EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

tolylene 2,4-diisocyanate
isocyanic acid, 4-methyl-m-phenylene ester (8CI)

Supplier Sponsors

Name:2,4-diisocyanato-1-methylbenzene
CAS Number: 584-84-9Picture of molecule3D/inchi
Other(deleted CASRN):1358624-38-0
ECHA EINECS - REACH Pre-Reg:209-544-5
FDA UNII: 17X7AFZ1GH
Nikkaji Web:J3.302B
Beilstein Number:0744602
MDL:MFCD00002011
XlogP3-AA:3.90 (est)
Molecular Weight:174.15922000
Formula:C9 H6 N2 O2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:indirect food additives: adhesives and components of coatings
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
DG SANTE Food Contact Materials:2,4-toluene diisocyanate
FDA Mainterm (IAUFC):584-84-9 ; TOLUENE 2,4-DIISOCYANATE
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.22500 @ 25.00 °C.
Flash Point: 250.00 °F. TCC ( 121.11 °C. )
Soluble in:
 water, 37.57 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Santa Cruz Biotechnology
For experimental / research use only.
Tolylene-2,4-diisocyanate ≥98%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Tolylene-2,4-diisocyanate 95%
Silver Fern Chemical
Toluene Diisocyanate (TDI)
Odor: characteristic
Use: Toluene Diisocyanate is primarily used as a chemical intermediate in the production of polyurenthane products. Most end-products are furniture, mattresses, and automotive seats. It can also be found in some coatings, sealants, and elastomers.
TCI AMERICA
For experimental / research use only.
Tolylene-2,4-diisocyanate >98.0%(GC)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-bird - wild LD50 100 mg/kg
Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.

intravenous-mouse LD50 56 mg/kg
U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#07807

oral-rat LD50 5800 mg/kg
GASTROINTESTINAL: OTHER CHANGES
AMA Archives of Industrial Health. Vol. 15, Pg. 324, 1957.

Dermal Toxicity:
skin-rabbit LD50 > 16 mL/kg
Union Carbide Data Sheet. Vol. 3/8/1973

Inhalation Toxicity:
inhalation-guinea pig LC50 13 ppm/4H
LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI LUNGS, THORAX, OR RESPIRATION: PLEURAL EFFUSION LUNGS, THORAX, OR RESPIRATION: CHANGES IN PULMONARY VASCULAR RESISTANCE
American Industrial Hygiene Association Journal. Vol. 23, Pg. 447, 1962.

inhalation-human TCLo 20 ppb/2Y
LUNGS, THORAX, OR RESPIRATION: COUGH LUNGS, THORAX, OR RESPIRATION: SPUTUM
Proceedings of the Royal Society of Medicine. Vol. 63, Pg. 372, 1970.

inhalation-human TCLo 80 ppb
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
Archiv fuer Toxikologie. Vol. 19, Pg. 364, 1962.

inhalation-human TCLo 500 ppb
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
Journal of Occupational Medicine. Vol. 1, Pg. 448, 1959.

inhalation-mouse LC50 10 ppm/4H
LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI LUNGS, THORAX, OR RESPIRATION: CHANGES IN PULMONARY VASCULAR RESISTANCE
American Industrial Hygiene Association Journal. Vol. 23, Pg. 447, 1962.

inhalation-rabbit LC50 11 ppm/4H
BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
American Industrial Hygiene Association Journal. Vol. 23, Pg. 447, 1962.

inhalation-rat LC50 14 ppm/4H
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: EXCITEMENT
American Industrial Hygiene Association Journal. Vol. 23, Pg. 447, 1962.

 
Safety in Use Information:
Category:
indirect food additives: adhesives and components of coatings
Recommendation for tolylene 2,4-diisocyanate usage levels up to:
 not for fragrance use.
 
Recommendation for tolylene 2,4-diisocyanate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):584-84-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :11443
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
2,4-diisocyanato-1-methylbenzene
Chemidplus:0000584849
EPA/NOAA CAMEO:hazardous materials
RTECS:584-84-9
 
References:
 2,4-diisocyanato-1-methylbenzene
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:584-84-9
Pubchem (cid):11443
Pubchem (sid):134978653
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2929.10.1000
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 benzene, 2,4-diisocyanato-1-methyl-
isocyanic acid, 4-methyl-m-phenylene ester (8CI)
2,4-diisocyanato-1-methylbenzene
2,4-diisocyanato-1-methylbenzene [toluenediisocyanates]
 hylene T
4-methyl-m-phenylene diisocyanate
 nacconate IOO
2,4-toluene diisocyanate
 
 
Notes:
None found
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