EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

chlorhexidine digluconate
1,6-bis(5-(p-chlorophenyl)biguandino)hexane digluconate

Sponsors

CAS Number: 18472-51-0Picture of molecule3D/inchi
Other:105791-72-8
ECHA EINECS - REACH Pre-Reg:242-354-0
FDA UNII:MOR84MUD8E
Beilstein Number:4348068
MDL:MFCD00083599
Molecular Weight:897.76718000
Formula:C34 H54 Cl2 N10 O14
NMR Predictor:Predict (works with chrome or firefox)
Category:cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
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Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 699.30 °C. @ 760.00 mm Hg (est)
Flash Point: 710.00 °F. TCC ( 376.70 °C. ) (est)
logP (o/w): 4.931 (est)
Soluble in:
 water, 65.36 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antimicrobial agents
oral care agents
preservatives
 
Suppliers:
American International Chemical, LLC.
Chlorhexidine Gluconate
BOC Sciences
For experimental / research use only.
Chlorhexidine Digluconate >98%
Odor: characteristic
Use: Chlorhexidine has been used to study how essential oils improve skin antisepsis when combined with chlorhexidine digluconate and is used for skin permeation studies.
George Uhe Company
CHLORHEXIDINE DIGLUCONATE 20% USP
Jiangyin Healthway
Chlorhexidine Gluconate 20%
New functional food ingredients
OQEMA
Chlorhexidine Gluconate
Sigma-Aldrich: Sigma
For experimental / research use only.
Chlorhexidine digluconate solution 20% in H2O
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 12900 ug/kg
Drugs in Japan Vol. 6, Pg. 255, 1982.

oral-mouse LD50 1260 mg/kg
Drugs in Japan Vol. 6, Pg. 255, 1982.

intravenous-rat LD50 24200 ug/kg
Drugs in Japan Vol. 6, Pg. 255, 1982.

oral-rat LD50 2000 mg/kg
Drugs in Japan Vol. 6, Pg. 255, 1982.

Dermal Toxicity:
subcutaneous-mouse LD50 1140 mg/kg
Drugs in Japan Vol. 6, Pg. 255, 1982.

subcutaneous-rat LD50 3320 mg/kg
Drugs in Japan Vol. 6, Pg. 255, 1982.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: cosmetic agents
Recommendation for chlorhexidine digluconate usage levels up to:
 not for fragrance use.
 
Recommendation for chlorhexidine digluconate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):18472-51-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :24838357
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0018472510
 
References:
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:18472-51-0
Pubchem (cid):24838357
Pubchem (sid):134993220
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
KEGG (GenomeNet):C08038
HMDB (The Human Metabolome Database):Search
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
Wikipedia2:View2
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 arlacide G
 betasept
 chloraprep
 chlorhexamed
 chlorhexidine bigluconate
 chlorhexidine D-digluconate
 chlorhexidine di-D-gluconate
4-chlorhexidine digluconate
 chlorhexidine gluconate
N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide di-D-gluconate
1,6-bis(5-(p-chlorophenyl)biguandino)hexane digluconate
 corsodyl
 disteryl
D-gluconic acid compd. with N,N''-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)
1,1'-hexamethylene bis(5-(p-chlorophenyl)biguanide), digluconate
1,1'-hexamethylenebis(5-(p-chlorophenyl)biguanide) di-D-gluconate
1,1'-hexamethylenebis(5-(p-chlorophenyl)biguanide)digluconate
N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)] - D-gluconic acid (1:2)
N,N''''-hexane-1,6-diylbis[N'-(4-chlorophenyl)(imidodicarbonimidic diamide)] - D-gluconic acid (1:2)
N,N''''-1,6-hexanediylbis[N'-(4-chlorophenyl)(imidodicarbonimidic diamide)] - D-gluconic acid (1:2)
 hexidine
 hibident
 hibisol
 imidodicarbonimidic diamide, N,N''''-1,6-hexanediylbis[N'-(4-chlorophenyl)-, compd. with D-gluconic acid (1:2)
 manusan
 maskin R
 orahexal
(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid - N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)] (2:1)
(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexansäure--N,N''''-hexan-1,6-diylbis[N'-(4-chlorphenyl)(imidodicarbonimidic diamid)](2:1)
 phiso-med
 plurexid
 rotersept
 sterilon
2,4,11,13-tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, di-D-gluconate
2,4,11,13-tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, digluconate
 unisept
 

Articles:

PubMed:Antibacterial paperboard packaging using microfibrillated cellulose.
PubMed:Survival and susceptibility of Burkholderia cepacia complex in chlorhexidine gluconate and benzalkonium chloride.
PubMed:Effect of the hand antiseptic agents benzalkonium chloride, povidone-iodine, ethanol, and chlorhexidine gluconate on atopic dermatitis in NC/Nga mice.
PubMed:Comparative efficacy of alcohol-based surgical scrubs: the importance of formulation.
PubMed:Prospective evaluation of 2% (w/v) alcoholic chlorhexidine gluconate as an antiseptic agent for blood donor arm preparation.
PubMed:Quantitative microbial risk assessment of antibacterial hand hygiene products on risk of shigellosis.
PubMed:Effects of food colouring added to 2% chlorhexidine gluconate and 70% alcohol for surgical site antisepsis.
PubMed:Nonsurgical management of inflammatory periimplant disease caused by food impaction: a clinical report.
PubMed:Effect of subinhibitory concentrations of four commonly used biocides on the conjugative transfer of Tn916 in Bacillus subtilis.
PubMed:Lethal and sub lethal effects of the biocide chlorhexidine on aquatic organisms.
PubMed:Involvement of leptin in the progression of experimentally induced peritoneal fibrosis in mice.
PubMed:Presence of antiseptic resistance genes in porcine methicillin-resistant Staphylococcus aureus.
PubMed:Efficacy of surgical preparation solutions in lumbar spine surgery.
PubMed:Neurologic complications after chlorhexidine antisepsis for spinal anesthesia.
PubMed:Comparative antibacterial efficacy of endemic satureja khuzistanica jamzad essential oil, sodium hypochlorite and chlorhexidine gluconate solutions as root canal irrigations.
PubMed:A meta-analysis of the published literature on the effectiveness of antimicrobial soaps.
PubMed:Avagard hand antisepsis vs. traditional scrub in 3600 pediatric urologic procedures.
PubMed:Clinical management of root caries.
PubMed:Application of the gingival contour plaque index: six-month plaque and gingivitis study.
PubMed:Comparison of the efficacy of three different mouthrinse solutions in decreasing the level of streptococcus mutans in saliva.
PubMed:Effects of commonly used food preservatives on biofilm formation of Streptococcus mutans in vitro.
PubMed:A review of anti-septic agents for pre-operative skin preparation.
PubMed:Characterization of predominant bacteria isolates from clean rooms in a pharmaceutical production unit.
PubMed:Susceptibility of Listeria monocytogenes strains isolated from dairy products and frozen vegetables to antibiotics inhibiting murein synthesis and to disinfectants.
PubMed:Comparative of a new and innovative 2% chlorhexidine gluconate-impregnated cloth with 4% chlorhexidine gluconate as topical antiseptic for preparation of the skin prior to surgery.
PubMed:In vivo efficacy of an alcohol-based surgical hand disinfectant containing a synergistic combination of ethylhexylglycerin and preservatives.
PubMed:A unique water optional health care personnel handwash provides antimicrobial persistence and residual effects while decreasing the need for additional products.
PubMed:Risk assessment of hand washing efficacy using literature and experimental data.
PubMed:Diazepam submicron emulsions containing soya-bean oil and intended for oral or rectal delivery.
PubMed:New drug approvals in 1998.
PubMed:Different responses of planktonic and attached Bacillus subtilis and Pseudomonas fluorescens to sanitizer treatment.
PubMed:Latest FDA approvals for dentistry.
PubMed:Development and evaluation of a new alcohol-based surgical hand scrub formulation with persistent antimicrobial characteristics and brushless application.
PubMed:Clinical efficacy of a chlorous acid preoperative skin antiseptic.
PubMed:Caries diagnosis and risk assessment. A review of preventive strategies and management.
PubMed:Identification and isolation of chlorhexidine digluconate impurities.
PubMed:Efficacy evaluations on five chlorhexidine teat dip formulations.
PubMed:How the FDA and the ADA affect development of prescription drugs for oral care.
PubMed:Quantitative relationship between oral nitrate-reducing activity and the endogenous formation of N-nitrosoamino acids in humans.
PubMed:Problems affecting the liquid chromatographic quantitation of chlorhexidine digluconate in ophthalmic solutions.
PubMed:Importance of neutralizers in the stripping fluid in a simulated healthcare personnel handwash.
PubMed:Evaluation of the skin disinfecting activity and cumulative effect of chlorhexidine and triclosan handwash preparations on hands artificially contaminated with Serratia marcescens.
PubMed:Comparison of the in vivo and in vitro antibacterial properties of antiseptic mouthrinses containing chlorhexidine, alexidine, cetyl pyridinium chloride and hexetidine. Relevance to mode of action.
 
Notes:
None found
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