chlorhexidine hydrochloride
imidodicarbonimidic diamide, N,N''''-1,6-hexanediylbis[N'-(4-chlorophenyl)-, hydrochloride (1:2)
None found
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      C1254 Chlorhexidine Hydrochloride >96.0%(T)
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(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;dihydrochloride (Click)
CAS Number: 3697-42-5Picture of molecule
ECHA EINECS - REACH Pre-Reg: 223-026-6
MDL: MFCD00068998
Molecular Weight: 578.37504000
Formula: C22 H32 Cl4 N10
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 564.5 mg/L @ 25 °C (est)
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Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antimicrobial agents
oral care agents
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BOC Sciences
For experimental / research use only.
Chlorhexidine DiHCl >98%
Odor: characteristic
Use: Chlorhexidine hydrochloride is an antiseptic effective against a wide variety of gram-negative and gram-positive organisms.
Santa Cruz Biotechnology
For experimental / research use only.
Chlorhexidine Hydrochloride ≥95%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Chlorhexidine Hydrochloride ≥98%
For experimental / research use only.
Chlorhexidine Hydrochloride >96.0%(T)
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Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
subcutaneous-mouse LD50 > 5000 mg/kg
British Journal of Pharmacology and Chemotherapy. Vol. 9, Pg. 192, 1954.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic agents
Recommendation for chlorhexidine hydrochloride usage levels up to:
 not for fragrance use.
Recommendation for chlorhexidine hydrochloride flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View search
Daily Med: search
AIDS Citations: Search
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Env. Mutagen Info. Center: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 9571016
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
Chemidplus: 0003697425
RTECS: XA5285000 for cas# 3697-42-5
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NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 9571016
Pubchem (sid): 135020186
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
KEGG (GenomeNet): D01345
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2925.29.9000
Household Products: Search
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
None Found
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Potential Uses:
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Occurrence (nature, food, other): note
 not found in nature
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 chlorhexidine dihydrochloirde
 chlorhexidine HCl
 chlorhexidinium dichloride
 dantroche hibitane
1,1'-hexamethylene bis(5-(p-chlorophenyl)biguanide), dihydrochloride
1,1'-hexamethylenebis(5-(p-chlorophenyl)biguanide) dihydrochloride
1,1'-hexamethylenebis[5-(p-chlorophenyl)-biguanide]-, dihydrochloride
N,N''''-hexane-1,6-diylbis[N'-(4-chlorophenyl)(imidodicarbonimidic diamide)] dihydrochloride
N,N''''-1,6-hexanediylbis[N'-(4-chlorophenyl)(imidodicarbonimidic diamide)] dihydrochloride
 imidodicarbonimidic diamide, N,N''''-1,6-hexanediylbis[N'-(4-chlorophenyl)-, hydrochloride (1:2)
2,4,11,13-tetraazatetradecanediimidamide, N,N'-bis(4-chlorophenyl)-3,12-diimino-, dihydrochloride
2,4,11,13-tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, dihydrochloride
2,4,11,13-tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-,dihydrochloride
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PubMed: Resins-based denture soft lining materials modified by chlorhexidine salt incorporation: an in vitro analysis of antifungal activity, drug release and hardness.
PubMed: Recurrent epistaxis in children.
PubMed: Formulation and evaluation of periodontal in situ gel.
PubMed: Antimicrobial activity of disinfectant agents incorporated into type IV dental stone.
PubMed: The antimicrobial activity of a dentin conditioner combined with antibacterial agents.
PubMed: Compressive strength of glass ionomer cements with dental antibacterial agents.
PubMed: Inhibitory effects on selected oral bacteria of antibacterial agents incorporated in a glass ionomer cement.
PubMed: Simultaneous determination of ingredients in an ointment by hydrophobic interaction electrokinetic chromatography.
PubMed: Chromatography of crotamiton and its application to the determination of active ingredients in ointments.
PubMed: An analysis of bacteremias during dental extractions. A double-blind, placebo-controlled study of chlorhexidine.
PubMed: Contact hypersensitivity to topical antibacterial agents.
PubMed: [Studies on the sensitivity of oral streptococci to chlorhexidine hydrochloride].
PubMed: [Clinical and bacteriological assessment of the usefulness of lozenges containing chlorhexidine hydrochloride and anaesthesin for maintaining adequate oral hygiene in cases of wire splints on the teeth].
PubMed: [Clinical and bacteriological evaluation of the usefulness of lozenges containing chlorhexidine hydrochloride and anesthesin in maintaining proper oral hygiene in cases of using wire dental splints].
PubMed: The influence of various counter ions on the interaction of chlorhexidine with the hydrophilic contact lens polymer, poly(2-hydroxyethyl methacrylate).
PubMed: Effect of chlorhexidine-coated dressings on plaque formation after gingivectomy.
PubMed: [Effect of chlorhexidine hydrochloride on the formation of dental plaque in man (author's transl)].
PubMed: Investigation on the effect on skin healing of a cream containing dexamethasone, chlorhexidine hydrochloride and nandrolone decanoate.
PubMed: [The treatment of acute inflammations of the oral mucosa with chlorhexidine-hydrochloride (Hibitane)].
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