sodium phosphate monobasic
phosphoric acid, sodium salt (2:3)
 
Notes:
Used in foods as a dry acidulant, buffering agent, emulsifier, leavening agent, protein modifier, sequestrant and nutrient supplement
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sodium dihydrogen phosphate (Click)
CAS Number: 7558-80-7Picture of molecule
ECHA EINECS - REACH Pre-Reg: 231-449-2
FDA UNII: KH7I04HPUU
MDL: MFCD00003527
Molecular Weight: 119.97627128
Formula: H2 Na O4 P
NMR Predictor: Predict (works with chrome or firefox)
Category: acidity regulators, sequestrants
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
1975 Sodium phosphate monobasic View-review
EU SANCO Sodium phosphates View-review
JECFA Food Additive: Sodium Dihydrogen Phosphate
GSFA Codex: Sodium dihydrogen phosphate (339(i))
DG SANTE Food Additives: sodium phosphate monobasic
FDA Mainterm: SODIUM PHOSPHATE, MONOBASIC
FDA Regulation:
FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.169 Pasteurized process cheese.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.173 Pasteurized process cheese food.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.179 Pasteurized process cheese spread.


FDA PART 150 -- FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products
Sec. 150.141 Artificially sweetened fruit jelly.


FDA PART 150 -- FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products
Sec. 150.161 Artificially sweetened fruit preserves and jams.


FDA PART 160 -- EGGS AND EGG PRODUCTS
Subpart B--Requirements for Specific Standardized Eggs and Egg Products
Sec. 160.110 Frozen eggs.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart I--Multipurpose Additives
Sec. 172.892 Food starch-modified.


FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart D--Specific Usage Additives
Sec. 173.310 Boiler water additives.


FDA PART 178 -- INDIRECT FOOD ADDITIVES: ADJUVANTS, PRODUCTION AIDS, AND SANITIZERS
Subpart B--Substances Utilized To Control the Growth of Microorganisms
Sec. 178.1010 Sanitizing solutions.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart B--Multiple Purpose GRAS Food Substances
Sec. 182.1778 Sodium phosphate.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart G--Sequestrants1
Sec. 182.6085 Sodium acid phosphate.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart G--Sequestrants1
Sec. 182.6778 Sodium phosphate.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart I--Nutrients
Sec. 182.8778 Sodium phosphate.


FDA PART 73 -- LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION
Subpart A--Foods
Sec. 73.85 Caramel.
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Physical Properties:
Appearance: white crystalline powder (est)
Assay: 97.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 158.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 1.410000 mm/Hg @ 25.00 °C. (est)
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -2.148 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Insoluble in:
 alcohol
 ether
 chloroform
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Organoleptic Properties:
Odor Description:
at 100.00 %. 
odorless
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: buffering agents
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Suppliers:
Allan Chemical
Monosodium Phosphate Anhydrous
American Elements
Sodium Phosphate Monobasic Anhydrous 99%
Odor: characteristic
Use: Sodium Phosphate Monobasic Anhydrous is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
American International Chemical
Sodium Phosphate
Charkit Chemical
MONOSODIUM PHOSPHATE ANHYDROUS FCC
Dow Chemical
Sodium Phos Monobasic Anhydrous USP
Foodchem International
Monosodium Phosphate
Graham Chemical
MonoSodium Phosphate
Jost Chemical
Sodium Phosphate Monobasic Anhydrous USP Granular
Lianyungang Yunbo Chemical
MONOSODIUM PHOSPHATE
Penta International
SODIUM PHOSPHATE MONOBASIC ANHYDROUS FCC, Kosher
Penta International
SODIUM PHOSPHATE MONOBASIC ANHYDROUS POWDER USP
Prinova
Monosodium Phosphate
Santa Cruz Biotechnology
For experimental / research use only.
Sodium phosphate monobasic, anhydrous ≥99%
Sigma-Aldrich
For experimental / research use only.
Sodium phosphate monobasic ReagentPlus®, ≥99.0%
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intramuscular-rat LD50  250 mg/kg
Experimental Medicine and Surgery. Vol. 4, Pg. 223, 1946.

oral-rat LD50  8290 mg/kg
"Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972Vol. -, Pg. 16, 1972.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: acidity regulators, sequestrants
Recommendation for sodium phosphate monobasic usage levels up to:
 not for fragrance use.
 
Recommendation for sodium phosphate monobasic flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on the safety evaluation of the active substances, iron, polyethyleneglycol, disodium pyrophosphate, monosodium phosphate and sodium chloride for use in food contact materials
View page or View pdf
Assessment of one published review on health risks associated with phosphate additives in food
View page or View pdf
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
NLM Hazardous Substances Data Bank: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 7558-80-7
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 23672064
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
 sodium dihydrogen phosphate
Chemidplus: 0007558807
RTECS: WA1900000 for cas# 7558-80-7
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References:
 sodium dihydrogen phosphate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 7558-80-7
Pubchem (cid): 23672064
Pubchem (sid): 134986681
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
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tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
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CHEBI: View
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KEGG (GenomeNet): D04400
HMDB (The Human Metabolome Database): Search
FooDB: FDB013365
Export Tariff Code: 2835.22.0000
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Formulations/Preparations:
•combinations include sodium phosphate & sodium biphosphate enema, usp dosage forms-- enema, usp; 6% sodium phosphate & 16% sodium biphosphate; sodium phosphate & sodium biphosphate oral soln, uspdosage forms-- soln, usp: 18% sodium phosphate & 48% sodium biphosphate. •fleet's enema: soln (sodium phosphate 6 g & sodium biphosphate 16 g). fleet's phospho-soda: (sodium phosphate 18 g & sodium biphosphate 48 g). sodium phosphate & sodium biphosphate- from table •sodium phosphates injection, usp, 3 mm pml (millimolesml)each ml contains 276 mg of monobasic sodium phosphate, monohydrate and 142 mg of dibasic sodium phosphate, anhydrous (equivalent to 268 mg of dibasic sodium phosphate, heptahydrate). it contains no bacteriostat, antimicrobial agent or added buffer. •purity: it is about 99% pure. •purity: theoretically contains about 26% phosphorus, but good grades only contain about 22%. •grades: commercial; food; fcc food chemicals codex sodium dihydrogen phosphate anhydrous; nf national formulary sodium dihydrogen phosphate monohydrate •sodium phosphate preparations: (ahfs, 2009) sodium phosphate preparations: (ahfs, 2009) route dosage form strength brand or generic name (manufacturer) tablet dibasic sodium phosphate (anhydrous) 0.398 g with monobasic sodium phosphate (monohydrate) 1.102 g osmoprep (salix) tablet dibasic sodium phosphate (anhydrous) 0.398 g with monobasic sodium phosphate (monohydrate) 1.102 g visicol (salix) rectal solution dibasic sodium phosphate 60 mgml with monobasic sodium phosphate 160 mgml fleet enema (fleet) rectal solution dibasic sodium phosphate 60 mgml with monobasic sodium phosphate 160 mgml fleet pediatric enema (fleet)
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 buffering agents 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 phosphoric acid sodium salt (1:1)
 phosphoric acid sodium salt (1:3)
 phosphoric acid, monosodium salt
 phosphoric acid, sodium salt
 phosphoric acid, sodium salt (2:3)
 sodium acid phosphate
 sodium dihydrogen monophosphate
monosodium dihydrogen orthophosphate
 sodium dihydrogen phosphate
monosodium dihydrogen phosphate
 sodium dihydrogenorthophosphate
monosodium hydrogen phosphate
 sodium hydrogen phosphate (1:2:1)
 sodium monobasic phosphate (NaH2PO4)
monosodium orthophosphate
monosodium phosphate
monobasic sodium phosphate
 sodiumdihydrogenorthophosphate
monosodiumphosphate
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PubMed: Formulation and evaluation of pharmaceutically equivalent parenteral depot suspension of methyl prednisolone acetate.
PubMed: Optimisation of the mechanical and handling properties of an injectable calcium phosphate cement.
PubMed: Determination of dopamine, serotonin, and their metabolites in pediatric cerebrospinal fluid by isocratic high performance liquid chromatography coupled with electrochemical detection.
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PubMed: Simple, economical, and reproducible LC-MS method for the determination of amoxicillin in human plasma and its application to a pharmacokinetic study.
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PubMed: [Study on bioavilability of oxymatrine-phospholipid complex in rats].
PubMed: Effect of buffer and antioxidant on stability of a mercaptopurine suspension.
PubMed: Development of a high performance size exclusion chromatography method to determine the stability of Human Serum Albumin in a lyophilized formulation of Interferon alfa-2b.
PubMed: Effect of intravenous calcium and oral sodium phosphate in cows with parturient paresis.
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PubMed: Determination of tetracyclines in ovine milk by high-performance liquid chromatography with a coulometric electrode array system.
PubMed: Determination of icariin and metabolites in rat serum by capillary zone electrophoresis: rat pharmacokinetic studies after administration of icariin.
PubMed: [Study on the determination of piperazinylethylestrone].
PubMed: Investigations on the availability of inorganic phosphate from different sources with growing White Pekin ducks.
PubMed: Hydrolysis of dicalcium phosphate dihydrate to hydroxyapatite.
PubMed: Liquid chromatography determination of the anti-androgen vinclozolin and its metabolites in rat serum.
PubMed: Resistotyping of Campylobacter jejuni.
PubMed: Effects of neutral sodium hydrogen phosphate on the setting property and hemostatic ability of hydroxyapatite putty as a local hemostatic agent for bone.
PubMed: The effect of an admixture of sodium hydrogen phosphate or heparin-coating to poly(D,L)lactide--results of an animal study.
PubMed: Premixed calcium-phosphate cement pastes.
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PubMed: Phosphate recovery from sewage sludge in combination with supercritical water oxidation.
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PubMed: Simultaneous LC determination of tiazofurin, its acetyl and benzoyl esters and their active metabolite thiazole-4-carboxamide adenine dinucleotide in biological samples.
PubMed: Surface properties of calcium phosphate particles for self setting bone cements.
PubMed: The Ca/P range of nanoapatitic calcium phosphate cements.
PubMed: Study of a hydraulic dicalcium phosphate dihydrate/calcium oxide-based cement for dental applications.
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PubMed: LC determination and degradation study of droperidol.
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