sodium trichloroacetate
acetic acid, 2,2,2-trichloro-, sodium salt (1:1)
 
Notes:
a strong acid used as a protein precipitant in clinical chemistry and also as a caustic for removing warts.
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sodium;2,2,2-trichloroacetate (Click)
CAS Number: 650-51-1Picture of molecule
ECHA EINECS - REACH Pre-Reg: 211-479-2
FDA UNII: 2N76A3BRJ0
Nikkaji Web: J74.800E
Beilstein Number: 3773249
MDL: MFCD00064198
Molecular Weight: 185.36616928
Formula: C2 Cl3 Na O2
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: antimicrobial agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Soluble in:
 water, 1.00E+06 mg/L @ 25 °C (exp)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antimicrobial agents
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Suppliers:
Santa Cruz Biotechnology
For experimental / research use only.
Sodium Trichloroacetate
Sigma-Aldrich: Aldrich
For experimental / research use only.
Sodium Trichloroacetate 97%
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-cat LD50  4000 mg/kg
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 32(1), Pg. 48, 1967.

oral-chicken LD50  4280 mg/kg
Down to Earth. Vol. 35, Pg. 25, 1979.

oral-guinea pig LD50  6000 mg/kg
BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 32(1), Pg. 48, 1967.

unreported-mammal (species unspecified) LD50  3300 mg/kg
"Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 121, 1971.

oral-mouse LD50  3600 mg/kg
Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 1061, 1966.

oral-rabbit LD50  6000 mg/kg
BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 32(1), Pg. 48, 1967.

oral-rat LD50  3320 mg/kg
Khimiya v Sel'skom Khozyaistve. Chemistry in Agriculture. Vol. 18(3), Pg. 46, 1980.

Dermal Toxicity:
skin-rabbit LD > 10100 mg/kg
BEHAVIORAL: FOOD INTAKE (ANIMAL)
National Technical Information Service. Vol. OTS0545852

skin-rat LD50 > 2000 mg/kg
"Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A377, Pg. 1983

Inhalation Toxicity:
inhalation-rat LC50 > 365000 mg/m3/4H
"Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc of Chemistry, 1983-86Vol. A377, Pg. 1983

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Safety in Use Information:
Category: antimicrobial agents
Recommendation for sodium trichloroacetate usage levels up to:
 not for fragrance use.
 
Recommendation for sodium trichloroacetate flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
NIOSH International Chemical Safety Cards: search
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
EPA Substance Registry Services (TSCA): 650-51-1
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 23681045
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 sodium;2,2,2-trichloroacetate
Chemidplus: 0000650511
RTECS: 650-51-1
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References:
 sodium;2,2,2-trichloroacetate
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 23681045
Pubchem (sid): 134976967
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C18808
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2915.40.5050
Haz-Map: View
ChemSpider: View
Formulations/Preparations:
•suspo-emulsion, water-dispersible granules, water-soluble powder •mixtures: (tca-sodium +) atrazine; amitrole + atrazine; diquat dibromide + simazine; amitrol + 2,4-d + mcpa; amitrole + 2,4-d + sodium chlorate.
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 acetic acid, 2,2,2-trichloro-, sodium salt (1:1)
 acetic acid, trichloro-, sodium salt
 ACP grass killer
 allied arcadian sodium TCA
 antiperz
 antyperz
 dow sodium TCA inhibited
 green cross couch grass killer
 natriumtrichlooracetaat
 natriumtrichloracetat
 sodio(tricloroacetato di)
 sodium (trichloracetate de)
 sodium TCA
 sodium TCA inhibited
 sodium trichloroacetic acid
 sodium;2,2,2-trichloroacetate
 TCA sodium
 TCA-sodium [ISO]
 trichloroacetic acid sodium salt
 varitox
 weedmaster grass killer
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Articles:
PubMed: Decarboxylative trichloromethylation of aromatic aldehydes and its applications in continuous flow.
PubMed: A secondary antibody format chemiluminescence immunoassay for the determination of estradiol in human serum.
PubMed: [The influence of halogenorganic compounds on radiation induced damage of rat eye lens components].
PubMed: Tethered dithiacyclopropenones. syntheses and structural properties of tetrathiacyclopropenonophanes.
PubMed: [Mechanisms of enhancing UV lihg-induced lipid peroxidation in isolated erythrocyte membranes by organohalogen compounds].
PubMed: Classical and biochemical endpoints in the evaluation of phytotoxic effects caused by the herbicide trichloroacetate.
PubMed: The reductive modulation of chloroplast fructose-1,6-bisphosphatase by tributylphosphine and sodium borohydride.
PubMed: Affinity purification and elimination of methionine oxidation in recombinant human cystatin C.
PubMed: Thermodynamic stability of the molten globule states of apomyoglobin.
PubMed: Structure and stability of a second molten globule intermediate in the apomyoglobin folding pathway.
PubMed: Dominant negative mutations of the guanylyl cyclase-A receptor. Extracellular domain deletion and catalytic domain point mutations.
PubMed: Perchlorate-induced formation of the alpha-helical structure of mastoparan.
PubMed: Enhancement of the reductive activation of chloroplast fructose-1,6-bisphosphatase by modulators and protein perturbants.
PubMed: Hydrocarbon biosynthesis in Triatoma infestans eggs.
PubMed: Inhibition of cuticular lipid synthesis and its effect on insect survival.
PubMed: Using different sorbents for the concentration of enteroviruses.
PubMed: Transcript mapping using [35S]DNA probes, trichloroacetate solvent and dideoxy sequencing ladders: a rapid method for identification of transcriptional start points.
PubMed: Dissociation of proteinase-inhibitor complexes by trichloroacetate.
PubMed: Simplified methods for isolation of ubiquitin from erythrocytes. Generation of ubiquitin polymers.
PubMed: Use of sodium trichloroacetate and mung bean nuclease to increase sensitivity and precision during transcript mapping.
PubMed: Methodology for enumeration of coliphages in foods.
PubMed: Modified membrane-filter procedure for concentration of enteroviruses from tap water.
PubMed: [Cytogenetic activity of the herbicide sodium trichloroacetate].
PubMed: A rapid method for preparation of bacterial plasmids.
PubMed: Method for recovery of enteric viruses from estuarine sediments with chaotropic agents.
PubMed: The influence of sodium trichloroacetate on the tryptophan fluorescence of sarcoplasmic reticulum ATPase.
PubMed: Purification of three iron-sulfur proteins from the iron-protein fragment of mitochondrial NADH-ubiquinone oxidoreductase.
PubMed: The cooperative role of the transformation-sensitive glycoproteins, GP140 and fibronectin, in cell attachment and spreading.
PubMed: Resolution of mitochondrial NADH dehydrogenase and isolation of two iron-sulfur proteins.
PubMed: alpha-Galactoside Binding Proteins from Plant Membranes: Isolation, Characterization, and Relation to Helminthosporoside Binding Proteins of Sugarcane.
PubMed: [Effect of sodium trichloroacetate on hydrochemical indices and on ichthyofauna].
PubMed: Immune and non-immune T4 radioassays utilizing albumin magnetic microparticles.
PubMed: Sodium trichloroacetate-induced helical conformation of poly(L-lysine).
PubMed: A simple and rapid radioimmunoassay of triiodothyronine in unextracted serum.
PubMed: [Determination of sodium trichloroacetate (TCA) in environmental objects and biosubstrates].
PubMed: Sodium trichloroacetate as a denaturation reagent for proteins.
PubMed: Glucosylation of teichoic acid: solubilization and partial characterization of the uridine diphosphoglucose: polyglycerolteichoic acid glucosyl transferase from membranes of Bacillus subtilis.
PubMed: The Effect of Sodium Trichloroacetate upon the Metabolism of Wheat Seedlings (Triticum Vulgare L.).
PubMed: Note on the Effect of Sodium Trichloroacetate on the Reduction of Copper Solutions by Glucose.
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