EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

bisacodyl
(4-((4-acetyloxyphenyl)-pyridin-2-ylmethyl)phenyl) acetate

Supplier Sponsors

Name:[4-[(4-acetyloxyphenyl)-pyridin-2-ylmethyl]phenyl] acetate
CAS Number: 603-50-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:210-044-4
FDA UNII: 10X0709Y6I
Nikkaji Web:J3.307C
Beilstein Number:0323727
MDL:MFCD00038039
XlogP3-AA:3.80 (est)
Molecular Weight:361.39723000
Formula:C22 H19 N O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 133.50 °C. @ 760.00 mm Hg
Boiling Point: 492.33 °C. @ 760.00 mm Hg (est)
Vapor Pressure:4.800000 mmHg @ 25.00 °C. (est)
Flash Point: 485.00 °F. TCC ( 251.60 °C. ) (est)
logP (o/w): 3.453 (est)
Soluble in:
 water, 139.2 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
American International Chemical, LLC.
Bisacodyl
BOC Sciences
For experimental / research use only.
Bisacodyl >98%
Odor: characteristic
Use: Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement.Bisacodyl works by stimulating enteric nerves to cause colonic contractions.
Penta International
BISACODYL USP
Sarchem Laboratories
For experimental / research use only.
Bisacodyl
Sigma-Aldrich
For experimental / research use only.
Bisacodyl
analytical standard, for drug analysis
Universal Preserv-A-Chem Inc.
BISACODYL USP
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-cat LDLo 40 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 19, 1953.

oral-dog LD50 > 15000 mg/kg
Drugs in Japan Vol. -, Pg. 854, 1990.

intravenous-dog LDLo 40 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 19, 1953.

oral-mouse LD50 17500 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: ATAXIA BLOOD: HEMORRHAGE
Toxicology and Applied Pharmacology. Vol. 2, Pg. 243, 1960.

intravenous-mouse LDLo 80 mg/kg
Toxicology and Applied Pharmacology. Vol. 2, Pg. 243, 1960.

intravenous-rabbit LDLo 40 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 3, Pg. 19, 1953.

oral-rat LD50 4320 mg/kg
BLOOD: CHANGES IN SPLEEN GASTROINTESTINAL: OTHER CHANGES BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Toxicology and Applied Pharmacology. Vol. 2, Pg. 243, 1960.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for bisacodyl usage levels up to:
 not for fragrance use.
 
Recommendation for bisacodyl flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):603-50-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :2391
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
[4-[(4-acetyloxyphenyl)-pyridin-2-ylmethyl]phenyl] acetate
Chemidplus:0000603509
RTECS:SM8750000 for cas# 603-50-9
 
References:
 [4-[(4-acetyloxyphenyl)-pyridin-2-ylmethyl]phenyl] acetate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):2391
Pubchem (sid):134976919
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D00245
HMDB (The Human Metabolome Database):Search
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•complex with tannin: bisacodyl tannex; clysodrast. •bisacodyl is available in an enteric-coated preparation given once daily, the usual oral dose for which is 10 to 15 mg for adults and 5 to 10 mg for children 6 to 12 years old. •bisacodyl enema is supplied in a 1.25 fluid ounce (37 ml) ready-to-use squeeze bottle. •bisacodyl stimulant laxative tablets are supplied in cartons of 25 tablets (5 mg each tablet) wrapped in a foil seal. •bisacodyl suppositories are supplied in cartons of 4 individually foil-wrapped suppositories.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 acetic acid 4-[(4-acetoxy-phenyl)-pyridin-2-yl-methyl]-phenyl ester
bis(p-acetoxyphenyl)-2-pyridylmethane
 acetphenolpicoline
4-[(4-acetyloxyphenyl)-2-pyridylmethyl]phenyl acetate
(4-((4-acetyloxyphenyl)-pyridin-2-ylmethyl)phenyl) acetate
[4-[(4-acetyloxyphenyl)-pyridin-2-ylmethyl]phenyl] acetate
 bisacodyl USP
 brocalax
 broxalax
 di-(4-acetoxyphenyl)-2-pyridylmethane
 di-(p-acetoxyphenyl)-2-pyridylmethane
(4,4'-diacetoxydiphenyl)(2-pyridyl)methane
2-(4,4'-diacetoxydiphenylmethyl)pyridine
4,4'-diacetoxydiphenylpyridyl-2-methane
 dulcolan
 dulcolax
 durolax
 endokolat
 eulaxan
 fenilaxan
 godalax
 hillcolax
 ivilax
 laxadin
 laxagetten
 laxanin N
 laxans
 laxine
 laxorex
 neolax
 nigalax
 perilax
(pyridin-2-ylmethanediyl)dibenzene-4,1-diyl diacetate
(pyridin-2-ylmethylene)bis(4,1-phenylene) diacetate
(pyridin-2-ylmethylene)di-4,1-phenylene diacetate
(2-pyridinylmethylene)di-4,1-phenylene diacetate
4,4'-(2-pyridylmethylene)bisphenol diacetate
 pyrilax
 sanvacual
 telemin
 theralax
 ulcolax
 zetrax
 

Articles:

PubMed:Component analysis of Pu-erh and its anti-constipation effects.
PubMed:Monitoring of 29 weight loss compounds in foods and dietary supplements by LC-MS/MS.
PubMed:Preventive effect of resistant starch on activated carbon-induced constipation in mice.
PubMed:Ion mobility spectrometry for the rapid analysis of over-the-counter drugs and beverages.
PubMed:Constipation in people prescribed opioids.
PubMed:Constipation in adults.
PubMed:Effect of bisacodyl on postoperative bowel motility in elective colorectal surgery: a prospective, randomized trial.
PubMed:Influence of thoracic epidural analgesia on postoperative pain relief and ileus after laparoscopic colorectal resection : Benefit with epidural analgesia.
PubMed:Constipation in adults.
PubMed:Constipation in people prescribed opioids.
PubMed:A prospective study to assess the efficacy and patient tolerance of three bowel preparations for colonoscopy.
PubMed:A prospective study comparing oral sodium phosphate solution to a bowel cleansing preparation with nutrition food package in children.
PubMed:Efficacy of bowel preparation with the use of a prepackaged, low fibre diet with a low sodium, magnesium citrate cathartic vs. a clear liquid diet with a standard sodium phosphate cathartic.
PubMed:Physiologic effects of bowel preparation.
PubMed:Results of 24-h manometric recording of colonic motor activity with endoluminal instillation of bisacodyl in patients with severe chronic slow transit constipation.
PubMed:Dietary potassium and laxatives as regulators of colonic potassium secretion in end-stage renal disease.
PubMed:The prevalence of constipation in institutionalized people with intellectual disability.
PubMed:Randomised trial of two pharmacological methods of bowel preparation for day case colonoscopy.
PubMed:Abdominal ultrasonography: improved image quality with the combined use of a diet and laxatives.
PubMed:[Prospective study of preparation for colon double-contrast studies with enemas compared to oral mannitol/Na-picosulfate administration with the same diet].
PubMed:Low residual diet and hydration improving double contrast examination of the colon.
PubMed:Comparison of three bowel management programs during rehabilitation of spinal cord injured patients.
 
Notes:
a diphenylmethane stimulant laxative used for the treatment of constipation and for bowel evacuation. (from martindale, the extra pharmacopoeia, 30th ed, p871)
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