EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

etidronic acid
phosphonic acid, (1-hydroxyethylidene)bis-

Sponsors

CAS Number: 2809-21-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:220-552-8
FDA UNII:M2F465ROXU
Nikkaji Web:J7.915D
Beilstein Number:1789291
MDL:MFCD00070585
XlogP3-AA:-3.70 (est)
Molecular Weight:206.02768400
Formula:C2 H8 O7 P2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:sequestrants
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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NCBI:Search
JECFA Food Additive: 1-Hydroxyethylidene-1,1-diphosphonic acid
FDA Mainterm: 1-HYDROXYETHYLIDENE-1,1-DIPHOSPHONIC ACID
FDA Regulation:
FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart D--Specific Usage Additives
Sec. 173.310 Boiler water additives.


FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart D--Specific Usage Additives
Sec. 173.315 Chemicals used in washing or to assist in the peeling of fruits and vegetables.


FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart D--Specific Usage Additives
Sec. 173.370 Peroxyacids.


FDA PART 178 -- INDIRECT FOOD ADDITIVES: ADJUVANTS, PRODUCTION AIDS, AND SANITIZERS
Subpart B--Substances Utilized To Control the Growth of Microorganisms
Sec. 178.1010 Sanitizing solutions.
 
Physical Properties:
Appearance:pale yellow clear liquid (est)
Food Chemicals Codex Listed: No
Specific Gravity:1.43000 to 1.47100 @ 20.00 °C.
Pounds per Gallon - (est).: 11.913 to 12.254
Boiling Point: 578.76 °C. @ 760.00 mm Hg (est)
Flash Point: 579.00 °F. TCC ( 303.80 °C. ) (est)
logP (o/w): -0.746 (est)
Soluble in:
 water, 690000 mg/L @ 20 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: chelating agents
 
Suppliers:
BOC Sciences
For experimental / research use only.
Etidronic acid >98%
Odor: characteristic
Use: Etidronate (Didronel) is a human protein tyrosine phosphatase inhibitor with IC50 of 0.2 nM.
Charkit Chemical
DEQUEST 2010
Connect Chemicals
1-Hydroxyethylidene-1,1-diphosphonic acid (HEDP)
Odor: characteristic
Use: 1-Hydroxyethylidene-1,1-diphosphonic acid (HEDP) is a cost effective scale inhibitor used in various industrial applications such as industrial water treatment and detergents. It further shows good stability in presence of chlorine as well as corrosion inhibition properties in presence of zinc and other phosphates. HEDP can be also used as chelating agent in the textile industry.
Santa Cruz Biotechnology
For experimental / research use only.
Etidronic Acid ≥90%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Etidronic Acid 60% aqueous solution
Strem Chemicals
For experimental / research use only.
1-Hydroxyethylidene-1,1-diphosphonic acid, min. 95% HEDP
TCI AMERICA
For experimental / research use only.
1-Hydroxyethane-1,1-diphosphonic Acid (ca. 60% in Water, ca. 4.2mol/L)
Universal Preserv-A-Chem Inc.
ETIDRONIC ACID
Odor: characteristic
Use: Is a bisphosphonate used in detergents, water treatment, cosmetics and pharmaceutical treatment. Etidronic acid (Didronel -) is a bisphosphonate used to strengthen bone, treat osteoporosis, and treat Paget's disease of bone.
Zschimmer & Schwarz
Cublen HE-K 60
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 1800 mg/kg
Angewandte Chemie, International Edition in English. Vol. 14, Pg. 94, 1975.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: sequestrants
Recommendation for etidronic acid usage levels up to:
 not for fragrance use.
 
Recommendation for etidronic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the evaluation of the safety and efficacy of peroxyacetic acid solutions for reduction of pathogens on poultry carcasses and meat
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
NLM Hazardous Substances Data Bank:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):2809-21-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :3305
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
(1-hydroxy-1-phosphonoethyl)phosphonic acid
Chemidplus:0002809214
RTECS:SZ8562100 for cas# 2809-21-4
 
References:
 (1-hydroxy-1-phosphonoethyl)phosphonic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:2809-21-4
Pubchem (cid):3305
Pubchem (sid):134983248
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C07736
HMDB (The Human Metabolome Database):HMDB15210
FooDB:FDB001018
Export Tariff Code:2931.90.9041
Haz-Map:View
Household Products:Search
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 chelating agents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 acetodiphosphonic acid
 cublen HE-K 60
 didronel IV
oxyethylidenediphosphonic acid
(1-hydroxy-1-phosphono-ethyl)-phosphonic acid
(1-hydroxy-1-phosphonoethyl)phosphonic acid
(1-hydroxy-1,1-ethanediyl)bis(phosphonic acid)
1-hydroxyethane-1,1-bisphosphonic acid
1-hydroxyethane-1,1-diphosphonic acid
(1-hydroxyethane-1,1-diyl)bis(phosphonic acid)
(1-hydroxyethane-1,1-diyl)diphosphonic acid
1-hydroxyethane-1,1,-diphosphonic acid
1-hydroxyethanediphosphonic acid
(1-hydroxyethylene)diphosphonic acid
1-hydroxyethylidene-1,1-diphosphonic acid
1-hydroxyethylidene-1,1-diphosphonicacid
(1-hydroxyethylidene)bis(phosphonic acid)
(1-hydroxyethylidene)bisphonic acid
(1-hydroxyethylidene)bisphosphonic acid
(1-hydroxyethylidene)diphoshonic acid
(hydroxyethylidene)diphosphonic acid
(1-hydroxyethylidene)diphosphonic acid
1-hydroxyethylidenediphosphonic acid
 phosphonic acid, (1-hydroxyethylidene)bis-
 

Articles:

PubMed:Biosorption of heavy metal ions onto agricultural residues buckwheat hulls functionalized with 1-hydroxylethylidenediphosphonic acid.
PubMed:Intravenous zoledronic acid: what are the indications for male osteoporosis?
PubMed:Effect of osteoporosis treatment on mortality: a meta-analysis.
PubMed:Comparison of the effects of once-monthly versus once-daily risedronate in postmenopausal osteoporosis: a phase II, 6-month, multicenter, randomized, double-blind, active-controlled, dose-ranging study.
PubMed:Risedronate dosing before breakfast compared with dosing later in the day in women with postmenopausal osteoporosis.
PubMed:Compatibility of risedronate sodium tablets with food thickeners.
PubMed:Paget disease of bone: therapeutic options.
PubMed:Nonvertebral fracture risk reduction with nitrogen-containing bisphosphonates.
PubMed:Effects of risedronate 5 mg/d on bone mineral density and bone turnover markers in late-postmenopausal women with osteopenia: a multinational, 24-month, randomized, double-blind, placebo-controlled, parallel-group, phase III trial.
PubMed:Evaluation of 41calcium as a new approach to assess changes in bone metabolism: effect of a bisphosphonate intervention in postmenopausal women with low bone mass.
PubMed:Effect of administration site in the gastrointestinal tract on bioavailability of poorly absorbed drugs taken after a meal.
PubMed:Importance of calcium co-medication in bisphosphonate therapy of osteoporosis: an approach to improving correct intake and drug adherence.
PubMed:Pharmaceutical care and community pharmacists' understanding of bisphosphonate dosing information.
PubMed:Clinical trial of risedronate in Japanese volunteers: a study on the effects of timing of dosing on absorption.
PubMed:An approach to postmenopausal osteoporosis treatment: a case study review.
PubMed:Prevention and treatment of osteoporosis.
PubMed:Bone density changes with once weekly risedronate in postmenopausal women.
PubMed:Treatment of hypercalcemia of malignancy with bisphosphonates.
PubMed:Food-drug interactions.
PubMed:Risedronate: a new oral bisphosphonate.
PubMed:Gender differences in osteoporosis treatment: a review of clinical research.
PubMed:Timing of cyclical etidronate.
PubMed:Prevention and treatment of osteoporosis.
PubMed:The effect of dosing regimen on the pharmacokinetics of risedronate.
PubMed:Evaluation of the effects of risedronate on hepatic microsomal drug metabolizing enzyme activities following administration to rats for 14 days: lack of an induction response.
PubMed:Risedronate released for Paget's disease.
PubMed:Bisphosphonates: preclinical aspects and use in osteoporosis.
PubMed:Adverse effects of bisphosphonates. A comparative review.
PubMed:Osteoporosis: pathophysiology, prevention, diagnosis, and treatment.
PubMed:Etidronate for hypercalcemia of malignancy and osteoporosis.
PubMed:Absorption of oral diphosphonate in normal subjects.
 
Notes:
a diphosphonate which affects calcium metabolism. it inhibits ectopic calcification and slows down bone resorption and bone turnover. Food contaminant arising from its use as a boiler water additive for prepn. of steam used in food processing. Component of antimicrobial washes for poultry carcasses and fruit Etidronic acid is a first generation (non-nitrogenous) bisphosphonate in the same family as clodronate and tiludronate. Etidronic acid affects calcium metabolism and inhibits bone resorption and soft tissue calcification. Of the etidronic acid that is resorbed (from oral preparation) or infused (for intravenous drugs), about 50% is excreted unchanged by the kidney. The remainder has a very high affinity for bone tissue, and is rapidly absorbed onto the bone surface. Etidronic acid has been shown to prevent or delay skeletal-related events and decrease bone pain as well as normalize calcium levels in the presence of hypercalcemia.
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