hydroxypropyl guar gum
guar gum, 2-hydroxypropyl ether
 
Notes:
None found
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CAS Number: 39421-75-5 
Other: 114680-41-0
ECHA EC Number: 270-497-9
FDA UNII: 3A1I7376TC
Formula: C3 H8 O2.x-Unspecified
CAS Number: 68442-94-4 
ECHA EC Number: 270-497-9
Formula: unspecified
Category: cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
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Organoleptic Properties:
Odor Strength: none
Odor Description:
at 100.00 %. 
odorless
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antistatic agents
binding agents
emulsion stabilisers
film formers
surfactants
viscosity controlling agents
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Suppliers:
Ashland
N-Hance™ HP Series hydroxypropyl guar
Odor: odorless
Use: N-Hance hydroxypropyl (HP) guar is a nonionic polymeric thickener and film former. It is often specified in personal care formulations to take advantage of its characteristic high level of lubricity as well as excellent salt and alcohol tolerance in aqueous solutions. N-Hance HP guar is offered in a buffered self-hydrating grade (HP-40S) as well as a non-buffered grade (HP-40). Solutions of HP guar will be slightly hazy.
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic agents
Recommendation for hydroxypropyl guar gum usage levels up to:
 not for fragrance use.
 
Recommendation for hydroxypropyl guar gum flavor usage levels up to:
 not for flavor use.
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Safety References:
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 39421-75-5
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
Chemidplus: 0039421755
Chemidplus: 0068442944
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References:
Canada Domestic Sub. List: 39421-75-5
Pubchem (sid): 135291388
Canada Domestic Sub. List: 68442-94-4
Pubchem (sid): 135293818
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Other Information:
HMDB (The Human Metabolome Database): Search
Household Products: Search
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 antistatic agents 
 binding agents 
 emulsion stabilisers 
 film formers 
 viscosity controlling agents 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 guar gum 2-hydroxypropyl ether
 guar gum, 2-hydroxypropyl ether
 guaraprolose
 hydroxypropyl guar
 N-hance HP series hydroxypropyl guar
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Articles:
PubMed: Stretching properties of xanthan and hydroxypropyl guar in aqueous solutions and in cosmetic emulsions.
PubMed: Tuning cellulose nanocrystal gelation with polysaccharides and surfactants.
PubMed: Performance of a new thermostable mannanase in breaking guar-based fracturing fluids at high temperatures with little premature degradation.
PubMed: Efficacy and safety of chondroitin sulfate/xanthan gum versus polyethylene glycol/propylene glycol/hydroxypropyl guar in patients with dry eye.
PubMed: Homogeneous synthesis of hydroxypropyl guar gum in an ionic liquid 1-butyl-3-methylimidazolium chloride.
PubMed: Stretching properties of xanthan, carob, modified guar and celluloses in cosmetic emulsions.
PubMed: Preparation and in vitro characterization of mucoadhesive hydroxypropyl guar microspheres containing amlodipine besylate for nasal administration.
PubMed: Lubricant with gelling agent in treating dry eye in adult Chinese patients.
PubMed: Modification of hydroxypropyl guar gum with ethanolamine.
PubMed: Prospective, randomized, controlled comparison of SYSTANE UD eye drops versus VISINE INTENSIV 1% EDO eye drops for the treatment of moderate dry eye.
PubMed: Evaluation of guar gum derivatives as gelling agents for microbial culture media.
PubMed: Characterization of the interaction between hydroxypropyl guar galactomannan and galectin-3.
PubMed: Systane lubricant eye drops in the management of ocular dryness.
PubMed: Charge regulation enables anionic hydroxypropyl guar-borate adsorption onto anionic and cationic polystyrene latex.
PubMed: The impact of artificial tears containing hydroxypropyl guar on mucous layer.
PubMed: Novel hydroxypropyl-guar gellable lubricant eye drops for treatment of dry eye.
PubMed: Cationic liposome colloidal stability in the presence of guar derivatives suggests depletion interactions may be operative in artificial tears.
PubMed: Efficacy in patients with dry eye after treatment with a new lubricant eye drop formulation.
PubMed: Novel ocular lubricant containing an intelligent delivery system: details of its mechanism of action.
PubMed: The effect of preservative-free HP-Guar on dry eye after phacoemulsification: a flow cytometric study.
PubMed: Comparison of the clinical effects of carbomer-based lipid-containing gel and hydroxypropyl-guar gel artificial tear formulations in patients with dry eye syndrome: a 4-week, prospective, open-label, randomized, parallel-group, noninferiority study.
PubMed: The effect of lubricating eye drop containing hydroxypropyl guar on perimetry results of patients with glaucoma and trachomatous dry eye.
PubMed: Not all anionic polyelectrolytes complex with DTAB.
PubMed: Protecting the ocular surface and improving the quality of life of dry eye patients: a study of the efficacy of an HP-guar containing ocular lubricant in a population of dry eye patients.
PubMed: Reversible flocculation with hydroxypropyl guar-borate, a labile anionic polyelectrolyte.
PubMed: Impact on ocular surface evaporation of an artificial tear solution containing hydroxypropyl guar.
PubMed: Extensional properties of hydroxypropyl ether guar gum solutions.
PubMed: TEMPO-mediated selective oxidation of substituted polysaccharides--an efficient approach for the determination of the degree of substitution at C-6.
PubMed: Hydroxypropyl-guar gellable lubricant eye drops for dry eye treatment.
PubMed: [Toxicity of a new moistening agent and preservative in vitro].
PubMed: Derivatization of guar to sodium carboxy methyl hydroxy propyl derivative; characterization and evaluation.
PubMed: An evaluation of tear film breakup time extension and ocular protection index scores among three marketed lubricant eye drops.
PubMed: Manipulating formation and drug-release behavior of new sol-gel silica matrix by hydroxypropyl guar gum.
PubMed: Study of hydroxy propyl guar derivative for its gelling property and it's use in the formulation of tenoxicam gels.
PubMed: Differential tissue-on-tissue lubrication by ophthalmic formulations.
PubMed: New semi-interpenetrating network hydrogels: synthesis, characterization and properties.
PubMed: A clinical evaluation of Systane.
PubMed: Hydroxypropyl guar-borate interactions with tear film mucin and lysozyme.
PubMed: A clinical comparison of two different prednisolone acetate formulations in patients undergoing cataract surgery.
PubMed: An open-label evaluation of HP-Guar gellable lubricant eye drops for the improvement of dry eye signs and symptoms in a moderate dry eye adult population.
PubMed: Pre-clinical investigation of the efficacy of an artificial tear solution containing hydroxypropyl-guar as a gelling agent.
PubMed: Clinical evaluation of an HP-guar gellable lubricant eye drop for the relief of dryness of the eye.
PubMed: Characterization and intermolecular interactions of hydroxypropyl guar solutions.
PubMed: [Investigation of the carboxymethyl hydroxypropyl guar gum cross-linked with metal ions].
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