EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

hydroxyproline
L-proline, 4-hydroxy-, (4S)-

Sponsors

Name:(2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid
CAS Number: 51-35-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-091-9
FDA UNII:RMB44WO89X
Nikkaji Web:J191.775G
Beilstein Number:081441
MDL:MFCD00064320
XlogP3-AA:-3.30 (est)
Molecular Weight:131.13133000
Formula:C5 H9 N O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:special dietary and nutritional additives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
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Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm: L-HYDROXYPROLINE
 
Physical Properties:
Appearance:white powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 274.00 °C. @ 760.00 mm Hg
Boiling Point: 355.00 to 356.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000001 mm/Hg @ 25.00 °C. (est)
Flash Point: 336.00 °F. TCC ( 168.60 °C. ) (est)
logP (o/w): -0.350 (est)
Soluble in:
 water, 361000 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antistatic agents
hair conditioning
skin conditioning
surfactants
 
Suppliers:
Aceto
L-Hydroxyproline
Glentham Life Sciences
trans-4-Hydroxy-L-proline
Sigma-Aldrich: Aldrich
For experimental / research use only.
trans-4-Hydroxy-L-proline ≥99%
TCI AMERICA
For experimental / research use only.
trans-4-Hydroxy-L-proline >99.0%(HPLC)(T)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: special dietary and nutritional additives
Recommendation for hydroxyproline usage levels up to:
 not for fragrance use.
 
Recommendation for hydroxyproline flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):51-35-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :440015
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid
Chemidplus:0000051354
 
References:
 (2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:51-35-4
Pubchem (cid):440015
Pubchem (sid):134972273
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
KEGG (GenomeNet):C01157
HMDB (The Human Metabolome Database):HMDB00725
YMDB (Yeast Metabolome Database):YMDB00723
Export Tariff Code:2933.99.9701
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 antistatic agents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
(2S,4S)-(-)-4-hydroxy-2-pyrrolidinecarboxylic acid
(2S,4S)-4-hydroxy-2-pyrrolidinecarboxylic acid
(4S)-4-hydroxy-L-prolin
(4S)-4-hydroxy-L-proline
trans-4-hydroxy-laevo-proline
L-hydroxyproline
L-4-hydroxyproline
laevo-4-hydroxyproline
(2S,4S)-(-)-4-hydroxypyrrolidine-2-carboxylic acid
(2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid
L-proline, 4-hydroxy-, (4S)-
 
 
Notes:
a hydroxylated form of the imino acid proline. a deficiency in ascorbic acid can result in impaired hydroxyproline formation.
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