EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

sulfanilamide
benzenesulfonamide, 4-amino-

Supplier Sponsors

CAS Number: 63-74-1Picture of molecule3D/inchi
Other(deleted CASRN):102489-34-9
ECHA EINECS - REACH Pre-Reg:200-563-4
FDA UNII: 21240MF57M
Nikkaji Web:J4.829A
Beilstein Number:511852
MDL:MFCD00007939
XlogP3:-0.60 (est)
Molecular Weight:172.20716000
Formula:C6 H8 N2 O2 S
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 165.50 °C. @ 760.00 mm Hg
Boiling Point: 400.48 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000007 mmHg @ 25.00 °C. (est)
Flash Point: 385.00 °F. TCC ( 196.00 °C. ) (est)
logP (o/w): -0.620
Soluble in:
 water, 2.032e+005 mg/L @ 25 °C (est)
 water, 7500 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Sulfanilamide >98%
Odor: characteristic
Use: Sulfanilamide is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 nM.
EMD Millipore
For experimental / research use only.
Sulfanilamide
sds
Glentham Life Sciences
Sulfanilamide
Penta International
SULFANILAMIDE PURE
Santa Cruz Biotechnology
For experimental / research use only.
Sulfanilamide
Sigma-Aldrich
For experimental / research use only.
Sulfanilamide ≥99%
TCI AMERICA
For experimental / research use only.
Sulfanilamide >99.0%(HPLC)(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-dog LD50 2000 mg/kg
Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 1079, 1966.

oral-guinea pig LD50 3130 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 82, Pg. 86, 1944.

intraperitoneal-mouse LD50 5 mg/kg
Antibiotics Annual. Vol. 5, Pg. 886, 1957/1958.

intravenous-mouse LD50 500 mg/kg
Antibiotics Annual. Vol. 5, Pg. 972, 1957/1958.

oral-mouse LD50 3000 mg/kg
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 48, Pg. 336, 1952.

oral-rabbit LD50 1300 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 31(3), Pg. 11, 1966.

intravenous-rat LD50 1400 mg/kg
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 211, Pg. 367, 1950.

oral-rat LD50 3900 mg/kg
"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1072, 1986.

Dermal Toxicity:
subcutaneous-mouse LD50 2900 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 213, 1955.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for sulfanilamide usage levels up to:
 not for fragrance use.
 
Recommendation for sulfanilamide flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):63-74-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5333
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
4-aminobenzenesulfonamide
Chemidplus:0000063741
EPA/NOAA CAMEO:hazardous materials
RTECS:WO8400000 for cas# 63-74-1
 
References:
 4-aminobenzenesulfonamide
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:63-74-1
Pubchem (cid):5333
Pubchem (sid):134971810
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
UM BBD:Search
KEGG (GenomeNet):C07458
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2935.90.9500
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•marketed in combination with aminacrine hydrochloride and allantoin •avc cream contains sulfanilamide 15.0%, aminacrine hydrochloride 0.2% and allantoin 2.0% per tube •avcdienestrol cream contains constituents of avc cream with 0.01% dienestrol in a water miscible base each 4 oz tube •avc suppositories contain sulfanilamide 1.05 g, aminacrine hydrochloride 0.014 g and allantoin 0.14 g per suppository •avcdienestrol suppositories contain constituents of avc suppositories with 0.70 mg dienestrol
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 albexan
 albosal
 ambeside
p-amino-benzene-sulfonamide
p-aminobenzenesulfamide
4-aminobenzenesulfonamide
p-aminobenzenesulfonamide
p-aminobenzenesulfonylamide
4-aminobenzenesulphonamide
p-aminobenzensulfonamide
4-aminophenylsulfonamide
p-aminophenylsulfonamide
 aniline-p-sulfonic amide
p-anilinesulfonamide
 antistrept
 astreptine
 bacteramid
 benzenesulfonamide, 4-amino-
 benzenesulfonamide, p-amino-
 collomide
 colsulanyde
 copticide
 deseptyl
 desseptyl
 ergaseptine
 erysipan
 estreptocida
 exoseptoplix
 fourneau 1162
 gombardol
 lysococcine
 neococcyl
 orgaseptine
 prontalbin
 prontosil I
 prontylin
 proseptal
 proseptine
 proseptol
 pysococcine
 rubiazol A
 septanilam
 septolix
 septoplix
 strepamide
 streptozone
 streptrocide
p-sulfamidoaniline
 sulfamidyl
4-sulfamoylaniline
p-sulfamoylaniline
 sulfanilamine
 sulfonamide P
 sulphanilamide
 therapol
 

Articles:

Info:Sulfanilamide
PubMed:Biofilm formation in Haemophilus parasuis: relationship with antibiotic resistance, serotype and genetic typing.
PubMed:Confirmation of 13 sulfonamides in honey by liquid chromatography-tandem mass spectrometry for monitoring plans: validation according to European Union Decision 2002/657/EC.
PubMed:Biocompatibility and antibacterial activity of photolytic products of sulfonamides.
PubMed:Development and validation of a procedure for determination of sulfonamide residues in pasteurized milk using modified QuEChERS method and liquid chromatography/tandem mass spectrometry.
PubMed:Evaluation and validation of two microbiological tests for screening antibiotic residues in honey according to the European guideline for the validation of screening methods.
PubMed:Two centuries of assessing drug risks.
PubMed:Validation of a commercial receptor kit Sulfasensor Honey for the screening of sulfonamides in honey according to Commission Decision 2002/657/EC.
PubMed:Rapid and sensitive determination of sulfonamide residues in milk and chicken muscle by microfluidic chip electrophoresis.
PubMed:Purification of carbonic anhydrase-II from sheep liver and inhibitory effects of some heavy metals on enzyme activity.
PubMed:Development of a high performance liquid chromatography method and a liquid chromatography-tandem mass spectrometry method with the pressurized liquid extraction for the quantification and confirmation of sulfonamides in the foods of animal origin.
PubMed:Effect of acid stress, antibiotic resistance, and heat shock on the resistance of Listeria monocytogenes to UV light when suspended in distilled water and fresh brine.
PubMed:Modification of AOAC method 973.31 for determination of nitrite in cured meats.
PubMed:A simplified approach to the determination of N-nitroso glyphosate in technical glyphosate using HPLC with post-derivatization and colorimetric detection.
PubMed:Pressurized liquid extraction combined with capillary electrophoresis-mass spectrometry as an improved methodology for the determination of sulfonamide residues in meat.
PubMed:Simultaneous determination of 17 sulfonamides and the potentiators ormetoprim and trimethoprim in salmon muscle by liquid chromatography with tandem mass spectrometry detection.
PubMed:Multiresidue determination of sulfonamides in edible catfish, shrimp and salmon tissues by high-performance liquid chromatography with postcolumn derivatization and fluorescence detection.
PubMed:Evaluation of three 2-thiobarbituric acid methods for the measurement of lipid oxidation in various meats and meat products.
PubMed:Lessons unlearned.
PubMed:Contamination of honey by the herbicide asulam and its antibacterial active metabolite sulfanilamide.
PubMed:Generation of group-specific antibodies against sulfonamides.
PubMed:Generation of class-selective monoclonal antibodies against the penicillin group.
PubMed:Frances Oldham Kelsey. FDA medical reviewer leaves her mark on history.
PubMed:Analysis of tea shoot catechins: spectrophotometric quantitation and selective visualization on two-dimensional paper chromatograms using diazotized sulfanilamide.
PubMed:Determination of sulfonamides in edible salmon tissue by liquid chromatography with postcolumn derivatization and fluorescence detection.
PubMed:Elixirs, diluents, and the passage of the 1938 Federal Food, Drug and Cosmetic Act.
PubMed:Elixir sulfanilamide-Massengill revisited.
PubMed:Determination of nitrate in vegetables by continuous flow: interlaboratory study.
PubMed:The performance of the local lymph node assay with chemicals identified as contact allergens in the human maximization test.
PubMed:Confirmatory method for sulfonamide residues in animal tissues by gas chromatography and pulsed positive ion-negative ion-chemical ionization mass spectrometry.
PubMed:High-performance liquid chromatography-thermospray mass spectrometry of ten sulfonamide antibiotics. Analysis in milk at the ppb level.
PubMed:Are newer scientific concepts in regulatory toxicology used timely and appropriately?
PubMed:Formation of triazene from sulphonamide and nitrite in acidic solution.
PubMed:Effect of pH on absorbance of azo dye formed by reaction between nitrite and sulfanilamide/N-(1-naphthyl)ethylenediamine in residual nitrite methods for foods.
PubMed:Comparison of chemiluminescent and AOAC methods for determining nitrite in commercial cured meat products.
PubMed:An h.p.l.c. method for the quantitative determination of asulam, acetylasulam and sulphanilamide in peaches.
PubMed:UV light-induced survival response in a highly radiation-resistant isolate of the Moraxella-Acinetobacter group.
PubMed:Sensitive gas-liquid chromatographic method for asulam residues in peaches.
PubMed:[Investigations on the effect of the combination sulfamoxole/trimethoprim on fertility and fetal development in rats and rabbits (author's tranls)].
PubMed:[Toxicological investigations of the combination sulfamoxole/trimethoprim, a new broad-spectrum chemotherapeutic (author's transl)].
 
Notes:
None found
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