lauryl betaine
1-tridecanaminium, 1-carboxy-N,N,N-trimethyl-, hydroxide, inner salt
None found
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2-(trimethylazaniumyl)tetradecanoate (Click)
CAS Number: 683-10-3Picture of molecule
Other: 103171-41-1
ECHA EINECS - REACH Pre-Reg: 211-669-5
FDA UNII: Y4P927Q133
Beilstein Number: 3670807
MDL: MFCD00084742
XlogP3-AA: 6.70 (est)
Molecular Weight: 271.44441000
Formula: C16 H33 N O2
NMR Predictor: Predict (works with chrome or firefox)
Category: cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
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Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): 0.350 (est)
Soluble in:
 water, 1.728e+004 mg/L @ 25 °C (est)
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Organoleptic Properties:
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antistatic agents
cleansing agents
hair conditioning
skin conditioning
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Chemical-navi - Nikkol
Odor: characteristic
Use: Exhibits thickening effect when used with anionic surfactants; low irritation.
Kao Corporation
Odor: characteristic
Use: Cosmetic use: Low irritation to skin and eye with high foam ability and good foam stability. Good stability in hard water. No dry tact after shampooing. Good compatibility with other surfactants.
Kao Corporation
Odor: characteristic
Use: Cosmetic use: Low irritation to skin and eye with high foam ability and good foam stability. Good stability in hard water. No dry tact after shampooing. Good compatibility with other surfactants.
Lubrizol Corporation
Chembetaine™ BW Surfactant
Odor: characteristic
Use:  Chembetaine™ BW is a mild amphoteric surfactant compatible with anionic, cationic and nonionic surfactants. Excellent viscosity builder and gelling agent. Hard water tolerance permits equally good foaming in hard and soft water. Stable in high-electrolyte solutions and will help solubilize other surfactants into these systems. Stable in acidic and alkaline conditions, functioning as cationic in acid media and as anionic in alkaline. Lime soap dispersant.
Sigma-Aldrich: Sigma
For experimental / research use only.
(Lauryldimethylammonio)acetate ≥95% (HPLC)
Vevy Europe
Odor: characteristic
Use: extremely pure foaming aminoacid. For special detergents (non sulphated).
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Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50  53 mg/kg
Fundamental and Applied Toxicology. Vol. 16, Pg. 41, 1991.

oral-rat LD50  71 mg/kg
Fundamental and Applied Toxicology. Vol. 16, Pg. 41, 1991.

Dermal Toxicity:
skin-rat LD50 1300 mg/kg
Fundamental and Applied Toxicology. Vol. 16, Pg. 41, 1991.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic agents
Recommendation for lauryl betaine usage levels up to:
 not for fragrance use.
Recommendation for lauryl betaine flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Cancer Citations: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 683-10-3
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 101833
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
Chemidplus: 0000686839
RTECS: JR2115000 for cas# 683-10-3
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NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 683-10-3
Pubchem (cid): 101833
Pubchem (sid): 135255812
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
ChemSpider: View
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Potential Blenders and core components note
None Found
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Potential Uses:
 antistatic agents 
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Occurrence (nature, food, other): note
 not found in nature
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 amfotex FV-30
 amonyl 265 BA
 amphitol 20BS
 amphitol 24B
(carboxylatomethyl) dodecyl dimethyl ammonium
 chembetaine BW surfactant
 chimin BX
 dehyton CB
 LMB (Vevy)
 nikkol AM-301
1-tridecanaminium, 1-carboxy-N,N,N-trimethyl-, hydroxide, inner salt
1-tridecanaminium, 1-carboxy-N,N,N-trimethyl-, inner salt
 zohartain AB
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PubMed: Visualizing oil displacement with foam in a microfluidic device with permeability contrast.
PubMed: Effect of mixed surfactants on stratum corneum: a drying stress and Raman spectroscopy study.
PubMed: Use of statistical modeling to predict the effect of formulation composition on conditioning shampoo performance.
PubMed: Survival, mobility, and membrane-bound enzyme activities of freshwater planarian, Dugesia japonica, exposed to synthetic and natural surfactants.
PubMed: Use of statistical modeling to predict the effect of formulation composition on coacervation, silicone deposition, and conditioning sensory performance of cationic cassia polymers.
PubMed: Morphological study of cationic polymer-anionic surfactant complex precipitated in solution during the dilution process.
PubMed: Quantitative analysis of surfactant deposits on human skin by liquid chromatography/electrospray ionisation tandem mass spectrometry.
PubMed: Flexibility and cross-sectional structure of an anionic dual-surfactant wormlike micelle explored with small-angle X-ray scattering coupled with contrast variation technique.
PubMed: Anionic linear aliphatic surfactants activate TRPV1: a possible endpoint for estimation of detergent induced eye nociception?
PubMed: Formation of Yolk/SiO(2) shell structures using surfactant mixtures as template.
PubMed: A novel, environmentally friendly sodium lauryl ether sulfate-, cocamidopropyl betaine-, cocamide monoethanolamine-containing buffer for MEKC on microfluidic devices.
PubMed: Simultaneous determination of three surfactants and water in shampoo and liquid soap by ATR-FTIR.
PubMed: Toothpaste detergents: a potential source of oral soft tissue damage?
PubMed: Evaluation of the irritant capacity of decyl polyglucoside.
PubMed: Evaulation of irritation potential of surfactant mixtures.
PubMed: Influence of cleansing on stratum corneum tryptic enzyme in human skin.
PubMed: Complete quality analysis of commercial surface-active products by Fourier-transform near infrared spectroscopy.
PubMed: Salt-induced vesicle formation from single anionic surfactant SDBS and its mixture with LSB in aqueous solution.
PubMed: Simultaneous sodium lauryl sulphate testing improves the diagnostic validity of allergic patch tests. Results from a prospective multicentre study of the German Contact Dermatitis Research Group (Deutsche Kontaktallergie-Gruppe, DKG).
PubMed: Transition from micelle to vesicle in aqueous mixtures of anionic/zwitterionic surfactants studied by fluorescence, conductivity, and turbidity methods.
PubMed: A novel role for vernix caseosa as a skin cleanser.
PubMed: Effects of a betaine-containing toothpaste on subjective symptoms of dry mouth: a randomized clinical trial.
PubMed: The effects of two sodium lauryl sulphate-containing toothpastes with and without betaine on human oral mucosa in vivo.
PubMed: Patch testing with the irritant sodium lauryl sulfate (SLS) is useful in interpreting weak reactions to contact allergens as allergic or irritant.
PubMed: Decrease in toxic potential of mixed tensides maintained below the critical micelle concentration: an in vitro study.
PubMed: The ability of betaine to reduce the irritating effects of detergents assessed visually, histologically and by bioengineering methods.
PubMed: The use of different concentrations of betaine as a reducing irritation agent in soaps monitored visually and non-invasively.
PubMed: Preparation of a stable double emulsion (W1/O/W2): role of the interfacial films on the stability of the system.
PubMed: Betaine reduces the irritating effect of sodium lauryl sulfate on human oral mucosa in vivo.
PubMed: Clinical allergy to cocamidopropyl betaine: reactivity to cocamidopropylamine and lack of reactivity to 3-dimethylaminopropylamine.
PubMed: Investigation of the Interactions of Polyvinylpyrrolidone with Mixtures of Anionic and Nonionic Surfactants or Anionic and Zwitterionic Surfactants by Pulsed Field Gradient NMR.
PubMed: Biophysical characterization of skin damage and recovery after exposure to different surfactants.
PubMed: Betaine-containing toothpaste relieves subjective symptoms of dry mouth.
PubMed: The effect of two toothpaste detergents on the frequency of recurrent aphthous ulcers.
PubMed: Oral mucosal desquamation caused by two toothpaste detergents in an experimental model.
PubMed: Effects of surfactants and protease inhibitors on nasal absorption of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in rats.
PubMed: Cocamidopropyl betaine: the significance of positive patch test results in twelve patients.
PubMed: Ranking of surfactant skin irritancy in vivo in man using the plastic occlusion stress test (POST).
PubMed: Conversion of CuA to a type II copper in cytochrome c oxidase.
PubMed: Skin irritancy of surfactants as assessed by water vapor loss measurements.
PubMed: Shampoo dermatitis due to cocobetaine and sodium lauryl ether sulphate.
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