selenium sulfide
selane, thioxo-, sulfide
 
Notes:
None found
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CAS Number: 7488-56-4Picture of molecule
Other: 12299-46-6
ECHA EINECS - REACH Pre-Reg: 231-303-8
FDA UNII: Z69D9E381Q
MDL: MFCD00011227
Molecular Weight: 143.09000000
Formula: S2 Se
Category: antidandruff agents
 
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Physical Properties:
Appearance: orange powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antidandruff agents
hair conditioning
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Suppliers:
Sigma-Aldrich: Aldrich
For experimental / research use only.
Selenium Sulfide
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  138 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toxicology and Applied Pharmacology. Vol. 20, Pg. 89, 1971.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antidandruff agents
Recommendation for selenium sulfide usage levels up to:
 not for fragrance use.
 
Recommendation for selenium sulfide flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
NLM Hazardous Substances Data Bank: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA GENetic TOXicology: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 7488-56-4
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 24087
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
Chemidplus: 0007488564
EPA/NOAA CAMEO: hazardous materials
RTECS: VS8925000 for cas# 7488-56-4
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References:
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 7488-56-4
Pubchem (cid): 24087
Pubchem (sid): 134987406
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
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(IUPAC): Periodic Table of the Elements
CHEMBL: View
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2813.90.5000
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ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Formulations/Preparations:
•grade: usp •seleen suspension liquid (topical) (merial ltd): selenium disulfide, 0.9% ww and 1% wv. •se s2 shampoo liquid (suspension) (topical ) (schering-plough animal health corp): selenium disulfide, 0.9% ww •dandrex liquid (suspension) (topical) (farnam companies, inc.): selenium disulfide, 0.9% ww and 1% wv •selenium sulfide is the active ingredient in several pharmaceutical & cosmetic products, including prescription drug for treatment of dandruff & non-prescription dandruff shampoo . •preparations: lotion shampoo, 1% and 2.5%. •a dandruff shampoo containing 1 percent selenium sulfide is available without prescription and is recommended for use once or twice a week. by prescription, a shampoo or lotion containing 2.5 percent selenium sulfide is available, with the recommended application limited to ten minutes for seven days to avoid the possibility of acute toxic effects. also, a 2.5 percent aqueous suspension of the chemical is approved for marketing by prescription for treatment of tinea versicolor fungal infection (fda communication). additionally, selenium sulfide is used topically in veterinary medicine for eczemas and dermatomycoses. selenium sulfide preparations route of exposure dosage form strength brand or generic name (manufacturer) topical lotion 1% selsun blue (chattem) topical lotion 1% selsun gold for women (chattem) topical lotion 2.5% selsun rx (chattem)
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 antidandruff agents 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 selane, thioxo-, sulfide
 selenium disulfide
 selenium disulfide [UN2657] [Poison]
 selenium disulphide
 selenium sulfide (SeS2)
 sulfur selenide
 thioxoselane sulfide
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Articles:
PubMed: Current and Emerging Therapeutic Strategies for the Treatment of Meibomian Gland Dysfunction (MGD).
PubMed: Seborrhoeic dermatitis of the scalp.
PubMed: Pityrosporum folliculitis in an immunocompetent patient: clinical case description.
PubMed: Comparative alternative materials assessment to screen toxicity hazards in the life cycle of CIGS thin film photovoltaics.
PubMed: Selenium sulfide.
PubMed: In vitro and in vivo percutaneous absorption of seleno-L-methionine, an antioxidant agent, and other selenium species.
PubMed: Scalp discoloration from selenium sulfide shampoo: a case series and review of the literature.
PubMed: The elimination of selenium(IV) from aqueous solution by precipitation with sodium sulfide.
PubMed: A randomized, double-blind study comparing the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children.
PubMed: Inflammatory tinea capitis: non-healing plaque on the occiput of a 4-year-old child.
PubMed: Progressive macular hypomelanosis arising in a young African American woman in association with pregnancy and a toxic nodular goiter.
PubMed: Tinea capitis: predictive value of symptoms and time to cure with griseofulvin treatment.
PubMed: Xanthotrichia (yellow hair) due to selenium sulfide and dihydroxyacetone.
PubMed: Sequential solvent extraction for the modes of occurrence of selenium in coals of different ranks from the Huaibei Coalfield, China.
PubMed: Confluent and reticulated papillomatosis : a review of the literature.
PubMed: [Modern management of dandruff].
PubMed: Tinea versicolor mimicking pityriasis rubra pilaris.
PubMed: Selenium sulfide.
PubMed: A double-blind comparative study of sodium sulfacetamide lotion 10% versus selenium sulfide lotion 2.5% in the treatment of pityriasis (tinea) versicolor.
PubMed: New treatments for tinea capitis.
PubMed: Therapeutic options in the treatment of tinea capitis.
PubMed: Selenium sulfide.
PubMed: Common hyperpigmentation disorders in adults: Part II. Melanoma, seborrheic keratoses, acanthosis nigricans, melasma, diabetic dermopathy, tinea versicolor, and postinflammatory hyperpigmentation.
PubMed: Tinea capitis due to Trichophyton soudanense in Cincinnati, Ohio, in internationally adopted children from Liberia.
PubMed: Tinea capitis: epidemiology, diagnosis and management strategies.
PubMed: Determination of selenium sulfide using 1,3-dibromo-5,5-dimethylhydantoin (DBH). Analytical methods of pharmacopeias with DBH in respect to environmental and economical concern Part 11.
PubMed: Management of seborrheic dermatitis and pityriasis versicolor.
PubMed: Treatment of seborrheic dermatitis.
PubMed: Successful treatment of tinea capitis with 2% ketoconazole shampoo.
PubMed: Clinical features and treatment of Malassezia folliculitis with fluconazole in orthotopic heart transplant recipients.
PubMed: Trace element content of commercial shampoos: impact on trace element levels in hair.
PubMed: Selenium.
PubMed: Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: a randomized controlled trial. MIN. VIT. AOX. geriatric network.
PubMed: Efficacy of itraconazole in children with Trichophyton tonsurans tinea capitis.
PubMed: Green hair discoloration due to selenium sulfide.
PubMed: Treatment of tinea capitis.
PubMed: Topical antifungal agents: an update.
PubMed: Hyperpigmentation associated with selenium sulfide lotion.
PubMed: Diagnosis and treatment of tinea versicolor.
PubMed: Outbreak of Tinea capitis caused by Microsporum ferrugineum in Thailand.
PubMed: Genotoxicity evaluation of selenium sulfide in in vivo and in vivo/in vitro micronucleus and chromosome aberration assays.
PubMed: Superficial fungal infections. Getting rid of lesions that don't want to go away.
PubMed: Comparison of 1% and 2.5% selenium sulfide in the treatment of tinea capitis.
PubMed: A case report of the management of demodicosis in the golden hamster.
PubMed: Comparison of results from mouse bone marrow chromosome aberration and micronucleus tests.
PubMed: Tinea capitis: epidemiology, diagnosis, treatment, and control.
PubMed: Dose-response relationship for rat liver DNA damage caused by 49 rodent carcinogens.
PubMed: A randomized, double-blind, placebo-controlled trial of ketoconazole 2% shampoo versus selenium sulfide 2.5% shampoo in the treatment of moderate to severe dandruff.
PubMed: Dermatophytosis of children in Kuwait: a prospective survey.
PubMed: Lack of serum selenium rise after overnight application of selenium sulfide.
PubMed: Increased levels of S-adenosylmethionine in the livers of rats fed various forms of selenium.
PubMed: Superficial fungal infections of the skin. Diagnosis and current treatment recommendations.
PubMed: Itraconazole in tinea versicolor: a review.
PubMed: The in vitro antifungal activity of ketoconazole, zinc pyrithione, and selenium sulfide against Pityrosporum and their efficacy as a shampoo in the treatment of experimental pityrosporosis in guinea pigs.
PubMed: Nail pigmentation resulting from selenium sulfide and copper.
PubMed: Volatilization of Selenium by Alternaria alternata.
PubMed: Measurement of unscheduled DNA synthesis and S-phase synthesis in rodent hepatocytes following in vivo treatment: testing of 24 compounds.
PubMed: The infected hairs of tinea capitis due to Microsporum canis: demonstration of uniqueness of the hair cuticle by scanning electron microscopy.
PubMed: Rapid response of transient acantholytic dermatosis to selenium sulfide treatment for pityriasis versicolor.
PubMed: Randomized comparative clinical trial of itraconazole and selenium sulfide shampoo for the treatment of pityriasis versicolor.
PubMed: Confluent and reticulated papillomatosis responsive to selenium sulfide.
PubMed: Confluent and reticulated papillomatosis of Gougerot and Carteaud: treatment with selenium sulfide lotion.
PubMed: Current treatment of cutaneous Pityrosporum and Candida-infections.
PubMed: Pityrosporum folliculitis: a common disease of the young and middle-aged.
PubMed: Selenium sulfide in tinea versicolor: blood and urine levels.
PubMed: Double-blind efficacy study of selenium sulfide in tinea versicolor.
PubMed: Doxorubicin (adriamycin) cardiomyopathy.
PubMed: A comparison of miconazole nitrate and selenium disulfide as anti-dandruff agents.
PubMed: [Clinical experience with a shampoo containing a suspension of 1% selenium sulfide].
PubMed: Antifungal activity of dermatological shampoos.
PubMed: Selenium sulfide: adjunctive therapy for tinea capitis.
PubMed: The safety of selenium sulfide, and other news from Washington.
PubMed: Bioassay of Selenium Sulfide (Gavage) for Possible Carcinogenicity (CAS No. 7446-34-6).
PubMed: Bioassay of Selenium Sulfide (Dermal Study) for Possible Carcinogenicity (CAS No. 7446-34-6).
PubMed: Bioassay of Selsun(R) for Possible Carcinogenicity.
PubMed: Confluent and reticulated papillomatosis (Gougerot-Carteaud).
PubMed: Role of microorganisms in dandruff.
PubMed: [Levels of selenium in urine after treatment of pityriasis versicolor with a 1.0% selenium sulfide].
PubMed: Selenium sulfide treatment of tinea flava in elementary school children.
PubMed: Safety evaluation of selenium sulfide antidandruff shampoos.
PubMed: [On the absorption and toxicity of selenium sulfide].
PubMed: Increased sebum secretion following selenium sulfide shampoos.
PubMed: Rapid treatment of tinea versicolor with selenium sulfide.
PubMed: [Selenium sulfide and its medicinal forms].
PubMed: [Selenium sulfide in the treatment of seborrhea].
PubMed: Selenium sulfide intoxication.
PubMed: Effect of selenium sulfide suspension on hair roots.
PubMed: [Use of selenium sulfide in the treatment of blepharitis].
PubMed: Observations on the use of selenium sulfide and hydrocortisone ointment.
PubMed: Selenium sulfide in treatment of pityriasis versicolor.
PubMed: [Use of selenium sulfide in blepharitis squamosa].
PubMed: Contact dermatitis from selenium sulfide shampoo.
PubMed: Use of selenium sulfide shampoo in seborrheic dermatitis.
PubMed: Selenium sulfide ointment in the treatment of seborrheic dermatitis of the glabrous skin; preliminary report.
PubMed: On the mode of action of selenium sulfide.
PubMed: NEW and nonofficial remedies: selenium sulfide.
PubMed: Treatment of seborrheic dermatitis ("dandruff") with selenium sulfide suspension.
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