EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

vinblastine sulfate
vincaleukoblastine, (2a,3a,4a,5b,19b)-, sulfate (1:1)

Supplier Sponsors

CAS Number: 143-67-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:205-606-0
FDA UNII: N00W22YO2B
Beilstein Number:3659812
MDL:MLS000069550
Molecular Weight:909.06680000
Formula:C46 H60 N4 O13 S
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:White to slightly yellow crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 211.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:1.030000 mmHg @ 25.00 °C. (est)
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 0.04458 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Vinblastine sulfate 98%
BOC Sciences
For experimental / research use only.
Vinblastine sulfate
Odor: characteristic
Use: Vinblastine sulfate, also called cellblastin, derived from C. roseus, as a microtubule disrupter and antineoplastic agent.
Coompo
For experimental / research use only.
Vinblastine Sulfate from Plants ≥98%
EMD Millipore
For experimental / research use only.
Vinblastine Sulfate
Glentham Life Sciences
Vinblastine sulfate
Santa Cruz Biotechnology
For experimental / research use only.
Vinblastine Sulfate ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Vinblastine Sulfate powder, ≥96% (HPLC)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-dog LDLo 500 ug/kg
BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii Vol. #3713-83

intraperitoneal-hamster LD50 4300 ug/kg
Cancer Letters Vol. 2, Pg. 267, 1977.

intravenous-human TDLo 557 ug/kg
BLOOD: LEUKOPENIA SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Cancer Chemotherapy Reports. Vol. 29, Pg. 111, 1963.

intraperitoneal-mouse LD50 2700 ug/kg
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 359, 1979.

intravenous-mouse LD50 9500 ug/kg
Cancer Research. Vol. 39, Pg. 3575, 1979.

oral-mouse LD50 423 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.

intraperitoneal-rat LD50 1 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii Vol. #3713-83

intravenous-rat LD50 37 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.

oral-rat LD50 305 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.

Dermal Toxicity:
subcutaneous-mouse LD50 324 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.

subcutaneous-rat LD50 355 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 68, 1969.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for vinblastine sulfate usage levels up to:
 not for fragrance use.
 
Recommendation for vinblastine sulfate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5388983
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0000143679
EPA/NOAA CAMEO:hazardous materials
RTECS:YY8400000 for cas# 143-67-9
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5388983
Pubchem (sid):134974081
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2939.90.5000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•parenteral injection, for iv use only 1 mgml, vinblastine sulfate injection (with benzyl alcohol 0.9%), abraxis; sterile, for iv use only 10 mg, bedford •vials, 10 mg vinblastine sulfate
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
 vinblastine sulphate
 vincaleucoblastine sulfate
 vincaleukoblastine sulfate (1:1)
(2a,3a,4a,5b,19b)-vincaleukoblastine sulfate (1:1)
 vincaleukoblastine, (2a,3a,4a,5b,19b)-, sulfate (1:1)
 vincaleukoblastine, sulfate (1:1)
 

Articles:

PubMed:Biochemical characterization and molecular dynamic simulation of β-sitosterol as a tubulin-binding anticancer agent.
PubMed:Identification of TGF-β-activated kinase 1 as a possible novel target for renal cell carcinoma intervention.
PubMed:Modulation in the expression of SHP-1, SHP-2 and PTP1B due to the inhibition of MAPKs, cAMP and neutrophils early on in the development of cerulein-induced acute pancreatitis in rats.
PubMed:Mirror-image organometallic osmium arene iminopyridine halido complexes exhibit similar potent anticancer activity.
PubMed:DNA binding studies of Vinca alkaloids: experimental and computational evidence.
PubMed:Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway.
PubMed:An HPLC method for the pharmacokinetic study of vincristine sulfate-loaded PLGA-PEG nanoparticle formulations after injection to rats.
PubMed:The rat gut micronucleus assay: a good choice for alternative in vivo genetic toxicology testing strategies.
PubMed:Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose-response relationships.
PubMed:TLC and HPLC methods to follow the synthesis of vinorelbine.
PubMed:Evaluation of a modified CD71 MicroFlow method for the flow cytometric analysis of micronuclei in rat bone marrow erythrocytes.
PubMed:International prevalidation studies of the EpiDerm 3D human reconstructed skin micronucleus (RSMN) assay: transferability and reproducibility.
PubMed:Rolipram and SP600125 suppress the early increase in PTP1B expression during cerulein-induced pancreatitis in rats.
PubMed:Optimization of the preparation process of vinblastine sulfate (VBLS)-loaded folate-conjugated bovine serum albumin (BSA) nanoparticles for tumor-targeted drug delivery using response surface methodology (RSM).
PubMed:High content flow cytometric micronucleus scoring method is applicable to attachment cell lines.
PubMed:Intralaboratory and interlaboratory evaluation of the EpiDerm 3D human reconstructed skin micronucleus (RSMN) assay.
PubMed:Reversal effects of Ca2+ antagonists on multidrug resistance via down-regulation of MDR1 mRNA.
PubMed:A novel human multidrug resistance gene MDR1 variant G571A (G191R) modulates cancer drug resistance and efflux transport.
PubMed:Changes in the expression and dynamics of SHP-1 and SHP-2 during cerulein-induced acute pancreatitis in rats.
PubMed:Polyoxyethylene 40 stearate modulates multidrug resistance and enhances antitumor activity of vinblastine sulfate.
PubMed:The drug loading, cytotoxicty and tumor vascular targeting characteristics of magnetite in magnetic drug targeting.
PubMed:Knock-down of sorcin induces up-regulation of MDR1 in HeLa cells.
PubMed:Development of a method for assessing micronucleus induction in a 3D human skin model (EpiDerm).
PubMed:The use of zebrafish for assessing ototoxic and otoprotective agents.
PubMed:Olfactory epithelial lesions induced by various cancer chemotherapeutic agents in mice.
PubMed:Value of reverse transcription polymerase chain assay in peripheral blood of patients with urothelial cancer.
PubMed:Evaluation of hyperdiploidy in the bladder epithelial cells of male F344 rats treated with ortho-phenylphenol.
PubMed:Effect of vinblastine sulfate on gamma-radiation-induced DNA single-strand breaks in murine tissues.
PubMed:Frequency of sex chromosomal mosaicism in bovine embryos and its effects on sexing using a single blastomere by PCR.
PubMed:A molecular basis explanation of the dynamic and thermal effects of vinblastine sulfate upon dipalmitoylphosphatidylcholine bilayer membranes.
PubMed:Enhancing the in vitro and in vivo detection of aneuploidy by fluorescence in situ hybridization with the use of bromodeoxyuridine as a proliferation marker.
PubMed:Sensitive and rapid spectrophotometric methods for determination of anticancer drugs.
PubMed:Screening for inhibitory effects of antineoplastic agents on CYP3A4 in human liver microsomes.
PubMed:Effects of endocrine disrupting chemicals on the microtubule network in Chinese hamster V79 cells in culture and in Sertoli cells in rats.
PubMed:Morphological classification of dental lesions induced by various antitumor drugs in mice.
PubMed:Effect of neutropenia and granulocyte colony stimulating factor-induced neutrophilia on blood-brain barrier permeability and brain edema after traumatic brain injury in rats.
PubMed:A serine 37 mutation associated with two missense mutations at highly conserved regions of p53 affect pro-apoptotic genes expression in a T-lymphoblastoid drug resistant cell line.
PubMed:Stabilization of vinca alkaloids encapsulated in poly(lactide-co-glycolide) microspheres.
PubMed:An integral membrane protein from the nuclear pore complex is also present in the annulate lamellae: implications for annulate lamella formation.
PubMed:Chromosomal diagnosis in each individual blastomere of 5- to 10-cell bovine embryos derived from in vitro fertilization.
PubMed:1H-cyclopenta[b]benzofuran lignans from Aglaia species inhibit cell proliferation and alter cell cycle distribution in human monocytic leukemia cell lines.
PubMed:[Intralesional injection of vinblastine in treatment of laryngeal Kaposi sarcoma associated with AIDS].
PubMed:Distribution of emerin during the cell cycle.
PubMed:The need for long-term treatment in the mouse lymphoma assay.
PubMed:Altered expression of beta 1 integrins in renal carcinoma cell lines exposed to vinblastine.
PubMed:Immunoblastic lymphadenopathy-like T-cell lymphoma complicated by multiple gastrointestinal involvement.
PubMed:In vivo model for the experimental manipulation of calcified tissues: a surgical approach for accessing the odontogenic organ and associated tissues of the rat incisor.
PubMed:3-Bromoacetylamino benzoylurea (3-BAABU), a new antimicrotubule cancericidal agent applied in cytogenetic analysis in hematology.
PubMed:Time course of vinblastine-induced autophagocytosis and changes in the endoplasmic reticulum in murine pancreatic acinar cells: a morphometric and biochemical study.
PubMed:Platinum-based chemotherapy for advanced transitional cell carcinoma of the upper urinary tract.
PubMed:A biochemical and immunological comparison of nuclear and cytoplasmic pore complexes.
PubMed:Intralesional vinblastine for treating AIDS-associated Kaposi's sarcoma of the oropharynx and larynx.
PubMed:Detection of centromeres in vinblastine- and radiation-induced micronuclei of human lymphocytes using FISH with an alpha satellite pancentromeric DNA probe.
PubMed:Analysis by fluorescence in situ hybridization with a mouse gamma satellite DNA probe of isolated micronuclei induced in mice by two clastogens and two spindle poisons.
PubMed:California: new drugs added to AIDS drug assistance program.
PubMed:Synergism between gonadotrophins and vinblastine relative to the frequencies of metaphase I, diploid and aneuploid mouse oocytes.
PubMed:Induction of aneuploidy in Chinese hamster oocytes following in vivo treatments with trimethoxybenzoic compounds and their analogues.
PubMed:Effects of vinblastine and colchicine on male rat meiosis in vivo: disturbances in spindle dynamics causing micronuclei and metaphase arrest.
PubMed:The influence of postovulatory ageing on the retardation of mouse oocyte maturation and chromosome segregation induced by vinblastine.
PubMed:Vancouver hybrid: preliminary experience in the treatment of Hodgkin's disease in childhood and adolescence.
PubMed:Effects of neutropenia on edema, histology, and cerebral blood flow after traumatic brain injury in rats.
PubMed:Induction of micronuclei in cultured human lymphocytes treated with vinblastine before and after mitogen stimulation.
PubMed:Isolation of micronuclei from mouse blood and fluorescence in situ hybridization with a mouse centromeric DNA probe.
PubMed:The effects of vinblastine in assessment of the influence of age on proliferative activity of murine palate and footpad epithelium.
PubMed:[Ultrafiltration failure in a peritoneal dialysis patient due to a marked increase in lymphatic absorption a case report].
PubMed:Analysis of micronuclei induced in mouse early spermatids by mitomycin C, vinblastine sulfate or etoposide using fluorescence in situ hybridization.
PubMed:Ototoxicity of chemotherapeutic agents.
PubMed:Light and electron microscopic observations on rat molar periodontal ligament after intraperitoneal injection of vinblastine.
PubMed:Effect of taxol on vinblastine sulfate-induced crystallization of tubulin.
PubMed:Cytoskeletal active drugs modulate signal transduction in the protein kinase C pathway.
PubMed:Severe leukocyte depletion does not affect follicular rupture in the rat.
PubMed:Cytoskeleton and ion movements during volume regulation in cultured PC12 cells.
PubMed:Investigation of aneuploidy induction in mouse oocytes following exposure to vinblastine-sulfate, pyrimethamine, diethylstilbestrol diphosphate, or chloral hydrate.
PubMed:Iontophoresis of vinblastine into normal skin and for treatment of Kaposi's sarcoma in human immunodeficiency virus-positive patients. The Military Medical Consortium for Applied Retroviral Research.
PubMed:Vinblastine treatment induces dose-dependent increases in the frequency of micronuclei in mouse bone marrow.
PubMed:Estramustine and vinblastine: use of prostate specific antigen as a clinical trial end point for hormone refractory prostatic cancer.
PubMed:Liver injury is a reversible neutrophil-mediated event following gut ischemia.
PubMed:Centromere detection in vinblastine- and radiation-induced micronuclei of cytokinesis-blocked mouse cells by using in situ hybridization with a mouse gamma (major) satellite DNA probe.
PubMed:Assessment of posttraumatic polymorphonuclear leukocyte accumulation in rat brain using tissue myeloperoxidase assay and vinblastine treatment.
PubMed:Primary cutaneous Langerhans cell histiocytosis in an adult.
PubMed:[Studies on in vitro anti-tumor activity of tumor necrosis factor alpha against human renal carcinoma cell line (KU-2)].
PubMed:Pancreatoblastoma: response to chemotherapy.
PubMed:Time course of quantitative morphological changes of the autophagic-lysosomal compartment of murine seminal vesicle epithelial cells under the influence of vinblastine.
PubMed:Effect of depletion of L3T4+ cells on resistance to early primary infection of mice with Taenia taeniaeformis.
PubMed:The micronucleus assay as a test for the detection of aneugenic activity.
PubMed:Randomized comparison of two chemotherapy, radiotherapy schemes for stage III and IV unresectable squamous cell carcinoma of the head and neck.
PubMed:Isolation of pancreatic autophagic vacuoles induced by vinblastine or neutral red. Separation of autophagosomes and autolysosomes by Percoll density gradient centrifugation.
PubMed:Reduction of vinblastine neurotoxicity in mice utilizing a collagen matrix carrier.
PubMed:Time course of the quantitative changes in the autophagic-lysosomal and secretory granule compartments of murine liver cells under the influence of vinblastine.
PubMed:Hodgkin's disease in children: correlation of clinical characteristics, staging procedures, and treatment at the University of Minnesota.
PubMed:Kinetochore localization in micronucleated cytokinesis-blocked Chinese hamster ovary cells: a new and rapid assay for identifying aneuploidy-inducing agents.
PubMed:Reversal of the multidrug-resistant phenotype of Chinese hamster ovary cells by L-histidinol.
PubMed:Studies on in vitro mechanisms of anti-tumor activity of the tumor necrosis factor alpha against human renal carcinoma cell line (KU-2).
PubMed:In vitro sensitivity of immature human mast cells to chemotherapeutic agents.
PubMed:The influence of subepithelial connective tissues on epithelial proliferation in the adult mouse.
PubMed:Interferon alpha-2a and vinblastine in the treatment of metastatic renal carcinoma.
PubMed:Synaptonemal complex damage as a measure of genotoxicity at meiosis.
PubMed:Meiotic arrest and aneuploidy induced by vinblastine in mouse oocytes.
PubMed:Synaptonemal complex damage induced by clastogenic and anti-mitotic chemicals: implications for non-disjunction and aneuploidy.
PubMed:Angiosarcoma of the breast: long-term survival following adjuvant chemotherapy.
PubMed:Combination chemotherapy and alpha-interferon in the treatment of Kaposi's sarcoma associated with acquired immune deficiency syndrome.
PubMed:Phase II trial of five day intravenous infusion vinblastine sulfate in patients with diffuse malignant mesothelioma: a Southwest Oncology Group study.
PubMed:Stability of vinblastine sulfate when exposed to light.
PubMed:Studies on the stability of vinblastine sulfate in aqueous solution.
PubMed:T cells recognizing polysaccharide-specific B cells function as contrasuppressor cells in the generation of T cell immunity to Pseudomonas aeruginosa.
PubMed:The effects of preoperative chemotherapy on the resectability of non-small cell lung carcinoma with mediastinal lymph node metastases (N2 M0).
PubMed:Exposure of mice to live Pseudomonas aeruginosa generates protective cell-mediated immunity in the absence of an antibody response.
PubMed:Allocation of newly synthesized proteins in spinal motoneurons.
PubMed:A multidisciplinary approach to primary nonseminomatous germ cell tumors of the mediastinum.
PubMed:Immunologic dysregulation in a patient with familial hemophagocytic lymphohistiocytosis.
PubMed:Interspecific genetic complementation analysis with fibroblasts from humans and four species of animals with Chediak-Higashi syndrome.
PubMed:Effects of L-histidinol on the susceptibility of P815 mastocytoma cells to selected anticancer drugs in vitro and in DBA/2J mice.
PubMed:The role of microtubules in human natural killer cell-mediated cytotoxicity.
PubMed:In vitro T cell-mediated killing of Pseudomonas aeruginosa. V. Generation of bactericidal T cells in nonresponder mice.
PubMed:The location and orientation of mitotic figures during histogenesis of the rat cerebellar cortex.
PubMed:Lithium and hematopoietic toxicity. II. Acceleration in vivo of murine hematopoietic progenitor cells (CFU-gm and CFU-meg) following treatment with vinblastine sulfate.
PubMed:Cellular behaviour in epithelial root sheath following vinblastine administration in mouse.
PubMed:Resistance of Rosa microtubule polymerization to colchicine results from a low-affinity interaction of colchicine and tubulin.
PubMed:A trial of continuous-infusion vinblastine in refractory endometrial adenocarcinoma.
PubMed:Microtubule disruption does not prevent intracellular transport and secretory processes of cultured fibroblasts.
PubMed:Lack of correlation between mutagen-induced chromosomal univalency and aneuploidy in mouse spermatocytes.
PubMed:In vitro T cell-mediated killing of Pseudomonas aeruginosa. IV. Nonresponsiveness in polysaccharide-immunized BALB/c mice is attributable to vinblastine-sensitive suppressor T cells.
PubMed:Curative, platinum-based cytoxic drug therapy in a renal transplant recipient with metastatic testicular cancer.
PubMed:Effect of alpha-difluoromethylornithine alone and in combination with doxorubicin hydrochloride, cis-diamminedichloroplatinum (II), and vinblastine sulfate on the growth of P3J cells in vitro.
PubMed:Colchicine inhibits ionophore-induced formation of leukotriene B4 by human neutrophils: the role of microtubules.
PubMed:Expression of a new beta tubulin subunit is induced by 20-hydroxyecdysone in Drosophila cultured cells.
PubMed:Fatal acute respiratory failure after vinblastine-mitomycin therapy in lung carcinoma.
PubMed:Unusual collagen aggregates induced in rat incisor dentin after vinblastine administration.
PubMed:Combined treatment approach in surgical management of carcinoma of the esophagus: a preliminary report.
PubMed:Interaction of vinblastine sulfate with artificial phospholipid membranes. A study by differential scanning calorimetry and spin labeling.
PubMed:The efficacy of three non-mammalian test systems in the identification of chemical teratogens.
PubMed:Continuous-infusion vinblastine in refractory carcinoma of the cervix: a phase II trial.
PubMed:Nonspecific cytotoxic cells in fish (Ictalurus punctatus). V. Metabolic requirements of lysis.
PubMed:Pharmacologic modulation of the IgE or Ca2+ ionophore A23187 mediated Ca2+ influx, phospholipase activation, and histamine release in rat basophilic leukemia cells.
PubMed:Phase I-II trial of a 5-day continuous infusion of vinblastine sulfate.
PubMed:Vinblastine-induced formation of annulated lamellae in SV3T3 cells.
PubMed:Nuclear elongation of dissociated newt spermatids in vitro and their nuclear shortening by antimicrotubule agents.
PubMed:Mitoxantrone, cyclophosphamide, and 5-fluorouracil in the treatment of hormonally unresponsive metastatic breast cancer.
PubMed:Angiolymphoid hyperplasia demonstrating extensive skin and mucosal lesions controlled with vinblastine therapy.
PubMed:Response of human adenocarcinoma to chemotherapy: as sole agents and in combination with sodium ibuprofen.
PubMed:Adoptive immunization against an established tumor with cytolytic versus memory T cells. Immediate versus delayed onset of regression.
PubMed:Effects of prolonged antitubulin culture on annulate lamellae in mouse alpha L929 fibroblasts.
PubMed:Effects of prolonged antitubulin culture on the ultrastructure of anterior limb bud cells of the chick embryo.
PubMed:In vitro assessment of cytotoxic agents in murine cancers: comparison between antiproliferative and antimetabolic assays.
PubMed:Acute megakaryocytic leukemia following chemotherapy for a malignant teratoma.
PubMed:Transplantation of human renal cell carcinoma into NMRI nu/nu mice. II. Evaluation of response to vinblastine sulfate monotherapy.
PubMed:Microtubule-depolymerizing agents inhibit asialo-orosomucoid delivery to lysosomes but not its endocytosis or degradation in isolated rat hepatocytes.
PubMed:Treatment and surgical staging of testicular and primary extragonadal germ cell cancer.
PubMed:Experimental induction of two inner cell masses in mouse embryos by vinblastine treatment in vitro.
PubMed:[Albumin receptors on isolated human hepatocytes. Studies by phase contrast and scanning electron microscopy].
PubMed:Different effects of neonatal vinblastine on peripheral and central noradrenaline neurons.
PubMed:Factors involved in the sensitivity of Stentor to colchicine, lumicolchicine, and vinblastine sulfate.
PubMed:The biologic activity of mast cell granules. VI. The effect of vinblastine-induced neutropenia on rat cutaneous late phase reactions.
PubMed:Combination chemotherapy with cis-diamminedichloroplatinum and vinblastine in advanced non-small cell lung cancer.
PubMed:Acceleration of cytokinesis in PtK1 cells treated with microtubule inhibitors.
PubMed:Relationship of developmental stage to effects of vinblastine on the artificial "embryo" of Hydra.
PubMed:Effect of vinblastine sulfate on the growth and histologic development of reaggregated Hydra.
PubMed:Brain angiotensinogen: in vitro synthesis and chromatographic characterization.
PubMed:Antiproliferative drugs in the treatment of experimental proliferative vitreoretinopathy.
PubMed:Enhanced radiation lethality in partially synchronized solid mouse tumors.
PubMed:Electron microscopic study on the effects of vinblastine on young odontoblasts in rat incisor.
PubMed:Response of nodular non-X histiocytosis to vinblastine.
PubMed:Advanced metastatic testicular cancer: the need for reporting results according to initial extent of disease.
PubMed:Phase II trial of vinblastine sulfate for metastatic urothelial tract tumors.
PubMed:A new suggestion of the design of rational anticancer therapy: experimental studies in mice.
PubMed:The arrangement of the Golgi complex beads is not controlled by the cytoskeleton.
PubMed:Evaluation of effective vinblastine-sulfate dosage in different renal cell carcinomas after transplantation to the NU/NU mice.
PubMed:Vindesine: a phase II study in childhood malignancies-a report for cancer and leukemia group B.
PubMed:Stability and compatibility of antitumor agents in glass and plastic containers.
PubMed:Investigations of cytoplasmic contractile and cytoskeletal elements in the kidney glomerulus.
PubMed:Ultrastructural changes in mouse hepatocytes exposed to vinblastine sulfate with special reference to the intercellular junctions.
PubMed:[Freeze fracturing and thin-section study of intercellular junctions between odontoblasts and the rat incisor. Changes induced by vinblastine].
PubMed:[Possibilities of cytostatic therapy in adenocarcinoma of the kidney. I. Influence of vinblastine on the growth of transplanted tumors].
PubMed:Tumor promoter-induced changes in the permeability of epithelial cell tight junctions.
PubMed:Characterization of free surface microprojections on the kidney glomerular epithelium.
PubMed:Ultrastructural and biochemical response of rat mammary epithelial cells to vinblastine sulfate.
PubMed:Monensin and FCCP inhibit the intracellular transport of alphavirus membrane glycoproteins.
PubMed:In vivo and in vitro effects of colchicine and vinblastine on the secretory process of antibody-producing cells.
PubMed:Skin infiltration in Hodgkin's disease.
PubMed:Genetics of cell-surface receptors for bioactive polypeptides: a variant of mouse BALBc/3T3 fibroblasts possessing altered insulin-binding ability.
PubMed:Effect of inline filtration on the potency of low-dose drugs.
PubMed:Relevance of biochemical tumor markers and lymphadenectomy in management of non-seminomatous testis tumors: current perspective.
PubMed:Treatment of Kaposi's sarcoma with vinblastine.
PubMed:Phase I evaluation of divided-dose vinblastine sulfate.
PubMed:Increased degradation in rat liver induced by vinblastine. I. Biochemical characterization.
PubMed:Kaposi's sarcoma--an overview.
PubMed:Autophagocytosis in mouse seminal vesicle cells in vitro. Temperature dependence and effects of vinblastine and inhibitors of protein synthesis.
PubMed:Characteristics of two cell lines (TE-1 and TE-2) derived from human squamous cell carcinoma of the esophagus.
PubMed:Expression of simian virus 40 gene A affects tubulin stability.
PubMed:Mutation in a structural gene for a beta-tubulin specific to testis in Drosophila melanogaster.
PubMed:Antibody-induced movement of common melanoma membrane antigens on the surface of unfixed human melanoma cells.
PubMed:Erythema annulare centrifugum and Hodgkin's disease: association with disease activity.
PubMed:A study of small intestinal dipeptidases of rats: effect of vinblastine treatment.
PubMed:A study of intestinal dipeptidases of rats: effect of in vivo mucosal exposure to vinblastine.
PubMed:[Kaposi's sarcoma. Pharyngo-laryngeal manifestation, treatment (author's transl)].
PubMed:Acute and protracted effects of vinblastine on odontoblasts and dentinogenesis in rat incisors.
PubMed:Effect of microtubule inhibitors on malignant invasion in vitro.
PubMed:Chemotherapy of head and neck cancer.
PubMed:Mechanisms of corticotropin action in rat adrenal cells. I. The effects of inhibitors of protein synthesis and of microfilament formation on corticosterone synthesis.
PubMed:An association between mitochondria and microtubules in synaptosomes and axon terminals of cerebral cortex.
PubMed:The chromosomes of cockerels (Gallus domesticus) during meiosis.
PubMed:Cellular dynamics of rats' submaxillary gland during heat acclimatization.
PubMed:Inhibition of surface immunoglobulin centeral capping of Daudi cells and cell spreading of HeLa-S3 cells by neocarzinostatin.
PubMed:Distribution and content of microtubules in relation to the transport of lipid. An ultrastructural quantitative study of the absorptive cell of the small intestine.
PubMed:Scanning electron microscopic study of the effect of vinblastine on podocytes of rat kidney.
PubMed:The effect of vinblastine-induced microtubule loss on kidney podocyte morphology.
PubMed:Nature of the lectin-induced activation of plasma membrane Mg2+ATPase.
PubMed:Ultrastructural studies of the superior cervical trunk of the mouse: distribution, cytochemistry and stability of fibrous elements in preganglionic fibers.
PubMed:Binding of [3H]ctyochalasin B and [3H]colchicine to isolated liver plasma membranes.
PubMed:A new combination chemotherapy for resistant Hodgkin disease.
PubMed:Light microscopical and ultrastructural observations on the effect of vinblastine on ameloblasts of rat incisors in vivo. I. Short-term effect on secretory ameloblasts.
PubMed:Differential binding of methyl benzimidazol-2-yl carbamate to fungal tubulin as a mechanism of resistance to this antimitotic agent in mutant strains of Aspergillus nidulans.
PubMed:Effect of vinblastine on the brush border of proximal tubule cells of rat kidney.
PubMed:Treatment of Kaposi sarcoma with vinblastine.
PubMed:Properties of tubulin in unfertilized sea urchin eggs. Quantitation and characterization by the colchicine-binding reaction.
PubMed:Coated-vesicle shells, particle/chain material, and tubulin in brain synaptosomes. An electron microscope and biochemical study.
PubMed:Toxicology of vindesine (desacetyl vinblastine amide) in mice, rats, and dogs.
PubMed:Attachment of ribosomes to endoplasmic membranes in mouse pancreas. Degranulation in vivo caused by the inducers of autophagocytosis neutral red, vinblastine, puromycin, and cadmium ions, and prevention by cycloheximide.
PubMed:Effect of vinblastine sulfate, colchicine and lumicolchicine on membrane organization of normal and transformed cells.
PubMed:Inhibition of formation of microtubular paracrystals in HeLa-S3 cells by neocarzinostatin.
PubMed:Vinblastine-induced microtubular paracrystals in prolactin cells of anterior pituitary gland of lactating rats.
PubMed:The interaction between Walker tumour cells and mucosa cells in the lamina propria of gastric mucosa in rats. The tumour behaviour in previously X-irradiated mucosa compared to normal mucosa.
PubMed:Photosensitivity reaction to vinblastine.
PubMed:Kinetics of cell proliferation and cell loss in the peripheral and central parts of Walker tumours growing in rats and nude mice.
PubMed:Inhibition of pancreatic exocrine secretion by vinblastine.
PubMed:Interactions of microtubule disorganizers, plant hormones, and red light in wheat coleoptile segment growth.
PubMed:Abnormal regeneration of hydra induced with vinblastine sulfate.
PubMed:Isolation and polymerization of brain actin.
PubMed:The regeneration of cilia in partially deciliated Tetrahymena.
PubMed:Kaposi's sarcoma in an Eskimo.
PubMed:Chronic disseminated histiocytosis X treated with vinblastine sulfate and prednisone.
PubMed:The effect of vinblastine sulfate on rat spermatogenesis.
PubMed:[In vitro effects of vinblastine sulfate, methotrexate and alkeran on human chromosomes].
PubMed:The fine structure and immunological labeling of the achromatic mitotic apparatus after disruption of cell membranes.
PubMed:The mechanism of action of colchicine. Colchicine binding properties of sea urchin sperm tail outer doublet tubulin.
PubMed:Virus-induced transformation without cell division.
PubMed:Acetylcholine: fast axoplasmic transport in insect chemoreceptor fibers.
PubMed:Separation of HeLa cells by colloidal silica density gradient centrifugation. I. Separation and partial synchrony of mitotic cells.
PubMed:Effect of vinblastine sulfate on the fine structure of cells of the rat renal corpuscle.
PubMed:Vinblastine sulfate. Its reversible thermal aggregation and interaction with hydrophobic groups.
PubMed:Axoplasmic transport in the crayfish nerve cord. The role of fibrillar constituents of neurons.
PubMed:Synthesis and storage of microtubule proteins by sea urchin embryos.
PubMed:Adrenal steroid release by vinblastine sulfate and its contribution to vinblastine sulfate effects on rat thymus.
PubMed:[Studies on the problem of combined radiologic-cytostatic therapy. 10. Syncytostatic studies with vinblastine sulfate].
PubMed:[Clinical experiences with vinblastine sulfate].
PubMed:Vinblastine sulfate (NSC-49842) in the treatment of bronchogenic carcinoma.
PubMed:Vinblastine sulfate: metaphase arrest, inhibition of RNA synthesis, and cytotoxicity in Novikoff rat hepatoma cells.
PubMed:Successful treatment of an infant with Letterer-Siwe disease with vinblastine sulfate.
PubMed:The effects of vinblastine sulfate on the microtubular organization of the ovary of Rhodnius prolixus.
PubMed:Precipitation of proteins by vinblastine and calcium ions.
PubMed:Ribosome-granular material complexes in human leukemic lymphoblasts exposed to vinblastine sulfate.
PubMed:A comparison of nitrogen mustard and vinblastine sulfate in the treatment of patients with Hodgkin's disease.
PubMed:Induction of helical arrays of ribosomes by vinblastine sulfate in Escherichia coli.
PubMed:Initiation of antibody responses by different classes of lymphocytes. I. Types of thoracic duct lymphocytes involved in primary antibody responses of rats.
PubMed:[Comments on the paper by E. Schultz, W. Jüngling and K. Hausmann: "Long term treatment of advanced lymphogranulomatosis using vinblastine sulfate" Klin Wschr 47,190 (1969)].
PubMed:Vinblastine sulfate in Hodgkin's disease.
PubMed:[Long term treatment of advanced lymphogranulomatosis with vinblastine sulfate].
PubMed:Failure of malignant epidermal cells to respond to vinblastine sulfate. A study in skin-tumor-resistant mice.
PubMed:Effect of the Vinca alkaloids on RNA synthesis in human cells in vitro.
PubMed:Hypertrophy of granular endoplasmic reticulum and annulate lamellae in Earle's L cells exposed to vinblastine sulfate.
PubMed:Time-lapse and ultrastructure studies on the reversal of mitotic arrest induced by vinblastine sulfate in Earle's L cells.
PubMed:Neurofibrillary tangles induced by vincristine and vinblastine sulfate in central and peripheral neurons in vitro.
PubMed:Fine structure of the kinetochores in vinblastine sulfate-treated cells.
PubMed:[Cytostatic treatment of lymphogranulomatosis. Experiences with ibenzmethyzine, cyclophosphamide and vinblastine sulfate].
PubMed:The response of Hodgkin's disease to treatment with oral vinblastine sulfate.
PubMed:[Clinical use of vinblastine sulfate for malignant lymphoma].
PubMed:Relative cytotoxicity of mithramycin and vinblastine sulfate in cell cultures of human neural tumors.
PubMed:[Use of vinblastine sulfate as a statmokinetic agent in vivo in the cytogenetic study of plasmocytoma].
PubMed:[Studies of the human marrow under the effect of vinblastine sulfate].
PubMed:Arterial infusion of vinblastine sulfate (NSC-49842) in patients with solid tumors.
PubMed:Synchronization of HeLa cells by vinblastine sulfate.
PubMed:Histiocytosis X: response to vinblastine sulfate.
PubMed:Oral vinblastine sulfate in Hodgkin's disease.
PubMed:Severe tumor pain with intravenous injection of vinblastine sulfate (NSC-49842).
PubMed:The different effects of vinblastine sulfate and nitrogen mustard upon neutrophil kinetics in the dog.
PubMed:Cyclophosphamide and vinblastine sulfate in Hodgkin's disease during pregnancy.
PubMed:Treatment of neoplastic diseases with an improvedoral preparation of vinblastine sulfate.
PubMed:Vinblastine sulfate vs cyclophosphamide in the therapy for lymphoma.
PubMed:Clinical experience with vincaleukoblastine sulfate in the treatment of 11 patients with Hodgkin's disease.
PubMed:ORAL ADMINISTRATION OF VINBLASTINE SULFATE (NSC-49842) TO CANCER PATIENTS.
PubMed:ANTINEOPLASTIC AGENTS DERIVED FROM THE PERIWINKLE PLANT: VINBLASTINE SULFATE: (VELBAN).
PubMed:SENSITIVITY OF CELL CULTURES OF NEURAL TUMORS TO VINBLASTINE SULFATE (NSC-49842).
PubMed:"HISTIOCYTOSIS X" TREATED WITH VINBLASTINE SULFATE (NSC-49842).
PubMed:USE OF VINBLASTINE SULFATE TO TREAT HODGKIN'S DISEASE DURING PREGNANCY.
PubMed:VINBLASTINE SULFATE IN HODGKIN'S DISEASE IN PREGNANCY.
PubMed:DELIVERY OF A NORMAL INFANT DURING THE COURSE OF ORAL VINBLASTINE SULFATE THERAPY FOR HODGKIN'S DISEASE.
PubMed:VINBLASTINE SULFATE TREATMENT OF HODGKIN'S DISEASE DURING A PREGNANCY.
PubMed:CLINICAL EXPERIENCE WITH VINBLASTINE SULFATE (NSC-49842) IN SQUAMOUS CELL CARCINOMA AND OTHER MALIGNANCIES.
PubMed:LEUKOKINETIC STUDIES. VII. MORPHOLOGY OF THE BONE MARROW AND BLOOD OF DOGS GIVEN VINBLASTINE SULFATE.
PubMed:TREATMENT OF RETICULOENDOTHELIOSIS WITH VINBLASTINE SULFATE: PRELIMINARY REPORT.
PubMed:Vinblastine sulfate (VLB) therapy of women with advanced breast cancer.
PubMed:[Preliminary observations on the therapeutic activity of vinblastine sulfate in some hemolymphoblastoses].
PubMed:Hodgkin's disease, carcinoma of the breast, and other tumors treated with vinblastine sulfate.
PubMed:Clinical experience with vinblastine sulfate.
 
Notes:
antitumor alkaloid isolated from vinca rosea. (merck, 11th ed.)
Please share your Comments.
Email Address:
Top of Page Home
Copyright © 1980-2021 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy