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pivalic acid
propionic acid, 2,2-dimethyl-

Supplier Sponsors

Name:2,2-dimethylpropanoic acid
CAS Number: 75-98-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-922-5
FDA UNII: 813RE8BX41
Nikkaji Web:J4.166A
Beilstein Number:0969480
MDL:MFCD00004194
XlogP3:1.50 (est)
Molecular Weight:102.13310000
Formula:C5 H10 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:colorless crystalline solid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.88900 @ 25.00 °C.
Melting Point: 35.00 °C. @ 760.00 mm Hg
Boiling Point: 164.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.907000 mmHg @ 25.00 °C. (est)
Flash Point: 147.00 °F. TCC ( 63.89 °C. )
logP (o/w): 1.480
Soluble in:
 water, 2.17E+04 mg/L @ 20 °C (exp)
 water, 1.559e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Trimethylacetic acid
EMD Millipore
For experimental / research use only.
Pivalic Acid
Inoue Perfumery
PIVALIC ACID
Penta International
PIVALIC ACID
Sigma-Aldrich: Aldrich
For experimental / research use only.
Pivalic acid 99%
TCI AMERICA
For experimental / research use only.
Pivalic Acid >99.0%(GC)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 900 mg/kg
"Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds. New York, John Wiley & Sons, Inc., 1978Vol. 4, Pg. 863, 1978.

Dermal Toxicity:
skin-rat LD50 1900 mg/kg
"Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds. New York, John Wiley & Sons, Inc., 1978Vol. 4, Pg. 863, 1978.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for pivalic acid usage levels up to:
 not for fragrance use.
 
Recommendation for pivalic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1]
View page or View pdf

EPI System: View
NIOSH International Chemical Safety Cards:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):75-98-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6417
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
2,2-dimethylpropanoic acid
Chemidplus:0000075989
EPA/NOAA CAMEO:hazardous materials
RTECS:75-98-9
 
References:
 2,2-dimethylpropanoic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:75-98-9
Pubchem (cid):6417
Pubchem (sid):134971231
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
UM BBD:Search
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2915.90.1800
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
>99% pure
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
2,2-dimethyl propanoic acid
2,2-dimethyl-propanoic acid
2,2-dimethylpropanoic acid
2,2-dimethylpropionic acid
tert-pentanoic acid
 propanoic acid, 2,2-dimethyl-
 propionic acid, 2,2-dimethyl-
 trimethyl acetic acid
 versatic 5
 

Articles:

PubMed:What Controls the Magnetic Exchange Interaction in Mixed- and Homo-Valent Mn7 Disc-Like Clusters? A Theoretical Perspective.
PubMed:Metal distribution and disorder in the crystal structure of [NH2Et2][Cr7MF8((t)BuCO2)16] wheel molecules for M = Mn, Fe, Co, Ni, Cu, Zn and Cd.
PubMed:A series of cobalt and nickel clusters based on thiol-containing ligands accompanied by in situ ligand formation.
PubMed:4,4',4″-Trimethyl-2,2':6',2″-terpyridine by Oxidative Coupling of 4-Picoline.
PubMed:Newborn hypocarnitinemia due to long-term transplacental pivalic acid passage.
PubMed:Tetrametallic lanthanide(III) phosphonate cages: synthetic, structural and magnetic studies.
PubMed:Ruthenium-catalyzed highly regio- and stereoselective hydroarylation of aromatic sulfoxides with alkynes via C-H bond activation.
PubMed:Synthesis, structure and magnetic properties of phenylhydroxamate-based coordination clusters.
PubMed:A family of novel Mn₃Ln₄ clusters displaying single-molecule magnet behavior.
PubMed:Hexanuclear, heterometallic, Ni₃Ln₃ complexes possessing O-capped homo- and heterometallic structural subunits: SMM behavior of the dysprosium analogue.
PubMed:Preclinical evaluation of 3-18F-fluoro-2,2-dimethylpropionic acid as an imaging agent for tumor detection.
PubMed:The coordination chemistry and magnetism of some 3d-4f and 4f amino-polyalcohol compounds.
PubMed:Structures and magnetic properties of two analogous Dy6 wheels with electron-donation and -withdrawal effects.
PubMed:Enantiospecific, nickel-catalyzed cross-couplings of allylic pivalates and arylboroxines.
PubMed:Hydroxide-free cubane-shaped tetranuclear [Ln4] complexes.
PubMed:Ruthenium-catalyzed hydroarylation of anilides with alkynes: an efficient route to ortho-alkenylated anilines.
PubMed:In situ generation of palladium nanoparticles: ligand-free palladium catalyzed pivalic acid assisted carbonylative Suzuki reactions at ambient conditions.
PubMed:Synthesis and characterization of nickel(II) phosphonate complexes utilizing pyridonates and carboxylates as co-ligands.
PubMed:Amides in one pot from carboxylic acids and amines via sulfinylamides.
PubMed:Surprising causes of C5-carnitine false positive results in newborn screening.
PubMed:Application of a second-tier newborn screening assay for c5 isoforms.
PubMed:Isolation, structure, and reactivity of an arylnickel(II) pivalate complex in catalytic C-H/C-O biaryl coupling.
PubMed:Tetranuclear lanthanide (III) complexes containing dimeric subunits: single-molecule magnet behavior for the Dy4 analogue.
PubMed:Influence of mitochondrion-toxic agents on the cardiovascular system.
PubMed:Octametallic 4f-phosphonate horseshoes.
PubMed:C-H functionalization of cyclopropanes: a practical approach employing a picolinamide auxiliary.
PubMed:Developments in Meyers' lactamization methodology: en route to bi(hetero)aryl structures with defined axial chirality.
PubMed:Octanuclear {Ln(III)8}(Ln = Gd, Tb, Dy, Ho) macrocyclic complexes in a cyclooctadiene-like conformation: manifestation of slow relaxation of magnetization in the Dy(III) derivative.
PubMed:UPLC-MS/MS analysis of C5-acylcarnitines in dried blood spots.
PubMed:Nickel-catalyzed cross-couplings of benzylic pivalates with arylboroxines: stereospecific formation of diarylalkanes and triarylmethanes.
PubMed:Slow magnetic relaxation in two new 1D/0D Dy(III) complexes with a sterically hindered carboxylate ligand.
PubMed:Octanuclear Mn(III)6Mn(II)Ln (Ln = Gd, Dy and Er) clusters with a novel core topology: syntheses, structures, and magnetic properties.
PubMed:Palladium-catalyzed asymmetric allylic alkylation of 3-aryloxindoles with allylidene dipivalate: a useful enol pivalate product.
PubMed:Comproportionation reactions to manganese(III/IV) pivalate clusters: a new half-integer spin single-molecule magnet.
PubMed:Syntheses, structures and magnetic properties of a family of heterometallic [Mn(II)2Mn(III)2Ln(III)2] clusters.
PubMed:Ruthenium-catalyzed highly regio- and stereoselective hydroarylation of aryl carbamates with alkynes via C-H bond activation.
PubMed:Fast Pd- and Pd/Cu-catalyzed direct C-H arylation of cyclic nitrones. Application to the synthesis of enantiopure quaternary α-amino esters.
PubMed:Cu-catalyzed reaction of 1,2-dihalobenzenes with 1,3-cyclohexanediones for the synthesis of 3,4-dihydrodibenzo[b,d]furan-1(2H)-ones.
PubMed:Biosynthesis and metabolic pathways of pivalic acid.
PubMed:Primary carnitine deficiency and pivalic acid exposure causing encephalopathy and fatal cardiac events.
PubMed:Rapid acyl migration between pyrogallyl 1,2- and 1,3-dipivaloates.
PubMed:A short-term high-dose administration of sodium pivalate impairs pyruvate metabolism without affecting cardiac function.
PubMed:Electronic structure and magnetic properties of a molecular octanuclear chromium-based ring.
PubMed:Novel coenzyme B12-dependent interconversion of isovaleryl-CoA and pivalyl-CoA.
PubMed:Palladium(II)-catalyzed direct intermolecular alkenylation of chromones.
PubMed:Structure, magnetism and theory of a family of nonanuclear Cu(II)5Ln(III)4-triethanolamine clusters displaying single-molecule magnet behaviour.
PubMed:Multifunctional 5-aminolevulinic acid prodrugs activating diverse cell-death pathways.
PubMed:Pivalic acid acts as a starter unit in a fatty acid and antibiotic biosynthetic pathway in Alicyclobacillus, Rhodococcus and Streptomyces.
PubMed:Continuous synthesis of tert-butyl peroxypivalate using a single-channel microreactor equipped with orifices as emulsification units.
PubMed:Nickel-catalyzed reductive cleavage of aryl-oxygen bonds in alkoxy- and pivaloxyarenes using hydrosilanes as a mild reducing agent.
PubMed:Intramolecular palladium-catalyzed alkane C-H arylation from aryl chlorides.
PubMed:Rapid determination of C4-acylcarnitine and C5-acylcarnitine isomers in plasma and dried blood spots by UPLC-MS/MS as a second tier test following flow-injection MS/MS acylcarnitine profile analysis.
PubMed:Synthesis, structures and magnetic properties of a series of 3d-4f tetranuclear Co(II)₂Ln(III)₂ cubanes.
PubMed:Nickel-catalyzed amination of aryl pivalates by the cleavage of aryl C-O bonds.
PubMed:An efficient protocol for alcohol protection under solvent- and catalyst-free conditions.
PubMed:Recognition of carboxylate anions and carboxylic acids by selenium-based new chromogenic fluorescent sensor: a remarkable fluorescence enhancement of hindered carboxylates.
PubMed:WITHDRAWN: Design and synthesis of pivalic acid linked tacrine-NO donor hybrids as novel anti-Alzheimer drug candidates.
PubMed:Children's toxicology from bench to bed--Liver injury (1): Drug-induced metabolic disturbance--toxicity of 5-FU for pyrimidine metabolic disorders and pivalic acid for carnitine metabolism.
PubMed:Modelling the magnetic behaviour of square-pyramidal Co(II)5 aggregates: tuning SMM behaviour through variations in the ligand shell.
PubMed:Interaction between pivaloylcarnitine and L-carnitine transport into L6 cells overexpressing hOCTN2.
PubMed:Tridecanuclear [Mn(III)5Ln(III)8] complexes derived from N-(t)butyl-diethanolamine: synthesis, structures, and magnetic properties.
PubMed:C(aryl)-O activation of aryl carboxylates in nickel-catalyzed biaryl syntheses.
PubMed:Establishment of broadly applicable reaction conditions for the palladium-catalyzed direct arylation of heteroatom-containing aromatic compounds.
PubMed:Phosphine-free, palladium-catalyzed arylation of heterocycles through C-H bond activation with pivalic acid as a cocatalyst.
PubMed:Cross-coupling of aryl/alkenyl pivalates with organozinc reagents through nickel-catalyzed C-O bond activation under mild reaction conditions.
PubMed:Novel multifunctional acyloxyalkyl ester prodrugs of 5-aminolevulinic acid display improved anticancer activity independent and dependent on photoactivation.
PubMed:Role of Na+/L-carnitine transporter (OCTN2) in renal handling of pivaloylcarnitine and valproylcarnitine formed during pivalic acid-containing prodrugs and valproic acid treatment.
PubMed:Enantioselective formation of ibuprofen-S-acyl-glutathione in vitro in incubations of ibuprofen with rat hepatocytes.
PubMed:Intramolecular Pd(II)-catalyzed oxidative biaryl synthesis under air: reaction development and scope.
PubMed:Au-catalyzed synthesis of (1Z,3E)-2-pivaloxy-1,3-dienes from propargylic pivalates.
PubMed:Ion-pair interaction in pyridinium carboxylate solutions.
PubMed:Protic ionic liquids: physicochemical properties and behavior as amphiphile self-assembly solvents.
PubMed:Toward a magnetostructural correlation for a family of Mn6 SMMs.
PubMed:Carnitine-associated encephalopathy caused by long-term treatment with an antibiotic containing pivalic acid.
PubMed:5(6)-carboxyfluorescein revisited: new protecting group, separation of isomers, and their spectral properties on oligonucleotides.
PubMed:Pivalate lowers litter sizes and weights in female rats independent of its effect on carnitine status.
PubMed:Chromium-catalyzed arylmagnesiation of alkynes.
PubMed:Palladium-catalyzed benzene arylation: incorporation of catalytic pivalic acid as a proton shuttle and a key element in catalyst design.
PubMed:Pyrones to pyrans: enantioselective radical additions to acyloxy pyrones.
PubMed:Magnesium bistrifluoromethanesulfonimide as a new and efficient acylation catalyst.
PubMed:Involvement of recognition and interaction of carnitine transporter in the decrease of L-carnitine concentration induced by pivalic acid and valproic acid.
PubMed:Hypocarnitinaemia induced by sodium pivalate in the rat is associated with left ventricular dysfunction and impaired energy metabolism.
PubMed:Cytotoxicity of pivoxil esters of antiviral acyclic nucleoside phosphonates: adefovir dipivoxil versus adefovir.
PubMed:Photocatalytic oxygenation of pivalic acid with molecular oxygen via photoinduced electron transfer using 10-methylacridinium ions.
PubMed:Possible mechanism for species difference on the toxicity of pivalic acid between dogs and rats.
PubMed:1,1,1-Tris(hydroxymethyl)propane in manganese carboxylate chemistry: synthesis, structure and magnetic properties of a mixed-valence [MnIII4MnII4] cluster featuring the novel [MnIII4MnII4(mu3-OR)6(mu2-OR)8]6+ core.
PubMed:2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands.
PubMed:[131I]Iodoazomycin arabinoside for low-dose-rate isotope radiotherapy: radiolabeling, stability, long-term whole-body clearance and radiation dosimetry estimates in mice.
PubMed:Carnitine deficiency and supplementation do not affect the gene expression of carnitine biosynthetic enzymes in rats.
PubMed:Isoelectric buffers for capillary electrophoresis. 2. Bismorpholine derivative of a carboxylic acid as a low molecular weight isoelectric buffer.
PubMed:Carnitine deficiency disorders in children.
PubMed:Synthesis and studies of a trinuclear Mn(II) carboxylate complex.
PubMed:Degradation of isooctane by Mycobacterium austroafricanum IFP 2173: growth and catabolic pathway.
PubMed:A mild and efficient protocol for the conversion of carboxylic acids to olefins by a catalytic decarbonylative elimination reaction.
PubMed:A stereodivergent approach to chiral nonracemic N-protected alpha,alpha-dialkylated amino acids.
PubMed:Anaerobic mineralization of quaternary carbon atoms: isolation of denitrifying bacteria on pivalic acid (2,2-dimethylpropionic acid).
PubMed:Selective desensitization of jasmonate- and pH-dependent signaling in the induction of benzophenanthridine biosynthesis in cells of Eschscholzia californica.
PubMed:Pivalate-generating prodrugs and carnitine homeostasis in man.
PubMed:Host-guest chemistry of the chromium-wheel complex [Cr8F8(tBuCO2)16]: prediction of inclusion capabilities by using an electrostatic potential distribution determined by modeling synchrotron X-ray structure factors at 16 K.
PubMed:Resorcinarenes with 2-benzimidazolone bridges: self-aggregation, self-assembled dimeric capsules, and guest encapsulation.
PubMed:Application of a surface plasmon resonance sensor to analyses of amine compounds with the use of a polymer film and an acid-base reaction.
PubMed:Evidence for tip velocity oscillations in dendritic solidification.
PubMed:Magnetic anisotropy of the antiferromagnetic ring [Cr8F8Piv16].
PubMed:Preparative route to glucuronyl donors bearing temporary protecting group at O-3 via 6,3-lactonisation by Bz(2)O or Piv(2)O.
PubMed:Molecular basis for the synergistic interaction of adriamycin with the formaldehyde-releasing prodrug pivaloyloxymethyl butyrate (AN-9).
PubMed:The effect of pivalate treatment of pregnant rats on body mass and insulin levels in the adult offspring.
PubMed:Up-regulation of carnitine transporters helps maintain tissue carnitine levels in carnitine deficiency induced by pivalic acid.
PubMed:Effect of various levels of supplementation with sodium pivalate on tissue carnitine concentrations and urinary excretion of carnitine in the rat.
PubMed:Carnitine protects mitochondria and removes toxic acyls from xenobiotics.
PubMed:Synthesis, characterization, and reactivity of ferrous and ferric oxo/peroxo pivalate complexes in relation to Gif-type oxygenation of substrates.
PubMed:Effect of carbonate salts on the kinetics of acid-catalyzed dimerization of adefovir dipivoxil.
PubMed:Functional and pharmacological characterization of human Na(+)-carnitine cotransporter hOCTN2.
PubMed:Formation of carboxylic acids from small alkanes in zeolite H-ZSM-5
PubMed:Modifications in electrospray tandem mass spectrometry for a neonatal-screening pilot study in Japan.
PubMed:Shifts of intracellular pH distribution as a part of the signal mechanism leading to the elicitation of benzophenanthridine alkaloids . Phytoalexin biosynthesis in cultured cells of eschscholtzia californica
PubMed:Diagnosis of isovaleric acidaemia by tandem mass spectrometry: false positive result due to pivaloylcarnitine in a newborn screening programme.
PubMed:14C-NaVP and 14C-PEV repeated dose study in rat. Pharmacokinetic study in rats after repeated oral administrations of 14C-valproic acid sodium salt and 14C-valproic acid pivaloyl oxymethyl ester.
PubMed:Crystal forms of piroxicam pivalate: preparation and characterization of two polymorphs.
PubMed:Successful lowering of epididymal carnitine by administration of pivalate to rats.
PubMed:Comparison of in vitro carnitine and glycine conjugation with branched-side chain and cyclic side chain carboxylic acids in rats.
PubMed:Effects of pivalic acid and sodium pivalate on L-carnitine concentrations in the cauda epididymidis and on male fertility in the hamster.
PubMed:Pivalic acid-induced carnitine deficiency and physical exercise in humans.
PubMed:Carnitine supplementation ameliorates the steatosis and ketosis induced by pivalate in rats.
PubMed:beta-Hydroxybutyrate oxidation is reduced and hepatic balance of ketone bodies and free fatty acids is unaltered in carnitine-depleted, pivalate-treated rats.
PubMed:[Influence of multiple-dose administration of cefetamet pivoxil on blood and urinary concentrations of carnitine and effects of simultaneous administration of carnitine with cefetamet pivoxil].
PubMed:A new esterase for the cleavage of pivalic acid-containing prodrug esters of cephalosporins.
PubMed:Pivalate affects carnitine status but causes no severe metabolic changes in rat liver.
PubMed:Gas chromatography/combustion/isotope ratio mass spectrometric comparison of N-acetyl- and N-pivaloyl amino acid esters to measure 15N isotopic abundances in physiological samples: a pilot study on amino acid synthesis in the upper gastro-intestinal tract of minipigs.
PubMed:Induction of peroxisomal beta-oxidation and P-450 4A-dependent activities by pivalic and trichloroacetic acid in rat liver and kidney.
PubMed:Selective depletion of mitochondrial glutathione content by pivalic acid and valproic acid in rat liver: possibility of a common mechanism.
PubMed:Transient reduction of human left ventricular mass in carnitine depletion induced by antibiotics containing pivalic acid.
PubMed:Formation of pivaloylcarnitine in isolated rat heart cells.
PubMed:L-carnitine improvement of cardiac function is associated with a stimulation in glucose but not fatty acid metabolism in carnitine-deficient hearts.
PubMed:Disposition of S-1108, a new oral cephem antibiotic, and metabolic fate of pivalic acid liberated from [pivaloyl-14C]S-1108 in rats and dogs.
PubMed:Effect of short-term treatment with pivalic acid containing antibiotics on serum carnitine concentration--a risk irrespective of age.
PubMed:Increased pivaloylcarnitine in the liver of the sodium pivalate treated rat exposed to clofibrate.
PubMed:Fatty acid oxidation and cardiac function in the sodium pivalate model of secondary carnitine deficiency.
PubMed:L-propionylcarnitine effects on cardiac carnitine content and function in secondary carnitine deficiency.
PubMed:Formation of pivaloylcarnitine in heart and brown adipose tissue in the rat.
PubMed:Carnitine depletion in rat pups of lactating mothers given sodium pivalate.
PubMed:Alteration of ammonia and carnitine levels in short-term treatment with pivalic acid-containing prodrug.
PubMed:Sodium pivalate reduces cardiac carnitine content and increases glucose oxidation without affecting cardiac functional capacity.
PubMed:Mean shape of three-dimensional dendrites: A comparison of pivalic acid and ammonium chloride.
PubMed:Impaired ketogenesis in carnitine depletion caused by short-term administration of pivalic acid prodrug.
PubMed:Erratum: Dendritic sidebranching with periodic localized perturbations: Directional solidification of pivalic acid-coumarin 152 mixtures
PubMed:Preferential elimination of pivalate with supplemental carnitine via formation of pivaloylcarnitine in man.
PubMed:[Effect of cefditoren pivoxil on carnitine metabolism in pediatric patients].
PubMed:Comment on "Surface-tension-anisotropy measurements of succinonitrile and pivalic acid: Comparison with microscopic solvability theory"
PubMed:Modulation of enantioselective metabolism and inversion of ibuprofen by xenobiotics in isolated rat hepatocytes.
PubMed:Solvent and steric effects on the extraction of copper(II) with pivalic acid.
PubMed:Dendritic sidebranching with periodic localized perturbations: Directional solidification of pivalic acid-coumarin 152 mixtures.
PubMed:Carnitine status and safety after administration of S-1108, a new oral cephem, to patients.
PubMed:Carnitine deficiency associated with long-term pivampicillin treatment: the effect of a replacement therapy regime.
PubMed:Determination of pivaloylcarnitine in human plasma and urine by high-performance liquid chromatography with fluorescence detection.
PubMed:Effects of pivalic acid-containing prodrugs on carnitine homeostasis and on response to fasting in children.
PubMed:Cleavage and deprotection of peptides on MBHA-resin with hydrogen bromide.
PubMed:Surface-tension-anisotropy measurements of succinonitrile and pivalic acid: Comparison with microscopic solvability theory.
PubMed:Phase I clinical studies of S-1108: safety and pharmacokinetics in a multiple-administration study with special emphasis on the influence on carnitine body stores.
PubMed:Metabolism of S-1108, a new oral cephem antibiotic, and metabolic profiles of its metabolites in humans.
PubMed:Fmoc-amino acid chlorides in solid phase synthesis of opioid peptides.
PubMed:Sodium pivalate treatment reduces tissue carnitines and enhances ketosis in rats.
PubMed:Metabolic effects of pivalate in isolated rat hepatocytes.
PubMed:[Antibiotics containing pivalic acid and carnitine deficiency. A report of the present status--therapeutic recommendations].
PubMed:Partial purification of esterases from rabbit serum and their use in regioselective deacylations of sugars.
PubMed:Carnitine supplementation in pivampicillin treatment.
PubMed:Evidence for acyloxymethyl esters of pyrimidine 5'-deoxyribonucleotides as extracellular sources of active 5'-deoxyribonucleotides in cultured cells.
PubMed:Carnitine deficiency induced by pivampicillin and pivmecillinam therapy.
PubMed:Characterization of apical and basolateral membrane conductances of rat inner medullary collecting duct.
PubMed:Potential tumor- or organ-imaging agents. 29. Radioiodinated esters and amides of 20-hydroxy- and 20-aminopregn-5-en-3 beta-ols.
PubMed:Identification and quantification of ethylene glycol and diethylene glycol in plasma using gas chromatography-mass spectrometry.
PubMed:Pivampicillin-promoted excretion of pivaloylcarnitine in humans.
PubMed:Improvement of the oral bioavailability of naltrexone in dogs: a prodrug approach.
PubMed:The simultaneous determination of chloroformates and phosgene at low concentrations in air using a solid sorbent sampling--gas chromatographic procedure.
PubMed:[Pharmacodynamics of etilfrine pivilate in the orthostatic syndrome].
PubMed:Carnitine and glucuronic acid conjugates of pivalic acid.
PubMed:Potential tumor or organ-imaging agents, 24. Radioiodinated pregnenolone esters.
PubMed:Metabolism of methyldopa in man after oral administration of the pivaloyloxyethyl ester.
PubMed:Comparison of ocular disposition of free pivalic acid and pivalic acid esterified in dipivefrin.
PubMed:Carcinogenicity of some pyrrolic pyrrolizidine alkaloid metabolites and analogues.
PubMed:Cytotoxicity of pivalylphenylephrine and pivalic acid to corneal endothelium.
PubMed:Dipivefrin: current concepts.
PubMed:Metabolism of quaternary carbon compounds: 2,2-dimethylheptane and tertbutylbenzene.
PubMed:The use of pivalic acid as a reference substance in measurements of production of volatile fatty acids by rumen micro-organisms in vitro.
PubMed:New inhibitors of methane production by rumen micro-organisms. Development and testing of inhibitors in vitro.
PubMed:New pivalic acid esters of synthetic corticosteroids with high local anti-inflammatory activity.
 
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