calcium disodium edetate
calcium disodium EDTA
 
Notes:
a chelating agent (chelating agents) that sequesters a variety of polyvalent cations. it is used in pharmaceutical manufacturing and as a food additive. Preservative and sequestrant in foods Ethylenediaminetetraacetic acid, widely abbreviated as EDTA, is a polyamino carboxylic acid and a colourless, water-soluble solid. Its conjugate base is named ethylenediaminetetraacetate. It is widely used to dissolve limescale. Its usefulness arises because of its role as a hexadentate ("six-toothed") ligand and chelating agent, i.e. its ability to "sequester" metal ions such as Ca2+ and Fe3+. After being bound by EDTA, metal ions remain in solution but exhibit diminished reactivity. EDTA is produced as several salts, notably disodium EDTA and calcium disodium EDTA. (Wikipedia)
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      A0235 CALCIUM DISODIUM EDETATE
       
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      05-00195 EDETATE CALCIUM DISODIUM
       
Synonyms   Articles   Notes   Search
calcium disodium 2-[2-[bis(2-oxido-2-oxoethyl)amino]ethyl-(2-oxido-2-oxoethyl)amino] acetate (Click)
CAS Number: 62-33-9Picture of molecule
Other: 100333-49-1
ECHA EINECS - REACH Pre-Reg: 200-529-9
FDA UNII: 8U5D034955
MDL: MFCD00148919
Molecular Weight: 374.27077856
Formula: C10 H12 Ca N2 Na2 O8
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: sequestrant, preservative
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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Google Patents: Search
US Patents: Search
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Pubchem Patents: Search
PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 363 Calcium disodium ethylenediaminetetraacetic acid (EDTA) and disodium EDTA View-notice PDF
EU SANCO Calcium disodium ethylene diamine tetra-acetate (Calcium disodium EDTA) View-review
GRN 573 Calcium disodium ethylenediaminetetraacetate (EDTA) View-notice
JECFA Food Additive: Calcium Disodium Ethylenediaminetetraacetate
GSFA Codex: Calcium disodium ethylenediaminetetraacetate (385)
DG SANTE Food Additives: calcium disodium EDTA
FDA Mainterm: EDTA, CALCIUM DISODIUM
FDA Regulation:
FDA PART 155 -- CANNED VEGETABLES
Subpart B--Requirements for Specific Standardized Canned Vegetables
Sec. 155.200 Certain other canned vegetables.


FDA PART 155 -- CANNED VEGETABLES
Subpart B--Requirements for Specific Standardized Canned Vegetables
Sec. 155.201 Canned mushrooms.


FDA PART 161 -- FISH AND SHELLFISH
Subpart B--Requirements for Specific Standardized Fish and Shellfish
Sec. 161.173 Canned wet pack shrimp in transparent or nontransparent containers.


FDA PART 166 -- MARGARINE
Subpart B--Requirements for Specific Standardized Margarine
Sec. 166.110 Margarine.


FDA PART 169 -- FOOD DRESSINGS AND FLAVORINGS
Subpart B--Requirements for Specific Standardized Food Dressings and Flavorings
Sec. 169.115 French dressing.


FDA PART 169 -- FOOD DRESSINGS AND FLAVORINGS
Subpart B--Requirements for Specific Standardized Food Dressings and Flavorings
Sec. 169.140 Mayonnaise.


FDA PART 169 -- FOOD DRESSINGS AND FLAVORINGS
Subpart B--Requirements for Specific Standardized Food Dressings and Flavorings
Sec. 169.150 Salad dressing.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart B--Food Preservatives
Sec. 172.120 Calcium disodium EDTA.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart B--Food Preservatives
Sec. 172.135 Disodium EDTA.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.170 Components of paper and paperboard in contact with aqueous and fatty foods.


FDA PART 73 -- LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION
Subpart A--Foods
Sec. 73.1 Diluents in color additive mixtures for food use exempt from certification.
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Physical Properties:
Appearance: white crystalline powder (est)
Assay: 97.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 613.00 to  615.00 °C. @ 760.00 mm Hg
Flash Point: 617.00 °F. TCC ( 325.00 °C. )
logP (o/w): -0.434 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Insoluble in:
 alcohol
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Organoleptic Properties:
Odor Description:
at 100.00 %. 
odorless
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: chelating agents
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Suppliers:
M&U International
CALCIUM DISODIUM EDETATE
Penta International
EDETATE CALCIUM DISODIUM
Prinova
Edta Ca-10 Calcium Disodium
Sigma-Aldrich: Sigma
For experimental / research use only.
Ethylenediaminetetraacetic acid calcium disodium salt
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  10000 mg/kg
Toxicology and Applied Pharmacology. Vol. 5, Pg. 142, 1963.

intravenous-rat LD50  3000 mg/kg
Compilation of LD50 Values of New Drugs.

intraperitoneal-rat LD50  3850 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 117, Pg. 20, 1956.

oral-rabbit LD50  7000 mg/kg
Toxicology and Applied Pharmacology. Vol. 5, Pg. 142, 1963.

oral-dog LD50  12000 mg/kg
Toxicology and Applied Pharmacology. Vol. 5, Pg. 142, 1963.

unreported-mammal (species unspecified) LD50  3000 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 8(7), Pg. 35, 1964.

intraperitoneal-mouse LD50  4500 mg/kg
Compilation of LD50 Values of New Drugs.

oral-mouse LD50  10000 mg/kg
Drugs in Japan Vol. -, Pg. 188, 1990.

intraperitoneal-rabbit LD50  6000 mg/kg
Drugs in Japan Vol. -, Pg. 188, 1990.

intravenous-rabbit LDLo  4000 mg/kg
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 11, Pg. 321, 1952.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: sequestrant, preservative
Recommendation for calcium disodium edetate usage levels up to:
 not for fragrance use.
 
Recommendation for calcium disodium edetate flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 62-33-9
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 6109
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 calcium disodium 2-[2-[bis(2-oxido-2-oxoethyl)amino]ethyl-(2-oxido-2-oxoethyl)amino] acetate
Chemidplus: 0000062339
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References:
 calcium disodium 2-[2-[bis(2-oxido-2-oxoethyl)amino]ethyl-(2-oxido-2-oxoethyl)amino] acetate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 62-33-9
Pubchem (cid): 6109
Pubchem (sid): 134971364
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
KEGG (GenomeNet): D07934
HMDB (The Human Metabolome Database): Search
FooDB: FDB000747
Haz-Map: View
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Formulations/Preparations:
•calcium disodium versenate injection, 5 ml ampul containing 200 mg of edetate calcium disodium per ml (1 g per ampul), in boxes containing 6 ampuls. •the food- and pharmaceutical-grade chemical is a mixture of the dihydrate and trihydrate of calcium disodium edta (predominantly the dihydrate), and contains not less than 97.0% and not more than 100.2% of c10h12can2na2o8, calculated on the anhydrous basis. •grades: usp, fcc
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 chelating agents 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 acetic acid, (ethylenedinitrilo)tetra-, calcium disodium salt
 calciate(2-), ((ethylenedinitrilo)tetraacetato)-, disodium
 calciate(2-), ((N,N'-1,2-ethanediylbis(N-((carboxy-kappaO)methyl)glycinato-kappaN,kappaO))(4-))-, disodium, (OC-6-21)-
 calciate(2-), ((N,N'-1,2-ethanediylbis(N-(carboxymethyl)glycinato))(4-)-N,N',O,O',O(N),O(N'))-, disodium, (OC-6-21)-
 calciate(2-), ((N,N'-1,2-ethanediylbis(N-(carboxymethyl)glycinato))(4-)-N,N',O,O',ON,ON')-, disodium, (OC-6-21)- (9CI)
 calciate(2-), ((N,N'-1,2-ethanediylbis(N-(carboxymethyl)glycinato))(4-)-N,N',O,O',ON,ON'), disodium, (OC-6-21)-
 calciate(2-), [[N,N'-1,2-ethanediylbis[N-(carboxymethyl)glycinato]](4-)-N,N',O,O',ON,ON']-, disodium, hydrate, (OC-6-21)-
 calcium disodium 2-[2-[bis(2-oxido-2-oxoethyl)amino]ethyl-(2-oxido-2-oxoethyl)amino] acetate
 calcium disodium 2,2',2'',2'''-(ethane-1,2-diylbis(azanetriyl))tetraacetate
 calcium disodium 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate
 calcium disodium edathamil
 calcium disodium EDTA
monocalcium disodium EDTA
 calcium disodium ethylene diamine tetraacetate
 calcium disodium ethylenediaminetetraacetate
 calcium disodium versenate
 calcium disodium(ethylenedinitrilo)tetraacetate
 calcium edetate sodium
 calcium sodium 2,2',2'',2'''-(1,2-ethanediyldinitrilo)tetraacetate (1:2:1)
 calcium sodium 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate (1:2:1)
 calcium sodium edetate
 calcium sodium EDTA
 calcium titriplex
 calciumdisodiumedetatedihydrate
 disodium ((ethylenedinitrilo)tetraacetato)calciate
 disodium calcium EDTA
 disodium calcium ethylenediaminetetraacetate
 disodium monocalcium EDTA
 edathamil calcium disodium
 edetate calcium disodium
 edetic acid calcium disodium salt
 edetic acid, calcium disodium salt
 EDTA Ca-10 calcium disodium
 EDTA calcium derivative disodium salt
 EDTA calcium disodium
 EDTA calcium disodium salt
 EDTA disodium calcium salt
[[N,N'-1,2-ethanediylbis[N-(carboxymethyl)glycinato]](4-)-N,N',O,O',O N,ON']calciate(2-)disodium
 ethylene diamine tetraacetic acid, disodium calcium salt
 ethylenediaminete traacetic acid,disodium calcium salt
 ethylenediaminetetraacetic acid calcium disodium salt
 ethylenediaminetetraacetic acid calcium disodium salt (1:1:2)
 ethylenediaminetetraacetic acid, calcium disodium chelate
 ethylenediaminetetraacetic acid, calcium disodium salt
[(ethylenedinitrilo)tetraacetato]calciate(2-) disodium
(ethylenedinitrilo)tetraacetic acid calcium disodium salt
 glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-, calcium sodium salt (1:1:2)
 sodium calcium edetate
 sodium calciumedetate
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Articles:
Info: EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS
PubMed: [A peculiar lead poisoning: a concern of team achievement].
PubMed: Mercury vapor inhalation and poisoning of a family.
PubMed: Edetate calcium disodium nanoparticle dry powder inhalation: a novel approach against heavy metal decorporation.
PubMed: Metal chelation therapy in rheumathoid arthritis: a case report. Successful management of rheumathoid arthritis by metal chelation therapy.
PubMed: A comparison of sodium calcium edetate (edetate calcium disodium) and succimer (DMSA) in the treatment of inorganic lead poisoning.
PubMed: [Cutaneous EBV-associated lymphoproliferative disorder in a dermatomyositis treated with immunosuppressive agents].
PubMed: Pediatric fatality secondary to EDTA chelation.
PubMed: Quadriplegia due to lead-contaminated opium--case report.
PubMed: Antidotes and their availability in South Africa.
PubMed: Lead toxicity and chelation therapy.
PubMed: Low-level environmental exposure to lead and progressive chronic kidney diseases.
PubMed: Comparative in vitro efficacies of various catheter lock solutions.
PubMed: [Severe lead intoxication after ingestion of lead shots].
PubMed: Calcium disodium edetate enhances type A monoamine oxidase activity in monkey brain.
PubMed: Oral treatment of avian lead intoxication with meso-2,3-dimercaptosuccinic acid.
PubMed: Severe congenital lead poisoning in a preterm infant due to a herbal remedy.
PubMed: Lead poisoning and chelation in a mother-neonate pair.
PubMed: A case of lead poisoning due to snooker chalk.
PubMed: Lightening the lead load in children.
PubMed: A phase II study of [90Y] yttrium-capromab pendetide in the treatment of men with prostate cancer recurrence following radical prostatectomy.
PubMed: Influence of combined therapeutic potential of meso 2,3-dimercaptosuccinic acid and calcium disodium edetate on lead-induced testicular alterations in rats.
PubMed: Effect of edetate calcium disodium on yttrium-90 activity in bone of mice.
PubMed: Localization of indium-111 in human malignant tumor xenografts and control by chelators.
PubMed: Mobilization of lead from bone in end-stage renal failure patients with secondary hyperparathyroidism.
PubMed: Urinary excretion of essential metals following intravenous calcium disodium edetate: an estimate of free zinc and zinc status in man.
PubMed: Back pain following epidural anesthesia with 2-chloroprocaine (EDTA-free) or lidocaine.
PubMed: Compared effects of high oral Mg supplements and of EDTA chelating agent on chronic lead intoxication in rabbits.
PubMed: [Possible role of the immune system in lead peripheral polyneuropathy. Case report].
PubMed: Purine metabolism in patients with gout: the role of lead.
PubMed: Lead and the kidney: nephropathy, hypertension, and gout.
PubMed: Moderate lead poisoning: trends in blood lead levels in unchelated children.
PubMed: The efficacy of chelation therapy and factors influencing mortality in lead intoxicated petrol sniffers.
PubMed: Combined therapeutic potential of meso-2,3-dimercaptosuccinic acid and calcium disodium edetate on the mobilization and distribution of lead in experimental lead intoxication in rats.
PubMed: Therapeutic efficacy of combined meso 2,3-dimercaptosuccinic acid and calcium disodium edetate treatment during acute lead intoxication in rats.
PubMed: Lead mobilization test in children with lead poisoning: validation of a 5-hour edetate calcium disodium provocation test.
PubMed: Does lead play a role in the development of renal insufficiency in some patients with essential hypertension?
PubMed: Declining blood lead levels and cognitive changes in moderately lead-poisoned children.
PubMed: Lead nephropathy, gout, and hypertension.
PubMed: [Late changes in renal function after lead poisoning and chelation therapy].
PubMed: Chelation therapy to treat lead toxicity in children.
PubMed: Chelated lead and bone lead.
PubMed: Ten cases of acute lead intoxication among bridge workers in Louisiana.
PubMed: Effects of iron deficiency on lead excretion in children with moderate lead intoxication.
PubMed: Dose-response study of oral 2,3-dimercaptosuccinic acid in children with elevated blood lead concentrations.
PubMed: Lead intoxication in Sydney Harbour Bridge workers.
PubMed: Mobilization of lead by calcium disodium edetate. A reappraisal.
PubMed: Chelation in metal intoxication XXVI : Influence of thiamine on the therapeutic efficacy of calcium disodium edetate in lead intoxication.
PubMed: Influence oe calcium disodium edetate on the toxic effects of lead administration in pregnant rats.
PubMed: Calcinosis at the site of leakage from extravasation of calcium disodium edetate intravenous chelator therapy in a child with lead poisoning.
PubMed: Childhood lead toxicity and impaired release of thyrotropin-stimulating hormone.
PubMed: In vivo cytotoxicity assays with 111In-labeled tumor cells: comparison with [125I]iododeoxyuridine-labeled cells and effects of chelators and inoculation site.
PubMed: Improved tumor localization of 111In labeled monoclonal antibody with chelator administration to host nude mice.
PubMed: Lead intoxication.
PubMed: Slow, natural reduction in blood lead level after chelation therapy for lead poisoning in childhood.
PubMed: Icterus and amaurosis caused by lead poisoning in a cynomolgus monkey (Macaca fascicularis).
PubMed: Urinary lead excretion in uremic patients.
PubMed: The fall of zinc protoporphyrin levels in workers treated for chronic lead intoxication.
PubMed: Adult lead poisoning.
PubMed: 111Indium labeling of cultured human tumor cells.
PubMed: Chronic renal failure with gout: a marker of chronic lead poisoning.
PubMed: Determination of cytotoxicity in vivo using 111indium-labeled human tumor cells.
PubMed: Calcium binding by radiopaque media.
PubMed: Acute zinc chloride ingestion in a young child.
PubMed: Evaluation of lead, zinc, and copper excretion in chronic moonshine drinkers.
PubMed: Short-term administration of dimercaptopropanol (BAL) and calcium disodium edetate (EDTA) for diagnostic and therapeutic lead mobilization.
PubMed: [Preliminary results of an atiepizootic field test using EDTA-Na extract vaccine from Escherichia coli strains pathogenic to swine in swine production industrial units].
PubMed: Ventricular fibrillation from diatrizoate with and without chelating agents.
PubMed: Lead, zinc, and erythrocyte delta-aminolevulinic acid dehydratase: relationships in lead toxicity.
PubMed: Lead poisoning in sandhill cranes.
PubMed: Chronic industrial exposure to lead in 63 subjects. II. Evaluation of chelation therapy.
PubMed: Automated method for determining calcium disodium edetate in iodinated contrast media parenterals.
PubMed: [Chronic nephropathy in saturnism. Comparative elimination of lead by classic chelating agents and peritoneal dialysis].
PubMed: The effect of intravital chelation with dimercaprol, calcium disodium edetate, 1-10-phenantroline and 2,2'-dipyridyl on the sulfide silver stainability of the rat brain.
PubMed: Calcium disodium edetate nephrosis in female rats of varying ages.
PubMed: Treatment of lead intoxication. Combined use of peritoneal dialysis and edetate calcium disodium.
PubMed: Severe nephrosis in older male rats given calcium disodium edetate.
PubMed: Calcium disodium edetate nephrosis in inbred rats. Variation in Marshall, Buffalo, Fischer, and ACI strains.
PubMed: LEAD POISONING DURING PREGNANCY. FETAL TOLERANCE OF CALCIUM DISODIUM EDETATE.
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