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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white crystals (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.97000 @ 25.00 °C.
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| Melting Point: | 123.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 307.00 °C. @ 760.00 mm Hg
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| Flash Point: | 263.00 °F. TCC ( 128.50 °C. ) (est)
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| logP (o/w): | 4.810 |
| Soluble in: |
| | water, 0.29 mg/L @ 25 °C (exp) | | | water, 4.285 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 6500 mg/kg
Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. Vol. 14, Pg. 227, 1979.
oral-mouse LD50 920 mg/kg
Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. Vol. 14, Pg. 227, 1979.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for trans-stilbene usage levels up to: | | | not for fragrance use.
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| Recommendation for trans-stilbene flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzene, 1,1'- (1,2-ethenediyl)bis-, (E)- | | | benzene, 1,1'-(1,2-ethenediyl)bis-, (E)- (9CI) | | | benzene, 1,1'-(1E)-1,2-ethenediylbis- | | | benzene, 1,1'-[(E)-1,2-ethenediyl]bis- | | trans- | bibenzylidene | | | dibenzal, (E)- | | | dibenzylidne, (E)- | | (E)-1,2- | diphenyl ethylene | | trans-1,2- | diphenyl ethylene | | (E)-1,2- | diphenylethene | | 1,trans-2- | diphenylethene | | trans- | diphenylethene | | trans-1,2- | diphenylethene | | 1,2- | diphenylethene, (E)- | | (E)-1,2- | diphenylethylene | | 1,trans-2- | diphenylethylene | | trans-1,2- | diphenylethylene | | trans-a,b- | diphenylethylene | | 1,2- | diphenylethylene (trans) | | 1,2- | diphenylethylene, trans | | 1,1'-(1,2- | ethanediyl)bis(benzene), (E)- | | 1,1'-(1,2- | ethanediyl)bis[benzene], trans | | 1,1'-(E)- | ethen-1,2-diyldibenzol | | 1,1'-[(E)-1,2- | ethendiyl]dibenzol | | (E)-1,1'-(1,2- | ethene diyl) bisbenzene | | 1,1'-[(1E)- | ethene-1,2-diyl]dibenzene | | 1,1'-(E)- | ethene-1,2-diyldibenzene | | (1,2- | ethenediyl)-1,1'-bisbenzene, (E)- | | (E)-1,1'-(1,2- | ethenediyl)bisbenzene | | 1,1'-[(E)-1,2- | ethenediyl]dibenzene | | ((E)-2- | phenylethenyl)benzene | | [(E)-2- | phenylethenyl]benzene | | ((1E)-2- | phenylvinyl)benzene | | (E)- | stilbene | | | stilbene, (E)- |
Articles:
| PubMed:Toward an understanding of the role of a catechol moiety in cancer chemoprevention: The case of copper- and o-quinone-dependent Nrf2 activation by a catechol-type resveratrol analog. |
| PubMed:Resveratrol and cardiovascular health--promising therapeutic or hopeless illusion? |
| PubMed:Preparation of chitosan-TPP microspheres as resveratrol carriers. |
| PubMed:Resveratrol down-regulates a glutamate-induced tissue plasminogen activator via Erk and AMPK/mTOR pathways in rat primary cortical neurons. |
| PubMed:Stilbene analogs of resveratrol improve insulin resistance through activation of AMPK. |
| PubMed:In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota. |
| PubMed:Resveratrol affects differently rat liver and brain mitochondrial bioenergetics and oxidative stress in vitro: investigation of the role of gender. |
| PubMed:Anti-obesity effect of resveratrol-amplified grape skin extracts on 3T3-L1 adipocytes differentiation. |
| PubMed:Piceatannol suppresses breast cancer cell invasion through the inhibition of MMP-9: involvement of PI3K/AKT and NF-κB pathways. |
| PubMed:A combination of resveratrol and melatonin exerts chemopreventive effects in N-methyl-N-nitrosourea-induced rat mammary carcinogenesis. |
| PubMed:3,4,4'-Trihydroxy-trans-stilbene, an analogue of resveratrol, is a potent antioxidant and cytotoxic agent. |
| PubMed:Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity. |
| PubMed:Structure-activity relationship of resveratrol and its analogue, 4,4'-dihydroxy-trans-stilbene, toward the endothelin axis in human endothelial cells. |
| PubMed:Extract of passion fruit (Passiflora edulis) seed containing high amounts of piceatannol inhibits melanogenesis and promotes collagen synthesis. |
| PubMed:Evaluation of anti-invasion effect of resveratrol and related methoxy analogues on human hepatocarcinoma cells. |
| PubMed:Physicochemical study of the complexation of pterostilbene by natural and modified cyclodextrins. |
| PubMed:Mechanisms of apoptotic effects induced by resveratrol, dibenzoylmethane, and their analogues on human lung carcinoma cells. |
| PubMed:Resveratrol analog-3,5,4'-trimethoxy-trans-stilbene inhibits invasion of human lung adenocarcinoma cells by suppressing the MAPK pathway and decreasing matrix metalloproteinase-2 expression. |
| PubMed:Structure-activity relationship and mechanism of the tocopherol-regenerating activity of resveratrol and its analogues. |
| PubMed:Thiomethylstilbenes as inhibitors of CYP1A1, CYP1A2 and CYP1B1 activities. |
| PubMed:The grape and wine constituent piceatannol inhibits proliferation of human bladder cancer cells via blocking cell cycle progression and inducing Fas/membrane bound Fas ligand-mediated apoptotic pathway. |
| PubMed:Antidiabetic properties of 2,5-dihydroxy-4,3'-di(beta-D-glucopyranosyloxy)-trans-stilbene from mulberry (Morus bombycis koidzumi) root in streptozotocin-induced diabetic rats. |
| PubMed:A pilot study of evaluation of the antioxidative activity of resveratrol and its analogue in a 6-month feeding test in young adult mice. |
| PubMed:Myricetin down-regulates phorbol ester-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking activation of nuclear factor kappa B. |
| PubMed:Oncogenicity evaluation of resveratrol in p53(+/-) (p53 knockout) mice. |
| PubMed:Antioxidant activity and inhibition of alpha-glucosidase by trans-resveratrol, piceid, and a novel trans-stilbene from the roots of Israeli Rumex bucephalophorus L. |
| PubMed:Structural basis for DNA-cleaving activity of resveratrol in the presence of Cu(II). |
| PubMed:Molecular mechanisms of the chemopreventive effects of resveratrol and its analogs in carcinogenesis. |
| PubMed:Metabolism and bioavailability of trans-resveratrol. |
| PubMed:A methoxy derivative of resveratrol analogue selectively induced activation of the mitochondrial apoptotic pathway in transformed fibroblasts. |
| PubMed:Structural basis for antioxidant activity of trans-resveratrol: ab initio calculations and crystal and molecular structure. |
| PubMed:The grape and wine polyphenol piceatannol is a potent inducer of apoptosis in human SK-Mel-28 melanoma cells. |
| PubMed:Grape polyphenol resveratrol and the related molecule 4-hydroxystilbene induce growth inhibition, apoptosis, S-phase arrest, and upregulation of cyclins A, E, and B1 in human SK-Mel-28 melanoma cells. |
| PubMed:Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. |
| PubMed:Resveratrol, a natural product derived from grapes, is a new inducer of differentiation in human myeloid leukemias. |
| PubMed:Mechanism of cardioprotection by resveratrol, a phenolic antioxidant present in red wine (Review). |
| PubMed:Evaluation of resveratrol derivatives as potential antioxidants and identification of a reaction product of resveratrol and 2, 2-diphenyl-1-picryhydrazyl radical. |
| PubMed:Fungitoxicity of chemical analogs with heartwood toxins. |
| PubMed:Epoxide-metabolizing enzymes in mammary gland and liver from BALB/c mice and effects of inducers on enzyme activity. |
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3D/inchi