EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
BT
 

laureth-4
poly(oxy-1,2-ethanediyl), .alpha.-dodecyl-.omega.-hydroxy- (4 mol EO average molar ratio)

Sponsors

CAS Number: 5274-68-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:226-097-1
Nikkaji Web:J151.203J
XlogP3:4.70 (est)
Molecular Weight:362.55074000
Formula:C20 H42 O5
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
CAS Number: 9002-92-0Picture of molecule3D/inchi
Other:101008-55-3
ECHA ELINCS - REACH Pre-Reg:500-002-6
FDA UNII:J89TKQ5R54
Nikkaji Web:J92.963H
XlogP3:5.10 (est)
Formula:(C2 H4 O)mult-C12 H26 O
NMR Predictor:Predict (works with chrome or firefox)
Also(can) Contains:C12-14 pareth-3
Category:emulsifiers, surfactants
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white waxy solid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 450.00 to 451.00 °C. @ 760.00 mm Hg (est)
Flash Point:> 200.00 °F. TCC ( > 93.33 °C. )
logP (o/w): 4.204 (est)
Soluble in:
 water, 12.3 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor Strength:low
Odor Description:at 100.00 %. mild alcoholic
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antistatic agents
emulsifying agents
masking agents
surfactants
 
Suppliers:
BOC Sciences
For experimental / research use only.
Brij30 95%
Chemical-navi - Nikkol
NIKKOL BL-4SY
Odor: characteristic
Use: Reagent of nonionic surfactant
Croda
Brij™ L4
Odor: bland
Use: Solubiliser. Dispersant.
ECSA Chemicals
Laureth-4
Company Profile
Kao Corporation
AKYPO ROX RLM40
Odor: characteristic
Use: Detergent, foaming, wetting, dispersing agent, emulsifier and solubilizer for different fields
Kao Corporation
EMULGEN 104P
Odor: characteristic
Use: Emulsifier for cosmetics
Kao Corporation
FINDET 1214N/16
Lipo Chemicals
Lipocol® L-4
Odor: characteristic
Use: Lipocol® L-4 is primarily used in oil-in-water emulsions as an auxiliary emulsifier and stabilizer with Lipocol® L-23. This pair of emulsifiers is particularly effective in systems with high HLB requirements such as antiperspirants, depilatories and cuticle removers.
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-guinea pig LD50 38 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) KIDNEY, URETER, AND BLADDER: HEMATURIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 162, 1957.

oral-guinea pig LD50 384 mg/kg
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 162, 1957.

intraperitoneal-mouse LD50 160 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.

intraperitoneal-mouse LD50 160 mg/kg
Drugs in Japan Vol. -, Pg. 1300, 1995.

intravenous-mouse LD50 100 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.

intravenous-mouse LD50 100 mg/kg
Toxicology and Applied Pharmacology. Vol. 7, Pg. 206, 1965.

oral-mouse LD50 1170 mg/kg
Toxicology and Applied Pharmacology. Vol. 2, Pg. 133, 1960.

oral-mouse LD50 1170 mg/kg
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 162, 1957.

oral-mouse LD50 3500 mg/kg
American Perfumer and Cosmetics. Vol. 77, Pg. 35, 1962.

oral-mouse LD50 4940 mg/kg
American Perfumer and Cosmetics. Vol. 77, Pg. 35, 1962.

intratracheal-rabbit LD50 > 15 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 78, 1976.

intravenous-rabbit LD50 36 mg/kg
KIDNEY, URETER, AND BLADDER: HEMATURIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 162, 1957.

parenteral-rabbit LD50 > 75 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 78, 1976.

intraperitoneal-rat LD50 125 mg/kg
GASTROINTESTINAL: OTHER CHANGES
Food and Cosmetics Toxicology. Vol. 8, Pg. 125, 1970.

intravenous-rat LD50 27 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.

intravenous-rat LD50 27 mg/kg
Drugs in Japan Vol. -, Pg. 1300, 1995.

intravenous-rat LD50 390 mg/kg
Toxicology and Applied Pharmacology. Vol. 2, Pg. 133, 1960.

oral-rat LD50 1000 mg/kg
LIVER: FATTY LIVER DEGERATION GASTROINTESTINAL: OTHER CHANGES GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Food and Cosmetics Toxicology. Vol. 8, Pg. 125, 1970.

oral-rat LD50 4150 mg/kg
Toxicology and Applied Pharmacology. Vol. 2, Pg. 133, 1960.

oral-rat LD50 8600 mg/kg
Soap, Perfumery & Cosmetics. Vol. 38, Pg. 47, 1965.

Dermal Toxicity:
subcutaneous-mouse LD50 792 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.

subcutaneous-mouse LD50 792300 ug/kg
Drugs in Japan Vol. -, Pg. 1300, 1995.

subcutaneous-rat LD50 953 mg/kg
Drugs in Japan Vol. -, Pg. 1300, 1995.

subcutaneous-rat LD50 954 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: emulsifiers, surfactants
Recommendation for laureth-4 usage levels up to:
 not for fragrance use.
 
Recommendation for laureth-4 flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):5274-68-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :78933
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethanolI
Chemidplus:0005274680
2-dodecoxyethanol (peg-4)
Chemidplus:0009002920
EPA/NOAA CAMEO:hazardous materials
 
References:
 2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethanolI
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:5274-68-0
Pubchem (cid):78933
Pubchem (sid):135034609
 2-dodecoxyethanol (peg-4)
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:9002-92-0
Pubchem (cid):24750
Pubchem (sid):134991393
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D01539
HMDB (The Human Metabolome Database):Search
Haz-Map:View
Household Products:Search
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 akypo ROX RLM40
 ameroxol le-4
 brij 30
 brij L4
 britex l 40
 emulgen 104P
 findet 1214N/16
 hetoxol l-4
 lipocol l-4
 nikkol BL-4SY
 peg-4 lauryl ether
 poly(oxy-1,2-ethanediyl), .alpha.-dodecyl-.omega.-hydroxy- (4 mol EO average molar ratio)
 polyethylene glycol (4) lauryl ether
 polyethylene glycol (4) monolauryl ether
 polyoxyethylene (4) lauryl ether
 polyoxyethylene (4) monolauryl ether
3,6,9,12-tetraoxatetracosan-1-ol
 volpo l-4
 
 
Notes:
None found
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