EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

tyramine hydrochloride
4-(2-aminoethyl)phenol hydrochloride (1:1)

Supplier Sponsors

Name:4-(2-aminoethyl)phenol;hydrochloride
CAS Number: 60-19-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-462-5
FDA UNII: Z5KDH3H147
Beilstein Number:3627058
MDL:MFCD00012901
Molecular Weight:173.64184000
Formula:C8 H12 Cl N O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
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PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 325.20 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000123 mmHg @ 25.00 °C. (est)
Flash Point: 247.00 °F. TCC ( 119.20 °C. ) (est)
logP (o/w): 0.722 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Tyramine-d4 HCl
Odor: characteristic
Use: Tyramine-d4 HCl is the labeled analogue of Tyramine HCl. Tyramine is a catecholamine releasing agent that binds to both TAAR1 and TAAR2 as an agonist. Tyramine is derived from Tyrosine.
Glentham Life Sciences
Tyramine hydrochloride
Santa Cruz Biotechnology
For experimental / research use only.
Tyramine Hydrochloride
Sigma-Aldrich: Sigma
For experimental / research use only.
Tyramine hydrochloride ≥98%
TCI AMERICA
For experimental / research use only.
Tyramine Hydrochloride >98.0%(T)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 710 mg/kg
Toxicology and Applied Pharmacology. Vol. 28, Pg. 227, 1974.

intravenous-mouse LD50 208 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
European Journal of Pharmacology. Vol. 9, Pg. 289, 1970.

unreported-mouse LDLo 2750 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 8, Pg. 126, 1916.

Dermal Toxicity:
subcutaneous-guinea pig LDLo 1044 mg/kg
BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Journal of Pharmacology and Experimental Therapeutics. Vol. 47, Pg. 339, 1933.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for tyramine hydrochloride usage levels up to:
 not for fragrance use.
 
Recommendation for tyramine hydrochloride flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):60-19-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :66449
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
4-(2-aminoethyl)phenol;hydrochloride
Chemidplus:0000060195
RTECS:SJ6050000 for cas# 60-19-5
 
References:
 4-(2-aminoethyl)phenol;hydrochloride
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:60-19-5
Pubchem (cid):66449
Pubchem (sid):135025578
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
Golm Metabolome Database:Search
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2922.50.4000
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
4-(2-amino-ethyl)-phenol;hydrochloride
p-(2-aminoethyl)-phenol hydrochloride
4-(2-aminoethyl)phenol hydrochloride
4-(2-aminoethyl)phenol hydrochloride (1:1)
4-(2-aminoethyl)phenol, chloride
4-(2-aminoethyl)phenol;hydrochloride
4-hydroxyphenethylamine hydrochloride
4-hydroxyphenethylammonium chloride
2-(4-hydroxyphenyl)ethylamine hydrochloride
4-hydroxyphenylethylamine hydrochloride
 phenol, 4-(2-aminoethyl)-, hydrochloride
 phenol, 4-(2-aminoethyl)-, hydrochloride (1:1)
 phenol, p-(2-aminoethyl)-, hydrochloride (8CI)
 phenol, p-(2-aminoethyl)-, monochloride
 phenol, p-(2-aminoethyl)-, monohydrochloride
p-tryamine hydrochloride
 tyraminehydrochloride
 

Articles:

PubMed:Fluorogenic substrate screening for G-quadruplex DNAzyme-based sensors.
PubMed:Assay and stability-indicating micellar electrokinetic chromatography method for the simultaneous determination of valacyclovir, acyclovir and their major impurity guanine in pharmaceutical formulations.
PubMed:Why do some dietary migraine patients claim they get headaches from placebos?
PubMed:Comparison of the effects of moclobemide and selegiline on tyramine-evoked mydriasis in man.
PubMed:Age-related changes in interstitial norepinephrine. A microdialysis study in spontaneously hypertensive rats.
PubMed:Comparison of the effects of clonidine on tyramine- and methoxamine-evoked mydriasis in man.
PubMed:Chemical constituents of halophilic facultatively anaerobic bacteria, 1.
PubMed:Monitoring norepinephrine levels by microdialysis in the white adipose tissue of spontaneously hypertensive rats.
PubMed:Histochemistry of MAO-A and MAO-B in the locus coeruleus of the Mongolian gerbil.
PubMed:Effect of centhaquine on spontaneous and evoked norepinephrine release from isolated perfused rabbit heart.
PubMed:The tyramine challenge test as a marker for melancholia.
PubMed:The influence of adrenergic receptor antagonists on the amnestic and antiamnestic actions of adrenaline and tyramine.
PubMed:Radical formation in single crystals of aromatic amines and radical transformation by light.
PubMed:Nicotine-induced release of noradrenaline from hypothalamic synaptosomes.
PubMed:Cactus alkaloids. XXXVI. Mescaline and related compounds from Trichocereus peruvianus.
PubMed:Effect of eltroxine and neomercazol on monoamine oxidase from rat tissues.
PubMed:The effect of oral inorganic sulphate on the metabolism of 4-hydroxyphenethylamine (tyramine) in man: tyramine O-sulphate measurement in human urine.
PubMed:Comparison of the histamine and tyramine hydrochloride tests in the diagnosis of pheochromocytoma.
PubMed:Studies on coccidioides immitis. II. Physiological studies on in vitro spherulation.
 
Notes:
an indirect sympathomimetic. tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and monoamine oxidase so it prolongs the actions of adrenergic transmitters. it also provokes transmitter release from adrenergic terminals. tyramine may be a neurotransmitter in some invertebrate nervous systems.
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