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magnesium aspartate tetrahydrate
magnesium DL-aspartate tetrahydrate

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CAS Number: 7018-07-7Picture of molecule3D/inchi
Other(deleted CASRN):111753-25-4
FDA UNII: R17X820ROL
Beilstein Number:6029702
MDL:MFCD00063084
Molecular Weight:360.55680000
Formula:C8 H20 Mg N2 O12
NMR Predictor:Predict (works with chrome, Edge or firefox)
Also(can) Contains:magnesium laevo-aspartate
Category:nutrient supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 264.00 to 265.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.002890 mmHg @ 25.00 °C. (est)
Flash Point: 236.00 °F. TCC ( 113.50 °C. ) (est)
logP (o/w): -0.669 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Magnesium aspartate tetrahydrate 95%
Jost Chemical
Magnesium Aspartate Dibasic Powder
Penta International
MAGNESIUM ASPARTATE
Sabinsa Corporation
Magnesium Aspartate
Sigma-Aldrich: Aldrich
For experimental / research use only.
DL-Aspartic acid magnesium salt ≥98.0%
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
nutrient supplements
Recommendation for magnesium aspartate tetrahydrate usage levels up to:
 not for fragrance use.
 
Recommendation for magnesium aspartate tetrahydrate flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Magnesium aspartate, potassium aspartate, magnesium potassium aspartate, calcium aspartate, zinc aspartate, and copper aspartate as sources for magnesium, potassium, calcium, zinc, and copper added for nutritional purposes to food supplements - Scientific Panel on Food Additives and Nutrient Sources added to food (ANS)
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):7018-07-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :119638
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
magnesium;(2S)-2-amino-4-hydroxy-4-oxobutanoate;tetrahydrate
Chemidplus:0007018077
 
References:
 magnesium;(2S)-2-amino-4-hydroxy-4-oxobutanoate;tetrahydrate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:7018-07-7
Pubchem (cid):119638
Pubchem (sid):135075332
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
FDA Listing of Food Additive Status:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
(DL-aspartato(2-))magnesium tetrahydrate
[DL-aspartato(2-)]magnesium tetrahydrate
 aspartic acid magnesium salt tetrahydrate
 aspartic acid, magnesium salt tetrahydrate
 aspartic acid, magnesium salt (1:1) tetrahydrate
DL-asparticacidhemimagnesiumsalt tetrahydrate
 magnesium;(2S)-2-amino-4-hydroxy-4-oxobutanoate;tetrahydrate
 magnesium 2-aminosuccinate tetrahydrate
 magnesium dihydrogen diaspartate
 magnesium DL-aspartate tetrahydrate
 

Articles:

PubMed:Evaluation of enantiomeric purity of magnesium-l-aspartate dihydrate.
PubMed:Identification and control of a Pseudomonas spp (P. fulva and P. putida) bloodstream infection outbreak in a teaching hospital in Beijing, China.
PubMed:Magnesium supplementation in pregnancy.
PubMed:[Biochemical changes in rats under the influence of cesium chloride].
PubMed:[Effect of the Na+, K(+)-ATPase modulation in neurons of the medulla oblongata on hemodynamic effects in spontaneously hypertensive rats].
PubMed:Emerging supplements in sports.
PubMed:[Clinical analysis of 17 cases of Gitelman syndrome].
PubMed:[The role of magnesium in the implementation of vascular reactions during anesthesia in cardiac surgery patients].
PubMed:Magnesium-aspartate-based crystallization switch inspired from shell molt of crustacean.
PubMed:[Attenuation of irreversible rat heart injury by reperfusion with metabolic protectors].
PubMed:[Use of a potassium and magnesium asparaginate solution to maintain the balance of potassium and magnesium during cardiosurgical interventions under extracorporeal circulation].
PubMed:Influence of the magnesium aspartate hydrochloride administration to the maternal circuit on the aspartate concentration of the fetal circuit under in vitro perfusion of human placenta.
PubMed:Effects of supplementing two levels of magnesium aspartate and transportation stress on pork quality and gene expression of micro-calpain and calpastatin of finishing pigs.
PubMed:Effects of potassium aspartate and magnesium on ventricular arrhythmia in ischemia-reperfusion rabbit heart.
PubMed:Effects of Zinc Magnesium Aspartate (ZMA) Supplementation on Training Adaptations and Markers of Anabolism and Catabolism.
PubMed:[Comparison of neuroprotective properties of nootropes, calcium channel blockers, and panangin].
PubMed:[Clinical investigation of the protective effects of potassium magnesium aspartate against arrhythmia and its possible anti-oxidative mechanism].
PubMed:Prevention of atrial fibrillation after coronary artery bypass graft surgery using a potassium-magnesium-aspartate solution (Inzolen).
PubMed:[Comparative study of the antiarrhythmic activity of L-, D-and DL-stereoisomers of potassium magnesium aspartate].
PubMed:Effect of cold blood cardioplegia enriched with potassium-magnesium aspartate during coronary artery bypass grafting.
PubMed:[Comparative study of the antiarrhythmic activity of magnesium aspartate L-, D- and DL-aspartate stereoisomers].
PubMed:Effect of interferon-gamma on hepatic fibrosis in chronic hepatitis B virus infection: a randomized controlled study.
PubMed:Does continuing oral magnesium supplementation until delivery affect labor and puerperium outcome?
PubMed:Comparative study of the efficacy of potassium magnesium L-, D- and DL-aspartate stereoisomers in overcoming digoxin- and furosemide-induced potassium and magnesium depletions.
PubMed:[Therapy of cardiac arrhythmias. Clinical significance of potassium- and magnesium aspartate in arrhythmias].
PubMed:[Simultaneous analysis of aspartic acid and sorbitol in potassium magnesium aspartate and sorbitol injection by ion-exclusion chromatography with evaporative light-scattering detection].
PubMed:Effect of panangin on activity of messengers systems in hypertrophied rat myocardium.
PubMed:[Angiotensin converting enzyme inhibitor enalapril in the treatment of endomyocardial fibrosis in patients with lymphogranulomatosis subjected to radio- and chemotherapy].
PubMed:[A case of familial restrictive cardiomyopathy].
PubMed:Bioavailability of US commercial magnesium preparations.
PubMed:[Methods of myocardium defense in radical correction of Ebstein anomaly].
PubMed:[Observation on effect of shenmai injection in treating patients of congestive heart failure].
PubMed:A trial of ademetionine in the treatment of intrahepatic biliary stasis viral hepatitis.
PubMed:Magnesium pidolate and magnesium aspartate effects on human amniotic membrane ionic permeability in vitro.
PubMed:[Efficacy and tolerance of a calcium-magnesium-aspartate solution in the treatment of hypocalcemic parturient paresis in cows].
PubMed:Comparison of different dietary magnesium supplements on pork quality.
PubMed:Sotalol associated torsades de pointes tachycardia in a 15-month-old child: successful therapy with magnesium aspartate.
PubMed:Alcohol-induced vascular damage of brain is ameliorated by administration of magnesium.
PubMed:The effect of dietary magnesium aspartate supplementation on pork quality.
PubMed:[Effect of magnesium on infarct size after coronary occlusion. Animal experiment studies].
PubMed:[A preclinical evaluation of the pharmacological activity of a mixed potassium and magnesium glutamate].
PubMed:[The role of magnesium in the pathogenesis and therapy of bronchial asthma].
PubMed:[Clinical and experimental study on effect of ganyan IV in treatment of chronic active hepatitis complicated with hyperbilirubinemia].
PubMed:[Sotalol-induced torsade de pointes tachycardia in a 15-month-old infant].
PubMed:[Effect of panangin on regenerative processes in tissues during lengthening of the extremities].
PubMed:Intracoronary magnesium is not protective against acute reperfusion injury in the regional ischaemic-reperfused dog heart.
PubMed:Effect of acute potassium-magnesium aspartate supplementation on ammonia concentrations during and after resistance training.
PubMed:Inhibition of mouse-killing behaviour in magnesium-deficient rats: effect of pharmacological doses of magnesium pidolate, magnesium aspartate, magnesium lactate, magnesium gluconate and magnesium chloride.
PubMed:[Psychopharmacological properties of three magnesium salts: pidolate, lactate and aspartate].
PubMed:[Supplemental potassium or magnesium via the trachea with ultrasonic aerosol inhalation].
PubMed:Nutritional dose of magnesium in hypertensive patients on beta blockers lowers systolic blood pressure: a double-blind, cross-over study.
PubMed:Reduction of blood pressure with oral magnesium supplementation in women with mild to moderate hypertension.
PubMed:Oral magnesium intake reduces permanent hearing loss induced by noise exposure.
PubMed:[Prevention of myopathies and cardiomyopathies in swine using magnesium aspartate hydrochloride].
PubMed:[Potassium substitution during coronary surgery: K(+)-Mg+(+)-aspartate-complex (Inzolen) versus potassium chloride].
PubMed:[Hemodynamics of coronary surgery patients following magnesium aspartate infusion].
PubMed:[Potentiated polarized liquid therapy and heart emergency].
PubMed:Anti-hypertensive treatment with magnesium-aspartate-dichloride and its influence on peripheral serotonin metabolism in man: a subacute study.
PubMed:[Observations on the pathomechanism of tetany reaction].
PubMed:Mg2+, Asp-, and Glu--effects in the processive and distributive DNA relaxation catalyzed by a eukaryotic topoisomerase.
PubMed:[Enzymatic status of leukocytes and its correction in acute stenosing laryngotracheitis in children].
PubMed:Radioprotective effect of inosine and its enhancement by magnesium and global hypoxia.
PubMed:[Anti-arrhythmia effectiveness of potassium-magnesium-aspartate infusion].
PubMed:A randomised study comparing intermittent to continuous administration of magnesium aspartate hydrochloride in cisplatin-induced hypomagnesaemia.
PubMed:Magnesium-aspartate-hydrochloride reduces weight loss in heat-stressed laying hens.
PubMed:[Magnesium and potassium aspartate during the third pregnancy trimester].
PubMed:[Magnesium, calcium, hemoglobin, hematocrit, estriol and human placental lactogen with magnesium substitution in pregnancy].
PubMed:[The pharmacological correction with asparkam of the functional status of pilots in army aviation in a hot climate].
PubMed:[Modification of catecholamine metabolism in rats by magnesium aspartate hydrochloride].
PubMed:Metabolic and hemodynamic effects of magnesium supplementation in patients with essential hypertension.
PubMed:Magnesium dietary intake modulates blood lipid levels and atherogenesis.
PubMed:Therapeutic effects of the joint administration of magnesium aspartate and adenosine monophosphate in gamma irradiated mice.
PubMed:A pilot study of magnesium aspartate hydrochloride (Magnesiocard) as a mood stabilizer for rapid cycling bipolar affective disorder patients.
PubMed:Restoring sinus rhythm after intraoperatively occurring isorhythmic AV dissociation by the use of K-Mg aspartate or Mg aspartate.
PubMed:Magnesium supplementation during pregnancy: a double-blind randomized controlled clinical trial.
PubMed:Magnesium supplementation in mild hypertensive patients on a moderately low sodium diet.
PubMed:The influence of rapid potassium administration on hemodynamics and endogenous catecholamine production during extracorporeal circulation.
PubMed:Effects of pH and anion substitution on magnesium accumulation in rabbit aortic smooth muscle.
PubMed:Strain differences in pulmonary hypertensive response to monocrotaline alkaloid and the beneficial effect of oral magnesium treatment.
PubMed:Magnesium aspartate hydrochloride attenuates monocrotaline-induced pulmonary artery hypertension in rats.
PubMed:[Magnesium substitution in pregnancy. A prospective, randomized double-blind study].
PubMed:Effects of peroral magnesium on plasma and skeletal muscle electrolytes in patients on long-term diuretic therapy.
PubMed:Magnesium supplementation in pregnancy. A double-blind study.
PubMed:Enhancement of radioprotective effectiveness of adenosine monophosphate by magnesium aspartate in mice.
PubMed:Late changes in serum proteins and possibilities of their influencing in irradiated rats.
PubMed:The effect of magnesium aspartate, xylazine and morphine on the immobilization-induced increase in the levels of prolactin in turkey plasma.
PubMed:[Magnesium-containing preparations in the complex treatment of rickets].
PubMed:[Comparative study on myocardial damage in irradiated for a long time and nonirradiated rats after administration of FCOL].
PubMed:[Immunostimulant properties of aspartic acid].
PubMed:[Effect of butadione on lipid metabolism in chronic ischemic heart disease patients].
PubMed:[Comparative evaluation of cardiotropic effects of nicamag, panangin and asparkam].
PubMed:Lack of effect of oral magnesium on high blood pressure: a double blind study.
PubMed:[Correction of intracellular metabolism in acute pneumonia in young children].
PubMed:[Correction of metabolic disorders of the myocardium in acute myocardial infarct as an important factor in preventing the development of circulatory insufficiency].
PubMed:[20 years' experience in using electric reversion of sinus rhythm in patients with atrial fibrillation].
PubMed:Effects of potassium + magnesium aspartate on muscle metabolism and force development during short intensive static exercise.
PubMed:Plasma aldosterone, cortisol and electrolyte concentrations in physical exercise after magnesium supplementation.
PubMed:[Studies on magnesium. 3. Effect of magnesium aspartate hydrochloride on stress reactions in magnesium-deficient animals].
PubMed:[Studies on magnesium. 2. Effect of magnesium chloride and magnesium aspartate hydrochloride on stress reactions].
PubMed:[Correction of protein metabolism in myocardial infarction according to the results of radionuclide studies with 131-albumin during during treatment with a number of drugs (retabolyl, methyluracil, panangin, strophanthin) and combinations of them].
PubMed:[Effect of potassium and magnesium aspartate on experimental myocardial ischemia and infarction].
PubMed:[Reduced frequency of gestoses in beta-mimetic treated risk pregnancies with added magnesium therapy].
PubMed:[Additional magnesium therapy in tocolysis: clinico-chemical monitoring parameters].
PubMed:[Infusion therapy in the prehospital phase].
PubMed:The effects of oral administration of salts of aspartic acid on the metabolic response to prolonged exhausting exercise in man.
PubMed:[The importance of betamimetics and magnesium for the outcome of pregnancy: I. Reduction of intrauterine growth retardation, premature rupture of membranes and premature birth after supplemental magnesium therapy].
PubMed:Influence of decreased and increased magnesium supply on the cardiotoxic effects of epinephrine in rats.
PubMed:[Characteristics of the action of different doses of panangin and isoptin on the collateral blood supply to the heart in coronarogenic myocardial lesion].
PubMed:[Magnesium aspartate as a cardioprotective agent and adjuvant in tocolysis with betamimetics. Animal experiments on the kinetics and calcium antagonist action of orally administered magnesium aspartate with special reference to simultaneous vitamin B administration].
PubMed:Absence of effect of potassium-magnesium aspartate on physiologic responses to prolonged work in aerobically trained men.
PubMed:[Therapy of acute cerebrovascular insufficiency].
PubMed:[Application of thermometric methods in pharmacoanalysis. III. Determination of potassium and magnesium content of Panangin tablets and injection solutions by titrated enthalpy and direct injection enthalpy].
PubMed:[Inhibition of stress reactions by magnesium. Beneficial effects of parenteral magnesium therapy on the development of stress ulcers in rats (author's transl)].
PubMed:The effect of magnesium aspartate hydrochloride on isoprenaline-induced cardiomegaly.
PubMed:Comparison of three methods of myocardial protection.
PubMed:[Quantitative determination of the ingredients in the preparation, Asparkam].
PubMed:Effect of K and Mg salts of aspartic acid on haemopoiesis and recovery from radiation damage in mice.
PubMed:[Potassium magnesium asparate in the treatment of myocardial infarct. Clinical experiences].
PubMed:Ultrastructural and biochemical changes of human papillary heart muscle during different methods of induced cardiac arrest.
PubMed:[Effect of panangin on potassium level in patients with non-specific ulcerative colitis].
PubMed:[Treatment of acute left-ventricular insufficiency complicated by tachyarrhythmia under conditions of cardiological emergency service].
PubMed:[Changes of the ventricular monophasic action potentials induced with imipramine. The effect of potassium and magnesium aspartate and of sodium bicarbonate].
PubMed:[Effectiveness of treatment of paroxysms of auricular flutter].
PubMed:[Potassium magnesium aspartate (K-Mg-aspartate) in the treatment of digitalis glycoside poisoning].
PubMed:[Potassium-magnesium-D,L-aspartate as a positive homotropic effector in the regulation of phosphofructokinase].
PubMed:[Effectiveness and comparative evaluation of various means of arrhythmia prophylaxis in acute period of myocardial infarction].
PubMed:[Behaviour of ATP and lactate in human papillary muscle during profound hypothermia and injection cardioplegia with magnesium-asparatate-procaine (author's transl)].
PubMed:[Comparative biochemical and histological studies of the effect of magnesium and profound hypothermia on the preservation of the isolated perfused rat liver (author's transl)].
PubMed:[Monitoring myocardial performance after open heart surgery by calculation of diastolic and systolic pressure time index (author's transl)].
PubMed:[Plasma Mg-levels during treatment of hypopotassaemia with Potassium-magnesium aspartate (author's transl)].
PubMed:[The protective effect of magnesium-aspartate-procaine cardioplegia on the hypertrophied left ventricle of the mini-pig (author's transl)].
PubMed:[Change in the protein and electrolyte metabolism under the effect of anabolic steroids and panangin in patients with myocardial infarct].
PubMed:Combined application of metabolic myocardial arrest and general profound hypothermia in aortic valve replacement.
PubMed:[Combined application of magnesium-aspartate-cardioplegia and general hypothermia in aortic valve replacement (author's transl)].
PubMed:[Isomerisation and bioavailability of beta- and alpha-acetyldigoxin (author's transl)].
PubMed:Aortic valve replacement utilizing induced ischemic arrest with magnesium-aspartate-procaine.
PubMed:[Effect of magnesium aspartate on the activity of cholinesterase].
PubMed:[Objective evaluation of the therapeutic effect of Coroverlan].
PubMed:[Various aspects of individualization of drug therapy of extrasystole].
PubMed:[Panangin treatment in cardiac insufficiency].
PubMed:[Therapy with cardiac glycosides and electrolytes with particular consideration of fixed combinations (author's transl)].
PubMed:The effect of magnesiumaspartate on preservation of the rat liver.
PubMed:[Bathmotropic effect of panangin and strophanthin in patients with extrasystole].
PubMed:[Effect of rheopolyglucin with panangin on the cytochemical indicators of leukocytes in patients with ischemic cerebral infarct].
PubMed:Suppression of the progress of necrosis after coronary artery ligation in the dog by pharmacologic interventions.
PubMed:[Use of steroid and nonsteroid anabolites in ischemic heart disease].
PubMed:Metabolism and structure of the magnesium aspartate-procaine-arrested ischaemic heart of rabbit and man.
PubMed:Magnesium concentrations in plasma and bone following enteral administration of Br-, Cl- and Mg++ in the form of different compounds and combinations.
PubMed:Long-term observations of cardiac arrhythmias during and after cardiac surgery. I. Acquired heart disease.
PubMed:Long-term observation of cardiac arrhythmias during and after cardiac surgery. II. Congenital heart disease.
PubMed:Induced ischemic cardiac arrest. Clinical and experimental results with magnesium-aspartate-procaine solution (Cardioplegin).
PubMed:Some biochemical aspects in the treatment of myocardial infarction with potassium magnesium aspartate.
PubMed:[Effect of potassium-magnesium aspartate on hemodynamics and myocardial metabolism of coronary disease patient during beta receptor stimulation].
PubMed:[Metabolism and ultrastructure of magnesium aspartate-procaine arrested hearts of rabbit and man (author's transl)].
PubMed:[Age-dependent reciprocal effect of potassium-magnesium-aspartate, during general anesthesia. Contribution to lactate-pyruvate and ATP metabolism].
PubMed:[Hemodynamics and myocardial metabolism in coronary disease during beta receptor stimulation and administration of postassium magnesium aspartate (PMA)].
PubMed:[Intracellular pH of cardiac muscle after administration of potassium-magnesium-aspartate (author's transl)].
PubMed:[Treatment of acute myocardial infarct and chronic heart failure using potassium-magnesium aspartate].
PubMed:Proceedings: Age-dependent interaction of potassium magnesium aspartate during general anesthesia. A contribution to lactate-pyruvate- and ATP-metabolism.
PubMed:[Studies on kidney preservation by means of potassium-magnesium-aspartate].
PubMed:Effect of potassium and magnesium aspartate on the serum free-fatty-acids levels in patients with acute myocardial infarction.
PubMed:[Digitalis and electrolytes. Mechanism of action of potassium-magnesium aspartate].
PubMed:Effect of potassium-magnesium aspartate on endurance work in man.
PubMed:[Practical experiences using procaine magnesium aspartate in open heart surgery].
PubMed:[Substrates of energy metabolism in parabiotically perfused rat hearts during and after cardioplegy by ischemia, potassium chloride and potassium-magnesium-aspartate].
PubMed:[Potassium-magnesium-aspartate therapy in operated cancer patients].
PubMed:[Reproducible, irreversible hemorrhagic shock in rabbits with determination of survival rate. Initial therapeutic experiments with adenosine triphosphate, potassium-magnesium aspartate and the proteinase inhibitor trasylol].
PubMed:[Comparative studies on the action of the polarizing mixture and potassium-magnesium aspartate in the treatment of dysrhythmia in coronary disease].
PubMed:[Experimental cytologic study of the effect of potassium-magnesium-aspartate on human fibroblasts and HeLa cells in tissue culture].
PubMed:Effect of potassium-magnesium-aspartate on the capacity for prolonged exercise in man.
PubMed:[Clinical studies on the therapeutic effect of potassium-magnesium aspartate in coronary disease].
PubMed:[Potassium-magnesium-aspartate in the therapy of heart diseases].
PubMed:[On infusion therapy with potassium-magnesium aspartate in acute myocardial infarct, chronically insufficient heart and digitalis intoxication].
PubMed:[On the treatment of the digitalis-induced atrial tachycardia with AV conduction disorder. Experiences with sodium-magnesium aspartate].
PubMed:[Therapy of disorders of myocardial metabolism with potassium-magnesium aspartate].
PubMed:[On the effect of potassium, magnesium aspartate therapy in various heart diseases].
PubMed:[The effects of potassium-magnesium aspartate on experimental bioelectric disturbances in cerebral activity induced by a "cardiopathogenic diet"].
PubMed:[THE EFFECTS OF CALCIUM AND MAGNESIUM ASPARTATE ON THE CELLULAR DEPLETION OF SKELETAL MUSCLES AND ITS MECHANISM].
PubMed:[The use of a potassium and magnesium aspartate in the treatment of myocardial infarction].
PubMed:[Clinical trials of potassium aspartate and magnesium aspartate in cardiovascular diseases].
 
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