magnesium aluminum silicate
aluminum magnesium silicon oxide
 
Notes:
None found
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aluminum magnesium silicate (Click)
CAS Number: 1327-43-1Picture of molecule
Other: 12768-32-0
ECHA EINECS - REACH Pre-Reg: 215-478-8
FDA UNII: 6M3P64V0NC
Molecular Weight: 143.36863860
Formula: Al Mg O4 Si +
NMR Predictor: Predict (works with chrome or firefox)
Category: cosmetic agents
 
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Physical Properties:
Appearance: white powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
logP (o/w): 0.650 (est)
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Organoleptic Properties:
Odor Strength: none
Odor Description:
at 100.00 %. 
odorless
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: absorbents
anticaking agents
opacifying agents
viscosity controlling agents
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Suppliers:
Kraft Chemical
Magnesium Aluminum Silicate
Penta International
MAGNESIUM ALUMINUM SILICATE NF TYPE 1A (225 - 600 CPS)
Penta International
MAGNESIUM ALUMINUM SILICATE NF TYPE 1B (150 - 450 CPS)
Penta International
MAGNESIUM ALUMINUM SILICATE NF TYPE 1C (800 - 2200 CPS)
Penta International
MAGNESIUM ALUMINUM SILICATE NF TYPE 2A (100 - 300 CPS)
Universal Preserv-A-Chem Inc.
MAGNESIUM ALUMINUM SILICATE
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  > 16000 mg/kg
Drugs in Japan Vol. -, Pg. 1164, 1990.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic agents
Recommendation for magnesium aluminum silicate usage levels up to:
 not for fragrance use.
 
Recommendation for magnesium aluminum silicate flavor usage levels up to:
 not for flavor use.
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Safety References:
Daily Med: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 1327-43-1
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 3084116
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: nwg
 aluminum magnesium silicate
Chemidplus: 0001327431
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References:
 aluminum magnesium silicate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 1327-43-1
Pubchem (cid): 3084116
Pubchem (sid): 135288911
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
Household Products: Search
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 absorbents 
 opacifying agents 
 viscosity controlling agents 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 aluminosilicic acid magnesium salt
 aluminum magnesium silicate
 aluminum magnesium silicon oxide
 magnesium aluminosilicate
 magnesium aluminum silicate NF type 1A (225 - 600 CPS)
 magnesium aluminum silicate NF type 1B (150 - 450 CPS)
 magnesium aluminum silicate NF type 1C (800 - 2200 CPS)
 magnesium aluminum silicate NF type 2A (100 - 300 CPS)
 magnesium silicate aluminate
 neusilin UFL2
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Articles:
PubMed: Amorphization of itraconazole by inorganic pharmaceutical excipients: comparison of excipients and processing methods.
PubMed: Quaternary polymethacrylate-magnesium aluminum silicate films: molecular interactions, mechanical properties and tackiness.
PubMed: The effect of polymer content on the non-newtonian behavior of acetaminophen suspension.
PubMed: Nicotine-magnesium aluminum silicate microparticle surface modified with chitosan for mucosal delivery.
PubMed: Characterization of chitosan-magnesium aluminum silicate nanocomposite films for buccal delivery of nicotine.
PubMed: The addition of modified attapulgite reduces the emission of nitrous oxide and ammonia from aerobically composted chicken manure.
PubMed: Novel composite blend microbeads of sodium alginate coated with chitosan for controlled release of amoxicillin.
PubMed: Influence of pH modifiers and HPMC viscosity grades on nicotine-magnesium aluminum silicate complex-loaded buccal matrix tablets.
PubMed: Synthesis of an attapulgite clay@carbon nanocomposite adsorbent by a hydrothermal carbonization process and their application in the removal of toxic metal ions from water.
PubMed: Preparation and characterization of nicotine-magnesium aluminum silicate complex-loaded sodium alginate matrix tablets for buccal delivery.
PubMed: Novel chitosan-magnesium aluminum silicate nanocomposite film coatings for modified-release tablets.
PubMed: The roughness, microhardness, and surface analysis of nanocomposites after application of topical fluoride gels.
PubMed: Chitosan-magnesium aluminum silicate nanocomposite films: physicochemical characterization and drug permeability.
PubMed: Propranolol-magnesium aluminum silicate complex dispersions and particles: characterization and factors influencing drug release.
PubMed: Alginate-magnesium aluminum silicate films for buccal delivery of nicotine.
PubMed: Physicochemical properties of magnesium aluminum silicate (smectone) gels prepared using electrolytic-reduction ion water (2): Effects of various salts on the phase diagram.
PubMed: Polymer-magnesium aluminum silicate composite dispersions for improved physical stability of acetaminophen suspensions.
PubMed: Dissolution and powder flow characterization of solid self-emulsified drug delivery system (SEDDS).
PubMed: Alginate-magnesium aluminum silicate films: importance of alginate block structures.
PubMed: Interaction of nicotine with magnesium aluminum silicate at different pHs: characterization of flocculate size, zeta potential and nicotine adsorption behavior.
PubMed: Chitosan-magnesium aluminum silicate composite dispersions: characterization of rheology, flocculate size and zeta potential.
PubMed: Sodium alginate-magnesium aluminum silicate composite gels: characterization of flow behavior, microviscosity, and drug diffusivity.
PubMed: Alginate-magnesium aluminum silicate composite films: effect of film thickness on physical characteristics and permeability.
PubMed: Alginate-magnesium aluminum silicate films: effect of plasticizers on film properties, drug permeation and drug release from coated tablets.
PubMed: Multi functional uptake behaviour of materials prepared by calcining waste paper sludge.
PubMed: Investigation of novel alginate-magnesium aluminum silicate microcomposite films for modified-release tablets.
PubMed: Molecular interaction in alginate beads reinforced with sodium starch glycolate or magnesium aluminum silicate, and their physical characteristics.
PubMed: Characteristics of bricks made from waste steel slag.
PubMed: Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate, sodium magnesium silicate, zirconium silicate, attapulgite, bentonite, Fuller's earth, hectorite, kaolin, lithium magnesium silicate, lithium magnesium sodium silicate, montmorillonite, pyrophyllite, and zeolite.
PubMed: [Personal experience with administration of Smektit (hydrated magnesium aluminum silicate) in the treatment of diarrhea of non-infectious origin and diarrhea after resection of the large intestine].
PubMed: Reduced tetracycline bioavailability caused by magnesium aluminum silicate in liquid formulations of bismuth subsalicylate.
PubMed: Stability of Allopurinol Suspension Compounded from Tablets.
PubMed: Interaction between polyethylene films and bromhexine HCl in solid dosage form. IV. Prevention of the sorption by addition of magnesium aluminum silicate.
PubMed: Stability of acetazolamide in suspension compounded from tablets.
PubMed: Physical and chemical changes of medicinals in mixtures with adsorbents in the solid state. IV. Study on reduced-pressure mixing for practical use of amorphous mixtures of flufenamic acid.
PubMed: Physical and chemical changes of medicinals in mixtures with adsorbents in the solid state. III. Determination of vapor pressure of solid drugs by steam distillation.
PubMed: Physical and chemical changes of medicinals in mixtures with adsorbents in the solid state. II. Application of reduced pressure treatment for the improvement of dissolution of flufenamic acid.
PubMed: Formulation and stability of diazepam suspension compounded from tablets.
PubMed: [Effect of antacids on mineral metabolism in persons with healthy kidneys. Double-blind study using an antacid containing magnesium aluminum silicate hydrate].
PubMed: Influence of viscosity on absorption from nitrofurantoin suspensions.
PubMed: [Azapropazone plasma levels under simultaneous treatment with an antacid or laxative].
PubMed: The effect of attapulgite and charcoal on enterotoxicity of Vibrio cholerae and Escherichia coli enterotoxins in rabbits.
PubMed: Correlation of absorption of sulfamethazine boluses with dissolution using a new dissolution apparatus for veterinary tablets.
PubMed: Benzoyl peroxide gel in acne therapy.
PubMed: Influence of monovalent and divalent electrolytes on sorption of neomycin sulfate to attapulgite and montmorillonite clays.
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