dextrans
 
Notes:
a group of glucose polymers made by certain bacteria. dextrans are used therapeutically as plasma volume expanders and anticoagulants. they are also commonly used in biological experimentation and in industry for a wide variety of purposes. Indirect food additive produced by bacterial fermentation of sucrose Dextran is a complex, branched glucan (polysaccharide made of many glucose molecules) composed of chains of varying lengths (from 10 to 150 kilodaltons). It is used medicinally as an antithrombotic (anti-platelet), to reduce blood viscosity, and as a volume expander in anemia.
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2,3,4,5-tetrahydroxy-6-[3,4,5-trihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyhexanal (Click)
CAS Number: 9004-54-0Picture of molecule
ECHA EINECS - REACH Pre-Reg: 232-677-5
FDA UNII: EW7Q6SVD0D
XlogP3-AA: -7.20 (est)
Molecular Weight: 504.44024000
Formula: C18 H32 O16
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: food-contact surface of paper and paperboard
 
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 FDA/DG SANTE Petitions, Reviews, Notices:
186.1275 Dextrans View-review
186.1275 Dextran View-review
FDA Mainterm: DEXTRANS (AVG M W LESS THAN 100,000)
FDA Regulation:
FDA PART 186 -- INDIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 186.1275 Dextrans.
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Physical Properties:
Food Chemicals Codex Listed: No
Boiling Point: 952.80 °C. @ 760.00 mm Hg (est)
Flash Point: 622.00 °F. TCC ( 327.70 °C. ) (est)
logP (o/w): -4.259 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: binding agents
viscosity controlling agents
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Suppliers:
BOC Sciences
For experimental / research use only.
Dextran 110 - MW: 100,000 to 120,000
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
unreported-mammal (species unspecified) LD50  13500 mg/kg
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gematologiya i Transfuziologiya. Hematology and Transfusion Science. Vol. 31(10), Pg. 38, 1986.

intravenous-mouse LD50  12100 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.

oral-mouse LD50  > 12000 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.

intravenous-rabbit LD50  17400 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.

intravenous-rabbit LD50  208000 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 201, 1975.

intravenous-rat LD50  6900 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.

oral-rat LD50  > 3000 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.

Dermal Toxicity:
subcutaneous-mouse LD50 13900 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.

subcutaneous-rat LD50 10700 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: food-contact surface of paper and paperboard
Recommendation for dextrans usage levels up to:
 not for fragrance use.
 
Recommendation for dextrans flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
Chemical Carcinogenesis Research Information System: Search
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Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 9004-54-0
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 4125253
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 2,3,4,5-tetrahydroxy-6-[3,4,5-trihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyhexanal
Chemidplus: 0009004540
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References:
 2,3,4,5-tetrahydroxy-6-[3,4,5-trihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyhexanal
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 9004-54-0
Pubchem (cid): 4125253
Pubchem (sid): 135289239
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
KEGG (GenomeNet): C00372
HMDB (The Human Metabolome Database): Search
FooDB: FDB012591
MedlinePlusSupp: View
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 binding agents 
 viscosity controlling agents 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 dextran 4
 dextran 8
2,3,4,5-tetrahydroxy-6-[3,4,5-trihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyhexanal
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