|
Category:preservatives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 303.71 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 279.00 °F. TCC ( 137.50 °C. ) (est)
|
| logP (o/w): | -1.078 (est) |
| Soluble in: |
| | water, 2.612e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| Acme-Hardesty |
| DMDM Hydantoin
Odor: characteristic Use: Antimicrobial Preservative Used in Personal Care Applications. |
| BOC Sciences |
| For experimental / research use only. |
| 1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione 98%
|
| Connect Chemicals |
| Dimethyl Dimethylhydantoin (DMDMH)
|
| Kingyoung Bio Technical |
| DMDM Hydantoin
|
| Kraft Chemical |
| DMDM Hydantoin
|
| Nanjing Jiancheng Chemical |
| DMDM hydantoin (DMDMH)
Odor: characteristic Use: DMDMH is widely used as antiseptic for its bactericidal effect. It can constrain the bacterium, yeast, mould, gram-positive bacterium and gram-negative bacterium. It can be applied in all kinds of cosmetics and Personal Care, such as shampoo, conditioner, cream, shower gel and so on. |
| Shiva Chemicals and Pharmaceuticals |
| Dimethyloldimethyl Hydantoin
|
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LDLo 1320 mg/kg
Agricultural and Biological Chemistry. Vol. 40, Pg. 1705, 1976.
oral-mouse LDLo 3000 mg/kg
Agricultural and Biological Chemistry. Vol. 40, Pg. 1705, 1976.
oral-rat LD50 2000 mg/kg
LIVER: OTHER CHANGES
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Journal of the American College of Toxicology. Vol. 7(3), Pg. 245, 1988.
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | preservatives |
| Recommendation for DMDM hydantoin usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for DMDM hydantoin flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Indirect Additives used in Food Contact Substances: | View |
| HMDB (The Human Metabolome Database): | Search |
| FooDB: | FDB004274 |
| ChemSpider: | View |
| Wikipedia: | View |
Formulations/Preparations:
•dantogard active ingredient 32.0% dmdm hydantoin, 7.5% mdm hydantoin
•dantogard plus industrial preservative active ingredient 4.5% 3-iodo-2-propynyl butylcarbamate, 87.0% dmdm hydantoin, 0.4% mdm hydantoin
•dantogard xl-1000 95.5% dmdm hydantoin, 4.0% mdm hydantoin
•dantogard ii preservative active ingredient 26.4% dmdm hydantoin, 23.2% mdm hydantoin
•dantocil ig active ingredient 0.04% 5-chloro-2-methyl-3(2h)-isothiazolone, 0.01% 2-methyl-3(2h)-isothiazolone, 29.4% dmdm hydantoin, 27.9% mdm hydantoin
•glycoserve active ingredient 45.0% dmdm hydantoin, 10.0% mdm hydantoin
•troy 2063 active ingredient 8.0% 1,2-benzisothiazolin-3-one, 9.6% dmdm hydantoin, 2.2% mdm hydantoin
•troysan 680 active ingredient 10.9% 1,2-benzisothiazolin-3-one, 12.5% dmdm hydantoin, 2.9% mdm hydantoin
|
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | dantoin-DMDMH | | 1,3- | di(hydroxymethyl)-5,5-dimethylhydantoin | | 1,3- | dihydroxymethyl-5,5-dimethylhydantoin | | 1,3- | dimethylol-5,5-dimethyl hydantoin | | 1,3- | dimethylol-5,5-dimethyl-hydantoin | | 1,3- | dimethylol-5,5-dimethylhydantion | | | dimethylol-5,5-dimethylhydantoin | | 1,3- | dimethylol-5,5-dimethylhydantoin | | | dimethyloldimethyl hydantoin | | | dimethyloldimethylhydantoin | | | DMDMH | | | glycoserve-DMDMH | | | hydantoin | | | hydantoin, 1,3-bis(hydroxymethyl)-5,5-dimethyl- | | 1,3-bis( | hydroxymethyl)-5,5-dimethyl-1,3-diazolidine-2,4-dione | | 1,3-bis( | hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione | | 1,3-bis( | hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione | | 2,4- | imidazolidinedione, 1,3-bis(hydroxymethyl)-5,5-dimethyl- | | | mackstat DM |
Articles:
| PubMed:Preservatives in cosmetics in the Israeli market conform well to the EU legislation. |
| PubMed:Cutaneous delayed-type hypersensitivity in patients with atopic dermatitis: reactivity to topical preservatives. |
| PubMed:Frequency of positive patch test reactions to preservatives: The Australian experience. |
| PubMed:Preservatives in cosmetics: reactivity of allergenic formaldehyde-releasers towards amino acids through breakdown products other than formaldehyde. |
| PubMed:Lavender, tea tree and lemon oils as antimicrobials in washing liquids and soft body balms. |
| PubMed:Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 2. Patch test relationship to formaldehyde contact allergy, experimental provocation tests, amount of formaldehyde released, and assessment of risk to consumers allergic to formaldehyde. |
| PubMed:Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 1. Characterization, frequency and relevance of sensitization, and frequency of use in cosmetics. |
| PubMed:Long-term trend in patch test reactions: a 32-year statistical overview (1970-2002), part II. |
| PubMed:Sensitivity of petrolatum and aqueous vehicles for detecting allergy to imidazolidinylurea, diazolidinylurea, and DMDM hydantoin: a retrospective analysis from the North American Contact Dermatitis Group. |
| PubMed:[Contact allergy to preservatives contained in cosmetics]. |
| PubMed:Contact sensitivity to preservatives in Turkey. |
| PubMed:[Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations]. |
| PubMed:Contact allergy from DMDM hydantoin, 1994-2000. |
| PubMed:Frequency of sensitization to 13 common preservatives in Switzerland. Swiss Contact Dermatitis Research Group. |
| PubMed:Patch test reactivity to DMDM hydantoin. Relationship to formaldehyde allergy. |
| PubMed:Contact allergy to preservatives--II. |
|
3D/inchi