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vincamine
eburnamenine-14-carboxylic acid, 14,15-dihydro-14-hydroxy-, methyl ester, (3alpha,14beta,16.)

Supplier Sponsors

CAS Number: 1617-90-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:216-576-3
FDA UNII: 996XVD0JHT
Nikkaji Web:J7.533G
MDL:MFCD00078054
Molecular Weight:354.44982000
Formula:C21 H26 N2 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:yellow crystals (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 231.50 °C. @ 760.00 mm Hg
Boiling Point: 508.90 °C. @ 760.00 mm Hg (est)
Flash Point: 503.00 °F. TCC ( 261.60 °C. ) (est)
logP (o/w): 3.100 (est)
Soluble in:
 water, 61.79 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Vincamine >98%
ExtraSynthese
For experimental / research use only.
Vincamine (HPLC) ≥90%
Glentham Life Sciences
Vincamine
Santa Cruz Biotechnology
For experimental / research use only.
Vincamine
Sigma-Aldrich: Aldrich
For experimental / research use only.
Vincamine 98%
TCI AMERICA
For experimental / research use only.
Vincamine >98.0%(T)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 195 mg/kg
European Patent Application. Vol. #0052238

intravenous-mouse LD50 47740 ug/kg
Agressologie. Revue Internationale de Physio-Biologie et de Pharmacologie Appliquees aux Effets de l'Agression. Vol. 19, Pg. 211, 1978.

oral-mouse LD50 460 mg/kg
United States Patent Document. Vol. #4011330

intravenous-rabbit LD50 33 mg/kg
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 236, Pg. 296, 1959.

intraperitoneal-rat LD50 253 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 601, 1982.

oral-rat LD50 1200 mg/kg
United States Patent Document. Vol. #3852453

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for vincamine usage levels up to:
 not for fragrance use.
 
Recommendation for vincamine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :15376
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0001617909
RTECS:YY8575000 for cas# 1617-90-9
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):15376
Pubchem (sid):134979517
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C09251
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2939.79.0000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
 anasclerol
 angiopac
 arteriovinca
 decincan
 devincan
 devinkan
14,15-dihydro-14-hydroxyeburnamenine-14-carboxylic acid methyl ester
 eburnamenine-14-carboxylic acid, 14,15-dihydro-14-hydroxy-, methyl ester, (3alpha,14beta,16.)
 equipur
 methyl vincaminate
 minorin
 minorine
 novicet
 ocu-vinc
 oxygeron
 perval
 pervincamine
 pervone
 tripervan
 vinca-ecobi
 vincachron
 vincadar
 vincafolina
 vincafor
 vincagil
 vincamidol
 vincamin
(+)-vincamine
 vincaminum
 vincapan
 vincapront
 vincasaunier
 vincimax
 vinkametrin
 vinodrel retard
 

Articles:

PubMed:Over-expression of Catharanthus roseus tryptophan decarboxylase and strictosidine synthase in rol gene integrated transgenic cell suspensions of Vinca minor.
PubMed:Regulation of vincamine biosynthesis and associated growth promoting effects through abiotic elicitation, cyclooxygenase inhibition, and precursor feeding of bioreactor grown Vinca minor hairy roots.
PubMed:Synthesis of 15-methylene-eburnamonine from (+)-vincamine, evaluation of anticancer activity, and investigation of mechanism of action by quantitative NMR.
PubMed:Studies on the interaction between vincamine and human serum albumin: a spectroscopic approach.
PubMed:Transcranial Doppler assessment of cerebral vasomotor reactivity in evaluating the effects of vinpocetine in cerebral small vessel disease: a pilot study.
PubMed:Vinpocetine attenuates lipid accumulation and atherosclerosis formation.
PubMed:Mechanochemical activation of vincamine mediated by linear polymers: assessment of some "critical" steps.
PubMed:Brain targeted solid lipid nanoparticles for brain ischemia: preparation and in vitro characterization.
PubMed:Rationale of using Vinca minor Linne dry extract phytocomplex as a vincamine's oral bioavailability enhancer.
PubMed:Drug salt formation via mechanochemistry: the case study of vincamine.
PubMed:Vinpocetine suppresses pathological vascular remodeling by inhibiting vascular smooth muscle cell proliferation and migration.
PubMed:Mechanochemically induced disordered structures of vincamine: the different mediation of two cross-linked polymers.
PubMed:DNA binding studies of Vinca alkaloids: experimental and computational evidence.
PubMed:The vincamine derivative vindeburnol provides benefit in a mouse model of multiple sclerosis: effects on the Locus coeruleus.
PubMed:Phytochemical Investigation of Vinca minor Cultivated in Iran.
PubMed:[Tissue culture of Vinca minor and determination of vincamine].
PubMed:Deviation from van't Hoff dependence in RP-LC induced by tautomeric interconversion observed for four compounds.
PubMed:Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids.
PubMed:Vincamine-producing endophytic fungus isolated from Vinca minor.
PubMed:Aggressive behavior during social interaction in mice is controlled by the modulation of tyrosine hydroxylase expression in the prefrontal cortex.
PubMed:Separation of vinca alkaloid enantiomers by capillary electrophoresis applying cyclodextrin derivatives and characterization of cyclodextrin complexes by nuclear magnetic resonance spectroscopy.
PubMed:Antinociceptive effect of vinpocetine--a comprehensive survey.
PubMed:Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophora.
PubMed:Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent but PDE-independent mechanism.
PubMed:WITHDRAWN: Interventions for normal tension glaucoma.
PubMed:Brain trace element concentration of rats treated with the plant alkaloid, vincamine.
PubMed:Neuroprotective effects of vinpocetine and its major metabolite cis-apovincaminic acid on NMDA-induced neurotoxicity in a rat entorhinal cortex lesion model.
PubMed:Seco-tabersonine alkaloids from Tabernaemontana corymbosa.
PubMed:Development and validation of an adsorptive stripping voltammetric method for the quantification of vincamine in its formulations and human serum using a Nujol-based carbon paste electrode.
PubMed:Effects of Vinpocetine on mitochondrial function and neuroprotection in primary cortical neurons.
PubMed:Simultaneous determination of piracetam and vincamine by spectrophotometric and high-performance liquid chromatographic methods.
PubMed:Smart stability-indicating spectrophotometric methods for determination of binary mixtures without prior separation.
PubMed:Mitigation of nociception via transganglionic degenerative atrophy: possible mechanism of vinpocetine-induced blockade of retrograde axoplasmic transport.
PubMed:In vitro anticholinesterase activity of various alkaloids.
PubMed:Application of unsymmetrical indirect covariance NMR methods to the computation of the (13)C <--> (15)N HSQC-IMPEACH and (13)C <--> (15)N HMBC-IMPEACH correlation spectra.
PubMed:Synthesis of (+/-)-3H-epivincamine via a Rh(II)-triggered cyclization/cycloaddition cascade.
PubMed:Effect of vinpocetine on retrograde axoplasmic transport.
PubMed:Syntheses of vinca alkaloids and related compounds. 104. A concise synthesis of (-)-vincapusine.
PubMed:Development and application of an automated solution stability assay for drug discovery.
PubMed:Eburnamine derivatives and the brain.
PubMed:Measurement and pharmacokinetics of vincamine in rat blood and brain using microdialysis.
PubMed:Catalytic N-sulfonyliminium ion-mediated cyclizations to alpha-vinyl-substituted isoquinolines and beta-carbolines and applications in metathesis.
PubMed:Stability-indicating methods for determination of vincamine in presence of its degradation product.
PubMed:[11C]vinpocetine: a prospective peripheral benzodiazepine receptor ligand for primate PET studies.
PubMed:[Neuroprotection strategies: effect of vinpocetine in vitro oxidative stress models].
PubMed:Enhanced tail pinch-induced activation of catecholamine metabolism in the pericerulean area of RU 24722-treated rats.
PubMed:Interventions for normal tension glaucoma.
PubMed:Lipophilicity of vinpocetine and related compounds characterized by reversed-phase thin-layer chromatography.
PubMed:Vinpocetine is a potent blocker of rat NaV1.8 tetrodotoxin-resistant sodium channels.
PubMed:[Investigation of vasoactive agents with indole skeletons at Richter Ltd].
PubMed:[Open-angle glaucoma clinical presentation and management].
PubMed:Chiral HPLC separation and CD spectra of the enantiomers of the alkaloid tacamonine and related compounds.
PubMed:Separation of the four pairs of enantiomers of vincamine alkaloids by enantioselective high-performance liquid chromatography.
PubMed:Cerebroprotective drugs shorten the hypoxia-induced onset of electrical silence in unanesthetized rats.
PubMed:Capillary electrophoresis separation of vinpocetine and related compounds: prediction of electrophoretic mobilities in partly aqueous media.
PubMed:Singular subsets of locus coeruleus neurons may recover tyrosine hydroxylase phenotype transiently expressed during development.
PubMed:In vitro-in vivo correlation and comparative bioavailablity of vincamine in prolonged-release preparations.
PubMed:In situ examination of tyrosine hydroxylase activity in the rat locus coeruleus using (3',5')-[(3)H(2)]-alpha-fluoromethyl-tyrosine as substrate of the enzyme.
PubMed:Proton speciation and microspeciation of vinpocetine and related compounds in aqueous and biomimetic media.
PubMed:[Comparison of the effect of vincamine and nicergoline in the treatment of ischemic stroke].
PubMed:Effects of oral brovincamine on visual field damage in patients with normal-tension glaucoma with low-normal intraocular pressure.
PubMed:[Effects of brovincamine fumarate on choroidal blood volume in rabbits].
PubMed:Plasticity of tyrosine hydroxylase gene expression within BALB/C and C57Black/6 mouse locus coeruleus.
PubMed:[A new approach to the treatment of patients with circulatory encephalopathy].
PubMed:Controlled targeting of tyrosine hydroxylase protein toward processes of locus coeruleus neurons during postnatal development.
PubMed:Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors.
PubMed:Synthesis of vinca alkaloids and related compounds. Part 84. Sulfonamide derivatives of some vinca alkaloids with cardiovascular activity.
PubMed:Vincamine and vincanol are potent blockers of voltage-gated Na+ channels.
PubMed:Pharmacological modulations of adrenergic phenotype in medullary C2 and C3 cell groups of adult rat.
PubMed:Positive allosteric action of eburnamonine on cardiac muscarinic acetylcholine receptors.
PubMed:Tyrosine hydroxylase expression within Balb/C and C57black/6 mouse locus coeruleus. I. Topological organization and phenotypic plasticity of the enzyme-containing cell population.
PubMed:Ion-molecule reactions of oxygenated chemical ionization reagents with vincamine.
PubMed:[Blood flow changes in the optic nerve head of albino rabbits following intravenous administration of brovincamine fumarate, an improver of cerebral circulation and metabolism].
PubMed:Prevention of visual field defect progression with brovincamine in eyes with normal-tension glaucoma.
PubMed:Therapeutic efficacy of vincamine in dementia.
PubMed:Therapeutic approaches for memory impairments.
PubMed:Phenotypic characteristics of expressed tyrosine hydroxylase protein in the adult rat nucleus tractus solitarius: plasticity revealed by RU24722 treatment.
PubMed:RU24722 induces spatially organized phenotypic plasticity in the locus coeruleus.
PubMed:Calcium antagonistic vasodilator mechanisms of brovincamine fumarate studied in canine cerebral artery.
PubMed:[Experimental study of radiation protective efficacy of Vinca alkaloid drugs].
PubMed:Long-term effect of RU24722 on tyrosine hydroxylase in the rat locus coeruleus: differential effects of two enantiomeric forms.
PubMed:Further characterization of the long-term effect of RU24722 on tyrosine hydroxylase in the rat locus coeruleus.
PubMed:Protective action of vinpocetine against experimentally induced gastric damage in rats.
PubMed:[Drug-induced ventricular tachycardia].
PubMed:Synthesis and pharmacological evaluation of (nitrooxy)alkyl apovincaminates.
PubMed:Decrease in the reactivity of locus coeruleus neurons to hypotension after an increase in their tyrosine hydroxylase content: a subregional in vivo voltammetry study in the rat.
PubMed:Somatotopic organization of tyrosine hydroxylase expression in the rat locus coeruleus: long term effect of RU24722.
PubMed:Evaluation of the hepatotoxicological effects of a drug in an in vivo/in vitro model.
PubMed:Determination of vincamine in human plasma by high-performance liquid chromatography with ultraviolet detection.
PubMed:Effect of brovincamine on cerebral circulation and metabolism in internal carotid artery occlusion examined by positron emission tomography.
PubMed:Inhibitory action of brovincamine on catecholamine secretion from cultured bovine adrenal medullary cells: possible relation to its blocking action on Ca2+ channels.
PubMed:Effects of several cerebroprotective drugs on NMDA channel function: evaluation using Xenopus oocytes and [3H]MK-801 binding.
PubMed:Effects of vinburnine on experimental models of learning and memory impairments.
PubMed:Ontogeny of tyrosine hydroxylase concentration in locus coeruleus of newborn rats: long-term effects of RU24722.
PubMed:The pharmacotherapy of focal cortical ischaemia in the mouse.
PubMed:Pharmacokinetic aspects of the sublingual administration of vincamine.
PubMed:Drug test value by transcranial Doppler in the diagnosis of neurologic vascular diseases.
PubMed:Effects of aging and vincamine derivatives on pericapillary microenvironment: stereological characterization of the cerebral capillary network.
PubMed:3,4-Dihydroxyphenylacetic acid (DOPAC) as an index of noradrenaline turnover: effects of Hydergine and vincamine.
PubMed:[Comparison of antagonistic effects of several drugs on calcium current in a giant neuron of an African snail (Achatina fulica Férussac)].
PubMed:The families of cognition enhancers.
PubMed:Flunarizine. A reappraisal of its pharmacological properties and therapeutic use in neurological disorders.
PubMed:[The effect of modification of excipients for the bioavailability of vinburnine].
PubMed:Effects of brovincamine on stereological capillary parameters in adult and old Fischer-344 rats.
PubMed:Muscarinic receptor-mediated regulation of OM-853-enhanced dopamine release in striatum of rat.
PubMed:Trachealis responses induced by vincamine and vinpocetine; inhibition by indomethacin and Ca2+ dependence.
PubMed:Effect of (+/-)-methyl 3-ethyl-2,3,3a,4-tetrahydro-1H-indolo-[3,2,1-de] [1,5] naphthyridine-6-carboxylate hydrochloride (OM-853), a new vincamine analogue, on the metabolism and function of cerebral serotonergic neurons.
PubMed:RU 24722, a new eburnamine derivative, induces selective alterations in cerebral glucose utilization in freely moving rat.
PubMed:[The oral liquid form of vinburnine: biopharmaceutics].
PubMed:Double tracer autoradiographic method for sequential evaluation of regional cerebral perfusion.
PubMed:Filterability of human erythrocytes--drug induced prevention of aging in vitro.
PubMed:Long-term effects of RU24722 on tyrosine hydroxylase of the rat brain.
PubMed:Effect of various classes of drugs on complete ischemia induced by decapitation and cyanide intoxication in mice.
PubMed:Use of alveolar macrophages in antianoxic drug studies.
PubMed:Effect of vasodilators on hepatic microcirculation: a study of the inhibition of norepinephrine-induced vasoconstriction in the isolated perfused rat liver.
PubMed:[Measurement of brain tyrosine hydroxylase concentrations by quantitative autoradiography after transfer of soluble proteins to nitro-cellulose].
PubMed:[Effect of brovincamine fumarate on cerebral ischemia acutely induced by BLCL in SHRSR].
PubMed:Flow-cytometric studies with eleutherococcus senticosus extract as an immunomodulatory agent.
PubMed:Cerebroprotective effect of nicergoline and interference with the anti-hypoxic effect of prostacyclin.
PubMed:Protective effects of vinpocetine and structurally related drugs on the lethal consequences of hypoxia in mice.
PubMed:Effects of brovincamine on the stereological parameters of corticocerebral capillaries.
PubMed:Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents.
PubMed:Vinpocetine enhances retrieval of a step-through passive avoidance response in rats.
PubMed:Neocortical rhythmic slow activity during wakefulness and paradoxical sleep in rats.
PubMed:A comparison of some of the pharmacological properties of the new eburnamenine derivative vindeburnol with those of vincamine, vinburnine, dihydroergotoxine mesilate and nicergoline.
PubMed:Disposition kinetics and oral bioavailability of vincamine-loaded polyalkyl cyanoacrylate nanoparticles.
PubMed:[Effects of three cerebral vasodilators--nimodipine, nifedipine and vincamine on chemically-induced amnesia in rodents].
PubMed:[Nimodipine, nifedipine and vincamine improve amnesia induced by anisodine and sodium nitrite in rats and mice].
PubMed:[Low molecular weight dextrans (Rheomacrodex) in the therapy of inner ear hearing loss].
PubMed:[Effects of Ginkgo biloba extract on a cerebral ischemia model in gerbils].
PubMed:Determination of vincamine in plasma by high-performance liquid chromatography with voltammetric detection.
PubMed:[Evaluation of the activity of vindeburnol by spectral analysis of human EEG].
PubMed:Vinpocetine: nootropic effects on scopolamine-induced and hypoxia-induced retrieval deficits of a step-through passive avoidance response in rats.
PubMed:[Synthesis of octahydroindolo [2,3-a] quinolizine derivatives].
PubMed:[Vincamine in cerebrovascular insufficiency. Occupational medicine approaches in cerebral diseases].
PubMed:Capillary gas chromatographic determination of vincamine in plasma.
PubMed:[Effects of vincamine and a vincamine-papaverine combination on erythrocyte flexibility in diabetic patients].
PubMed:[Effects of a vincamine-papaverine combination on platelet aggregation in geriatric patients with glucose and/or lipid metabolism disorders].
PubMed:[Influence of nitrogenous fertilizer on the growth of Vinca minor].
PubMed:The metabolic fate of 11-bromo[15-3H]vincamine in man.
PubMed:Experimental cerebral infarction in Mongolian gerbils: effects of vincamine on lesion size, survival and behavior.
PubMed:Pharmacokinetics and metabolism of vincamine and related compounds.
PubMed:Biopharmaceutic and pharmacokinetic aspects of vincamine HCl.
PubMed:Cardiovascular effects of brovincamine and possible mechanisms involved.
PubMed:[Biopharmaceutics of vincamine salts after oral administration in humans].
PubMed:[Agents to improve cerebrovascular circulation and cerebral metabolism--brovincamine].
PubMed:[How the production of an alkaloid leads to tissue culture of higher plants. Assay of vincamine production].
PubMed:Effects of the new eburnamenine derivative RU 24722 on EEG recovery and cerebral energy metabolism after complete ischemia.
PubMed:In vivo effect of RU 24722 and drugs used for the treatment on senile cerebral insufficiency on rat brain ornithine decarboxylase.
PubMed:Alteration of enzymes in ageing human fibroblasts in culture. III. Modification of superoxide dismutase as an environmental and reversible process.
PubMed:Dose-response relationship of vindeburnol based on spectral analysis of posturographic recordings.
PubMed:Memory dysfunction and vigilance: neurophysiological and psychopharmacological aspects.
PubMed:Locus coeruleus as a target for psychogeriatric agents.
PubMed:Effect of a new eburnamine derivative, RU 24722, on the turnover of monoamines in mouse brain: selective and reversible decrease of noradrenaline.
PubMed:[Application of spectrum analysis of equilibration recordings (posturography) in clinical pharmacology of vindeburnol].
PubMed:Role of drugs in recovery of metabolic function of rat brain following severe hypoglycemia.
PubMed:Classification and determination of pharmacodynamics of a new antihypoxidotic drug, vinconate, by pharmaco-EEG and psychometry.
PubMed:[Biologic availability of vincamine from tablets with a hydrophilic matrix. II].
PubMed:The effects of vincamine on experimental cerebral infarction in Mongolian gerbils: a pilot study.
PubMed:[Comparative study of the in vitro availability of vincamine from delayed-release forms. 1].
PubMed:Effects of brovincamine on the autonomic nervous function in the dog and rat.
PubMed:Cerebral and cerebellar metabolic changes induced by drugs during the recovery period after profound hypoglycemia.
PubMed:Calcium antagonistic action involved in vasodilation by brovincamine.
PubMed:Preparation and in vivo studies of a new drug delivery system. Nanoparticles of alkylcyanoacrylate.
PubMed:Evaluation of the effect of vincamine teprosilate on behavioural performances of patients affected with chronic cerebrovascular disease.
PubMed:Acute i.v. vincamine teprosilate administration: quantified investigation in elderly subjects.
PubMed:Pharmaco-EEG study on vincamine and on teproside in patients with chronic cerebrovascular disease.
PubMed:Pharmacokinetic study of vincamine teprosilate.
PubMed:Vincamine TPS activity on glycoconjugate metabolism of the brain: effect on lysosomal enzymes.
PubMed:Cerebral antioedematous effect of Teproside and of some vincamine derivatives.
PubMed:The effects of bromvincamine and vincamine on regional cerebral blood flow and mental functions in patients with multi-infarct dementia.
PubMed:Potentiation of the anticonvulsant effects of antiepileptic drugs by "nootropics"; a potential new therapeutic approach.
PubMed:Effects induced by vincamine teprosilate on chronic cerebrovascular disease: preliminary results.
PubMed:Effect of ischaemia and pharmacological treatment on enzyme activities of cortical mitochondria and synaptosomes.
PubMed:[Determination of vincamine in Vinca minor].
PubMed:Determination of vincamine by high-performance liquid chromatography with dual-wavelength ultraviolet detection.
PubMed:Study on the anti-hypoxic effect of some drugs used in the pharmacotherapy of cerebrovascular disease.
PubMed:Pharmacokinetic study of two pharmaceutical preparations containing alkaloid vincamine administered orally to human subjects.
PubMed:The effect of some drugs with purported antianoxic effect on veratridine-induced purine release from isolated rat hypothalamic synaptosomes.
PubMed:[Synthesis of 1-ethyl-1,2,3,4,6,7-hexahydroindolo-[2,3a]-quinolizinium perchlorate, a key intermediate of vincamine].
PubMed:'Cerebroactive' drugs. Clinical pharmacology and therapeutic role in cerebrovascular disorders.
PubMed:Gas chromatographic assay of pramiracetam in human plasma using nitrogen specific detection.
PubMed:Alkaloids from Tabernaemontana psorocarpa.
PubMed:[Evaluation of the anti-platelet aggregation action of oxovinca in the diffuse vascular deterioration syndrome].
PubMed:Cerebro-circulatory effects of so-called 'vasodilators' in the anaesthetised rat.
PubMed:[Study of 2 antianoxic agents by a method of decreased barometric pressure: demonstration of a different rate of action].
PubMed:[Treatment of sudden deafness. Apropos of the parenteral and peroral administration of Cerebroxine].
PubMed:The efficacy of the cerebral metabolic enhancers in the treatment of senile dementia.
PubMed:[Nicergoline and steal effect in favor of zones of hypoperfusion in cerebral ischemic accidents].
PubMed:The metabolic fate of 11-bromo-[15-3H] vincamine in rats, dogs and humans.
PubMed:[Controlled clinical study on the activity of vincamine-teprosylate in the so-called aging brain syndrome].
PubMed:Vincamine: a psychogeriatric agent blocking synaptic potentiation in hippocampus.
PubMed:[12-Methoxy-17,18-dehydro-vincamine and 16-epi-isositsirikine, alkaloids from Tabernaemontana psorocarpa].
PubMed:[Effect of vincamine on blood viscosity].
PubMed:[Autoradiographic demonstration of the passage of vincamin through the blood-brain barrier].
PubMed:Determination of 11-bromovincamine in human plasma by high-performance liquid chromatography.
PubMed:[Multi-center study of Cetal retard. Results of 60 studies].
PubMed:[Clinical and Neuropsychological changes associated with vincamin treatment in cerebrovascular disease (author's transl)].
PubMed:Changes in mouse hepatocytes caused by vincamin. A thin-sectioning and freeze-fracture study.
PubMed:A new phthalidyl derivative of apovincaminic acid: (3 alpha,16 alpha)-eburnamenine-14 carboxylic acid phthalidyl ester (AF 698). A preliminary report on its chemical and pharmacological properties.
PubMed:The effect of vincamine, hydergine and piracetam on the firing rate of locus coeruleus neurons.
PubMed:Effects of agents used in the pharmacotherapy of cerebrovascular disease on the oxygen consumption of isolated cerebral mitochondria.
PubMed:[Treatment of acoustic traumatism with injectable vincamine. Random double blind clinical trial with a complementary comparative element (author's transl)].
PubMed:Cerebral vasodilators (second of two parts).
PubMed:[Cerebrovascular insufficiency. Diagnosis, therapy and control of its course].
PubMed:[Clinical evaluation of treatment with Vincimax in 60 cases of cerebral circulatory insufficiency].
PubMed:[Assay and bioavailability of vincamine (author's transl)].
PubMed:Rapid communication the activating activity of vincamine, piracetam, and hydergine on the activity of the noradrenergic neurons of the locus coeruleus.
PubMed:The effect of ischemia and pharmacological treatment evaluated on synaptosomes and purified mitochondria from rat cerebral cortex.
PubMed:[Effect of Bromovincamine on noradrenaline and 5-hydroxytryptamine contents, and glucose metabolism in rat brain: analysis using spontaneously hypertensive rats (SHR) (author's transl)].
PubMed:Effect of vincamine on some enzymatic activities from various areas of the beagle dog cerebral cortex.
PubMed:[Cerebral ischemic vasculopathy: clinical and thermographic study in patients treated with papaveroline].
PubMed:[In vitro dissolution test: evaluation criterion for prolonged release dosage forms vincamine example (author's transl)].
PubMed:[Experimental electropharmacologic studies of cerebral ischemia (author's transl)].
PubMed:Comparative in vitro evaluation of six commercial vincamine prolonged-release dosage forms.
PubMed:High-performance liquid chromatographic determination of vincamine.
PubMed:[Multi-center clinical study of the effects of a vasoregulatory-eumetabolic drug (vincamine hydrochloride) on the psychological symptoms of cerebrovascular insufficiency].
PubMed:High-performance liquid chromatography of eburnane alkaloids. I. Separation on reversed phases.
PubMed:Determination of vincamine in human plasma using automated high-performance liquid chromatography.
PubMed:Direct vascular effects of agents used in the pharmacotherapy of cerebrovascular disease on isolated cerebral vessels.
PubMed:[Therapeutic action of a combination of vincamine and piracetam in peripheral labyrinthine syndromes with a vascular component].
PubMed:[Cardiac toxicity of vincamine: a seven cases report of ventricular arrhythmias by parenteral administration of vincamine (author's transl)].
PubMed:The effect of Cavinton on cerebrovascular resistance and its use in ophthalmological patients. A double-blind trial.
PubMed:Contact sensitivity to vincamine tartrate.
PubMed:Cerebral blood flow: physiology, pathophysiology and pharmacological effects.
PubMed:[Parieval in 52 cases of internal ear deafness].
PubMed:Drug interference on some biochemical parameters of rat cerebral cortex during post-ischemic recovery.
PubMed:[Therapeutic use of a new vasoactive drug in cerebral vascular diseases in elderly patients].
PubMed:[Neuropsychologic evaluation of the action of oxovinca in the syndrome of diffuse deterioration of vascular origin (author's transl)].
PubMed:[Changes in the condition for the use of Cavinton and Devincan. New regulation concerning the prescription and use of these 2 drugs].
PubMed:[Pharmacologic modification of the circulation in the brain].
PubMed:[Successful resuscitation from sudden death caused by Cavinton].
PubMed:Effects of vincamine on EEG sleep patterns in man: a pilot study.
PubMed:Age-associated changes in deoxyglucose uptake in whole brain.
PubMed:The effect of an acute infusion of vincamine and ethyl apovincaminate on cerebral blood flow in healthy volunteers.
PubMed:[Medical treatment of acute disorders of cerebral circulation].
PubMed:Cerebral regulation-cerebral regulators.
PubMed:Metabolism of vincamine in the rat in vivo and in vitro.
PubMed:[The use of the Mongolian gerbil as a model for cerebrovascular involvement].
PubMed:[Severe ventricular arrhythmia following parenteral administration of vincamine. Predisposing factors in 6 cases].
PubMed:Age-dependent modification of drug interference on the enzymatic activities of the rat brain.
PubMed:[Double-blind controlled study of the effects of vincamine hydrochloride on some parameters of cardiovascular function in aged bronchopneumopathic patients].
PubMed:[Cerebroxine and the treatment of sudden deafness. Apropos of 2 representative cases].
PubMed:[Vincapront Retard in geriatrics. Results of a multicenter study on patients with organic psychoses].
PubMed:[Pathopharmacologic models of cerebral disorders].
PubMed:[Use of the anti-hypoxia agent vincamine in disorders of the blood supply in the eye].
PubMed:[Treatment of acoustic trauma with Cetal retard].
PubMed:[Drug therapy in cerebral disorders. A double-blind study with Cetal retard in aged subjects].
PubMed:[Efficacy of Cetal retard in cerebral insufficiency in general practice].
PubMed:[Evaluation of Cetal in patients with acute confusion].
PubMed:[Proof of the efficacy of parenteral Cetal in psychopathologic conditions after brain concussion].
PubMed:[Measurement of regional brain circulation by means of xenon 133 inhalation].
PubMed:[Controlled testing of vincamine with special reference to the flow properties of blood].
PubMed:[Therapy with cerebral anti-hypoxidotics].
PubMed:[Therapeutic influence of vincamine on impairment of cerebral performance in elderly patients. Results of a double-blind study (author's transl)].
PubMed:[High altitude insomnia. Efficacy of flunitrazepam].
PubMed:[Quantitative determination of drugs by in situ spectrophotometry of chromatograms for pharmacokinetic studies. I. Sulpiride and other benzamides, vincamine, naftazone (author's transl)].
PubMed:[The chronic, recurrent, cervical and lumbar vertebrae syndromes. Effect of vincamine depot in patients with chronic, recurrent, cervical and lumbar vertebrae syndromes].
PubMed:[Experience with the combination of vincamine and papaverine in chronic brain syndrome].
PubMed:[Vincamine in the therapy of cerebral vascular diseases in the aged].
PubMed:[Double-blind study of the therapeutic activity of cerebroxine in the treatment of chronic cerebral circulatory insufficiency].
PubMed:[Vincamine in cerebral arteriosclerosis: therapeutic effects evaluated clinically and by retinal fluoro-angiography].
PubMed:[Therapy of chronic cerebrovascular arteriosclerotic insufficiency in a geriatric patient].
PubMed:[Chronic, recurrent, cervical-spine syndrome. Therapeutic observations with vincamin-depot].
PubMed:Hydergine and vincamine derivative LD 4298 exhibit no anti-sickling properties in vitro.
PubMed:Pharmacokinetics of vinpocetine in humans.
PubMed:Comparative study of the clinical effect of vincamine versus papaverine given parenterally in the acute phase of stroke.
PubMed:[32P-incorporation in adenosine phosphates of the rat brain after oral application of vincamine for 2 weeks (author's transl)].
PubMed:[Propharmacopoea technical notes].
PubMed:The effect of a vincamine derivative on vegetative reactions provoked by labyrinth stimulation.
PubMed:[Verapamil and torsade de pointe (author's transl)].
PubMed:Influence of various vasodilatory drugs on the cerebral circulation in rabbits and rats.
PubMed:Autoradiographic evidence for passage of vincamine through the blood-brain barrier.
PubMed:Electronystagmographic study in rabbits on the vestibular effect of vincamine.
PubMed:Studies on the vincamine-papaverine association. VI. Interference with alpha receptors. Preliminary clinical evidence.
PubMed:Studies on the vincamine-papaverine association. V. Interference with alpha receptors. Experimental study.
PubMed:Cerebral metabolic and hemodynamic activities of l-eburnamonine in the anesthetized dog. A comparison with vincamine.
PubMed:[The effect of vincamine on vigilance disorders in the elderly (author's transl)].
PubMed:[Controlled clinical study of the effects of Anasclerol in hospitalized patients with cerebrovascular disorders].
PubMed:[Vincamine N4-mononitrate (author's transl)].
PubMed:[Interaction of vincamine on various effects of amphetamine at the central level].
PubMed:[Effect of vincamine on platelet respiration].
PubMed:[Metabolism of vincamine in the rat].
PubMed:Severe hypocapnia applied to study the effect of vincamine on cerebral circulation.
PubMed:Influence of vincamine and piracetam on sleep--waking pattern of the cat.
PubMed:[Effects of vincamine on the mesenteric circulation in the rat. Microcirculatory evaluation of the vasodilator activity of vincamine].
PubMed:[Respiratory effects of vincamine hydrochloride].
PubMed:[Cardiovascular action of vincamine hydrochloride].
PubMed:Pharmacological actions on hypoxic increase of rat brain cortex extracellular K+ ion.
PubMed:[Treatment of initial cerebrovascular insufficiency with vincamine. Polycentric research on 828 cases].
PubMed:[Absorption, distribution and elimination of vincamine hydrochloride in the rat].
PubMed:[Comparative study of 2 drugs used in the treatment of cerebral vascular insufficiency: I-Eburnamonine and Vincamine].
PubMed:Circulatory effect of several cerebral circulatory drugs in man, with special reference to aminophylline, papaverine, cyclandelate, vincamine, prostaglandin E1 and isoxsuprine.
PubMed:[Kinetic behavior of 3H-vincamine in man. Compartmental analysis].
PubMed:[Metabolic study of Vincamine in cranial trauma (author's transl)].
PubMed:[A case of "torsade de pointe" during vincamine therapy].
PubMed:Determination of vincamine in plasma by selected ion monitoring.
PubMed:Medical therapy of cerebral ischemia. Vasoactive and eumetabolic therapy.
PubMed:Assessment of pharmacological effects on cerebral blood flow.
PubMed:Cerebral metabolic, hemodynamic and antihypoxic properties of l-eburnamonine.
PubMed:Hydergine and vincamine derivative LD 4298 exhibit no anti-sickling properties in vitro.
PubMed:Studies on the vincamine-papaverine association iii. clinical use in cardiac patients.
PubMed:Studies on the vincamine-papaverine association ii. acute toxicity in experimental animals as a function of the speed of infusion.
PubMed:Studies on the vincamine-papaverine association. i. biochemical investigations.
PubMed:[Interpretation of mean dissolution kinetics in multidimentional analysis. Application to quinidine and vicamine preparations].
PubMed:[Blood levels of vincamine. Comparative study of vincamine in delayed and immediate actions].
PubMed:Central effects of vincamine in intact and "encéphale isolé" fowl preparations.
PubMed:Comparative evaluation of peripheral effects of vincamine and serotonin in various in vitro and in vivo preparations.
PubMed:The effect of vincamine on the regional cerebral blood flow in man.
PubMed:[Relative bioavailability of a vincamine retard formulation. Pharmacokinetic study in normal subjects (author's transl)].
PubMed:[Clinical, psychological and neurophysiological results of double-blind study on vincamine-cromesilate in patients with cerebro-vascular insufficiency (author's transl)].
PubMed:[Pharmacokinetics of multilayer vincamine dragees. Study of normal subjects].
PubMed:Comparative study of the clinical effects of vincamine + glycerol versus glycerol + placebo in the acute phase of stroke.
PubMed:[Demonstrating the effectiveness of cerebroactive drugs in aged patients. Results of a randomized double-blind study of a vincamine containing special preparation].
PubMed:[Effect of L-eburnamonine on bronchial respiratory resistance in the anesthetized guinea pig. Comparison with vincamine].
PubMed:[Modifications by 1-eburnamonine and vincamine on 2,3-diphosphoglycerate blood levels in the presence or absence of histotoxic hypoxia produced by potassium cyanide in the awake rat].
PubMed:Studies on the vincamine-papaverine association. IV. Interference with beta-receptors in experimental animals.
PubMed:Gas chromatographic method for the determination of vincamine in blood.
PubMed:[Disparity in the kinetics of vincamine and vincamine hydrochloride absorption in the rat].
PubMed:[Comparative study of vincamine and rutovincine (LJ 533) on the cerebral hyperemia in rats with chronic hypoxia].
PubMed:Multi-compartmental modeling and kinetic parameter identification of the systemic distribution of vincamine after oral administration in the rat and in the man.
PubMed:[Effect of vincamine on the fibrocellular smooth muscle].
PubMed:[Alerting effect of vincamine in rats (author's transl)].
PubMed:[Effect of vincamine on sleep-wakefulness equilibrium in the cat (author's transl)].
PubMed:[Comparative pharmacodynamic properties of apolar alkaloids of Vinca minor L. (Apocynaceae) (vincamine, vinca fraction and vinacamine free vinca fraction)].
PubMed:Hemodynamic profile of a new cerebral vasodilator, vincamine and of one of its derivatives, apovincaminic acid ethylester (RGH-4405).
PubMed:[Cerebral protecting activity of 1-eburnamonine studied on 3 models of acute hypoxic agression. Comparison with vincamine].
PubMed:[Experimental studies on the effects of vincamine and its analogues on cerebrovascular circulation].
PubMed:[Application of multicompartimental analysis to the pharmacokinetics of vincamine in man].
PubMed:[Effect of technologic factors on the release of vincamine incorporated into hydrophilic matrices].
PubMed:A new enantioselective total synthesis of natural vincamine via an intramolecular Mannich reaction of an silyl enol ether.
PubMed:[Pharmacology of vincamine and its derivatives].
PubMed:[Effects of vincamine on in vitro cultured nerve tissue of mice embryos].
PubMed:Influence of hypercapnia on the cerebrovascular activities of some drugs used in the treatment of cerebral ischemia.
PubMed:[The effect of vincamine on cerebral blood flow as a function of application rate (author's transl)].
PubMed:[On the influence of vincamine on human cerebral blood flow in the acute test. Studies with 133Xe clearance method (author's transl)].
PubMed:[The influence of vincamine on global and regional cerebral blood flow in acute and subchronic human cerebral ischimia (author's transl)].
PubMed:[Vincamine concentrations in plasma and cerebrospinal fluid in patients following intravenous infusion (author's transl)].
PubMed:[Plasma concentrations and renal excretion of vincamine after oral administration in man (author's transl)].
PubMed:[Cardiac effects of vincamine].
PubMed:[Fluorescence assay and pharmacokinetics of vincamine in rats (author's transl)].
PubMed:[Double-blind comparison of vincamine and placebo in patients with presbyacusis (author's transl)].
PubMed:[On the role of vincamine in the therapy of cerebrovascular diseases and impairment of cerebral function (author's transl)].
PubMed:Effect of Vincamine on CBF under pharmacokinetic aspects.
PubMed:The cerebral hemodynamic effect of Vincamine.
PubMed:[Study of the antihypoxic effect of eburnamonine in acute and recurrent anoxia on the cerebral electric activity in curarized rats. Comparison with vincamine].
PubMed:[On the pharmacokinetics of vincamine after i.v. and oral application to the dog (author's transl)].
PubMed:[Effect of vincamine, vinervine and serotonin on the sexual cycle in rats].
PubMed:[Effect of vincamine on the re-establishment of wakefulness after fluothane narcosis].
PubMed:[Specific assessment of the cerebral and cardiac effects of asphyxic hypoxia. Application to the study of substances with protective activity].
PubMed:In vivo antispasmodic activity of Sulcotidil.
PubMed:[Effects of vincamine treatment on cerebral arteriosclerotic vasculopathy].
PubMed:The synthesis of ethyl apovincaminate.
PubMed:[A cholinergic participation in the increase of cerebral cortical blood flow induced by vincamine (rat) (author's transl)].
PubMed:[Pharmacokinetic study of oral vincamine].
PubMed:[Experimental and clinical studies on various metabolic effects of vincamine].
PubMed:[Psychoactive effect of vincamine in a group of subjects affected by recurrent depressive syndrome. Preliminary note].
PubMed:[Gastrokinetic effect of Vincamine].
PubMed:[Stereoselective synthesis of optically active vincamine].
PubMed:[Vincamine in patients with cerebral vascular insufficiency].
PubMed:Indolizines II: search for potential oral hypoglycemic agents.
PubMed:[Vincamine in the treatment of cerebral circulatory insufficiency in old age].
PubMed:[Indole alkaloids induction of tremors: effect on photosensible epilepsy in Papiopapio].
PubMed:Letter: A high yield stereospecific total synthesis of vincamine.
PubMed:[Clinical, rheoencephalographic and ophthalmodynamographic double-blind studies of the effects of vincamine in the treatment of cerebrovascular diseases].
PubMed:[Vincamine in the treatment of minor ictus (due to transient cerebral ischemia)].
PubMed:[Letter: Syncope due to arrhythmia. Role of vincamine apropos of 3 observations].
PubMed:[Use of an original protocol in the study of the action of vincamine on cerebral metabolism].
PubMed:[Vincamine effects on cultured chicken fibroblasts in vitro].
PubMed:[Changes in cerebral electrogenesis caused by vincamine in the baboon, Papio papio].
PubMed:[Clinical and electroencephalographic results of a double-blind test with vincamine (Pervincamine) in advanced cerebral sclerosis (author's transl)].
PubMed:[Use of a cerebral oxygenator drug in chronic encephalopathies (apropos of the trial of vincamine)].
PubMed:[Effects of vincamine on patients with head injuries. Clinical and laboratorial studies of 50 cases].
PubMed:Studies on indole alkaloid biosynthesis. VI. The eburnamine-vincamine alkaloids.
PubMed:[Therapeutic trial of vincamine].
PubMed:Chemical structure and pharmacological properties of synthetic vincamine derivatives. I. Systemic circulatory effects.
PubMed:[Vinca minor L. alkaloids. II. On the decomposition products of vincamine].
PubMed:[Mechanism of the therapeutic effect of vincamine in disorders of the cerebral circulation].
PubMed:[Electroencephalographic study of the effect of vincamine on the central nervous systme in rabbits].
PubMed:The action of vincamine on the isolated trachea.
PubMed:[A micro-method for the determination of vincamine by thin-layer chromatography].
PubMed:Absolute configuration of vincamine and some other alkaloids of the eburnamonine type.
PubMed:THE ANALYSIS OF THE MODE OF ACTION OF VINCAMINE AND SOME OTHER DIHYDROEBURNAMENINE LIKE COMPOUNDS ON THE ISOLATED INTESTINE.
PubMed:Alterations in renal haemodynamics and urine flow in the dog after administration of vincamine. I.
PubMed:Alterations of renal haemodynamics and urine flow in the dog after administration of vincamine. II.
PubMed:The effect of vincamine on the blood pressure of the rat.
PubMed:[Pharmacology of substances isolated from Vinca minor L. I. Effect of vincamine on arterial blood pressure].
PubMed:[Various physiological properties of vincamine, a crystallized alkaloid of lesser periwinkle (Vinca minor L.)].
 
Notes:
a major alkaloid of vinca minor l., apocynaceae. it has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders.
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