uric acid
1H-purine-2,6,8(3H)-trione, 7,9-dihydro- (9CI)
 
Notes:
an oxidation product, via xanthine oxidase, of oxypurines such as xanthine and hypoxanthine. it is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals urate oxidase further oxidizes it to allantoin. Occurs as phosphate in yeast and meat products For example, some researchers propose that hyperuricemia-induced oxidative stress is a cause of metabolic syndrome. On the other hand, plasma uric acid levels correlate with longevity in primates and other mammals. This is presumably a function of urate's antioxidant properties.; Uric acid (or urate) is an organic compound of carbon, nitrogen, oxygen and hydrogen with the formula C5H4N4O3.; Uric acid is a heterocyclic purine derivative that is the final oxidation product of purine metabolism. It is produced by the enzyme xanthine oxidase, which oxidizes oxypurines such as xanthine into uric acid. In most mammals, except humans and higher primates, the enzyme uricase further oxidizes uric acid to allantoin. Uric acid is also the end product of nitrogen metabolism in birds and reptiles. In such species, it is excreted in feces as a dry mass. Humans produce only small quantities of uric acid with excess accumulation leading to a type of arthritis known as gout. The loss of uricase in higher primates parallels the similar loss of the ability to synthesize ascorbic acid vitamin C. This may be because in higher primates uric acid partially replaces ascorbic acid.
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7,9-dihydro-3H-purine-2,6,8-trione (Click)
CAS Number: 69-93-2Picture of molecule
Other: 13154-20-6
ECHA EINECS - REACH Pre-Reg: 200-720-7
FDA UNII: 268B43MJ25
Nikkaji Web: J2.372H
Beilstein Number: 1111913
MDL: MFCD00005712
XlogP3-AA: -1.90 (est)
Molecular Weight: 168.11248000
Formula: C5 H4 N4 O3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: buffering agents
 
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 863.00 °C. @ 760.00 mm Hg (est)
Flash Point: 888.00 °F. TCC ( 475.70 °C. ) (est)
logP (o/w): -1.730 (est)
Soluble in:
 water, 60 mg/L @ 20 °C (exp)
 water, 2.192e+005 mg/L @ 25 °C (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: buffering agents
skin conditioning
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Suppliers:
Sigma-Aldrich: Sigma
For experimental / research use only.
Uric Acid ≥99%, crystalline
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: buffering agents
Recommendation for uric acid usage levels up to:
 not for fragrance use.
 
Recommendation for uric acid flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 69-93-2
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 1175
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 7,9-dihydro-3H-purine-2,6,8-trione
Chemidplus: 0000069932
RTECS: YU7050080 for cas# 69-93-2
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References:
 7,9-dihydro-3H-purine-2,6,8-trione
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 69-93-2
Pubchem (cid): 1175
Pubchem (sid): 134971817
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
Golm Metabolome Database: Search
Metabolomics Database: Search
KEGG (GenomeNet): C00366
HMDB (The Human Metabolome Database): HMDB00289
FooDB: FDB015350
YMDB (Yeast Metabolome Database): YMDB01494
Export Tariff Code: 2933.90.9500
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 buffering agents 
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Occurrence (nature, food, other): note
 cress garden cress seed
Search Trop  Picture
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Synonyms:
7,9-dihydro-1H-purine-2,6,8(3H)-trione
7,9-dihydro-3H-purine-2,6,8-trione
6-hydroxy-1H-purine-2,8(7H,9H)-dione
 purine-2,6,8-(1H,3H,9H)-trione
 purine-2,6,8(1H,3H,9H)-trione
1H-purine-2,6,8(3H)-trione, 7,9-dihydro- (9CI)
1,3,7-trihydropurine-2,6,8-trione
 trioxopurine
2,6,8-trioxopurine
2,6,8-trioxypurine
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