tromethamine
methylamine, 1,1,1-tris(hydroxymethyl)-
 
Notes:
an organic amine proton acceptor. it is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (from merck, 11th ed; martindale, the extra pharmacopoeia, 30th ed, p1424)
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2-amino-2-(hydroxymethyl)propane-1,3-diol (Click)
CAS Number: 77-86-1Picture of molecule
Other: 108195-86-4
ECHA EINECS - REACH Pre-Reg: 201-064-4
FDA UNII: 023C2WHX2V
Nikkaji Web: J4.214E
Beilstein Number: 741883
MDL: MFCD00004679
XlogP3-AA: -2.90 (est)
Molecular Weight: 121.13627000
Formula: C4 H11 N O3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: buffering agents and neutralizing agents
 
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 171.00 to  172.00 °C. @ 760.00 mm Hg
Boiling Point: 357.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.000001 mm/Hg @ 25.00 °C. (est)
Flash Point: 337.00 °F. TCC ( 169.70 °C. ) (est)
logP (o/w): -2.515 (est)
Soluble in:
 water, 550000 mg/L @ 25 °C (exp)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: buffering agents
masking agents
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Suppliers:
American International Chemical
Tris Optimum USP, ACS
Dow Chemical
TRIS AMINO™
EMD Millipore
For experimental / research use only.
Tris(hydroxymethyl)aminomethane
Santa Cruz Biotechnology
For experimental / research use only.
Tris base ≥99%
Sigma-Aldrich
For experimental / research use only.
Tris(hydroxymethyl)aminomethane ACS reagent, ≥99.8%
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  5900 mg/kg
Bollettino Chimico Farmaceutico. Vol. 110, Pg. 653, 1971.

intravenous-rat LD50  1800 mg/kg
Drugs in Japan Vol. -, Pg. 419, 1990.

intravenous-mouse LD50  1210 mg/kg
Acta Biologica et Medica Germanica. Vol. 17, Pg. 217, 1966.

oral-rabbit LDLo  1000 mg/kg
BEHAVIORAL: COMA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS
Journal of Industrial Hygiene and Toxicology. Vol. 22, Pg. 315, 1940.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: buffering agents and neutralizing agents
Recommendation for tromethamine usage levels up to:
 not for fragrance use.
 
Recommendation for tromethamine flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
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NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 77-86-1
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 6503
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
 2-amino-2-(hydroxymethyl)propane-1,3-diol
Chemidplus: 0000077861
RTECS: TY2900000 for cas# 77-86-1
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References:
 2-amino-2-(hydroxymethyl)propane-1,3-diol
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 77-86-1
Pubchem (cid): 6503
Pubchem (sid): 134972802
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
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KEGG (GenomeNet): C07182
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Export Tariff Code: 2922.19.5000
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Formulations/Preparations:
•tromethamine formulations: parenteral injection 36 mgml (18 g) tham, hospira. •tromethamine, nf (tham), is avail as 0.3 molar soln adjusted to ph 8.6 with acetic acid. it is also supplied as powder (tham-e) to be dissolved in 1 l of sterile water. each l contains 300 mmoles (36 g) of tromethamine, 30 mmoles of sodium chloride, & 5 mmoles of potassium chloride.
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 buffering agents 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
2-amino-2-(hydroxymethyl)-1,3-propane diol
2-amino-2-(hydroxymethyl)-1,3-propanediol
2-amino-2-(hydroxymethyl)propan-1,3-diol
2-amino-2-(hydroxymethyl)propane-1,3-diol
2-amino-2-hydroxymethyl-1,3-propanediol
2-amino-2-hydroxymethylpropane-1,3-diol
2-amino-2-methylol-1,3-propanediol
 aminotris(hydroxymethyl)methane
tris(hydroxymethyl) aminomethane
2-(hydroxymethyl)-2-amino-1,3-propanediol
1,1,1-tris(hydroxymethyl)-methanamine
tris(hydroxymethyl)aminomethane ACS
1,1,1-tris(hydroxymethyl)methanamine
tris(hydroxymethyl)methanamine
1,1,1-tris(hydroxymethyl)methylamine
tris(hydroxymethyl)methylamine
tris(hydroxymethyly)amino methane
 methanamine, 1,1,1-tris(hydroxymethyl)-
 methylamine, 1,1,1-tris(hydroxymethyl)-
1,3-propanediol, 2-amino-2- (hydroxymethyl)-
1,3-propanediol, 2-amino-2-(hydroxymethyl)-
 tri(hydroxymethyl)aminomethane
 trimethylol aminomethane
 tris amino
 trometamol
 trometamole
 tromethamolum
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PubMed: Retrospective case-control evaluation of the use of parenteral ketorolac tromethamine in patients after surgery.
PubMed: The effect of food and an antacid on the bioavailability of dexketoprofen trometamol.
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PubMed: Single-dose treatment of acute cystitis with fosfomycin tromethamine.
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