Use: •Surfactant free system, Water resistant, Ultra-light sensation.
Lubrizol Corporation
Schercemol™ PGML Ester
Odor: charateristic
Use: Schercemol™ PGML ester is non-occlusive ester with fast absorbance properties that functions as a refatting agent and auxiliary emulsifier. Schercemol PGML ester can be used in oil-based make-up removers, lipsticks and alcohol-based products.
Sigma-Aldrich: Fluka
Propylene glycol monolaurate, European Pharmacopoeia (EP) Reference Standard
For experimental / research use only.
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
  Not determined
Dermal Toxicity:
  Not determined
Inhalation Toxicity:
  Not determined
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Safety in Use Information:
Category: surfactant, skin conditioning
Recommendation for propylene glycol laurate usage levels up to:
 not for fragrance use.
Recommendation for propylene glycol laurate flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Chemicalize.org: Calculate predicted properties
EPA Substance Registry Services (TSCA): 27194-74-7
EPA ACToR: Toxicology Data
National Institute of Allergy and Infectious Diseases: Data
 2-hydroxypropyl dodecanoate
Chemidplus: 0027194747
 2-hydroxypropyl dodecanoate
Chemidplus: 0000142552
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References:
 2-hydroxypropyl dodecanoate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 27194-74-7
Pubchem (cid): 14870
Pubchem (sid): 135229389
 2-hydroxypropyl dodecanoate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 142-55-2
Pubchem (cid): 14870
Pubchem (sid): 3884882
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
Household Products: Search
ChemSpider: View
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Potential Blenders and core components note
None Found
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Potential Uses:
 emollients 
 emulsifying agents 
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Natural Occurrence in: note
 not found in nature
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Synonyms:
 capmul PG-12 EP/NF
 dermol PGML
 dodecanoic acid monoester with 1,2-propane diol
 emulfree P
2-hydroxypropyl dodecanoate
2-hydroxypropyl laurate
 lauric acid monoester with propane-1,2-diol
 propylene glycol monododecanoate
 propylene glycol monolaurate
 schercemol PGML Ester
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Articles:
PubMed: Influence of skin penetration enhancers on skin barrier function and skin protease activity.
PubMed: Formulation and in vitro/in vivo evaluation of levodopa transdermal delivery systems.
PubMed: In vitro-in vivo correlation in skin permeation.
PubMed: In vitro and in vivo evaluation of a self-microemulsifying drug delivery system for the poorly soluble drug fenofibrate.
PubMed: Formulation of carbenoxolone for delivery to the skin.
PubMed: Effects of vehicles on the percutaneous absorption of donepezil hydrochloride across the excised hairless mouse skin.
PubMed: Self-microemulsifying formulation-based oral solution of coenzyme Q10.
PubMed: Formulation and evaluation of ubidecarenone transdermal delivery systems.
PubMed: Pharmacokinetics of formulated tenoxicam transdermal delivery systems.
PubMed: Potential mucoadhesive dosage form of lidocaine hydrochloride: II. In vitro and in vivo evaluation.
PubMed: Formulation and evaluation of ketorolac transdermal systems.
PubMed: The effect of vehicles and pressure sensitive adhesives on the percutaneous absorption of quercetin through the hairless mouse skin.
PubMed: Transdermal delivery of ketorolac tromethamine: effects of vehicles and penetration enhancers.
PubMed: A new oral testosterone undecanoate formulation.
PubMed: Effect of vehicles and enhancers on the in vitro permeation of melatonin through hairless mouse skin.
PubMed: Effect of vehicles and penetration enhancers on the in vitro percutaneous absorption of tenoxicam through hairless mouse skin.
PubMed: In vitro percutaneous absorption of tenoxicam from pressure-sensitive adhesive matrices across the hairless mouse skin.
PubMed: Effect of PGML excipient mixture in a transdermal system on the in vitro transport of estradiol across skin.
PubMed: A comparison of in vitro skin-penetration cells.
PubMed: Transdermal delivery of buprenorphine through cadaver skin.
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Soluble in:
 water, 6.301 mg/L @ 25 °C (est)
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